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18,621 results for “development;”
Preclinical developent of an innovative drug candidate in systemic fungal therapy
<p>The dataset documents results of studies in the area of drug development co-founded by the National Centre for Research and Development <strong>(Poland), grant number </strong> <strong>POIR.01.01.01-00-1990/15-00, tytuł: <em>Badania przedkliniczne i kliniczne kandydata na innowacyjny lek w terapii inwazyjnych grzybic układowych.</em></strong></p> <p>The objective of the project was to conduct preclinical and potantially Phase I clinical studies of a new compound to develop an innovative drug for treatment of invasive systemic mycoses. The compound will be selected from the group of innovative Amphotericin B derivatives developed during the BLIRT project co-funded under the 1.4–4.1 Innovative Economy Operational Programme, which have shown significant improvement of selective toxicity compared to the native drug. Moreover, the solubility of the compounds has been ensured, which enables their bioavailability. The innovative derivatives have characteristics of an ideal antifungal drug – fungicidal activity, low toxicity, aqueous solubility, no induction of resistance, activity against MDR strains, and a broad antifungal<br> spectrum. Their therapeutic efficacy has been preliminarily proven on a model of systemic candidiasis in mice.</p> <p>The project was unsuccesful due to not enough competitive advantages of developed candidates regarding their antifungla efficacy and safety which did not justify further investments of both public and private funds.</p> <p>The dataset contain reports from the conducted studies performed both in house but also in well established CROs. It cover the chemical sythesis of compounds, preparation of their liposomal formulations and preclinical studies in vitro and in vivo performed until the project was stopped, due to not achieving the set development milestone (preclinical stage). It is widely communicatd to the scientific community so that future projects could benefit form the generated know-how.</p> <p> </p> <p> </p>
Auditory brainstem development of Naked Mole-Rats (Heterocephalus glaber)
<p>Life underground often leads to animals having specialized auditory systems to accommodate the constraints of acoustic transmission in tunnels. Despite living underground, naked mole-rats use a highly vocal communication system, implying that they rely on central auditory processing. However, little is known about these animals' central auditory system, and whether it follows a similar developmental time course as other rodents. Naked mole-rats show slowed development in the hippocampus suggesting they have altered brain development compared to other rodents. Here, we measured morphological characteristics and voltage-gated potassium channel Kv3.3 expression and protein levels at different key developmental time points (postnatal days 9, 14, 21, and adulthood) to determine whether the auditory brainstem (lateral superior olive (LSO) and medial nucleus of the trapezoid body (MNTB)), develops similarly to two common auditory rodent model species: gerbils and mice. Additionally, we measured the hearing onset of naked mole-rats using auditory brainstem response (ABR) recordings at the same developmental timepoints. In contrast to other work in naked mole-rats showing that they are highly divergent in many aspects of their physiology, we show that naked mole-rats have a similar hearing onset, between P9-P14, to many other rodents. On the other hand, we show some developmental differences, such as a unique morphology and Kv3.3 protein levels in the brainstem.</p>
Design and development remote monitoring agent for energy service companies in the telecommunication industry
<p>Data set downloaded from the remote monitoring agent (RMA) over its local webpage using WiFi connection.</p>
Impacts of development and adult sex on brain cell numbers in the Black Soldier Fly, Hermetia illucens L. (Diptera: Stratiomyidae)
<p>The Black Soldier Fly (<em>Hermetia illucens</em>, Diptera: Stratiomyidae) has been introduced across the globe, with numerous industry applications predicated on its tremendous growth during the larval stage. However, basic research on <em>H. illucens</em> biology (for example, studies of their central nervous system) are lacking. Despite their small brain volumes, insects are capable of complex behaviors; understanding how these behaviors are completed with such a small amount of neural tissue requires understanding processing power (e.g. number of cells) within the brain. Brain cell counts have been completed in only a few insect species (mostly Hymenoptera), and almost exclusively in adults. This limits the taxonomic breadth of comparative analyses, as well as any conclusions about how development