Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
2,227
datasets available to search
ShareScore release 0.9.0
Dataset results
2,227 results for “Tissue expression”
Dataset related to article "Independent expression of circulating and tissue levels of PD-L1: correlation of clusters with tumor metabolism and outcome in patients with non-small cell lung cancer."
<p>PURPOSE:</p> <p>To evaluate the clinical-pathological and prognostic significance of the circulating PD-L1 level in patients with surgically treated NSCLC, by combining data for PD-L1 expression with other immune-related markers and tumor metabolism.</p> <p>METHODS:</p> <p>Overall, 40 patients with resected NSCLC (stage Ia-IIIa) who had preoperative blood storage and underwent staging PET/CT were enrolled for the study. In all cases, we determined plasma levels of PD-L1 (pg/ml), immune-reactive areas (IRA %) covered by CD3, CD68, CD20, CD8, PD-1, and PD-L1 in the tumor specimen, and metabolic parameters on PET, i.e., SUV<sub>max</sub>, SUV<sub>peak</sub>, metabolic tumor volume (MTV), and total lesion glycolysis (TLG). Variables were statistically analyzed to establish their association with disease-free survival (DFS).</p> <p>RESULTS:</p> <p>The circulating levels of PD-L1 in the bloodstream could be determined in 38/40 (95%) samples. The mean and median expression levels were 34.86 pg/ml and 24.83 pg/ml, respectively. We did not find any statistically significant correlation between circulating PD-L1 and tissue expression of PD-L1/PD-1. Some mild degree of positive correlation was determined between tissue PD-L1 and SUV<sub>max</sub> (ρ =&thinsp;0.390; p =&thinsp;0.0148). Hierarchical clustering combining circulating, tissue, and metabolic parameters identified clusters with high metabolic tumor burden or high expression of plasma PD-L1 levels (Z score ≥ 2) as having a poor DFS (p =&thinsp;0.033). The multivariate analysis detected stage and metabolism (i.e., SUV<sub>max</sub> and SUV<sub>peak</sub>) as independent prognostic factors for DFS.</p> <p>CONCLUSION:</p> <p>Plasma levels of PD-L1 are independent of the expression of PD-1/PD-L1 in NSCLC tumor tissue and, when combined with other clinical-pathological parameters, allow for the identification of clusters with different outcomes.</p>
Expression profiling of long noncoding RNAs and mRNAs in mouse kidney tissue
GEO Series GSE60723. Mus musculus. 2 samples. Type: Non-coding RNA profiling by array.
Gene expression in a 3D skin tissue subjected to bystander alpha-particle irradiation
GEO Series GSE32541. Homo sapiens. 24 samples. Type: Expression profiling by array.
Aberrant lncRNA expression profiles in OSCC tissues compared with paired normal oral mucosa
GEO Series GSE84805. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by array.
Gene expression profiles of PGAM5-knockout brown adipose tissue
GEO Series GSE138782. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Expression data of rat prostate cancer tissue treated with OBP-801, novel HDAC inhibitor
GEO Series GSE75022. Rattus norvegicus. 6 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
Gene-expression patterns at transcriptional ans translational levels in the tissues of colorectal cancer are different from that in the correspondent adjacent regions
GEO Series GSE124029. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Early and late changes in gene and miRNA expression after hepatitis B or C infection in human hepatocyte chimeric mice [tissue_mRNA]
GEO Series GSE52752. Homo sapiens. 51 samples. Type: Expression profiling by array.
Atypical modes of CTCF binding facilitate tissue-specific and neuronal activity-dependent gene expression states [CTCF_ChIP-seq]
GEO Series GSE235970. Mus musculus. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Gene expression profiling of colorectal cancer tissues, matched normal tissues, colorectal cancer cell lines, and primary cultures (2D organoids)
GEO Series GSE305538. Homo sapiens. 25 samples. Type: Expression profiling by array.
Subcutaneous adipose tissue transcriptome highlights specific expression profiles in pediatric severe obesity: a pilot study
GEO Series GSE228892. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Comparison of mRNA expression in white adipose tissue from LLC tumor-bearing mice and controls
GEO Series GSE242812. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Differential gene expression between human colon cancers and the adjacent nomral colon tissues.
GEO Series GSE137327. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Development of gene expression signatures for neonatal tissues of mice with Usp10 gene knockout
GEO Series GSE198574. Mus musculus. 6 samples. Type: Expression profiling by array.
lncRNA and mRNA expression data in Heart Tissue associated with Tetralogy of Fallot
GEO Series GSE146218. Homo sapiens. 9 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
Differential expression of Triggering Receptor Expressed on Myeloid Cells (Trem)-2 in tissue eosinophils
GEO Series GSE158666. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Circular RNA expression profile from murine ocular tissues
GEO Series GSE202822. Mus. 4 samples. Type: Expression profiling by high throughput sequencing.
Gene expression in lung tissue, blood and spleen of mice with severe acute pancreatitis
GEO Series GSE244335. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Expression data from rat heart tissue ischemia/reperfusion (I/R) treated for 12,24 hours
GEO Series GSE313546. Rattus norvegicus. 15 samples. Type: Expression profiling by array.
Promoter G-quadruplex structures regulate tissue-specific gene expression and functional differentiation in Bombyx mori [RNA-seq]
GEO Series GSE303266. Bombyx mori. 3 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.