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3,223
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ShareScore release 0.9.0
Dataset results
3,223 results for “Human Study”
HSP90 specific nIR probe identifies aggressive prostate cancers: a translational study from preclinical models to a human pilot study
GEO Series GSE164865. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
A Human Induced Pluripotent Stem Cell Array-Based Genome Wide Association Study Identifies Virus Susceptibility Locus and Variants
GEO Series GSE182376. Homo sapiens. 48 samples. Type: Expression profiling by high throughput sequencing.
Plasma and CSF Proteomic Signatures of Acutely Sleep-Deprived Humans: An Exploratory Study
GEO Series GSE244817. Homo sapiens. 40 samples. Type: Protein profiling by protein array.
Distinguish response of low-dose radiation with different dose-rate on gene expression of human coronary artery endothelial cells: A bioinformatic study based on transcriptomic sequencing
GEO Series GSE261231. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
A study of how homozygous ALS-linked FUS P525L mutations perturb transcriptome profile in human iPSC-derived microglia
GEO Series GSE172459. Homo sapiens. 334 samples. Type: Expression profiling by high throughput sequencing.
Studying human embryonic stem cell reveals molecular mechanisms of cold resistance
GEO Series GSE179344. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Human Ex Vivo Lung Perfusion: A Model System to study Lung diseases and direct targeted therapies
GEO Series GSE146436. Homo sapiens. 26 samples. Type: Expression profiling by high throughput sequencing.
A study of the effect of OxLDL on C/EBP beta binding in human macrophages using chromatin immunoprecipitation for C/EBP beta with high throughput sequencing (ChIP-seq)
GEO Series GSE66192. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Study of differentiation of human adipocytes using SBGS cells in vitro.
GEO Series GSE76131. Homo sapiens. 26 samples. Type: Expression profiling by array.
Profile of macrophages in human abdominal aortic aneurysms: a transcriptomic, proteomic and antibody protein array study
GEO Series GSE21803. Homo sapiens. 8 samples. Type: Expression profiling by array.
Transcriptional responses to RTS,S induced vaccination in controlled human malaria infection studies
GEO Series GSE107672. Homo sapiens. 0 samples. Type: Expression profiling by array; Expression profiling by high throughput sequencing; Other.
Study of sarcopenia in human muscle biopsies of elderly individuals, Singapore Sarcopenia Study
GEO Series GSE111016. Homo sapiens. 40 samples. Type: Expression profiling by high throughput sequencing.
Methylation studies in human and mouse placenta
GEO Series GSE184220. Homo sapiens; Mus musculus; Rattus norvegicus. 47 samples. Type: Methylation profiling by array.
Custom scripts used in the study "Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome"
<p>Custom scripts and associated data used in the study "Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome"</p>
Molecular reorganization during formation of the human skin barrier studied in situ - Dataset
<p>Dataset for the paper "Molecular reorganization during formation of the human skin barrier studied in situ"</p>
Data from: Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate
Cleft lip with or without cleft palate (CL/P) is the most commonly occurring craniofacial birth defect. We provide insight into the genetic etiology of this birth defect by performing genome-wide association studies in two species: dogs and humans. In the dog, a genome-wide association study of 7 CL/P cases and 112 controls from the Nova Scotia Duck Tolling Retriever (NSDTR) breed identified a significantly associated region on canine chromosome 27 (unadjusted p=1.1 x 10-13; adjusted p= 2.2 x 10-3). Further analysis in NSDTR families and additional full sibling cases identified a 1.44 Mb homozygous haplotype (chromosome 27: 9.29 – 10.73 Mb) segregating with a more complex phenotype of cleft lip, cleft palate, and syndactyly (CLPS) in 13 cases. Whole-genome sequencing of 3 CLPS cases and 4 controls at 15X coverage led to the discovery of a frameshift mutation within ADAMTS20 (c.1360_1361delAA (p.Lys453Ilefs*3)), which segregated concordant with the phenotype. In a parallel study in humans, a family-based association analysis (DFAM) of 125 CL/P cases, 420 unaffected relatives, and 392 controls from a Guatemalan cohort, identified a suggestive association (rs10785430; p =2.67 x 10-6) with the same gene, ADAMTS20. Sequencing of cases from the Guatemalan cohort was unable to identify a causative mutation within the coding region of ADAMTS20, but four coding variants were found in additional cases of CL/P. In summary, this study provides genetic evidence for a role of ADAMTS20 in CL/P development in dogs and as a candidate gene for CL/P development in humans.