and body size growth may impact brain cell populations. Here, we present the first images and cell counts of the <em>H. illucens</em> brain at four time points across development (early, mid, and late larval stages, and both male and female adults) using immunohistochemistry and isotropic fractionation. To assess sexual dimorphism in adults, we quantified the number of cells in the central brain vs. optic lobes of males and females separately. To assess if increases in body size during development might independently affect different regions of the CNS, we quantified the larval ventral nerve cord and central brain separately at all three stages. Together, these data provide the first description of the nervous system of a popular, farmed invertebrate and the first study of brain cell numbers using IF across developmental stages in any insect.</p>
Implementing blended learning for clinician teachers: Identifying their needs and its impact on faculty development initiatives
<p>Learning Technologies has been a fast-growing field in Health Professions Education (HPE). Approaches to teaching, learning and assessment has been increasingly influenced by learning technologies which requires HPE teachers to adapt their teaching practices and with that identify areas for professional development. The implementation of blended learning in HPE, has shown improvements in student performance. However, it seems as if there are challenges with the implementation of a blended learning approach and that there might be some needs that clinical teachers have that are not being addressed in order to implement blended learning successfully. We used a qualitative exploratory design to identify clinician teachers' needs. Semi-structured, individual interviews were conducted with a total of eight (n=8) module coordinators in the third year of the MBChB programme, Stellenbosch University, Faculty of Medicine and Health Sciences. Results indicated the need for continuous technical and pedagogical support which refers to a longitudinal faculty development approach. Additionally, faculty development should include the support in structuring and rethinking the blended curriculum, as well as assisting in the clinicians' development in their role and identity as a clinical teacher. These results reveal the importance of faculty development as a targeted longitudinal approach</p>
How does the selection of National Development Zones affect urban green innovation?
<p><span><span>The launch of the selection process for National Development Zones (NDZs) marked a fundamental change in the construction of development zones, making it an essential position for local authorities to implement high-quality development. Based on the data of prefecture-level cities in China from 2000 to 2018, this paper examines the impact and mechanism of selecting NDZs on urban green innovation through a double-difference spatial durbin model using the selection of NDZs as a "quasi-natural experiment". The study finds that the selection of NDZs can promote green innovation in cities and has a significant window-radiating effect. The heterogeneity test results show that the implementation of the selection policy for development zones in non-old industrial cities, large and medium-sized cities, cities with easy access to transportation, and cities with high market orientation are more likely to promote urban green innovation. At the same time, the higher the level of government governance and the better the level of economic development of the development zones, the more it helps to realize the effects of the selection policy. The results of the mechanism test show that the selection of NDZs has a positive impact on urban green innovation through environmental regulation effects, resource allocation effects, and policy amplification effects. </span></span>Data on development zones are sourced from the China Directory of Development Zones Audit and Announcement (2006) and the China Directory of Development Zones Audit and Announcement (2018 Edition)(http://www.gov.cn/xinwen/2018-03/03/content_5270330.htm); data on patents are sourced from the China Intellectual Property Office (https://www.cnipa.gov.cn/); Other city-level data from China City Statistical Yearbook, China Regional Economic Statistical Yearbook, China Statistical Yearbook (https://data.cnki.net/Yearbook/Navi?type=type&code=A). Our data is collated from the above sources using Python software. </p>
Model parameter time series of the Business Roadmap for sustainable development of the Mar Menor and surrounding Campo de Cartagena
