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1,944 results for “Class I”
Control of Th17 Cell Development Through Cooperative Transcriptional Activities of Class IIa HDAC4 and HDAC7
GEO Series GSE144830. Mus musculus. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Landscape of ribosome-engaged alternative transcript isoforms across neuronal cell classes
GEO Series GSE133291. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
Class IIa HDACs reprogram mitochondrial metabolism to inhibit apoptosis and ferroptosis in response to lipotoxicity
GEO Series GSE215185. Mus musculus. 19 samples. Type: Expression profiling by array.
Characterization of a new class of RNA products from the Pax-5 oncogene: circular RNAs
GEO Series GSE188623. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Cold-inducible brown fat thermogenesis enhances MHC class I expression and antitumor immunity in ovarian cancer.
GEO Series GSE264447. Mus musculus. 28 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Pretransplant active disease status and HLA class II mismatching are associated with increased incidence and severity of cytokine release syndrome after haploidentical transplantation with posttransplant cyclophosphamide."
<p>Cytokine release syndrome (CRS) represents a life-threatening side effect after haploidentical stem cell transplantation (Haplo-SCT) with posttransplant cyclophosphamide (PT-Cy). Factors predictive of CRS development is still a matter of debate. We retrospectively analyzed 102 consecutive patients receiving a bone marrow (BM) (n = 42) or peripheral blood stem cells (PBSC) (n = 60) Haplo-SCT with PT-Cy. The two cohorts were similar in main patients' characteristics besides disease type (P = .02). Cumulative incidence of grades 1, 2, and ≥3 CRS was 80%, 52%, and 15% at a median of 2, 4, and 7 days, respectively. Moderate/High-grade fever (39°-41°), grade 1 and grade ≥3 CRS occurred more frequently after PBSC relative to BM grafts (68% vs 33%, P = .0005; 87% vs 71%, P = .009; 20% vs 7%, P = .07). Only patients experiencing grade ≥3 CRS had a worse outcome in terms of 1-year overall survival (OS) and nonrelapse mortality (NRM): 39% vs 80% (P = .002) and 40% vs 8% (P = .005), respectively. By univariate analysis the only factors associated with the increased risk of ≥3 CRS were pretransplant disease status (8% for complete remission, 11% for partial remission, and 38% for active disease, P = .002), HLA-DRB1 mismatching (57% vs 14%, P = .007), and PBSC graft (P = .07). By multivariable analysis, only pretransplant disease status (hazard ratio, HR: 6.84, P = .005) and HLA-DRB1 mismatching (HR: 17.19, P = .003) remained independent predictors of grade ≥3 CRS. Only grade ≥3 CRS is clinically relevant for the final outcome of patients receiving Haplo-SCT with PT-Cy, is more frequent after a PBSC graft and is associated with pretransplant active disease and HLA-DRB1 mismatching.</p>
Dataset from thesis entitled: Analysis of the relationship between the phylogeny and the spontaneous misfolding proneness of the prion protein across hundreds of species of the class Mammalia.
<p>This entry contains raw data from the PhD thesis entitled "Analysis of the relationship between the phylogeny and the spontaneous misfolding proneness of the prion protein across hundreds of species of the class Mammalia." presented by Cristina Sampedro Torres-Quevedo in july 2024 at the University of the Basque Country (UPV/EHU). </p> <p>Among these raw data we include the alignment of 876 recombinant prion protein sequences from mammalian species, the phylogenetic tree that resulted from this alignment and PrPDex files that summarize the information obtained for many of the proteins included in the thesis (also available at prpdex.com). </p> <p>Abstract from the thesis: </p> <p>Transmissible spongiform encephalopathies (TSEs) or prion diseases are a group of invariably fatal neurodegenerative diseases that affect a range of mammalian species, including humans. These diseases are caused by the misfolding of the cellular prion protein (PrP<sup>C</sup>) into a toxic, aggregation-prone isoform (PrP<sup>Sc</sup>, from scrapie, the first identified prion disease). Despite this misfolding being the primary pathogenic event, the molecular mechanisms underlying this process remain largely unknown.</p> <p>The prion protein is highly conserved across species. However, despite the similarity between the amino acid sequences of the prion protein (PrP) among mammals, some species present much lower susceptibility to prion diseases. The key to this behaviour likely lays on the enhanced resistance of these animal species’ prion proteins to acquire a <em>bona fide</em> prion conformation. It is, therefore, conceivable that the tertiary structure and interspecific variations, ultimately encoded in the primary structure, determine the proneness of a PrP to misfolding. For this reason, the differences in the PrP sequence between mammalian species were systematically analysed to study the <em>PRNP</em> gene from a phylogenetic perspective, potentially unveiling evolutionary events related to prion diseases.</p> <p>A comprehensive database of hundreds of mammalian PrP sequences, the largest collection gathered so far, was generated, and phylogenetic trees were constructed based on nucleotide sequence variations. To this aim, 876 prion protein genetic sequences (from codon 90 to codon 231 approximately) from over 600 different mammalian species were aligned and a <em>PRNP</em> gene-based phylogenetic tree was built.