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1,986 results for “valve”
Dataset related to the article "MiRNA profiling revealed enhanced susceptibility to oxidative stress of endothelial cells from bicuspid aortic valve"
<p>This record contains raw data related to the article "MiRNA profiling revealed enhanced susceptibility to oxidative stress of endothelial cells from bicuspid aortic valve"</p> <p> </p> <p><strong>Abstract</strong></p> <p>Aims</p> <p>Calcific <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-valve-stenosis">aortic valve stenosis</a> (CAVS) is the most frequent manifestation of <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-valve-disease">aortic valve disease</a> and the third leading cause of cardiovascular disease in the Western countries associated with significant morbidity and mortality. An active biological progression involving inflammation and <a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/alpha-oxidation">oxidation</a> leading to valve endothelial damage is considered a hallmark of the early stages of valve degeneration. However, tricuspid (TAV) and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/premolar">bicuspid</a> (BAV) <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-valve">aortic valve</a> deterioration are considered to differ only by shear stress. We hypothesized that <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/endothelial-cell">endothelial cells</a> (EC) derived from BAV and TAV patients have different <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/microrna">miRNA</a> expression patterns and thus distinct pathways could lead to endothelial damage in BAV than TAV patients.</p> <p>Methods and results</p> <p>We isolated ECs from patients with bicuspid or tricuspid aortic valve, which underwent surgery due to CAVS. MiRNA expression profile by PCR revealed eight upregulated <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/microrna">miRNAs</a> between BAV and TAV ECs. Functional analysis identified that BAV ECs presented altered cellular response to <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/oxidative-stress">oxidative stress</a> and DNA damage stimulus <em>via</em> <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/protein-p53">p53</a> and alteration in the intrinsic apoptotic <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/signal-transduction">signaling pathway</a>. <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/gpx3">GPX3</a> and SRXN1 <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/messenger-rna">mRNA</a> were express at lower levels in BAV compared to TAV ECs, leading to an increment of <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/double-stranded-dna">DNA double-strand</a> breaks. BAV ECs had a sustained <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/programmed-cell-death">apoptosis</a> activation when compared to TAV ECs. This difference was exacerbated by oxidative stress stimulus leading to a reduced survival rate but completely reverted by miR-328-3p inhibition.</p> <p>Conclusion</p> <p>The present data showed molecular differences in oxidative stress susceptibility, DNA damage magnitude, and apoptosis induction between ECs derived from BAV and TAV patients.</p>
Dataset related to the article "Aortic Valve Sclerosis Adds to Prediction of Short-Term Mortality in Patients with Documented Coronary Atherosclerosis"
<p>This record contains raw data related to the article "Aortic Valve Sclerosis Adds to Prediction of Short-Term Mortality in Patients with Documented Coronary Atherosclerosis".</p> <p> </p> <p><strong>Abstract</strong></p> <p>Aims: Aortic valve sclerosis (AVSc), a non-uniform thickening of leaflets with an unrestricted opening, is characterized by inflammation, lipoprotein deposition, and matrix degradation. In the general population, AVSc predicts long-term cardiovascular mortality (+50%) even after adjustment for vascular risk factors and clinical atherosclerosis. We have hypothesized that AVSc is a risk-multiplier able to predict even short-term mortality. To address this issue, we retrospectively analyzed 90-day mortality of all patients who underwent isolated coronary artery bypass grafting (CABG) at Centro Cardiologico Monzino over a ten-year period (2006–2016). Methods: We analyzed 2246 patients and 90-day all-cause mortality was 1.5% (31 deaths). We selected only patients deceased from cardiac causes (n = 29) and compared to alive patients (n = 2215). A cardiologist classified the aortic valve as no-AVSc (n = 1352) or AVSc (n = 892). Cox linear