<p>The Business Roadmap and Policy Recommendations (BRM) represents 14 solutions for sustainable development of the Mar Menor and surrounding Campo de Cartagena that were developed during an extensive co-design process (workshops, expert interviews, online questionnaires) with representatives from all relevant sectors involved. A full description of the BRM, its co-development, and the modelled impacts on Key Performance Indicators of sustainability can be found in<a href="http://doi.org/10.5281/zenodo.7142764"> Martínez-López et al (2022)</a>.</p> <p>The model parameter time-series in this dataset indicate if and when a solution is turned on or off between 1964 and 2070 based on preferences indicated by stakeholders. These time-series represent input parameters for the System Dynamics model of the socio-ecosystem of the Mar Menor-campo de Cartagena developed in the COASTAL project and that is used to quantify impacts on key performance indicators of sustainability. This System Dynamics based model, developed by Martínez-López et al (2022) can be consulted <a href="http://doi.org/10.5281/zenodo.7142764">here</a>.</p> <p>The Business Road Map and Policy Recommendations (BRM) consists of the following 4 milestones and related 14 solutions:</p> <p>(I) <strong>Rural ecotourism</strong>:</p> <p>1. The promotion of rural ecotourism activities.</p> <p>(II) <strong>Coastal ecotourism</strong>:</p> <p>2. The promotion of coastal ecotourism activities.</p> <p>(III) <strong>Sustainable agriculture</strong>:</p> <p>3. Implementation of nutrients, soil, and water retention measures</p> <p>4. Reduction in fertilizer use</p> <p>5. Denitrification of brine wastes from groundwater treated for irrigation</p> <p>6. Decrease in agricultural water demand per hectare (i.e. 10% of decrease by default in the model)</p> <p>(IV) <strong>Integrated sustainable management</strong>:</p> <p>7. Control of the extension of irrigated areas</p> <p>8. Promotion of environmental education</p> <p>9. Control of the number of groundwater wells (i.e. maximum 500 wells by default in the model)</p> <p>10. Promotion of small (<10MW) (agro)photovoltaic facilities</p> <p>11. Surface water pumping from the Albujón ephemeral stream</p> <p>12. Control of other point sources of pollution to the lagoon</p> <p>13. Groundwater pumping and treatment</p> <p>14. Increase in sea water desalination amount (twice the BAU value)</p>
MICRO AND MACRO - Developing New Accessible Musicking Technologies - Video Attachment
<p>Six demonstration videos that are attached to the article "MICRO AND MACRO - Developing New Accessible Musicking Technologies". Published in Proceedings of the Audio Mostly 2022.</p> <p>Video1.mp4 is showing a demonstration of Macro 1.0 app 1, app 2 and app3</p> <p>Video2.mp4 is showing a demonstration of Macro 2.1 app 1</p> <p>Video3.mp4 is showing a demonstration of Macro 2.1 app 2</p> <p>Video4.mp4 is a demonstration and presentation of Micro 1.0 app 1, app 2 and app 3.</p> <p>Video5.mp4 demonstrates and present Micro 2.1 app 1.</p> <p>Video6.mp4 demonstrates Micro 2.1 app 2.</p>
Dataset for an analysis of selected studies on software development and reuse in the field of software documentation
<p>The data record contains bibliographical metadata from 2012 to 2023, which have been extracted from the databases ScienceDirect, SpringerLink and IEEE Xplore. It was created in the context of a master thesis which will be published later. The aim was to make a selection of studies on software documentation from the perspective of software development based on the master thesis.</p>
The visualization of the collected data corresponding to the following paper: "The development of a Self-Rated ICF-based questionnaire (HEAR-COMMAND Tool) to evaluate Hearing, Communication, and Conversation disability: multinational experts' and patients' perspectives"
<p>These two PDF files include the data collected for a study conducted by Afghah et.al, 2022. They include the responses of the participant in this study to a newly developed self-rated ICF-based questionnaire. One file includes the responses to 30 demographic questions and the other one 88 ICF-based questions. The presented data were collected in Germany, the USA, and Egypt as well as overall data.</p> <p>The design of the questionnaire is described here:<br> Afghah, T., Alfakir, R., Meis, M., van Leeuwen, L. M., Kramer, S. E., Hammady, M., Youssif, M., & Wagener, K. C. (2021). The development of a Self-Rated ICF-based questionnaire (HEAR-COMMAND Tool) to evaluate hearing, communication, and conversation disability: multinational experts' and patients' perspectives. Zenodo. https://doi.org/10.5281/zenodo.5534360.</p> <p>This study was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Project ID: 352015383 – SFB 1330, C4.</p>
Dataset: Inverse responses of species richness and niche specialization to human development
