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Fig. 6 in Arachidonic acid-dependent carbon-eight volatile synthesis from wounded liverwort (Marchantia polymorpha)

Fig. 6. Resolution of enantiomers of 5 formed from racemic 3. The crude enzyme extract prepared from des6KO thalli was reacted with racemic 3, and the 5 formed by enzyme catalyzed hydrolysis was subjected to chiral phase GC analysis (upper chromatogram). 5 was not detected with the reaction mixture prepared without substrate (middle chromatogram) or without enzyme (lower chromatogram).

Fig. 3 in Arachidonic acid-dependent carbon-eight volatile synthesis from wounded liverwort (Marchantia polymorpha)

Fig. 3. Time course of emission of 1 and 5 after mechanical wounding of M. polymorpha thallus grown in a field. Average ± s.e. (n = 6) is shown. Different letters for each compound refer to significant differences (ANOVA, Bonferroni, P <0.01).

Fig. 5 in Arachidonic acid-dependent carbon-eight volatile synthesis from wounded liverwort (Marchantia polymorpha)

Fig. 5. Effect of incubation after tissue disruption on C8 volatile formation. The thalli were frozen and the volatiles were extracted (white bars), or the frozen thalli were thawed, and incubated for 5 min at 24 °C to facilitate the enzyme reaction (gray bar). Average ± s.e. (n = 4) is shown. Asterisks indicate significant differences for the noted compound (Student's t-test, ⁄⁄⁄P <0.001).

Fig. 8 in Arachidonic acid-dependent carbon-eight volatile synthesis from wounded liverwort (Marchantia polymorpha)

Fig. 8. Effect of addition of NAD(P)H on the C8 volatiles emitted from M. polymorpha thalli. C8 volatiles extracted from intact (white bars), partially wounded (50%, gray bars), totally disrupted (black bars), totally disrupted in the presence of NADH (coarse stripe), and totally disrupted M. polymorpha thalli in the presence of NADPH (dense stripe) were quantified. The average ± s.e. (n = 4–5) is shown. Different letters for each compound refer to significant differences (one way ANOVA, Fisher, P <0.05).

opencc-by-4.0Mar 2024View details →

m6A-dependent 7-dehydrocholesterol reductase facilitates bladder cancer metastasis via cAMP/PKA/FAK axis

Cholesterol homeostasis dysregulation appears in multiple tumors. However, the specific processes that cause abnormal cholesterol metabolism to affect the invasion and metastasis of bladder cancer (BC) are still unclear. In our investigation, we found a notable rise in the expression of 7-dehydrocholesterol reductase (DHCR7), a key enzyme involved in the synthesis of cholesterol, within BC tissues in comparison to normal tissues and correlated to the invasion and metastasis of BC. This elevated expression of DHCR7 in BC was attributed to the decreased degradation of mRNA mediated by YTHDF2. We discovered that DHCR7 plays a role in promoting bladder cancer invasion and metastasis by activating the cAMP-PKA-FAK pathway. Specifically, DHCR7 was found to increase the levels of cAMP by enhancing cholesterol content in lipid rafts, thereby facilitating the transduction of signaling pathways mediated by cAMP receptors. Additionally, DHCR7 was found to enhance the cAMP signaling pathway by reducing the concentration of 7-DHC and promoting the transcription of GIPR. Overall, our findings demonstrated that DHCR7 plays a crucial role in BC invasion and metastasis by modulating cholesterol synthesis and cAMP signaling pathways. Furthermore, AY9944, which acts as an inhibitor of DHCR7, shows promise as a viable therapeutic strategy for the suppression of invasion and metastasis in BC.

dryad32/100

Cooperation in public goods game does not require assortment and depends on population density

The threshold public goods game is one of the best-known models of nonlinear public goods dilemmas. Cooperators and defectors typically coexist in this game when the population is assumed to follow the so-called structured deme model. In this paper we develop a dynamical model of a general N-player game in which there is no deme structure: individuals interact with randomly chosen neighbours and selection occurs between randomly chosen pairs of indi- viduals. We show that in the deterministic limit the dynamics in this model leads to the same replicator dynamics as in the structured deme model, i.e. coexistence of cooperators and defectors is typical in threshold public goods game even when the population is completely well-mixed. We extend the model to study the effect of density dependence and density fluctuation on the dynamics. We show analytically and numerically that decreasing population density increases the equilibrium frequency of cooperators till the fixation of this strategy, but below a critical density coop- erators abruptly disappear from the population. Our numerical investigations show that weak density fluctuations enhance cooperation, while strong fluctuations suppress it.

opencc-zeroMar 2024View details →

opencc-by-4.0Jul 2021View details →

Multi-objective particle swarm optimization and training of datasheet-based load dependent lithium-ion voltage models