regression and integrated discrimination improvement (IDI) analyses were used to evaluate AVSc in predicting 90-day mortality. Results: AVSc 90-day survival (97.6%) was lower than in no-AVSc (99.4%; p < 0.0001) with a hazard ratio (HR) of 4.0 (95%CI: 1.78, 9.05; p < 0.0001). The HR for AVSc, adjusted for propensity score, was 2.7 (95%CI: 1.17, 6.23; p = 0.02) and IDI statistics confirmed that AVSc significantly adds (p < 0.001) to the identification of high-risk patients than EuroSCORE II alone. Conclusion: Our data supports the hypothesis that a risk stratification strategy based on AVSc, added to ESII, may allow better recognition of patients at high-risk of short-term mortality after isolated surgical myocardial revascularization. Results from this study warrant further confirmation.</p>
Dataset related to the article "Impact of Oxidative Stress and Protein S-Glutathionylation in Aortic Valve Sclerosis Patients with Overt Atherosclerosis"
<p>This record contains raw data related to the article "Impact of Oxidative Stress and Protein S-Glutathionylation in Aortic Valve Sclerosis Patients with Overt Atherosclerosis"</p> <p> </p> <p><strong>Abstract</strong></p> <p>Aortic valve sclerosis (AVSc) is characterized by non-uniform thickening of the leaflets without hemodynamic changes. Endothelial dysfunction, also caused by dysregulation of glutathione homeostasis expressed as ratio between its reduced (GSH) and its oxidised form (GSSG), could represent one of the pathogenic triggers of AVSc. We prospectively enrolled 58 patients with overt atherosclerosis and requiring coronary artery bypass grafting (CABG). The incidence of AVSc in the studied population was 50%. The two groups (No-AVSc and AVSc) had similar clinical characteristics. Pre-operatively, AVSc group showed significantly lower GSH/GSSG ratio than No-AVSc group (<em>p = </em>0.02). Asymmetric dimethylarginine (ADMA) concentration was significantly higher in AVSc patients compared to No-AVSc patients (<em>p < </em>0.0001). Explanted sclerotic aortic valves presented a significantly increased protein glutathionylation (Pr-SSG) than No-AVSc ones (<em>p = </em>0.01). In vitro, inhibition of glutathione reductase caused β-actin glutathionylation, activation of histone 2AX, upregulation of α2 smooth muscle actin (<em>ACTA2</em>), downregulation of platelet and endothelial cell adhesion molecule 1 (<em>PECAM1</em>) and cadherin 5 (<em>CDH5</em>). In this study, we showed for the first time that the dysregulation of glutathione homeostasis is associated with AVSc. We found that Pr-SSG is increased in AVSc leaflets and it could lead to EndMT via DNA damage. Further studies are warranted to elucidate the causal role of Pr-SSG in aortic valve degeneration.</p>
Dataset related to the article "Outcomes of Transcatheter Aortic Valve Replacement Patients With Different Transvalvular Flow-gradient Patterns"
<p>This record contains raw data related to the article "Outcomes of Transcatheter Aortic Valve Replacement Patients With Different Transvalvular Flow-gradient Patterns".</p><p>Low-flow low-gradient (LF-LG) aortic stenosis (AS) may occur with preserved or depressed left ventricular ejection fraction (LVEF). Both situations represent the most challenging subset of patients to manage and generally have a poor prognosis. Few and controversial data exist on the outcomes of these patients compared to normal-flow high-gradient (NF-HG) AS following transcatheter aortic valve replacement (TAVR). We sought to characterize different transvalvular flow-gradient patterns and to examine their prognostic value after TAVR. We enrolled 1208 patients with severe AS and categorized as follow: 976 patients NF-HG (mean aortic pressure gradient, MPG≥40mmHg), 107 paradoxical cLF-LG (pLF-LG, MPG<40mmHg, LVEF≥50%, stroke volume index, SVi<35mL/m2), and 125 cLF-LG (MPG<40mmHg, LVEF<50%, SVi<35mL/m2). When compared with NF-HG and pLF-LG, cLF-LG had a worse symptomatic status (NYHA III-IV 86% vs 62% and 67%, p<0.001), a higher prevalence of eccentric hypertrophy and a higher level of LV global afterload reflected by a higher valvuloarterial impedance. Valvular function after TAVR was excellent over time in all patients. While 30-day mortality (p=0.911) did not differ significantly among groups, cLF-LG had a lower 5-year survival rate (LF-LG 50% vs pLF-LG 62% and NF-HG 68%, p<0.05). cLF-LG was associated with a hazard ratio for mortality of 2.41 (95% CI: 1.65-3.52, p<0.001). In conclusion, TAVR is an effective procedure regardless of transvalvular flow-gradient patterns. However, special care should be given to characterized hemodynamic of AS, as patients with pLF-LG had similar survival rates than patients with NF-HG, whereas cLF-LG is associated with a 2-fold increased risk of mortality at 5-year follow-up.</p>
