Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
2,009
datasets available to search
ShareScore release 0.9.0
Dataset results
2,009 results for “Disruption”
Neutrophilic inflammation and epithelial barrier disruption in nasal polyps characterize NSAID-exacerbated respiratory disease
GEO Series GSE189690. Homo sapiens. 26 samples. Type: Expression profiling by high throughput sequencing.
Disrupted gene networks in subfertile hybrid mice
GEO Series GSE136886. Mus musculus. 499 samples. Type: Expression profiling by array.
Evaluating genome-wide expression following the disruption of CDK12 reveals a bimodal pattern of gene regulation
GEO Series GSE181905. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Impaired GSH biosynthesis disrupts eye development and PAX6 function
GEO Series GSE175394. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Assessment of Endocrine Disruption in the Shenandoah River Watershed – Transcriptome Data from Mobile Laboratory Fish Exposures and Other Experiments Conducted during 2014
GEO Series GSE111965. Pimephales promelas. 31 samples. Type: Expression profiling by array.
Loss of miR-9-2 Causes Cerebral Hemorrhage and Hydrocephalus by Widespread Disruption of Cell-Type-Specific Neurodevelopmental Gene Networks
GEO Series GSE304879. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Assessment of Endocrine Disruption in the Shenandoah River Watershed – Transcriptome Data from Mobile Laboratory Fish Exposures and Other Experiments Conducted during 2014-2016
GEO Series GSE111967. Pimephales promelas. 96 samples. Type: Expression profiling by array.
POT1 mutations identify inferior outcomes in chronic lymphocytic leukemia and disrupted telomere biology function
GEO Series GSE261569. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
N6-methyladenine DNA demethylase ALKBH1 promotes gastric carcinogenesis via disrupting NRF1 binding capacity [ALKBH1-6mA-seq]
GEO Series GSE214125. Homo sapiens. 10 samples. Type: Other.
NSD2 E1099K Drives Relapse in Pediatric Acute Lymphoblastic Leukemia by Disrupting 3D Chromatin Organization
NSD2 p.E1099K (EK) is a mutation shown to be enriched in patients that relapse with pediatric Acute Lymphoblastic Leukemia (ALL). This work aims to uncover 3D chromatin architecture-related mechanisms responsible for drug resistance or therapy failure in these patients. We investigated this by performing Hi-C, ATAC-Seq, and RNA-Seq on three B-ALL cell lines heterozygous for EK either expressing a NSD2 targeting small RNA (sRNA) or a non-targeting small hairpin RNAs (shRNA). We also performed RNA-Seq on three matched diagnosis/relapse B-ALL samples with the relapse enriched EK mutation.
Neofusicoccum laricinum disrupts larch defenses through coordinated cell wall degradation and antioxidant suppression
GEO Series GSE317540. Larix kaempferi. 6 samples. Type: Expression profiling by high throughput sequencing.
Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice
GEO Series GSE37080. Mus musculus. 8 samples. Type: Expression profiling by array.
Rice interploidy crosses disrupt epigenetic regulation, gene expression, and seed development
GEO Series GSE65149. Oryza sativa Japonica Group. 7 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
N6-methyladenine DNA demethylase ALKBH1 promotes gastric carcinogenesis via disrupting NRF1 binding capacity
GEO Series GSE214127. Homo sapiens. 12 samples. Type: Other; Expression profiling by high throughput sequencing.
HRM in disruptive contexts
<p>PLS SEM methodology used to analyse quantiatative data from physicians.</p>
Dataset related to article "Duplications disrupt chromatin architecture and rewire GPR101-enhancer communication in X-linked acrogigantism"
<p>This record contains raw data related to article “Duplications disrupt chromatin architecture and rewire GPR101-enhancer communication in X-linked acrogigantism"</p> <p>X-linked acrogigantism (X-LAG) is the most severe form of pituitary gigantism and is characterized by aggressive growth hormone (GH)- secreting pituitary tumors that occur in early childhood. X-LAG is associated with chromosome Xq26.3 duplications (the X-LAG locus typically includes VGLL1, CD40LG, ARHGEF6, RBMX, and GPR101) that lead to massive pituitary tumoral expression of GPR101, a novel regulator of GH secretion. The mechanism by which the duplications lead to marked pituitary misexpression of GPR101 alone was previously unclear. Using Hi-C and 4C-seq, we characterized the normal chromatin structure at the X-LAG locus.We showed that GPR101 is located within a topologically associating domain (TAD) delineated by a tissue-invariant border that separates it from centromeric genes and regulatory sequences. Next, using 4C-seq with GPR101, RBMX, and VGLL1 viewpoints, we showed that the duplications in multiple X-LAG-affected individuals led to ectopic interactions that crossed the invariant TAD border, indicating the existence of a similar and consistent mechanism of neo-TAD formation in X-LAG.We then identified several pituitary active cis-regulatory elements (CREs) within the neo-TAD and demonstrated in vitro that one of them significantly enhanced reporter gene expression. At the same time, we showed that the GPR101 promoter permits the incorporation of new regulatory information. Our results indicate that X-LAG is a TADopathy of the endocrine system in which Xq26.3 duplications disrupt the local chromatin architecture forming a neo-TAD. Rewiring GPR101- enhancer interaction within the new regulatory unit is likely to cause the high levels of aberrant expression of GPR101 in pituitary tumors caused by X-LAG.</p>
Dataset The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions and is susceptible to pharmacological disruption
<p>This dataset is related to <strong>"</strong>MLL1 minimal catalytic complex is a dynamic conformational ensemble susceptible to pharmacological allosteric disruption<strong>" </strong>(Lilia Kaustov, Alexander Lemak, Hong Wu, Marco Faini, Lixin Fan, Xianyang Fang, Hong Zeng, Shili Duan, Abdellah Allali-Hassani, Yong Wei, Masoud Vedadi, Ruedi Aebersold, Yunxing Wang, Scott Houliston, Cheryl H. Arrowsmith) . </p> <p>The repository contains the data used in the modeling of WDR5-RbBP5-MLL1 trimeric complex, the optimal ensemble of models, and the representative models for major and minor populations. The modeling is performed based on saxs and cross-link MS data, crystallographic structures, and comparative models using coarse-grained MD simulations and Sparse Ensemble Selection method (SES) for optimal ensemble selection.</p>
datset related to article "PATHOLOGICAL MITOPHAGY DISRUPTS MITOCHONDRIAL HOMEOSTASIS IN LEBER'S HEREDITARY OPTIC NEUROPATHY"
<p><strong>Raw data from Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy – experiments of</strong> <strong>mito-autophagy present in specific regions of the idNeurons (soma and axon-dendrite (Ax-De) regions) </strong></p>
DCHP targets lipid associated macrophages to disrupt lipid metabolism via crosstalk with adipocyte precursor cells
GEO Series GSE246564. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
The Medusa Mutant Disrupts Ovule Integument Identity Specification and Female Gametophyte Development in Mimulus nudatus
GEO Series GSE297725. Erythranthe nudata. 6 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.