</p> <p>Classical phylogenetic orders, classified according to multigenic analyses, tend to maintain their clusterization when using the <em>PRNP</em> gene as a readout of phylogenetic similarity. Nonetheless, the few differences found may shed some light on potential evolutionary constraints posed by prion disorders. Moreover, this phylogenetic study was combined with an <em>in vitro</em> misfolding study. The recently developed Protein Misfolding Shaking Amplification (PMSA), which allows to generate <em>bona fide</em> prions spontaneously, was used to evaluate the tendency of many of these proteins to misfold. This comprehensive analysis spanned a wide range of mammalian prion protein sequences. <span> </span></p> <p>This study has allowed to assign a numerical misfolding proneness score to each protein variant studied, ranking them based on their capacity to misfold spontaneously. Furthermore, this study presents data, on top of the tendency to misfold, on predicted protein stability, <em>in vitro </em>propagation, and <em>in vivo</em> infectious capabilities, whenever known. It also includes phylogenetic information about the species and lists of species with identical sequences.</p> <p>Both the phylogeny and misfolding studies have given rise to a large volume of data that may allow to determine the effect of distinct amino acids at each polymorphic position of the PrP on misfolding. This extremely complex phenomenon, influenced by multiple residues and the overall amino acidic context, will be the basis for future studies. These studies may require more sophisticated computational analyses or machine learning approaches than the visual analysis performed for this work. Nevertheless, our approach of coupling the phylogenetic information of the <em>PRNP</em> gene tree with misfolding capacity assessment has allowed us to conclude, among others, that prion diseases have not posed a constraint on the evolution of the <em>PRNP</em> gene. There are no clusters of phylogenetically distant species grouped by distinct prion-disease-resistant mutations. Moreover, the misfolding propensity does not correlate with general sequence similarity to the gold standard, the so-called universal prion acceptor, bank vole prion protein, nor with the predicted stability of the globular form of each PrP. In addition, from a more practical perspective, the resources and the wealth of data generated offer abundant models for structural and pathobiological studies. Among these, we can highlight designing new substrates for ultrasensitive prion detection methods, developing animal models with enhanced susceptibility to speed up preclinical studies, or designing dominant negative proteins for therapeutic applications.</p>
Offensive Content: A Tale of Two Classes
<p>This dataset contains 6000 rows evenly distributed between hate speech, trolling and normal. Data source primary from Twitter, Reddit and Wikipedia Talk pages. No metadata about posts is included. Posts have been anonymized to protect user privacy. </p>
Spatio-Temporal Activity Data Across Professional Classes in Kandy, Sri Lanka
<h1>Overview</h1> <p>This dataset includes motion data from 100 people in Kandy District, Sri Lanka, collected over approximately 21 days from 13 different professional categories using GPS tracking. The GPS coordinates are clustered and presented as location strings, which show each person's visited locations along with timestamps recorded every minute. The dataset covers 7 zones: 'IndustrialManufactureZone', 'CommercialFinancialZone', 'AdministrativeZone', 'AgriculturalZone', 'EducationZone', 'ResidentialZone', and 'MedicalZone', and features 18 unique locations within these zones.</p> <h1>Request Access</h1> <p>To obtain access, users <strong>must</strong> provide the following details in the request message:</p> <ul> <li>A brief description of the intended use of the dataset, outlining the purpose of their study (maximum 250 words).</li> <li>Principal Investigator’s name</li> <li>Affiliation</li> <li>Affiliated website</li> </ul>
A comparative assessment of the BioBiteCorrector® and Herbst appliances in the treatment of Class II malocclusion: a retrospective cohort study on treatment outcome
<p>Dataset for all analyses. Initially, access will be given to editor/reviewers for the peer review process. After publication, the dataset will be available openly for everyone.</p>
Fig. 5 in Natural sucrose esters: Perspectives on the chemical and physiological use of an under investigated chemical class of compounds
Fig. 5. NSEs extracted from Physalis alkekengi var. franchetii.
DNA methylation profiles of fibroblasts and induced pluripotent stem cells (iPSCs) from individuals with Zellweger spectrum disorder (ZSD), a class of peroxisome biogenesis disorder, and healthy contr
GEO Series GSE68134. Homo sapiens. 41 samples. Type: Methylation profiling by genome tiling array.
MYC plus class IIa HDAC inhibiton potentiates mitochondrial dysfunction in non-small cell lung cancer [I]
GEO Series GSE281767. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Two novel PLS-class pentatricopeptide repeat proteins are involved in the group II intron splicing of mitochondrial transcripts in the moss Physcomitrella patens
GEO Series GSE145050. Physcomitrium patens. 4 samples. Type: Expression profiling by array.
Tumor intrinsic PRMT5 inhibition through MTAP loss predicts response to the first-in-class type I PRMT inhibitor, GSK3368715
GEO Series GSE126651. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
Pseudocell Tracer - a method for inferring dynamic trajectories using scRNAseq and its application to B cells undergoing immunoglobulin class switch recombination
GEO Series GSE171867. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
The class-specific BCR tonic signal modulates lymphomagenesis in a transgenic model of c-myc transgene deregulation.
GEO Series GSE32229. Mus musculus. 16 samples. Type: Expression profiling by array.
Gene and protein sequence features augment HLA class I ligand predictions.
GEO Series GSE211000. Homo sapiens. 12 samples. Type: Other; Expression profiling by high throughput sequencing.
The complex transcriptomics of RNA classes for biomonitoring and mechanistic studies
GEO Series GSE311255. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by high throughput sequencing.
First-in-Class Substrate- and Function-Selective p38alpha Inhibitors with Anti-inflammatory and Endothelial-stabilizing Activities
GEO Series GSE262079. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.