Dataset related to the article "Whole-blood transcriptome unveils altered immune response in acute myocardial infarction patients with aortic valve sclerosis"
<p>This record contains raw data related to the article "Whole-blood transcriptome unveils altered immune response in acute myocardial infarction patients with aortic valve sclerosis"</p><p><strong>Abstract</strong></p><p><strong>Background: </strong>Aortic valve sclerosis (AVSc) presents similar pathogenetic mechanisms to coronary artery disease (CAD) and is associated with short- and long-term mortality in CAD patients. Evidence of AVSc-specific pathophysiological traits in acute myocardial infarction (AMI) is currently lacking. Thus, we aimed to identify a blood-based transcriptional signature that could differentiate AVSc from non-AVSc patients during AMI.</p><p><strong>Methods: </strong>Whole-blood transcriptome of AVSc (n = 44) and no-AVSc (n = 66) patients with AMI was assessed by RNA-sequencing on hospital admission. Feature selection, differential expression, and enrichment analyses were performed to identify gene expression patterns discriminating AVSc from no-AVSc and infer functional associations. Multivariable Cox regression analysis was used to estimate the hazard ratios of cardiovascular events in AVSc versus no-AVSc patients.</p><p><strong>Results:</strong> This cross-sectional study identified a panel of 100 informative genes capable of distinguishing AVSc from no-AVSc patients with 94% accuracy. Further analysis revealed significant mean differences in 143 genes, of which 30 genes withstood correction for age and previous AMI or coronary interventions. Functional inference unveiled a significant association between AVSc and key biological processes, including acute inflammatory responses, type I interferons (IFN) response, platelet activation, and hemostasis. Notably, AMI patients with AVSc exhibited a significantly higher incidence of adverse cardiovascular events during a 10-year follow-up period, with a full adjusted hazard ratio of 2.4 (95% CI 1.3–4.5).</p><p><strong>Conclusions:</strong> Our findings shed light on the molecular mechanisms underlying AVSc and provide potential prognostic insights for AMI patients with AVSc. During AMI, AVSc patients showed increased type I IFN response and earlier adverse cardiovascular outcomes. Novel pharmacological therapies aiming at limiting type I IFN response during or immediately after AMI might improve poor cardiovascular outcomes of AMI patients with AVSc.</p><p><strong>Keywords:</strong></p><p> Aortic valve sclerosis; acute myocardial infarction; immune response; inflammation; cardiovascular adverse events; risk stratification.</p>
Dataset related to the article "Circulating mircoRNAs linked to inflammatory pathways are altered in subject with aortic valve sclerosis"
<p><span>Plasma miRNA profiling performed by HTG EdgeSeq miRNA whole transcriptome assay in subjects with and without aortic valve sclerosis (AVSc).</span></p>
Gas valves
<u>Source</u>: Flickr <br><u>4DCity URL</u>: <a href="https://4dcity.org/imgupload/1661456391.1258.jpg">https://4dcity.org/imgupload/1661456391.1258.jpg</a> <br><u>Original Image URL</u>: <a href="https://live.staticflickr.com/65535/52303242692_c6f3db03b6_m.jpg">https://live.staticflickr.com/65535/52303242692_c6f3db03b6_m.jpg</a> <br><br><u>Image-Metadata:</u><br>Filename: 1661456391.1258.jpg<br>Image Dimensions: 240x240<br>Megapixels: 0.06 MP<br>Filesize: 26.39 KB<br><br>ExifOffset: 38
PLATE 8. Eunotia pseudoambivalens Q. Liu, S. L in New and Interesting Diatoms from the Shiwan Wetwalls, Yunnan Province, China. III. Valve ultrastructure of four new species of Eunotia (Bacillariophyceae: Eunotiales)
PLATE 8. Eunotia pseudoambivalens Q. Liu, S. L. Xie & Kociolek, sp. nov. Figures 60–65. Scanning electron microscope images. Figures 60–62, external views. Fig. 60. Whole valve view. A single, thick spine is present at each apex. Fig. 61. Apex of the valve showing spine with thick base, distal raphe end curving from the ventral mantle to the dorsal mantle. Areolae are occluded. Fig. 61. Mid-valve showing uniseriate striae with occlusions. Figs 63–65, internal views. Fig. 63. Whole valve with a pseudoseptum present at each apex. Fig. 64. Valve apex showing pseudoseptum, thickened rimoportula and helictoglossa. Fig. 65. Mid-valve with striae in trough-like openings.
