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2,281 results for “laboratories”
Figure 11 in Basic laboratory and field manual for conducting research with the entomopathogenic nematodes, Steinernema and Heterorhabditis, and their bacterial symbionts
Figure 11. Enumeration of nematodes in Petri dishes.
Rapid phenotypic and genotypic change in a laboratory schistosome population
<p>The present dataset contains all phenotype data and input files, as well as shell and R scripts used for data analysis and generation of figures (1-5, S1-S2) present in the manuscript entitled "Rapid phenotypic and genotypic change in a laboratory schistosome population."</p> <p><strong><span>Abstract</span></strong></p> <p><strong><span>Background:</span></strong><span> Genomic analysis has revealed extensive contamination among laboratory-maintained microbes including malaria parasites, <em>Mycobacterium tuberculosis</em> and <em>Salmonella </em>spp. Here, we provide direct evidence for recent contamination of a laboratory schistosome parasite population, and we investigate its genomic consequences. The Brazilian <em>Schistosoma mansoni</em> population SmBRE has several distinctive phenotypes, showing poor infectivity, reduced sporocysts number, low levels of cercarial shedding and low virulence in the intermediate snail host, and low worm burden and low fecundity in the vertebrate rodent host. In 2021 we observed a rapid change in SmBRE parasite phenotypes, with a ~10x increase in cercarial production and ~4x increase in worm burden. </span></p> <p><strong><span>Methods:</span></strong><span> To determine the underlying genomic cause of these changes, </span><span>we sequenced pools of SmBRE adults collected during parasite maintenance between 2015 and 2023. We also sequenced another parasite population (SmLE) maintained alongside </span><span>SmBRE without phenotypic changes. </span></p> <p><strong><span>Results:</span></strong><span> While SmLE allele frequencies remained stable over the eight-year period, we observed sudden changes in allele frequency across the genome in SmBRE between July 2021 and February 2023, consistent with expectations of laboratory contamination. (i) SmLE-specific alleles rose in the SmBRE population from 0 to 41-46% across the genome between </span><span>September and October 2021, documenting the timing and magnitude of the contamination event.</span><span> (ii) After contamination, strong selection (<em>s</em> = ~0.23) drove replacement of low fitness SmBRE with high fitness SmLE alleles. (iii) Allele frequency changed rapidly across the whole genome, except for a region on chromosome 4 where SmBRE alleles remained at high frequency. </span></p> <p><strong><span>Conclusions:</span></strong><span> We were able to detect contamination in this case because SmBRE shows distinctive phenotypes. However, this would likely have been missed with phenotypically similar parasites. These results provide a cautionary tale about the importance of tracking the identity of parasite populations, but also showcase a simple approach to monitor changes within populations using molecular profiling of pooled population samples to characterize fixed single nucleotide polymorphisms. We also show that genetic drift results in continuous change even in the absence of contamination, causing parasites maintained in different labs (or sampled from the same lab at different times) to diverge.</span></p>
TMC-1 line parameters and laboratory line-list for two cyano derivatives of acenaphthylene
<p>Observed line parameters towards TMC-1 and laboratory-observed transition frequencies for the of 1- and 5-cyanoacenaphthylene isomers.</p>
MM laboratory analyses datasets Oct2023-Sept2024 for CS#2 water
<p>Collection of results for the analyses performed by MM on samples from Milan in the timeframe of October 2023 to September 2024 on drinking water public fountains, DWTPs and drinking water houses.</p> <p> </p> <p>Analyses results include THM, Epichloridrine, TOC, CVM and on field analyses such as pH and free chlorine</p>
Figure 5 in Juvenile development and growth patterns in the mud crab Eurytium limosum (Say, 1818) (Decapoda, Brachyura, Xanthidae) under laboratory conditions
Figure 5. Eurytium limosum. Pleopods of early juvenile stages.
Fig. 2 in The Lecithotrophic Zoea Of Chirostylus Ortmanni Miyake & Baba, 1968 (Crustacea: Anomura: Galatheoidea: Chirostylidae) Described From Laboratory Hatched Material
Fig. 2. Chirostylus ortmanni Miyake & Baba, 1968: a, mandible; b maxillule; c, maxilla.
