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Efficacy of switching from teriparatide to zoledronic acid or denosumab on bone mineral density and bone markers in patients with severe fractured osteoporosis: a real-life study
<p><strong>Abstract</strong></p> <p>Purpose: Osteoporosis is characterized by a loss of bone mass, increased bone fragility and susceptibility to fracture. Sequential treatment with bisphosphonates or denosumab (Dmab) after teriparatide (TPT) discontinuation may represent a valid treatment option, but the optimal sequential treatment strategy is unknown.</p> <p>Methods: This retrospective study enrolled 56 osteopenic/osteoporotic patients with fragility fractures who received 24 months of treatment with TPT followed by 24 months of treatment with zoledronic acid (ZOL) (TPT+ZOL) or Dmab (TPT+Dmab). Clinical features, incident fractures, bone mineral density (BMD) measurements, and bone marker profiles were characterized. Ordinary one-way ANOVA adjusted for multiple testing analyzed the difference between median T-scores at baseline, after 24 months of TPT, and after 2 doses of ZOL or at least 3 doses of Dmab when variables failed the normality test.</p> <p>Results: Twenty-three patients received TPT+ZOL (19 females, 4 males; median [IR] age, 74.3 [66.9, 78.6] years) and 33 patients received TPT+Dmab (31 females, 2 males; mean±SD age, 66.6±11.3 years). Mean lumbar and hip T-scores were significantly higher after sequential treatment with both TPT+ZOL and TPT+Dmab (all p<0.05 vs baseline). In particular, the mean lumbar T-score increased in about 80% of patients by 8.5±58% after ZOL, while after Dmab, the mean lumbar T-score was -9.6±36%. Mean±SD femur neck and hip T-scores increased by 12±13% and 9±31%, respectively, after treatment with ZOL, while the change in femur neck and hip T-scores after Dmab were 5±41% and 27±36%, respectively, No significant between-group differences were identified. Fragility fractures occurred in 3 (13%) patients treated with TPT+ZOL and in 5 (15%) patients treated with TPT+Dmab.</p> <p>Conclusion: Sequential therapy with TPT+ZOL increased bone mineralization at the lumbar level and stabilized bone mineralization at the femoral level. Both ZOL and Dmab are effective sequential treatments after TPT.</p>
Multimedia mixed reality interactive shared decision-making game in children with moderate to severe atopic dermatitis, a pilot study
<p><strong>Multimedia mixed reality interactive shared decision-making game in children with moderate to severe atopic dermatitis, a pilot study</strong></p>
Determination of the Damage Severity of Wood-Boring Beetles According to the Bevan Damage Classification System
<p>The aim of the study was to determine damage severity of wood-destroying insects on logs stored in forest depots. The Bevan damage classification (BDC) system, developed in 1987, was utilized to determine damage severity in log depots in 21 locations throughout seven provinces in Turkey. Pheromone traps were placed in those locations at the beginning of April in 2015 and 2016. Furthermore some stored wood within the log depots were checked and split into small pieces to collect insects that damage wood. The BDC system was used for the first time to measure the severity of insect damage in log depots. Twenty-eight families, 104 genera and 123 species were identified in this study. Based on the BDC system, the highest damage was found from the Cerambycidae and Buprestidae families. <em>Arhopalus rusticus</em> was determined as the insect responsible for the highest amount of damage with 8.8% severity rating in the pheromone-trapped insects group. When the stored wood material was considered, <em>Hylotrupes bajulus</em> was found to be the cause of the highest damage. The lowest damage values were among the predator insects (Cleridae, Trogossitidae, Cantharidae) and those feeding on fungi colonized on the wood (Mordellidae, Cerylonidae, Nitidulidae). Some other predator insects of the Tenebrionidae family (<em>Uloma cypraea, Uloma culinaris, Menephilus cylindricus</em>) and Elateridae family (<em>Lacon punctatus</em>, <em>Ampedus</em> sp.) exhibited relatively higher damage severity values since they had built tunnels and made holes in the stored wood material. When the environmental factors were considered, the Buprestidae family exhibited a very strong positive relationship (<em>p</em> <0.005) with insect frequency distribution (r = 0.922), number of species (r = 0.879) and insect density (r = 0.942). Both families showed the highest number and frequency during July and August, highlighting the importance of insect control and management during these months.</p>
Supplementary material 2 from: Korshunova T, Martynov A, Bakken T, Evertsen J, Fletcher K, Mudianta WI, Saito H, Lundin K, Schrödl M, Picton B (2017) Polyphyly of the traditional family Flabellinidae affects a major group of Nudibranchia: aeolidacean taxonomic reassessment with descriptions of several new families, genera, and species (Mollusca, Gastropoda). ZooKeys 717: 1-139. https://doi.org/10.3897/zookeys.717.21885
Table S1 : Explanation note: List of samples, localities, GenBank accession numbers, and voucher references.
