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1,813 results for “outcome study”
Registry to Assess Long-term Outcome in HIV Subjects Who Participated in Phase 2 and 3 Clinical Trials Involving Vicriviroc (Study P04999)
ClinicalTrials.gov study NCT00705419. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Relationship of Point-of-care Coagulation Assays with Clinical Outcomes in Cardiac Surgery: a Retrospective Cohort Study
ClinicalTrials.gov study NCT06882759. IPD Sharing: NO. Countries: 0. Publications: 0.
Outcomes of mCRPC Patients Treated With Ra-223 Concomitant With Abiraterone or Enzalutamide- A Chart Review Study
ClinicalTrials.gov study NCT03325127. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Molecular analysis of gastric cancer identifies discrete subtypes associated with distinct clinical characteristics and survival outcomes: the ACRG (Asian Cancer Research Group) study
GEO Series GSE66229. Homo sapiens. 400 samples. Type: Expression profiling by array.
RUNX1 mutated cases in acute myeloid leukemia share a distinct biological subgroup and are associated with inferior outcome. Results of the AML Study Group (AMLSG).
GEO Series GSE23312. Homo sapiens. 269 samples. Type: Expression profiling by array.
Molecular analysis of gastric cancer identifies discrete subtypes associated with distinct clinical characteristics and survival outcomes: the ACRG (Asian Cancer Research Group) study [gastric tumors]
GEO Series GSE62254. Homo sapiens. 300 samples. Type: Expression profiling by array.
Health outcomes in SARS survivors 18 years after infection: A longitudinal cohort study
GEO Series GSE216357. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Analysis of endometrial mRNA in patients with different pregnancy outcomes after immunotherapy: A cohort study
GEO Series GSE272778. Homo sapiens. 29 samples. Type: Expression profiling by high throughput sequencing.
Perioperative Testosterone Supplementation Improves Short-Term Outcomes of Anterior Urethroplasty in Hypogonadal Models: Insights from a Preclinical Rabbit Study
GEO Series GSE292557. Oryctolagus cuniculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Re-irradiation for recurrent glioma: outcome evaluation, toxicity and prognostic factors assessment. A multicenter study of the Radiation Oncology Italian Association (AIRO)"
<p>Abstract</p> <p>INTRODUCTION:</p> <p>The prognosis of glioma is dismal, and almost all patients relapsed. At recurrence time, several treatment options are considered, but to date there is no a standard of care. The Neurooncology Study Group of the Italian Association of Radiation Oncology (AIRO) collected clinical data regarding a large series of recurrent glioma patients who underwent re-irradiation (re-RT) in Italy.</p> <p>METHODS:</p> <p>Data regarding 300 recurrent glioma patients treated from May 2002 to November 2017, were analyzed. All patients underwent re-RT. Surgical resection, followed by re-RT with concomitant and adjuvant chemotherapy was performed. Clinical outcome was evaluated by neurological examination and brain MRI performed, 1 month after radiation therapy and then every 3 months.</p> <p>RESULTS:</p> <p>Re-irradiation was performed at a median interval time (IT) of 16 months from the first RT. Surgical resection before re-RT was performed in 19% of patients, concomitant temozolomide (TMZ) in 16.3%, and maintenance chemotherapy in 29%. Total doses ranged from 9 Gy to 52.5 Gy, with a median biological effective dose of 43 Gy. The median, 1, 2 year OS were 9.7 months, 41% and 17.7%. Low grade glioma histology (p  ≪ 0.01), IT > 12 months (p = 0.001), KPS > 70 (p = 0.004), younger age (p = 0.001), high total doses delivered (p = 0.04), and combined treatment performed (p = 0.0008) were recorded as conditioning survival.</p> <p>CONCLUSION:</p> <p>our data underline re-RT as a safe and feasible treatment with limited rate of toxicity, and a combined ones as a better option for selected patients. The identification of a BED threshold able to obtain a greater benefit on OS, can help in designing future prospective studies.</p>
Dataset related to article "The 70-year-old newly diagnosed glioblastoma patients are older thanthe 65-year-old? Outcome evaluation of the two categories in a matchedcase control study with propensity score balancing"
<p>This record contains raw data related to article “The 70-year-old newly diagnosed glioblastoma patients are older thanthe 65-year-old? Outcome evaluation of the two categories in a matchedcase control study with propensity score balancing"</p> <p>Background: The standard of care for elderly, newly-diagnosed glioblastoma patients consists, if feasible,</p> <p>of surgical resection followed by a short course of radiation therapy (RT) with concomitant and adjuvant</p> <p>temozolomide chemotherapy (TMZCHT). To date, the literature lacks of consistence in the definition of</p> <p>elderly, if older than 65 years, or 70 years. Aim of this study was to explore whether differences exist</p> <p>between these two cohorts, comparing outcomes using a propensity score matched analysis (PSM).</p> <p>Conclusions: The PSM analyses showed a similar outcome in 65–69-year old patients compared to older</p> <p>ones notwithstanding a more burdensome RT schedule. Hypofractionated RT treatment has to be considered</p> <p>also in this group of younger elderly, newly-diagnosed GBM patients.</p>
