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12,683 results for “tolerability”
Data from: Host developmental stage effects on parasite resistance and tolerance
<p><span>Hosts can defend themselves against parasites by either preventing or limiting infections (resistance), or limiting parasite-induced damage (tolerance). However, it remains underexplored how these defense types vary over host development with shifting patterns of resource allocation priorities. Here, we studied the role of developmental stage on resistance and tolerance in Atlantic salmon (<em>Salmo salar</em>). This anadromous fish has distinct life stages related to living in fresh and sea water. We experimentally exposed one-year old salmon, either at the freshwater stage or at the stage transitioning to the marine phase, to the trematode <em>Diplostomum pseudospathaceum</em>. Using 56 pedigreed families and multivariate animal models, we show that developmental transition is associated with reduced resistance, but does not affect tolerance. Furthermore, by comparing tolerance slopes (host fitness against parasite load) based on additive genetic effects among infected and unexposed control relatives, we observed that the slopes can be largely independent of the infection, that is they may not reflect tolerance. Together, our results suggest that the relative importance of different defense types may vary with host development and emphasize the importance of including control treatments for more confident interpretations of tolerance estimates.</span></p>
Thermal tolerance of Arbacia lixula
<p>As the ocean warms, the thermal tolerance of marine invertebrates is key to determining their distributional change, where acclimation to low pH may impact the thermal range of optimal development. We compared thermal tolerance of progeny from a low pH-acclimated sea urchin (<em>Arbacia lixula</em>) population from the CO2 vents of Ischia (Italy), and a nearby population living at ambient pH. The percentage of normally developing gastrulae and two-armed larvae were determined across 10 temperatures representing present and future temperature conditions (16-34 ˚C). Vent-acclimated sea urchins showed a greater percentage of normal development at 24 hours, with a larger optimal developmental temperature range than control sea urchins (12.3 ˚C vs 5.4 ˚C range, respectively). At 48 hours, upper lethal temperatures for 50% survival with respect to ambient temperatures were similar between control (+6.8 ˚C) and vent (+6.2 ˚C) populations. Thus, acclimation to low pH did not impact the broad thermal tolerance of <em>A. lixula</em> progeny. With<em> A. lixula</em>'s barrens forming abilities, its wide thermotolerance and its ability to acclimate to low pH, this species will continue to be an important ecological engineer in Mediterranean macroalgal ecosystems in a changing ocean.</p>
The effects of antibiotic combination treatments on Pseudomonas aeruginosa tolerance evolution and coexistence with Stenotrophomonas maltophilia
<p><em>Pseudomonas aeruginosa</em> bacterium is a common pathogen of Cystic Fibrosis (CF) patients due to its ability to evolve resistance to antibiotics during treatments. While <em>P. aeruginosa</em> resistance evolution is well characterised in monocultures, it is less well understood in polymicrobial CF infections. Here, we investigated how exposure to ciprofloxacin, colistin, or tobramycin antibiotics, administered at sub-MIC doses alone and in combination, shaped the tolerance evolution of <em>P. aeruginosa</em> (PAO1 lab and clinical CF LESB58 strains) in the absence and presence of a commonly co-occurring species, <em>Stenotrophomonas maltophilia</em>. Increases in antibiotic tolerances were primarily driven by the presence of that antibiotic in the treatment. We observed a reciprocal cross-tolerance between ciprofloxacin and tobramycin, and when combined these antibiotics selected increased MICs for all antibiotics. Though the presence of <em>S. maltophilia</em> did not affect the tolerance or the MIC evolution, it drove <em>P. aeruginosa</em> into extinction more frequently in the presence of tobramycin due to its relatively greater innate tobramycin tolerance. In contrast, <em>P. aeruginosa</em> dominated and drove <em>S. maltophilia</em> extinct in most other treatments. Together, our findings suggest that besides driving high-level antibiotic tolerance evolution, sub-MIC antibiotic exposure can alter competitive bacterial interactions, leading to target pathogen extinctions in multi-species communities.</p>
O2-tolerant CO dehydrogenase via tunnel redesign for the removal of CO from industrial flue gas
<p>Molecular dynamics simulations for CODH enzymes studied in "<strong>O<sub>2</sub>-tolerant CO dehydrogenase via tunnel redesign for </strong><strong>the </strong><strong>removal of CO from industrial flue gas</strong><strong>".</strong></p> <p>The repository contains the 10 nanoseconds of NAMD simulation of CODH enzymes.</p>
Dataset_ metabolic scope performance and tolerance of juvenile European sea bass Dicentrarchus labrax upon acclimation to high temperatures
