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111,247 results for “cells”
carbon per cell: carbon per cell
<p>data coverage snapshot, carbon per cell</p>
Assessment of changes in circRNA expression based on transcripts of genes encoding ADAMTS proteins in patients with non-small cell lung carcinoma compared to normal tissue
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Electroluminiscence Dataset of Photovolaic Cells of several technologies
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Data from: Antineoplastic Nature of WWOX in Glioblastoma Is Mainly a Consequence of Reduced Cell Viability and Invasion
<p>Supporting data for the article "Antineoplastic Nature of WWOX in Glioblastoma Is Mainly a Consequence of Reduced Cell Viability and Invasion ", published in Biology (DOI: <span>10.3390/biology12030465</span>).</p>
Figure 2 in Explore the antiproliferative phytocompounds from ethanolic extracts of Citrus paradisi against liver cancer cell line by chemical analysis using TLC and FT-IR spectroscopy
Figure 2. Anti-proliferative activity of ethanolic Citrus paradisi leaves extract.
Figure 3 in Explore the antiproliferative phytocompounds from ethanolic extracts of Citrus paradisi against liver cancer cell line by chemical analysis using TLC and FT-IR spectroscopy
Figure 3. FTIR analysis of ethanolic Citrus paradisi fruits extract.
Figure 1 in Explore the antiproliferative phytocompounds from ethanolic extracts of Citrus paradisi against liver cancer cell line by chemical analysis using TLC and FT-IR spectroscopy
Figure 1. Anti-proliferative activity of ethanolic Citrus paradisi fruit extract.
Dataset related to article "Tumor Treating Fields enhance chemotherapy efficacy by increasing cellular drug uptake and retention in mesothelioma cells"
<p>This record contains data related to article “Tumor Treating Fields enhance chemotherapy efficacy by increasing cellular drug uptake and retention in mesothelioma cells”</p> <p><span>Tumor Treating Fields (TTFields) applied with standard chemotherapy have been approved for the first-line treatment of unresectable pleural mesothelioma (PM), an aggressive malignancy with limited effective therapy options.</span></p> <p><span>In this study, we demonstrated that the simultaneous exposure to TTFields and doxorubicin or vinorelbine enhanced treatment efficacy in patient-derived PM cells by increasing intracellular drug concentrations. This was achieved by modulating several genes that encode transport proteins, such as the downregulation of P-glycoprotein.</span></p> <p><span>Using specific, sensitive and quantitative analytical techniques, we observed a more than 70% increase in intracellular concentrations of doxorubicin and vinorelbine in samples treated with TTFields, and a greater than 50% increase in drug uptake in cells exposed to TTFields and pemetrexed. This result indicates that the increased drug concentration observed in TTFields treated cells is significant not only for drugs that are P-gp substrates but also suggests that TTFields could potentially affect other efflux pumps. However, the co-exposure to the drug and TTFields was critical to increasing intracellular drug levels, highlighting the necessity of concurrent use with drugs to enhance the antiproliferative effects of treatment.</span></p> <p><span>The <em>in vitro</em> findings were further corroborated by <em>in vivo</em> pharmacokinetic experiments in mice subcutaneously injected with epithelioid PM tumors. Indeed, a 30% increase in intratumor concentrations was observed when vinorelbine was administered with TTFields.</span></p> <p><span>Our findings suggest that TTFields could be a well-tolerated approach for enhancing intratumoral drug levels and potentially achieving a more significant therapeutic impact on PM treatment.</span></p>
Benchmarking Illumina RNA-seq fusion transcript detection methods - cancer cell lines RNA-seq
<p>Cancer cell line RNA-seq data (reads or names of reads from CCLE data) used for benchmarking Illumina-based fusion detection methods as used in:</p> <p>Haas, B.J., Dobin, A., Li, B. <em>et al.</em> Accuracy assessment of fusion transcript detection via read-mapping and de novo fusion transcript assembly-based methods. <em>Genome Biol</em> <strong>20</strong>, 213 (2019). https://doi.org/10.1186/s13059-019-1842-9</p> <p> </p> <p>For CCLE data, direct sharing of fastq files was not possible. CCLE data must be obtained from:</p> <p> https://portals.broadinstitute.org/ccle/home</p> <p>Instead, the identifiers for the reads leveraged as part of our study are made available, and these reads can be extracted from the CCLE fastq files directly once obtained from the primary source.</p> <p><br>For the non-CCLE data, the exact reads leveraged by our study are made directly available here in fastq format.</p>
Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets
<p>Contains the input data used in the analysis of the paper: Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets (Su, Hauenstein, Somuncular et al., Nature Communications, 2024).</p>
scDenorm: a denormalisation tool for Integrating Single-cell Transcriptomics Data