A comparative assessment of the BioBiteCorrector® and Herbst appliances in the treatment of Class II malocclusion: a retrospective cohort study on treatment outcome
<p>Dataset for all analyses. Initially, access will be given to editor/reviewers for the peer review process. After publication, the dataset will be available openly for everyone.</p>
Body mass index trends and its impact of under and overweight on outcome among PLHIV on antiretroviral treatment in rural Tanzania: A prospective cohort study
<p>This is anonymized datasets used for assessment of body mass index (BMI) trends among HIV positive individuals enrolled in HIV care and initiated on antiretroviral therapy. The study is an observational and prospective study. This dataset is a subset of the on-going Kilombero and Ulanga Antiretroviral Cohort (KIULARCO). The dataset uploaded is Stata datasets and their corresponding codebook is included in word format.</p>
Validation of a clinicopathological classification for predicting outcomes of pituitary tumours: retrospective cohort study in a pituitary tumour centre of excellence, 2013–2023
<p><strong>Simple Summary:</strong> This retrospective study aims to classify a series of pituitary neuroendocrine tumours (PitNETs), typified according to the WHO 2017 recommendations, using Trouillas et al.’s clinicopathological classification from 2013. We analysed 166 patients who underwent PitNET surgery from 2013 to 2023. The tumours were identified according to the gene and immunohistochemistry expression of pituitary transcription factors and adenohypophyseal hormones. The PitNETs were graded based on the invasion observed in MRI and the Ki-67 index. The study found that grade 2a and 2b tumours, T2 signal intensity ratio (SIR), and silent corticotroph tumours were associated with lower progression-free survival rates. Tumour volume and T2 SIR were independent predictors of recurrence/progression, with a T2 SIR of 2 or more showing a significantly higher risk. These findings emphasise the prognostic value of the five-grade classification and underscore the importance of radiological evaluation for managing PitNETs.</p> <p> </p> <p><strong>Abstract: </strong>Immunostaining of transcription factors allows a more exact classification of pituitary neuroendocrine tumours (PitNETs), but not a better prediction of their clinical behaviour. This retrospective, single-centre study aims to classify a series of PitNETs using Trouillas et al.’s clinicopathological classification from 2013. We analysed 166 patients undergoing PitNET surgery in 2013–2023. Tumours were identified according to the gene and immunohistochemical expression of PitNET transcription factors plus adenohypophyseal hormones. Tumours were classified according to a grading system based on MRI invasion and Ki-67 index. Eighty-one (48.8%) patients had grade 2a tumours; 71 (42.8%), grade 1a; 8 (4.8%), 2b; and 6 (3.6%), 1b. At a mean follow-up of 57.8 (standard deviation 30) months, 13.9% (n=23) showed recurrence/progression; independent predictors of recurrence were tumour volume (p=0.031) and T2 signal intensity ratio (SIR) (p<0.001). This risk was 18.6-fold higher for a T2 SIR of 2 or more. Grade 2a and 2b tumours, T2 SIR, and silent corticotroph adenomas (SCAs) were associated with lower progression-free survival. Our results add more evidence to the prognostic value of the five-grade PitNET classification and suggest higher clinical surveillance of patients with SCAs is warranted. The MRI findings highlight the increasing value of radiological evaluation for managing PitNETs.</p>
Clinical Outcome of Neonates With GBS Positive Culture-12 Year Retrospective Study
ClinicalTrials.gov study NCT00326313. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Epidemiologic Study of Reproductive Outcome in Women With Systemic Lupus Erythematosus
ClinicalTrials.gov study NCT00004663. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Transcriptional profiling of primary prostate tumor in metastatic hormonesensitive prostate cancer and association with clinical outcomes: correlative analysis of the E3805 CHAARTED study
GEO Series GSE201805. Homo sapiens. 160 samples. Type: Expression profiling by array.
Dataset related to article "Survival outcomes of robotic radical hysterectomy for early stage cervical cancer: A 9-year study."