<p class="CxSpFirst">Humans impact biodiversity by altering land use and introducing nonnative species. Yet the extent to which coexistence processes, such as competition and niche shifts, mediate these relationships is not clear. This dataset was used in a study that aims to compare how human development influences wetland plant diversity by examining patterns of species richness, niche specialization, and nonnative species occurrences along a human development gradient.</p> <p class="CxSpFirst">This dataset can be used to analyzed species richness and niche specialization (a measure of the range of human development extents over which a species occurs) patterns from species occurrence data across 1582 wetlands in Alberta, Canada. Associations between human development extent and species richness, niche specialization, and nonnative species can be tested using linear mixed models. Also, nonmetric multidimensional scaling ordination can be applied from raw data (see usage notes) to examine whether community composition differed among wetlands surrounded by different human development extents.</p> <p class="CxSpFirst">Note that human development data are accessible only through a data sharing agreement with ABMI. See the readme document for more details on how to obtain assess to these data.</p> <p class="CxSpFirst">Results of these analyses can be found in the corresponding publication: Inverse responses of species richness and niche specialization to human development, Journal of Biogeography. https://doi.org/10.1111/jbi.14240</p> <ul> </ul>
Data from: Climate warming leads to advanced fruit development period of temperate woody species but divergent changes in its length
<p><span>Climate warming has significantly altered the phenology of plants</span><span> in recent decades. However, in contrast to the widely reported warming-induced extension of vegetative growing season, the response of fruit development period (FDP) from flowering to fruiting remains largely unexplored, particularly for woody plants. Analyzing >560,000 <em>in situ</em> observations of both flowering and fruiting dates for six temperate woody species across 2958 European phenological observations sites during </span><span>1980 – 2013</span><span>, we found that in all species both flowering and fruiting phenology, i.e., the FDP, advanced with climate warming. However, the advancing rates of the two events were not necessarily equal for any given species, resulting in divergent changes in the length of FDP among species with climate warming. During </span><span>1980 – 2013</span><span>, not only the temperature during FDP but also the forcing requirement for fruit development increased, both affecting the length of FDP. The shortened FDP was mainly due to elevated temperature, thus accelerating the accumulation of forcing, whereas the prolonged FDP was primarily caused by the substantial increase of the forcing requirement of fruiting, which could be fulfilled only in a longer time and thus slowed down the advance of fruiting. This study provides large-scale empirical evidence of warming-induced </span><span>advances of FDP but divergent changes in its length in temperate woody species. Our findings demonstrate the contrasting reproductive phenological strategies among temperate woody species under the pressure of warming climate, contrary to the lengthening of vegetative growing season, which is by and largely similar with different woody species.</span></p>
Meiotic drive adaptive testes enlargement during early development in the stalk-eyed fly.
<p><span>The sex ratio 'SR' X-linked meiotic drive system in stalk-eyed flies destroys Y-</span><span>bearing sperm. Unlike other SR systems, drive males do not suffer fertility loss. They have greatly enlarged testes which compensate for gamete killing. We predicted that enlarged testes arise from extended development with resources re-allocated from the accessory glands, as these tend to be smaller in drive males. To test this, we tracked the growth of the testes and accessory glands of wild-type and drive males over 5–6 weeks post-eclosion before males attained sexual maturity. Neither of the original predictions is supported by these data. Instead, we found that the drive male testes were enlarged at eclosion, reflecting a greater allocation of resources to the testes during pupation. Testes grow at a higher rate during early adult development, but there was no evidence that this retards the growth of the accessory glands. Further experiments are proposed to investigate whether smaller accessory glands only arise in drive males post-copulation or when flies are subjected to nutritional stress. Our experimental findings support the idea that enlarged testes in drive males arise as an adaptive allocation of resources to traits that enhance male reproductive success.</span></p>
An inventory of school buildings in Central Sulawesi (Indonesia) developed through a mixed-mode data collection approach