MiRLog and dbmiR: prioritization and functional annotation tools to study human microRNA sequence variants
<p>dbmiR is a comprehensive database for functional annotation of miRNA SNVs (Single Nucleotide Variants). It includes a precompiled list of all possible miRNA allelic SNVs, providing their biological annotations at nucleotide and miRNA levels. In dbmiR we also integrated MiRLog, a new meta-predictor we implemented to predict the functional effect of miRNA SNVs.</p> <p>dbmiR can be used only for non-commercial purposes because of the licenses associated with some of the included tools and databases.</p>
Dendritic morphologies of human cortical neurons and Supplementary Materials for comparative studies in mice and humans
<p>This dataset includes local dendritic reconstructions of 2,363 human cortical neurons from the frontal, temporal, and parietal lobes. Together with the related Supplementary Materials in the paper. </p>
Single-arm, open-label, multicenter first in human study to evaluate the safety and performance of Dura Sealant Patch in reducing CSF leakage following elective cranial surgery: The ENCASE trial
<p><span><span><span><span><span><span><span><span><span><span><span><b>Objective:</b> The Dural Sealant Patch (DSP) is designed for watertight dural closure after cranial surgery. The goal of this study is to assess, for the first time, safety and performance of the DSP as a means of reducing CSF leakage in patients undergoing elective cranial intradural surgery with a dural closure procedure.</span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Design:</b> First in human, open-label, single-arm, multicenter study with 360 days (12 months) follow up. </span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Setting: </b>Three large tertiary reference neurosurgical centers, 2 in the Netherlands and 1 in Switzerland. </span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Participants</b>: Forty patients undergoing elective cranial neurosurgical procedures, stratified into 34 supra- and 6 infratentorial trepanations.</span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Intervention:</b> Each patient received one DSP after cranial surgery and closure of the dura mater with sutures.</span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Outcome measures:</b> Primary composite endpoint was occurrence of one of the following events: postoperative percutaneous CSF leakage, intraoperative leakage at 20 cm H2O positive end-expiratory pressure or postoperative wound infection. Overall success was defined as achieving the primary endpoint in no more than 2 patients. Secondary endpoints were device related serious adverse events (SAEs) or adverse events (AEs), pseudomeningocele and thickness of dura + DSP. Additional endpoints were reoperation in 30 days and user satisfaction. </span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Results:</b> No patients met the primary endpoint. No device related (S)AEs were observed. There were two incidences of self-limiting pseudomeningocele as confirmed on MRI. Thickness of dura and DSP were (mean +/- SD) 3.5 mm +/- 2.0 at day 7 and 2.1 mm +/- 1.2 at day 90. No patients were re-operated within 30 days. Users reported a satisfactory design and intuitive application.</span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><strong>Conclusions: </strong>DSP, later officially named Liqoseal, is a safe and potentially efficacious device for reducing CSF leakage after intracranial surgery, with favorable clinical handling characteristics. A randomized controlled trial is needed to assess Liqoseal efficacy against the best current practice for reducing postoperative CSF leakage.</span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Strengths and limitations</b></span></span></span></span></span></span></span></span></span></span></span></p> <ul> <li>The trial studies a device to prevent postoperative cerebrospinal fluid (CSF) leakage, which is one of the most common neurosurgical complications.</li> <li>The study protocol was performed in multiple centers, registered, pre-published and strictly followed.</li> <li>The composite endpoint of the trial reduced the number of inclusions needed.</li> <li>The study did not involve a comparison to current clinical standard and has a potential selection bias, so generalization of results with regard to DSP efficacy needs to be cautiously undertaken.</li> </ul>
Figure 1 from: Abbas AH, Mahmood AAR, Tahtamouni LH, Al-Mazaydeh ZA, Rammaha MS, Alsoubani F, Al-bayati RI (2021) A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity. Pharmacia 68(3): 679-692. https://doi.org/10.3897/pharmacia.68.e70654
Figure 1 Synthesis of the target compounds (4–7).
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.