Suspended and bedload transport in an open channel laboratory flume
<p>Notwithstanding the large number of studies on bedforms such as dunes and antidunes, performing quantitative predictions of bedform type and geometry remains an open problem. Here we present the results of laboratory experiments specifically designed to study how sediment supply and caliber may impact equilibrium bedform type and geometry in the upper regime. Experiments were performed in a sediment feed flume with flow rates varying between 8 l/s and 15 l/s, sand supply rates varying between 0.6 kg/min and 16 kg/min, uniform and non-uniform sediment grain sizes with geometric mean diameter varying between 0.22 mm and 0.87 mm. The experimental data and the comparison with datasets available in the literature revealed that the ratio of the volume transport of sediment to the volume transport of water <em>Q<sub>s</sub></em>/<em>Q<sub>w</sub></em> plays a prime control in the equilibrium bed configuration. The equilibrium bed configuration transitions from washed-out dunes (lower regime), to downstream migrating antidunes (upper regime) for <em>Q<sub>s</sub></em>/<em>Q<sub>w</sub></em> between 0.0003 and 0.0007. For values of <em>Q<sub>s</sub></em>/<em>Q<sub>w</sub></em> greater than those typical of downstream migrating antidunes, the bedform wavelength increases with <em>Q<sub>s</sub></em>/<em>Q<sub>w</sub></em>. At these high values of <em>Q<sub>s</sub></em>/<em>Q<sub>w</sub></em> equilibrium bed configurations with fine sand are characterized by upstream migrating antidunes or cyclic steps, and significant suspended load. In experiments with coarse sand, equilibrium is characterized by plane bed with bedload transport in sheet flow mode. Standing waves form at the transition between downstream migrating antidunes and bed configurations with upstream migrating bedforms. </p>
Laboratory Investigation of Scale Effects in Bursting Failure of Quasi-brittle Materials
<p>Videos of bursting failure process of coal samples</p>
Lateral flow immunoassay-based laboratory algorithm for rapid diagnosis of diphtheria
<p><strong>Results of the ‘DIFTERIA’ Lateral Flow Immunoassay (LFIA) validation.</strong></p>
A Comparison of Laboratory Versus Point of Care (Bedside) APTT Testing
ClinicalTrials.gov study NCT04744701. IPD Sharing: NO. Countries: 1. Publications: 0.
A Comparison of Acute Psychobiological Responses to Laboratory Stress Tests
ClinicalTrials.gov study NCT06066320. IPD Sharing: NO. Countries: 1. Publications: 0.
Laboratory-Treated T Cells and Aldesleukin After Cyclophosphamide in Treating Patients With Stage IV Melanoma
ClinicalTrials.gov study NCT00553306. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Improving Laboratory Monitoring in Community Practices: A Randomized Trial
ClinicalTrials.gov study NCT00789594. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Blood Specimen Collection For Laboratory Assay Research
ClinicalTrials.gov study NCT06046651. IPD Sharing: NO. Countries: 1. Publications: 0.
Development of Human Laboratory Study Model of Cocaine Relapse Prevention. - 1
ClinicalTrials.gov study NCT00040066. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Laboratory Aspirin Resistance in Diabetics and Non-Diabetics
ClinicalTrials.gov study NCT00563875. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Assessment of Laboratory Parameters and Imaging Findings in Patients With Gastrointestinal Bleeding
ClinicalTrials.gov study NCT07002359. IPD Sharing: NO. Countries: 1. Publications: 0.
Correlation of Non Invasive Hemoglobin Measurement With Laboratory Hemoglobin Measurement in Living Liver Donors
ClinicalTrials.gov study NCT04664777. IPD Sharing: NO. Countries: 1. Publications: 0.
Infusion Laboratory: Protocol 2 (Lisuride) - 3
ClinicalTrials.gov study NCT00000338. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Influence of Authorized Smokeless Tobacco Product Modified Risk Claims II: Laboratory Assessment of Sensory and Subjective Effects
ClinicalTrials.gov study NCT07107139. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.