<p>BACKGROUND:</p> <p>Recently, the results of a RCT have raised concerns on the management of cervical cancer through a minimally invasive approach. This study reports on the outcomes of patients with early stage cervical cancer submitted to robotics.</p> <p>METHODS:</p> <p>Retrospective review of a consecutive series of patients with an early cervical cancer treated with robotics at a single Institution over a 9-year period.</p> <p>RESULTS:</p> <p>A total of 91 women were managed; 39 (41.1%) had cervical adenocarcinoma. One (1.1%) conversion to laparotomy and one (1.1%) intraoperative complication occurred. Five (5.5%) patients experienced postoperative (>G2) complications; 24 (26.4%) patients required further adjuvant therapies. After a median follow-up of 40.7 (3.8-96.6) months, the DFS and OS were 90.4 (95%CI 85.3-95.6)% and 94.5 (95%CI 91.8-97.2)%, respectively.</p> <p>CONCLUSIONS:</p> <p>According to the available literature, the survival outcomes of this series of RRH for ECC are not inferior to what recorded in the past by an open approach.</p>
Data set from the article Lévesque V, Laplante L, Shohoudi A, Apers S, Kovacs AH, Luyckx K, Thomet C, Budts W, Enomoto J, Sluman MA, Lu CW, Jackson JL, Cook SC, Chidambarathanu S, Alday L, Eriksen K, Dellborg M, Berghammer M, Johansson B, Mackie AS, Menahem S, Caruana M, Veldtman G, Soufi A, Fernandes SM, White K, Callus E, Kutty S, Brouillette J, Casteigt B, Moons P, Khairy P; APPROACH-IS Consortium and the International Society for Adult Congenital Heart Disease (ISACHD). Implantable cardioverter-defibrillators and patient-reported outcomes in adults with congenital heart disease: An international study. Heart Rhythm. 2020 May;17(5 Pt A):768-776. doi: 10.1016/j.hrthm.2019.11.026. Epub 2019 Nov 30. PMID: 31790832.
<p>Data set from the article Lévesque V, Laplante L, Shohoudi A, Apers S, Kovacs AH, Luyckx K, Thomet C, Budts W, Enomoto J, Sluman MA, Lu CW, Jackson JL, Cook SC, Chidambarathanu S, Alday L, Eriksen K, Dellborg M, Berghammer M, Johansson B, Mackie AS, Menahem S, Caruana M, Veldtman G, Soufi A, Fernandes SM, White K, Callus E, Kutty S, Brouillette J, Casteigt B, Moons P, Khairy P; APPROACH-IS Consortium and the International Society for Adult Congenital Heart Disease (ISACHD). Implantable cardioverter-defibrillators and patient-reported outcomes in adults with congenital heart disease: An international study. Heart Rhythm. 2020 May;17(5 Pt A):768-776. doi: 10.1016/j.hrthm.2019.11.026. Epub 2019 Nov 30. PMID: 31790832.</p> <p> </p> <p>This is the abstract:</p> <p><strong>Background: </strong>Implantable cardioverter-defibrillators (ICDs) are increasingly being used to prevent sudden death in the growing population of adults with congenital heart disease (CHD). However, little is known about their impact on patient-reported outcomes (PROs).</p> <p><strong>Objective: </strong>The purpose of this study was to assess and compare PROs in adults with CHD with and without ICDs.</p> <p><strong>Methods: </strong>A propensity-based matching weight analysis was conducted to evaluate PROs in an international cross-sectional study of adults with CHD from 15 countries across 5 continents.</p> <p><strong>Results: </strong>A total of 3188 patients were included: 107 with ICDs and 3081 weight-matched controls without ICDs. ICD recipients were an average age of 40.1 ± 12.4 years, and >95% had moderate or complex CHD. Defibrillators were implanted for primary and secondary prevention in 38.3% and 61.7%, respectively. Perceived health status, psychological distress, sense of coherence, and health behaviors did not differ significantly among patients with and without ICDs. However, ICD recipients had a more threatening view of their illness (relative % difference 8.56; P = .011). Those with secondary compared to primary prevention indications had a significantly lower quality-of-life score (Linear Analogue Scale 72.0 ± 23.1 vs 79.2 ± 13.0; P = .047). Marked geographic variations were observed. Overall sense of well-being, assessed by a summary score that combines various PROs, was significantly lower in ICD recipients (vs controls) from Switzerland, Argentina, Taiwan, and the United States.</p> <p><strong>Conclusion: </strong>In an international cohort of adults with CHD, ICDs were associated with a more threatening illness perception, with a lower quality of life in those with secondary compared to primary prevention indications. However, marked geographic variability in PROs was observed.</p> <p> </p>
Clinical Pilates and Prenatal Education: A Prospective Cohort Study on Mitigating Postpartum Depression and Improving Maternal Outcomes
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.