<p>This dataset contains the data associated with the article 'Metabolic scope, performance and tolerance of juvenile European sea bass Dicentrarchus labrax upon acclimation to high temperatures' by Stavrakidis-Zachou et al. accepted for publication on Plos one in July 2022.</p>
Genome-wide association mapping for component traits of drought and heat tolerance in wheat
<p>The study material in GWAS panel with 282 advanced breeding line of bread wheat genotypes from IARI stress breeding program was selected to map the genomic regions responsible for Drought and heat tolerance component traits.</p> <p>Phenotypic data:</p> <p>The GWAS panel was evaluated at multiple locations namely, IARI, New Delhi - DL (28.6550° N, 77.1888° E, MSL 228.61 m), ARI, Pune - PUNE (18.5204° N, 73.8567° E, MSL 560m), IIWBR, Karnal - IIWBR (29.6857° N, 76.9905°E, MSL 243m), IARI, Jharkhand - JR (24.1929° N, 85.3756° E, MSL 580m) and IARI RS, Indore - IND (22.7196° N, 75.8577° E, MSL 553 m) with augmented RCBD design. Three tratments viz, IR (Irrigated), RI (Restricted irrigated) and LS (Late sown) were imposed for control, drought and heat stress, respectively. Data was collected on traits like Days to heading (DH), Days to maturity (DM), Normalized Difference Vegetation Index (NDVI) at anthesis and grain filling stage, chlorophyll content (SPAD) of flag leaf at post anthesis stage, Plant height (PH), Canopy temperature (CT), Grain weight per spike (GWPS), Thousand Grain weight (TGW), Plot Yield (PLTY) and Biomass.</p> <p>Genotypic data:</p> <p>Genomic DNA of the GWAS panel was extracted from the leaves of seedlings by Cetyl Trimethyl Ammonium Bromide (CTAB) method. The panel was genotyped using Axiom Wheat Breeder's Genotyping Array (Affymetrix, Santa Clara, CA, United States) having 35,143 genome-wide SNPs. The monomorphic, markers with minor allele frequency (MAF) of <5%, missing data of >20%, and heterozygote frequency >25% were removed from the analysis. The remaining set of 10546 high-quality SNPs was used in GWAS analysis.</p> <p>The detailed information of the methods and software used, data analysis and GWAS is provided at doi: 10.3389/fpls.2022.943033</p>
Data from: Plasticity drives extreme cold tolerance of emerald ash borer (Agrilus planipennis) during a polar vortex
<p>Invasive species must often survive combinations of environmental conditions that differ considerably from their native range; however, for a given species it is unclear whether improved tolerance is the result of phenotypic plasticity or genetic adaptation (or both).</p> <p><em>Agrilus planipennis</em> (Coleoptera: Buprestidae; the emerald ash borer) is an invasive pest of <em>Fraxinus</em> trees in North America and Europe. Previous studies in southwestern Ontario, Canada, showed that <em>A. planipennis</em> is freeze avoidant, preventing internal ice formation by accumulating molar concentrations of glycerol in its hemolymph and depressing its supercooling point (SCP, the temperature at which it freezes). The cold tolerance of these southwestern Ontario animals was used to predict potential distribution, revealing that some Canadian cities should be too cold to allow populations to persist. However, a small population of <em>A. planipennis</em> has persisted in Winnipeg, Manitoba, Canada, through several severe 'polar vortex' events.</p> <p>In 2018/19, we collected <em>A. planipennis</em> larvae and prepupae from Winnipeg, Manitoba and Southern Ontario, and found that individuals from Winnipeg were extremely cold tolerant – with SCPs as low as -52 °C in prepupae (compared to 32 °C in Southern Ontario), and survival of unfrozen individuals exposed to -50 °C for one hour. This cold tolerance was accompanied by higher hemolymph osmolality and glycerol concentration than in the SW Ontario individuals. To distinguish between phenotypic plasticity and local adaptation, in 2020/21 we overwintered Winnipeg-sourced individuals either outdoors in southwestern Ontario or in a simulated Winnipeg winter. Simulated Winnipeg winter individuals had cold tolerance similar to those overwintered in Winnipeg, while southwestern Ontario overwintered individuals had cold tolerance similar to those collected previously in the region. The simulated winter individuals had higher hemolymph glycerol concentrations than southwestern Ontario overwintered animals, at least in part due to greater dehydration. Thus, <em>A. planipennis</em> are cold-tolerant enough to survive some of the harshest winters where their host trees can grow, and most likely attain this cold tolerance via phenotypic plasticity. These findings raise the importance of delineating sensitivity of conclusions to unexpected phenotypic plasticity when predicting potential distributions of new invasives or responses to climate change.</p> <p>The data in this dataset are the SCPs and treatment data for the experimental animals used in these cold tolerance experiments. </p>
PRISMA Checklist for for systematic review: Use of CRISPR technology in gene editing for tolerance to biotic factors in plants: A systematic review.