Effectiveness of Mannitol Use on Clinical Outcomes of Severe Traumatic Brain Injury Patients
<p>Dataset for article entitled: </p> <p><span>Effectiveness of Mannitol Use on Clinical Outcomes of Severe Traumatic Brain Injury Patients</span></p>
Several movies of TC genesis under rotating RCE
<p>Here we put several movie of TC genesis under rotating RCE together for comparison. </p> <p>Reference:</p> <p>Fu, H., and O'Neill, M., 2024: The Small-Amplitude Dynamics of Spontaneous Tropical Cyclogenesis. Part l: Experiments with Amplified Longwave Radiative Feedback J. Atmos. Sci., 81(2), 381-399.</p> <p>Wing A., S. J. Camargo, and A. H. Sobel, 2016: Role of Radiative–Convective Feedbacks in Spontaneous Tropical Cyclogenesis in Idealized Numerical Simulations, , J. Atmos. Sci., 73, 2633-2642.</p> <p>Yang, B., J. Nie, Z. Tan, and J. Fang, 2024: Phase Match of Quasi-Periodic Behavior with Diurnal Cycle Accelerates Tropical Cyclone Genesis, manuscript submitted. </p>
Stratified analyses refine association between TLR7 rare variants and severe COVID-19 - Datasets
<p>This dataset comprises single variant summary statistics (MAF>0.01%) and the results of the burden analyses for the publication <em>Stratified analyses refine association between TLR7 rare variants and severe COVID-19 </em>by Boos et al. 2024 in HGG Advances.</p> <p>Please refer to the respective README-Files for a description of the file contents.</p>
Data from: Contextualizing the 2019–2020 Kangaroo Island Bushfires: Quantifying Landscape-Level Influences on Past Severity and Recovery with Landsat and Google Earth Engine
<p><strong>Paper Abstract:</strong></p> <p>The 2019–2020 Kangaroo Island bushfires in South Australia burned almost half of the island. To understand how to avoid future severe ‘mega-fires’ and how vegetation may recover from 2019–2020, we can utilize information from the bulk of historical fires in an area. Landsat time-series of vegetation change provide this opportunity, but there has been little analysis of large numbers of fires to build a landscape-level understanding and quantify drivers in an Australian context. In this study, we built a yearly cloud-free surface reflectance normalized burn ratio (NBR) time-series (1988–2020) using all available summer Landsat images over Kangaroo Island. Data were collected in Google Earth Engine and fitted with LandTrendr. Burn severity and post-fire recovery were quantified for 47 fires, with a new recovery metric facilitating comparison where fire frequency is high. Variables representing the current burn, fire history, vegetation structure, and topography were related to severity and yearly recovery with random forest and bivariate analysis. Results show that the 2019–2020 bushfires were the most widespread and severe, followed by 2007–2008. Vegetation recovers quickly, with NBR stabilizing ten years post-fire on average. Severity is most influenced by fire frequency, vegetation capacity and land use with more severe burns in nature conservation areas with dense vegetation and a history of frequent fires. Influence on recovery varied with time since fire, with initial (year 1–3) faster recovery observed in areas with less surviving vegetation. Later (year 6–10) recovery was most influenced by a variable representing burn year and further investigation indicates that precipitation increases in later post-fire years likely facilitated faster recovery. The relative abundance of eucalypt woodlands also has a positive influence on recovery in middle and later years. These results provide valuable information to land managers on Kangaroo Island and in similar environments, who should consider adjusting practices to limit future mega-fire risk and potential ecosystem shifts if severe fires become more frequent with climate change.</p> <p> </p> <p><strong>Data details:</strong></p> <p>See paper: <a href="https://www.mdpi.com/2072-4292/12/23/3942">Remote Sensing | Free Full-Text | Contextualizing the 2019–2020 Kangaroo Island Bushfires: Quantifying Landscape-Level Influences on Past Severity and Recovery with Landsat and Google Earth Engine (mdpi.com)</a></p> <p>See code on GitHub: <a href="https://github.com/ZZMitch/KangarooIslandFireHistory_1988to2020">ZZMitch/KangarooIslandFireHistory_1988to2020: Code from "Contextualizing the 2019–2020 Kangaroo Island Bushfires: Quantifying Landscape-Level Influences on Past Severity and Recovery with Landsat and Google Earth Engine" (RS, 2020) (github.com)</a></p> <p> </p> <p><strong>If you use these data, please reference: </strong></p> <p>Bonney, M.T., He, Y., Myint, S.W., 2020. Contextualizing the 2019–2020 Kangaroo Island bushfires: Quantifying landscape-level influences on past severity and recovery with Landsat and Google Earth Engine. Remote Sensing 12(23), <a href="https://doi.org/10.3390/rs12233942" rel="nofollow">https://doi.org/10.3390/rs12233942</a>.</p>
A brief online transdiagnostic measure: psychometric properties of the Overall Anxiety Severity and Impairment Scale (OASIS) among Spanish patients with emotional disorders
<p>This dataset contains demographic and clinical data about 583 patients with anxiety and depressive disorders that participated in a study whose objective is to examine the psychometric properties of the online version of the Overall Anxiety Severity and Impairment Scale in Spanish clinical population. </p>
PRPs' performance on the assessment of periodontitis severity and extent
<p>Partial recording protocols performance on the assessment of periodontitis severity and extent: bias magnitudes, sensibility, and specificity data</p>
FIGURES 55‒57 in Gloora gen. nov. (Lepidoptera: Erebidae: Arctiinae: Arctiini: Ctenuchina) for several Agylla - like Arctiinae
FIGURES 55‒57. Gloora alba comb. nov., scanning electron micrographs of a female tymbal organ after brushing off the overlying scales (55, 56) and a spectrogram (57) showing a modulation cycle with ten clicks in the active and passive modulation half cycle. The acoustic structure of sounds produced in response to manual stimulation meets the general assumptions on arctiine sound production (Blest et al. 1963; Fullard & Fenton 1977) but differ insofar as the passive modulation half cycles are in comparison to the respective active cycles less emphasized, i.e. with lower overall amplitude of the click trains. Courtesy of Philipp Klein, FZE, Freiburg (cf. Klein et al. 2018). Scale bars: 100 µm / 5 msec.