Open the record for dataset details and reuse information.

opencc-by-4.0Oct 2023View details →

Data release: "The metallicity dependence and evolutionary times of merging binary black holes: Combined constraints from individual gravitational-wave detections and the stochastic background"

This data release contains the data to reproduce the results of "The metallicity dependence and evolutionary times of merging binary black holes: Combined constraints from individual gravitational-wave detections and the stochastic background" (<a href="https://arxiv.org/abs/2310.17625">arXiv:2310.17625</a>, published version <a href="https://iopscience.iop.org/article/10.3847/1538-4357/ad3d5c">here</a>). The code that was used to generate this data can be found on <a href="https://github.com/kevinturbang/bbh_gwb_time_delay_inference">this GitHub repository</a>. Jupyter notebooks to reproduce the figures of the paper are also included, and can be found <a href="https://github.com/kevinturbang/bbh_gwb_time_delay_inference/tree/main/figures">here</a>.

The commit history of the dependent libraries.

Each file represents a software library and is named accordingly. These files store a commit history, where each commit signifies modifications between when a dependent library involve this library as dependency and when it subsequently removed the dependency. Note: The commits history is not later than 2019.

Fig. 4 in Density dependent variation in the life history traits of mottled emigrant butterfly, Catopsilia pyranthe (Linnaeus, 1758) (Lepidoptera: Pieridae)

Fig. 4. The variations (Mean ± SE) of density impact (DI) on different life history traits of C. pyranthe butterfly species under intraspecific competitions. Shaded bars represent ♀ while nonshaded bars represent ♂. The life history traits are shown in sequence as (a) age at pupation (AP, in days), (b) pupal weight (PW, in mg), (c) adult weight (AW, in mg), (d) adult length (AL, in mm), (e) forewing length (FWL, in mm), (f) forewing breadth (FWB, in mm), (g) hindwing length (HWL, in mm), and (h) hindwing breadth (HWB, in mm). Values less than zero indicates density impact. Рис. 4. Вариации (среднее ± SE) влиЯниЯ плотности (DI) на раЗличные приЗнаки жиЗненного цикла бабочек C. pyranthe в условиЯх внутривидовой конкуренции. ЗаШтрихованные столбцы представлЯют ♀, а неЗаШтрихованные столбцы представлЯют ♂. Параметры жиЗненного цикла покаЗаны в следуюЩей последовательности: (а) воЗраст окукливаниЯ (AP, в днЯх), (b) вес куколки (PW, в мг), (c) вес вЗрослой особи (AW, в мг), (d) вЗрослаЯ особь. длина (AL, в мм), (e) длина переднего крыла (FWL, в мм), (f) Ширина переднего крыла (FWB, в мм), (g) длина Заднего крыла (HWL, в мм) и (h) Ширина Заднего крыла (HWB, в мм). ЗначениЯ меньШе нулЯ укаЗывают на влиЯние плотности.

Fig. 2 in Density dependent variation in the life history traits of mottled emigrant butterfly, Catopsilia pyranthe (Linnaeus, 1758) (Lepidoptera: Pieridae)

Fig. 2. The proportion of survivorship of C. pyranthe in different initial larval rearing density (ranging from 1 through 4). Рис. 2. ДолЯ выживШих C. pyranthe при раЗной начальной плотности выраЩиваниЯ личинок (от 1 до 4).

Fig. 1 in Density dependent variation in the life history traits of mottled emigrant butterfly, Catopsilia pyranthe (Linnaeus, 1758) (Lepidoptera: Pieridae)

Fig. 1. The outline of the experimental design followed for the evaluation of the density dependent effects on the life history traits of the butterfly C. pyranthe. Рис. 1. План Эксперимента, испольЗованный длЯ оценки влиЯниЯ плотности на особенности жиЗненного цикла бабочки C. pyranthe.

Fig. 3 in Density dependent variation in the life history traits of mottled emigrant butterfly, Catopsilia pyranthe (Linnaeus, 1758) (Lepidoptera: Pieridae)

Fig. 3. The differences in the life history traits of C. pyranthe considering male and female separately under intraspecific competitions in minimalist form of density of the individuals The life history traits considered are (a) age at pupation (AP, in days), (b) pupal weight (PW, in mg), (c) adult weight (AW, in mg), (d) adult length (AL, in mm), (e) forewing length (FWL, in mm), (f) forewing breadth (FWB, in mm), (g) hindwing length (HWL, in mm), and (h) hindwing breadth (HWB, in mm). Рис. 3. РаЗличиЯ приЗнаков жиЗненного цикла C. pyranthe с учетом самцов и самок отдельно при внутривидовой конкуренции в минималистской форме плотности особей. (b) масса куколки (PW, в мг), (c) масса вЗрослой особи (AW, в мг), (d) длина вЗрослой особи (AL, в мм), (e) длина переднего крыла (FWL, в мм), (f) Ширина переднего крыла (FWB, в мм), (g) длина Заднего крыла (HWL, в мм) и (h) Ширина Заднего крыла (HWB, в мм).