<p>Urban disaster risk management and reduction requires the development and periodic updating of regional building inventories. However, the development of such inventories can be very cost-intensive and time-consuming, making this a challenging task, particularly for low- and middle-income countries.</p> <p>We used a combination of side-walk and remote survey methods to develop an inventory of 2536 school buildings in Central Sulawesi, Indonesia. The Central Sulawesi region was affected by the 28th September 2018 Palu earthquake. The moment magnitude (Mw) 7.5 earthquake caused intense ground shaking in the epicentral area, triggering liquefaction, tsunami and major landslides, leading to over 4,000 fatalities and 165,000 displaced people. At least 1299 schools were reported to have been damaged or collapsed, affecting about 184,000 students.</p> <p>The developed inventory includes information on location, number of stories, occupancy characteristics (building use and population), age, type of lateral load resisting systems, building materials, structural vulnerabilities, and structural conditions following the 2018 earthquake.</p> <p>The developed database can be used in pre-event/long-term risk analysis and management, post-event/near-real-time loss estimation, and regional-level decision-making on school assets and related policies. The database has been made available for public use and can be readily harmonised with similar databases for other regions.</p> <p>This data repository also contains information on interviews with 30 school principals in the region. The interview details the damage states and functional recovery trajectory of school buildings in the 30 schools.</p>
Development of Rotaxanes as E-Field Sensitive Superstructures in Plasmonic Nano-Antennas
<p>NMR, HR-MS, UV-VIS, Fluorescence, and Photoluminescence data of the graphs and supplementary data provided with the manuscript.</p>
Genetic and transcriptomic datasets characterizing gene drive mosquitoes expressing antimicrobial peptides that retard Plasmodium sporogonic development
<p><span>Gene drives hold promise for the genetic control of malaria vectors. The development of vector population modification strategies hinges on the availability of effector mechanisms impeding parasite development in transgenic mosquitoes. We augmented a midgut gene of the malaria mosquito <em>Anopheles gambiae</em> to secrete two exogenous antimicrobial peptides, Magainin 2 and Melittin. This small genetic modification, capable of efficient non-autonomous gene</span> drive, hampers oocyst development in both <em>Plasmodium falciparum</em> and <em>Plasmodium berghei</em>. It delays the release of infectious sporozoites while it simultaneously reduces the lifespan <span>of homozygous female transgenic mosquitoes. Modeling the spread of this modification using a large-scale agent-based model of malaria epidemiology reveals that it can break the cycle of disease transmission across a range of transmission intensities.</span></p>
Lakkasuo carbon isotope and AWEN extraction data for Yasso-C13 model development
<p>This package contains carbon isotope and AWEN extraction data from litterbag experiments (5 year) at Lakkasuo, a raised bog complex near Hyytiälä weather station in Finland. Additionally present are driving data and parameter values needed to run soil carbon model Yasso. The given data is used to implement and calibrate carbon-13 related soil organic matter decomposition in the Yasso model. The dataset also contains calibration results, scripts to run the results anew and to produce plots and images. The updated dataset uses new Yasso20 parameter values.</p>
Data for: Development of a method for the measurement of human scent samples using comprehensive two-dimensional gas chromatography with mass detection
<p>This dataset was used for development of a method for the measurement of human scent samples using comprehensive two-dimensional gas chromatography with mass detection [<a href="https://doi.org/10.1016/j.forsciint.2016.09.011">https://doi.org/10.1016/j.forsciint.2016.09.011</a>].</p> <p>The dataset contains chromatograms of a model mixture of human scent and chromatograms of the human scent of one volunteer measured on different column setups. Each sample was processed in ChromaToF(version 4.72.0.0) by LECO corp. The processing step was executed at the signal-to-noise (SN) ratio levels 100, 300, and 500 (human scent samples chromatograms).</p>
Indicators of the regional rehabilitation systems development in Russia 2018-2020
<p>Indicators of the regional rehabilitation systems development in Russia 2018-2020</p>
Application demonstrating results of application of show view updates developer option on MainActivity with onBind Recyclerview call
<p>Results demonstrating results of application of show view updates developer option on MainActivity with onBind Recyclerview call</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.