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3,183 results for “parenting”
The impact of a parent education workshop about children's sensory processing differences on parental sense of competence
<p><i>Aims. </i>This study aimed to: (1) examine the impact of a parent education workshop on the parental sense of competence (PSOC) of parents of children with sensory processing differences (SPD); and (2) explore parents' perspectives regarding workshop content and delivery.</p> <p><i>Methods</i>. This pilot study was a randomized waitlist-controlled trial. Parents were recruited from a neurodevelopmental assessment waitlist (for their children) and randomly selected to attend one of two identical workshops (two weeks apart). The workshops provided education about SPD and strategies for managing children's behaviors related to SPD. The PSOC Scale and demographics and feedback questionnaires were administered to all parents before and after each workshop. Descriptive statistics and content analysis were used to analyze the quantitative and qualitative data, respectively.</p> <p><i>Results</i>. Nine parents were recruited (six in the experimental group, three in the control group). PSOC Scale scores increased following workshop attendance. Three overarching themes of workshop components contributed to an enhanced PSOC: (1) learning specific strategies, (2) reframing children's behavior, and (3) peer support.</p> <p><i>Conclusions</i>. Parent education workshops showed promise for enhancing PSOC of parents of children with SPD. PSOC can promote positive mental health outcomes for parents, and help them to support their children's occupational performance.</p>
Data from: Krabbe disease variant classification using parental blood-based diagnostic RNA-seq
<p>Krabbe disease (KD) is a rare autosomal recessive lysosomal storage disorder (LSD) associated with severe neurodegeneration and high mortality and is one of most prevalent LSDs at a recent estimate of 1 in 12,080 live births. The disease pathogenesis is related to low/undetectable galactocerebrosidase (GALC) activity resulting in an accumulation of a cytotoxic GALC substrate, psychosine (Psy), that leads to diffuse demyelination, psychomotor delays, and high morbidity/mortality across the disease spectrum. <span>Although</span> phenotypic prediction in newborns with a more common, homozygous 30kb deletion and very high Psy levels is straightforward, <u>there is a larger subset of patients identified through newborn screening with missense variants of uncertain significance (VUSs) that present with mildly elevated Psy levels that are difficult to interpret.</u> Functional data for a small set of missense variants support altered GALC trafficking and lysosomal localization in KD compared to a loss of catalytic function; however, there are >130 unclassified <i>GALC</i> VUSs (ClinVar; 73 missense) with no clear prognostic impact and differential onset. We are starting to performed blood-based diagnostic RNAseq (whole transcriptomics) to classify such VUSs. Here in this dataset, we performed blood-based diagnostic RNAseq on a couple to try to classify GALC gene variants in a family with Krabbe Disease (KD) and Phenylketonuria (PKU) clinical history. The single p.T513M variant carried by one of the couple was known to be pathogenic or likely pathogenic variant (ClinVar). Using RNAseq, we identified leaky splicing abnormality of portion of transcripts skipping of GALC exon 14 casuig a frameshift and a premature stop codon allowing us to confirm its classifciation as pathogenic. The single c.442+5G>A GALC variant carried by the other individual did not show any splicing defect suggesting this variant to be likely benign. This shows that blood-based targeted or whole mRNAseq can be perforemd for fater effieicnt diagnostis and varoant classification of GALC gene and confirmation of molecular diagnosis of KD. This dataset also shows that carrier individuals or parental RNAseq can be performed if children peripheral blood or dried blood spots (DBSs) are not available to diagnose and classify GALC variants. This type of usafe of clinical-grade functional omics platforms will enahance rare neurological disease diagnosis. </p>
Data from: The ability of Drosophila hybrids to locate food declines with parental divergence.