FIGURES 59‒62 in Gloora gen. nov. (Lepidoptera: Erebidae: Arctiinae: Arctiini: Ctenuchina) for several Agylla - like Arctiinae
FIGURES 59‒62. Eucereon vestalis (Schaus, 1892a), habitus male (59, 60), dorsal (left) and ventral (right) view; male genitalia; dorsal (61), ventral (62), lateral (63), phallus (64). Scale bars: 0.5 / 1 mm.
FIGURES 1‒4 in Gloora gen. nov. (Lepidoptera: Erebidae: Arctiinae: Arctiini: Ctenuchina) for several Agylla - like Arctiinae
FIGURES 1‒4. Gloora alba comb. nov., habitus female (1, 2) and male (3) and both sexes gathering pyrrolizidine alkaloids from dry roots of Emilia sp. (Asteraceae) (4).
FIGURES 47‒50 in Gloora gen. nov. (Lepidoptera: Erebidae: Arctiinae: Arctiini: Ctenuchina) for several Agylla - like Arctiinae
FIGURES 47‒50. Dense clusters of scales, representing crystal scales (cs)(sensu Boppré et al. 2018) at the base of coremata (co) as seen in a freshly killed specimen in which coremata were artificially protruded (47) and in a KOH abdominal preparation of Gloora alba comb. nov. Same structures in KOH preparations of G. sericea comb. nov. (49) and G. canae sp. nov. (50).
FIGURES 35‒38 in Gloora gen. nov. (Lepidoptera: Erebidae: Arctiinae: Arctiini: Ctenuchina) for several Agylla - like Arctiinae
FIGURES 35‒38. Gloora mundula comb. nov., male genitalia; dorsal (35), ventral (36), lateral (37), phallus (38). Scale bar: 1 mm.
FIGURES 31‒34 in Gloora gen. nov. (Lepidoptera: Erebidae: Arctiinae: Arctiini: Ctenuchina) for several Agylla - like Arctiinae
FIGURES 31‒34. Gloora alba comb. nov., male genitalia; dorsal (31), ventral (32), lateral (33), phallus (34). Scale bar: 1 mm.
FIGURES 15‒30 in Gloora gen. nov. (Lepidoptera: Erebidae: Arctiinae: Arctiini: Ctenuchina) for several Agylla - like Arctiinae
FIGURES 15‒30. Gloora alba comb. nov. (15‒18), G. mundula comb. nov. (19‒22), G. sericea comb. nov. (23‒26), and G. canae sp. nov. (27‒30), habitus male (15, 16, 19, 20, 23, 24, 27, 28) and female (17, 18, 21, 22, 25, 26, 29, 30), dorsal (left) and ventral (right) view. Scale bar: 5 mm.
FIGURES 43‒46 in Gloora gen. nov. (Lepidoptera: Erebidae: Arctiinae: Arctiini: Ctenuchina) for several Agylla - like Arctiinae
FIGURES 43‒46. Gloora canae sp. nov., male genitalia; dorsal (43), ventral (44), lateral (45), phallus (46). Scale bar: 1 mm.
FIGURE 58 in Gloora gen. nov. (Lepidoptera: Erebidae: Arctiinae: Arctiini: Ctenuchina) for several Agylla - like Arctiinae
FIGURE 58. Neighbour-joining distance tree for Gloora gen.nov. obtained from the analysis of 19 DNA barcode sequences from BOLDSYSTEMS plus 2 new ones of G. alba; from BIN BOLD:AAA4772 6 out of <100 identical barcodes were selected. Distances in % and bootstrap supports (in bold and only if larger than 70 %) are given near each branch (obtained with MEGA6, cf. Tamura et al. 2013).
FIGURES 5‒13 in Gloora gen. nov. (Lepidoptera: Erebidae: Arctiinae: Arctiini: Ctenuchina) for several Agylla - like Arctiinae
FIGURES 5‒13. Holotypes (♀♀) of Gloora alba comb. nov.: Idalus alba Druce, 1894 (5‒7) and Hyaleucerea agylloides Dyar, 1912 (8‒10), and, for comparison, of Eucereon vestalis: Theages vestalis Schaus, 1892a (11‒13).
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.