Distance Dependence of the Energy Transfer Mechanism in WS2-Graphene Heterostructures

<h2>Description of Uploaded Raw Data and Programs for Recreating Figures</h2> <h3>Raw Data</h3> The raw data in this dataset is primarily in  ".np" binary format, which is used by the python package numpy. <h3>Software and Programs</h3> The figures in the paper were generated using Python programs, as well as Jupiter Notebooks, which are included in the dataset. These programs are sorted in their respective folders.

opencc-by-4.0Nov 2024View details →

Enhancing gene transfer to renal tubules and podocytes by context-dependent selection of AAV capsids

RawData.zip file provides AAV Barcode-Seq raw read count data used for Figure 1 and Supplementary Figure 1. Each file represents NGS read count data of each barcode (BC) PCR product indicated in the file name. VBC_AAV_capsid_Conversion_Table.csv provides information about the barcodes, CAGBC101 to CAGBC223, used for AAV capsids contained in the library.

Schiff Base Crosslinked Hyaluronic Acid Hydrogels with Tunable and Cell Instructive Time-Dependent Mechanical Properties

This folder contains raw data for the paper titled "Schiff Base Crosslinked Hyaluronic Acid Hydrogels with Tunable and Cell Instructive Time-Dependent Mechanical Properties" authored by Taha Behroozi Kohlan, Yanru Wen, Carina Milena Mini, and Anna Finne-Wistrand, published in Carbohydrate Polymers journal. The raw data presented here contains NMR, FTIR, SEC, swelling and stability, and rheology data used to create figures. Abstract: The dynamic interplay between cells and their native extracellular matrix (ECM) influences cellular behavior, imposing a challenge in biomaterial design. Dynamic covalent hydrogels are viscoelastic and show self-healing ability, making them a potential scaffold for recapitulating native ECM properties. We aimed to implement kinetically and thermodynamically distinct crosslinkers to prepare self-healing dynamic hydrogels to explore the arising properties and their effects on cellular behavior. To do so, aldehyde-substituted hyaluronic acid (HA) was synthesized to generate imine, hydrazone, and oxime crosslinked dynamic covalent hydrogels. Differences in equilibrium constants of these bonds yielded distinct properties including stiffness, stress relaxation, and self-healing ability. The effects of degree of substitution (DS), polymer concentration, crosslinker to aldehyde ratio, and crosslinker functionality on hydrogel properties were evaluated. The self-healing ability of hydrogels was investigated on samples of the same and different crosslinkers and DS to obtain hydrogels with gradient properties. Subsequently, human dermal fibroblasts were cultured in 2D and 3D to assess the cellular response considering the dynamic properties of the hydrogels. Moreover, assessing cell spreading and morphology on hydrogels having similar modulus but different stress relaxation rates showed the effects of matrix viscoelasticity with higher cell spreading in slower relaxing hydrogels.

State-dependent mortality, not behavior, fragments population distribution of a long-lived mammal after ecological disturbance

Data and code used to produce figures and analyses for the peer-reviewed paper "State-dependent mortality, not behavior, fragments population distribution of a long-lived mammal after ecological disturbance". All demographic and GPS data were collected by the authors as part of the Wyoming Range Mule Deer Project, and spatial data were derived from publicly available GIS platforms.  Questions about data and code can be directed to rraffer1@uwyo.edu and tlasharr@uwyo.edu.

opencc-by-4.0Oct 2024View details →

Spns1-dependent endocardial lysosomal function drives valve morphogenesis through Notch1-signaling

This doi contains raw data related to  the article "Spns1-dependent endocardial lysosomal function drives valve morphogenesis through Notch1-signaling" Authors: Myra N. Chávez, Prateek Arora, Marco Meer, Ines J. Marques, Alexander Ernst, Rodrigo A. Morales Castro, Nadia Mercader the DOI of the manuscript is <a title="Persistent link using digital object identifier" href="https://doi.org/10.1016/j.isci.2024.111406" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.isci.2024.111406</a>

opencc-by-4.0Nov 2024View details →

Data for Influence of Coverage Dependence on the Thermophysical Properties of Adsorbates and its Impact on Microkinetic Models

Data and scripts for the preprint "Influence of Coverage Dependence on the Thermophysical Properties of Adsorbates and its Impact on Microkinetic Models".