Hybrids between two species are generally less fit than the parental species, and the mechanisms underlying their fitness reductions can manifest through different traits and at different life history stages. For example, hybrids can have physiological, behavioral, or ecological defects, resulting in postzygotic isolation between their parental species. However, mechanisms of postzygotic isolation other than sterility and inviability have remained largely uninvestigated. Isolated studies have found that other postzygotic defects are not only possible but might be widespread. Here, we study a fundamental animal behavior - the ability of individuals to find food - and test the rate at which it breaks down in hybrids. We measured the ability of hybrids from 94 pairs of Drosophila species to find food and show that hybrids are generally less successful than their parental species. We then show that the ability of hybrid offspring to locate food decreases with increasing genetic divergence between the parental species. Our findings quantify the rate that hybrid dysfunction evolves across the diverse radiation of Drosophila and highlight the need for future investigations of the genetic and neurological mechanisms that affect a hybrid's ability to find a suitable substrate on which to feed and breed.
Data from: Parental separation and behaviours that influence the health of infants aged 7 to 11 months: a cross-sectional study
Objective: Analyse the parental behaviours that are recognized as influencing the health of very young children based on family structure (parents separated or not). Design: Cross-sectional study, examining 79,701 infants aged 7 to 11 months as part of a free preventive medicine consultation. The data came from an assessment conducted 7 to 11 months after birth during which information was collected, namely about the parents' use of tobacco, the infant's type of nutrition, and adherence to vaccination schedules. Results: The percentage of infants whose parents were separated was 6.6%. After adjusting for the cultural and socioeconomic environment as well as for other potential confounders, in the event of separation as compared with non-separated parents, the adjusted ORs (95% CI) were as follows: 1.5 (1.3–1.7) for the infant's exposure to tobacco; 1.3 (1.2–1.4) for total lack of exclusive breastfeeding; 1.3 (1.1–1.4) and 1.2 (1.1–1.2) for breastfeeding for a duration of less than 3 and 6 months, respectively; 1.2 (1.1–1.4) for noncompliance with the vaccination schedule against rotavirus. The duration of exclusive breastfeeding was shorter when parents were separated (p<0.001; median: 10 vs. 13 weeks). Conclusions: This study reinforces the possibility that parental separation is independently associated with certain parental at-risk behaviours regarding the children's health. This observation should be verified because this could result in major consequences for the work of family doctors, in particular in terms of parent information and targeted prevention.
Data from: Heterozygosity–fitness correlations in a wild mammal population: accounting for parental and environmental effects
HFCs (heterozygosity–fitness correlations) measure the direct relationship between an individual's genetic diversity and fitness. The effects of parental heterozygosity and the environment on HFCs are currently under-researched. We investigated these in a high-density U.K. population of European badgers (Meles meles), using a multimodel capture–mark–recapture framework and 35 microsatellite loci. We detected interannual variation in first-year, but not adult, survival probability. Adult females had higher annual survival probabilities than adult males. Cubs with more heterozygous fathers had higher first-year survival, but only in wetter summers; there was no relationship with individual or maternal heterozygosity. Moist soil conditions enhance badger food supply (earthworms), improving survival. In dryer years, higher indiscriminate mortality rates appear to mask differential heterozygosity-related survival effects. This paternal interaction was significant in the most supported model; however, the model-averaged estimate had a relative importance of 0.50 and overlapped zero slightly. First-year survival probabilities were not correlated with the inbreeding coefficient (f); however, small sample sizes limited the power to detect inbreeding depression. Correlations between individual heterozygosity and inbreeding were weak, in line with published meta-analyses showing that HFCs tend to be weak. We found support for general rather than local heterozygosity effects on first-year survival probability, and g2 indicated that our markers had power to detect inbreeding. We emphasize the importance of assessing how environmental stressors can influence the magnitude and direction of HFCs and of considering how parental genetic diversity can affect fitness-related traits, which could play an important role in the evolution of mate choice.