<p>PRISMA Checklist for for systematic review: Use of CRISPR technology in gene editing for tolerance to biotic factors in plants: A systematic review.</p>
PRISMA Checklist for systematic review: Use of CRISPR technology in gene editing for tolerance to biotic factors in plants: A systematic review.
<p>PRISMA Checklist for systematic review: Use of CRISPR technology in gene editing for tolerance to biotic factors in plants: A systematic review.</p>
PRISMA Checklist for systematic review: Use of CRISPR technology in gene editing for tolerance to biotic factors in plants: A systematic review.
<p>PRISMA Checklist for systematic review: Use of CRISPR technology in gene editing for tolerance to biotic factors in plants: A systematic review.</p>
Dataset and R-script for Article: Increased heat tolerance of geothermal plants at the cost of reduced performance under cooler conditions
Open the record for dataset details and reuse information.
Data for "An insect pheromone primes tolerance of herbivory in goldenrod plants"
<p>Data for "An insect pheromone primes tolerance of herbivory in goldenrod plants"</p><p>Data include all raw data necessary for the analyses of the manuscript. These include data on the growth, flower production, rhizome production, and gall induction of goldenrod plants (<i>Solidago altissima</i>) after exposure to a priming cue gradient and a specialist herbivore that is the source of the priming cue. It also contains data on female herbivore oviposition preference.</p><p> </p><p>Description of the data and file structure</p><p>The data are divided into four sheets. The first contains data necessary for analyses presented in the main text. The second contains data for analyses presented in the supplement. The third presents data from a separate experiment presented in the supplement, and the fourth contains R code for the analyses performed.</p><p> </p><p>Sharing/Access information</p><p>These data are currently only available on Zenodo.</p>
Contrasting disease progression, microglia reactivity, tolerance, and resistance to Toxoplasma gondii infection in two mouse strains
<p><strong><span>Figure S1</span></strong><span>. Stereological Sampling: Low-power photomicrographs (A and B) displaying the molecular layer of the dentate gyrus, the area of interest, alongside the sampling grid (C). Additionally, a high-power photomicrograph (D) showcases IBA-1 immunolabeled microglia (the object of interest). Scale bar: A - 250µm, and D: 25µm.</span></p> <p> </p> <p><strong><span>Figure S2</span></strong><span>. The recovery of BALB/c microglia in the molecular layer of dentate gyrus was observed 43 days after infection. At this point, only minor morphological changes were observed, and all the morphological changes induced by <em>T. gondii</em> infection at 22 dpi have disappeared. The analysis methods used included hierarchical cluster analysis (A), discriminant function analysis (C and E), morphological complexity (B), and convex hull volume (D).</span></p>
Data and code for: Heat tolerance and its plasticity in freshwater and marine fishes are linked to their thermal regimes (v0.1).
<p>Data and code for: Heat tolerance and its plasticity in freshwater and marine fishes are linked to their thermal regimes (v0.1).</p>
Fault-Tolerant Computing with Single Qudit Encoding in a Molecular Spin. Open data set
<div> <p>Data supporting the original figures 2, 3 and 4 (ESI) of the related manuscript.</p> </div>
Complete dataset for the publication "Phage Paride can kill dormant, antibiotic-tolerant cells of Pseudomonas aeruginosa by direct lytic replication"
<p>This dataset enlists all individual datapoints shown in the publication "Phage Paride can kill dormant, antibiotic-tolerant cells of Pseudomonas aeruginosa by direct lytic replication" (https://doi.org/10.1038/s41467-023-44157-3). For detailed information regarding the individual contributions please check the "Author information" section in the publication. </p>
Dephasing-tolerant quantum sensing of transverse magnetic fields with spin qudits. Open data set
<p>Data supporting Figs. 1, 2, 3, 4 of the related manuscript.</p>
StArt Protocol for systematic review: Use of CRISPR technology in gene editing for tolerance to biotic factors in plants: A systematic review.
Open the record for dataset details and reuse information.
Funaria hygrometrica Hedw. elevated tolerance to D2O: its use for the production of highly deuterated metabolites
<p>Data set for doi: <a href="https://doi.org/10.1007/s00425-017-2794-5">10.1007/s00425-017-2794-5</a></p>
Supplementary material for "Molecular dynamics gives new insights into the glucose tolerance and inhibition mechanisms on β-glucosidases" (2 video files)
<p>Video S1: MD of the glucose exit in a glucose-tolerant GH1 β-Glucosidase</p> <p>Video S2: Interactions among glucose, D228, K257, and N312 in a glucose-tolerant GH1 β-glucosidase</p>
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.