Partial dataset related to the article "Sport PRactice and its Effects on aortic size and valve function in bicuspid Aortic valve Disease: a cross-sectional report from the SPREAD study".
<p>This record contains raw data related to the article "<span>Sport PRactice and its Effects on aortic size and valve function in bicuspid Aortic valve Disease: a cross-sectional report from the SPREAD study"</span></p> <p><span>The bicuspid aortic valve (BAV) is the most common congenital heart defect among adults, often leading to severe valve dysfunction and aortic complications. Despite its clinical significance, uncertainties persist regarding the impact of sports participation on the natural course of BAV disease. The SPREAD (Sport PRactice and its Effects on Bicuspid Aortic valve Disease) study is a multicenter and multinational project designed to investigate this relationship. This paper outlines the study's design, and objectives. The study is divided into two phases; phase one involves a cross-sectional analysis comparing aortic dimensions and valve function among competitive athletes with BAV, athletes with tricuspid aortic valves (TAV), and sedentary individuals with BAV. The second phase is a prospective, longitudinal follow-up aiming to evaluate the impact of regular sports training on disease progression. The SPREAD study seeks to provide evidence-based insights into the effects of sports participation on BAV disease progression, guiding clinical decision-making regarding sports eligibility and risk stratification for individuals with BAV.</span></p>
Haemodynamic assessment and the outcomes of aortic valvuloplasty for aortic regurgitation in patients with bicuspid aortic valve
Open the record for dataset details and reuse information.
FIGS 42 in A morphological study of the enteric valves of the Afrotropical Apicotermitinae (Isoptera: Termitidae)
FIGS 42±45. 'Kaktotermes lawtoni', everted part of enteric valve. (42) side view, scale bar 5120 mm; (43) side view, scale bar 5136 mm; (44) surface view, scale bar 5120 mm; (45) detail of armature on distal end of one ridge, scale bar 523 mm.
The Six-Valve Trombone
Adolph Sax, the inventor of the saxophone, didn't invent the saxophone on his first try. He had plenty of ideas that seemed ingenious for his time, but failed in practice. This is one of those ideas: the six-valved trombone, or as I like to call it, Saxenstine's monster. I highly encourage any history buffs to look it up. Sax had other interesting fails too, such as the multi-bell saxophone. That one may appear here soon, once I take a break from instrument modeling for a bit. Source: Objaverse 1.0 / Sketchfab
China Valve Registry Study-1
ClinicalTrials.gov study NCT02623907. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Anticoagulant After Implantation of Biological Aortic Valve Comparing With Aspirin
ClinicalTrials.gov study NCT01452568. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Impact of Tilt Angle on Conduction Defects During Transcatheter Aortic Valve Implantation (TAVI)
ClinicalTrials.gov study NCT04083040. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Ahmed Glaucoma Valve Alone, With Amniotic Membrane or With Mitomycin C (MMC) for Treatment of Refractory Glaucoma
ClinicalTrials.gov study NCT00893490. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Carotid Filtration During Endovascular Aortic Valve Implantation
ClinicalTrials.gov study NCT01484249. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Results of Different Location of Ahmed Glaucoma Valve Implantation in Refractory Glaucoma, Superior Versus Inferior
ClinicalTrials.gov study NCT00628173. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Streamlined One-wire Logistics Optimize Transcatheter Aortic Valve Replacement
ClinicalTrials.gov study NCT07090811. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Safety and Feasibility of Early Discharge for Transfemoral Transcatheter Aortic Valve Replacement
ClinicalTrials.gov study NCT03600935. IPD Sharing: Not stated. Countries: 0. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.