ALISHER NAVOI ABOUT THE DUTIES AND RESPONSIBILITIES OF PARENTS
Open the record for dataset details and reuse information.
maDLC Parenting Benchmark Dataset - Training
<p>see https://benchmark.deeplabcut.org/ for more information.</p>
Figure 6 from: Özcan T (2019) Defining phylogenetic relationship of Nepeta x tmolea and its parents via DNA barcoding. PhytoKeys 134: 83-96. https://doi.org/10.3897/phytokeys.134.38238
Figure 6 Insertions, deletions and single nucleotide polymorphisms based on trnL-F sequences.
Figure 5 from: Özcan T (2019) Defining phylogenetic relationship of Nepeta x tmolea and its parents via DNA barcoding. PhytoKeys 134: 83-96. https://doi.org/10.3897/phytokeys.134.38238
Figure 5 Insertions, deletions and single nucleotide polymorphisms based on rpl32-trnL sequences.
Figure 4 from: Özcan T (2019) Defining phylogenetic relationship of Nepeta x tmolea and its parents via DNA barcoding. PhytoKeys 134: 83-96. https://doi.org/10.3897/phytokeys.134.38238
Figure 4 Dendroscope cladogram and PCA diagram based on rpl32-trnL data.
One-Way ANOVA Results on Family's Role in Addressing Gender-Based Violence in Early Childhood in Jordan by Parental Occupation
<p><strong>One-Way ANOVA Results on Family's Role in Addressing Gender-Based Violence in Early Childhood in Jordan by Parental Occupation</strong></p>
Scheffe Test Results for Educational Disparities in Parental Views on Family's Role in Preventing GBV
<p><strong><span>Scheffe Test Results for Educational Disparities in Parental Views on Family’s Role in Preventing GBV</span></strong></p>
THE INFLUENCE OF PARENTS ON THE FORMATION OF THE AUTONOMY OF TEENAGE CHILDREN
<p><em><span>Concepts describing the phenomenology of autonomy and developmental laws in adolescence can be divided depending on what the sources and driving forces of the development of adolescent independence mean. the analysis of views is written and conclusions are given.</span></em></p>
Data from: QTL detection power of multi-parental RIL populations in Arabidopsis thaliana
A major goal of today's biology is to understand the genetic basis of quantitative traits. This can be achieved by statistical methods that evaluate the association between molecular marker variation and phenotypic variation in different types of mapping populations. The objective of this work was to evaluate the statistical power of QTL detection of various multi-parental mating designs as well as to assess the reasons for the observed differences. Our study was based on empirical data of 20 Arabidopsis thaliana accessions which have been selected to capture the maximum genetic diversity. The examined mating designs differed strongly with respect to the statistical power to detect QTL. We observed the highest power to detect QTL for the diallel cross with random mating design. The results of our study suggested that performing sibling mating within subpopulations of joint linkage mapping populations has the potential to considerably increase the power for QTL detec tion. Our results, however, revealed that using designs in which more than two parental alleles segregate in each subpopulation increases the power even more.
The Role of Parents in Adolescent Obesity Treatment
ClinicalTrials.gov study NCT02586090. IPD Sharing: NO. Countries: 1. Publications: 0.
Effectiveness of Acceptance and Commitment Therapy Versus Active Controls in Improving Psychological Functions of Parents and Children With Adolescent Idiopathic Scoliosis: A Randomized Controlled Tri
ClinicalTrials.gov study NCT05919459. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Awareness-Based Stress Reducatıon Program Applıed to Parents Wıth A Chıld Wıth Autısm
ClinicalTrials.gov study NCT05877287. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Mindfulness-based Zentangle for Parents
ClinicalTrials.gov study NCT06094803. IPD Sharing: Not stated. Countries: 1. Publications: 0.
French Linguistic and Metric Validations of Parent-proxy QOL Chronic Cough Specific Questionnaire (PC-QOL)
ClinicalTrials.gov study NCT01865422. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Use of the Diary in Neonatal Pathology: a Mixed-method Study for Collecting and Analyzing the Experience of Parents and Health Care Personnel.
ClinicalTrials.gov study NCT06316193. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.