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12,455 results for “Promoters”
Data from: The extracellular and cytoplasmic domains of Syndecan cooperate postsynaptically to promote synapse growth at the Drosophila neuromuscular junction
The heparan sulfate proteoglycan (HSPG) Syndecan (Sdc) is a crucial regulator of synapse development and growth in both vertebrates and invertebrates. In Drosophila, Sdc binds via its extracellular heparan sulfate (HS) sidechains to the receptor protein tyrosine phosphatase LAR to promote the morphological growth of the neuromuscular junction (NMJ). To date, however, little else is known about the molecular mechanisms by which Sdc functions to promote synapse growth. Here we show that all detectable Sdc found at the NMJ is provided by the muscle, strongly suggesting a post-synaptic role for Sdc. We also show that both the cytoplasmic and extracellular domains of Sdc are required to promote synapse growth or to rescue Sdc loss of function. We report the results of a yeast two-hybrid screen using the cytoplasmic domains of Sdc as bait, and identify several novel candidate binding partners for the cytoplasmic domains of Sdc. Together, these studies provide new insight into the mechanism of Sdc function at the NMJ, and provide enticing future directions for further exploring how Sdc promotes synapse growth.
Data from: Microbial expansion-collision dynamics promote cooperation and coexistence on surfaces
Microbes colonizing a surface often experience colony growth dynamics characterized by an initial phase of spatial clonal expansion followed by collision between neighboring colonies to form potentially genetically heterogeneous boundaries. For species with life cycles consisting of repeated surface colonization and dispersal, these spatially-explicit "expansion-collision dynamics" generate periodic transitions between two distinct selective regimes, "expansion competition" and "boundary competition", each one favoring a different growth strategy. We hypothesized that this dynamic could promote stable coexistence of expansion- and boundary-competition specialists by generating time-varying, negative frequency-dependent selection that insulates both types from extinction. We tested this experimentally in budding yeast by competing an exo-enzyme secreting "cooperator" strain (expansion-competition specialists) against non-secreting "defectors" (boundary-competition specialists). As predicted, we observed cooperator-defector coexistence or cooperator dominance with expansion-collision dynamics, but only defector dominance otherwise. Also as predicted, the steady-state frequency of cooperators was determined by colonization density (the average initial cell-cell distance) and cost of cooperation. Lattice-based spatial simulations give good qualitative agreement with experiments, supporting our hypothesis that expansion-collision dynamics with costly public goods production is sufficient to generate stable cooperator-defector coexistence. This mechanism may be important for maintaining public-goods cooperation-and-conflict in microbial pioneer species living on surfaces.
Data from: The roles of geography and founder effects in promoting host-associated differentiation in the generalist bogus yucca moth Prodoxus decipiens
[No abstract entered]
Enhanced mutualisms: a promotion effect driven by bacteria in early invasion of Phytolacca americana L
<p>Enhanced mutualism hypothesis considers that invasive plants promote self-growth by enriching beneficial microbial to establish positive soil feedback. However, the roles of soil microorganisms may vary with increasing time of plant growth. Here, we present results of a two-stage experiment conducted in field and greenhouse to explore the soil feedback changes with the duration growth using invasive plant <em>Phytolacca americana</em> L., as a model. Three <em>P. americana</em> individuals of varying ages were chosen based on the number of growth rings in the underground main root. We determined the effects of different growth age of <em>P. americana</em> on soil microbial community and physicochemical properties and performed a soil inoculation experiment to quantify the influence of microbial community structure on seed germination and seedling performance of <em>P. americana</em>, in the different growth age treatments. Increasing <em>P. americana</em> growth age altered soil properties, with significant reductions in total nitrogen (N), total phosphorus (P), nitrate-N, and ammonium-N. However increasing <em>P. americana</em> growth age reduced nitrogen availability in the soil; increased available potassium and available P concentrations in soil were observed in Age5 and in all growth ages, respectively. Increasing growth age influenced the soil microbial community structure, with substantial changes in the relative abundance of bacteria, including that of a few relevant to nutrient cycling; however, there was no significant change in the relative abundance of fungi. Soil inoculation experiments corroborated the change in soil microbial community structure caused by <em>P. americana</em> growth promoted self seed germination and biomass accumulation, which further intensified its invasion. We conclude that the early growth stages of invasive plants could promotes their growth and detailedly explained its mechanism by enrich plant growth-promoting bacteria in soil, establishing a positive nutrient cycle. When making control of invasive plants, the early detection and management should been attach importance to it.</p>
LRRC8A promotes Glaesserella parasuis cytolethal distending toxin-Induced p53-dependent apoptosis in NPTr cells
<p>The rawdata supporting the results or analyses</p>
ALKBH5 promotes tumour proliferation, migration, and invasion by regulating the lncRNA MIR210HG/Mir-206/WEE1 signalling pathway in glioma
<p>GRAPH</p>
Patterns of recombination in snakes reveal a tug of war between PRDM9 and promoter-like features
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scRNA-seq data for "Bacteroides fragilis toxin suppresses METTL3-Mediated m6A modification in macrophage to promote inflammatory bowel disease"
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QUALITY MANAGEMENT STRATEGIES FOR EDUCATIONAL INSTITUTIONS Promoting excellence in teaching and learning
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Blockade of LAG3 and PD1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity
<p>This is the data necessary to reproduce the figures from "<em>Blockade of LAG3 and PD1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity</em>" by Cillo et al.</p>
Computational dataset, scripts and models for 'Lipid unsaturation promotes BAX and BAK pore activity during apoptosis'
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Fire promotes passive directed dispersal by birds
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Flow_Data_of_Promoter_Library_MT
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Flow_Data_of_Promoter_Library_WT
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raw data of BUB1B promotes gemcitabine resistance in lung adenocarcinoma by activating the PI3K/AKT signaling pathway
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The unsteady shock boundary layer interaction in a compressor cascade - Part 3: Mechanisms of shock oscillation - Promotional video 1
<p>Promotional video for the ASME Turbo Expo 2024 open access publication with identifier GT2024-128197 and title "The unsteady shock boundary layer interaction in a compressor cascade - Part 3: Mechanisms of shock oscillation."</p>
Carbazole derivatives binding to Bcl-2 promoter sequence G-quadruplex
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Fig. 2 in Skin extract from Rhamdia quelen (Siluriformes: Heptapteridae) does not promote stress in conspecifics
Fig. 2. Epidermis of R. quelen under light microscopy, PAS and hematoxylin staining. (A) Broad view showing the different skin layers: epidermis (e), dermis (d), and skeletal muscle (m). Scale bar = 5 µm; (B) club cells within the epidermis (star). Scale bar = 3 µm; (C) larger magnification of a club cell, with the arrow indicating the presence of the two nuclei. Scale bar = 1 µm.
Scripts and data for: Increased host diversity limits bacterial generalism but may promote microbe-microbe interactions
<p>Research Overview: In this project, we compared cloacal microbiome communities from reptiles from six localities that spanned a gradient in host taxonomic diversity. We found that diversity of the bacterial communities was relatively stable across locations, but that host-specific taxa were overrepresented in high host diversity communities. ASVs in high host diversity communities were more likely to have strong interactions with other bacterial lineages across multiple hosts. Host generalist bacteria were more likely to be from a generalist phylum.</p> <p>Methodology: We used a 16S rRNA metabarcoding approach to quantify bacterial community diversity. We processed the output fastq files using qiime2, and processed the output files using the qiime2R package. We performed our analyses in R. Processed input files and scripts are described below. </p>
Dry pyroconvection promotes longer-lasting wildfire intensification
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.