<p>Datasets and Jupyter notebooks to reproduce the analyses presented in the manuscript, scDenorm: a denormalisation tool for Integrating Single-cell Transcriptomics Data.</p>
Flow Cytometry Data from "Bacterial cell surface characterization by phage display coupled to high-throughput sequencing"
<p>This record contains the flow cytometry data from the manuscript "Bacterial cell surface characterization by phage display coupled to high-throughput sequencing."</p> <p>Files are in <a href="https://docs.flowjo.com/flowjo/advanced-features/fj-acs/">Archive Cytometry Standard (ACS) format</a> . Each <code>.acs</code> file is a zip container which holds both the raw <code>.fcs</code> files and a FlowJo workspace (<code>.wsp</code>) file.</p> <p>Keywords in the workspace file identify which primary antibody (<code>primary</code>) was used and which cell genotype (<code>strain</code>) was used for each sample. The workspace also encodes the gating scheme and compensation matrix applied to each sample. Plots in the manuscript are exported from Layout views in the workspace.</p>
Effect of Presodiation Additive on Structural and Interfacial Stability of Hard Carbon | P2-Na0.66Mn0.75Ni0.2Mg0.05O2 Full Cell
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Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling: single cell RNA sequencing data
<p>Meningeal single cell RNA sequencing data</p> <p>Meningeal samples were collected from both dorsal and ventral skull, avoiding inclusion of choroid plexus. Samples were digested in 2.5 mg/mL Collagenase D (Cat. #11088858001; Roche) and 12.5 μL of 0.5 mg/mL DNAseI (Cat. #L5002139; Worthington), put on a shaker at 370C for 30 m, diluted with cold HBSS + 0.1% BSA, and mashed through a 70 μm cell strainer prior to sorting.</p> <p>Data represent live, nucleated, singlet cells (DAPI-DRAQ5+) sorted on a BD FACS Aria Fusion into HBSS + 10% FBS prior to droplet encapsulation using 10x Genomics’ Drop-seq platform (Chromium v2).</p> <p>10X chip lane is indicate by 'group' column</p> <p>Group 1 = 4 pooled homecage control (unstressed) mice</p> <p>Group 2 = 4 pooled homecage control (unstressed) mice</p> <p>Group 3 = 4 pooled mice exposed to chronic social defeat for 14 days; tissue was collected 2 hours following final defeat</p> <p>See the following repositories for data processing:</p> <p><a href="https://github.com/maryellenlynall/2019_bcell_stress/blob/master/bcellstress20.Rmd">https://github.com/maryellenlynall/2019_bcell_stress/</a> (processing from raw files starts at bcellstress020.Rmd)</p> <p><a href="https://github.com/staceykigar/meningeal_neut/">https://github.com/staceykigar/meningeal_neut/</a></p> <p>We also provide a processed dataset (processed.RData) with assays 'counts' and 'logcounts' which is the processed single cell object saved at line "# Save object for upload to Zenodo" in script <a href="https://github.com/staceykigar/meningeal_neut/">https://github.com/staceykigar/meningeal_neut/</a>neutrophilstress01.Rmd </p> <p>Cluster annotations are in sce$Annotation</p> <p>Neutrophil subcluster annotations are in sce$Subcluster</p> <p>Sample condition is in sce$cond, where "HC" indicates homecage control and "SD" indicates chronic social defeat</p> <p>10X chip lane is in sce$group</p>
Digital twin of a standard electrochemical cell for cyclic voltammetry based on Nernst-Planck-Poisson model
<p>The project contains a COMSOL file used for the simulations in the publication "<em>Digital twin of a standard electrochemical cell for cyclic voltammetry based on Nernst-Planck-Poisson model</em>".</p>
Data from: Molecular landscapes of glioblastoma cell lines revealed a group of patients that do not benefit from WWOX tumor suppressor expression
<p>Supporting data for the article "Molecular landscapes of glioblastoma cell lines revealed a group of patients that do not benefit from WWOX tumor suppressor expression", published in Frontiers in Neuroscience (DOI: 10.3389/fnins.2023.1260409).</p>
Single-cell embryo dataset for X-scPAE
<p>The E-MTAB-3929 dataset is a human embryo dataset that includes 1,096 samples from three developmental stages: day 5 (E5), day 6 (E6), and day 7 (E7) of embryonic development. These samples belong to three cell lineages: PE, TE, and EPI, with 11,662 gene features.</p> <p>The GSE36552 dataset is a human embryo dataset that includes 66 samples from the 8-cell stage, morula stage, and late blastocyst, with 15,143 gene features.</p> <p>The GSE109071 dataset is a mouse embryo dataset that includes 1,724 samples from embryonic developmental stages E5.25, E5.5, E6.25, and E6.5, with 7,565 gene features.</p>
Analysis of single-cell CRISPR perturbations indicates that enhancers predominantly act multiplicatively
<p>This repository contains simulated data generated with GLiMMIRS-sim that was analyzed and presented in Zhou & Guyuvayurappan et al, as well as data pertaining to the <em>NMU</em> RT-qPCR experiment described in the manuscript. </p> <p> </p> <ul> <li><span>sim_base_data.tar.gz: directory containing simulated data for baseline model </span></li> <li> <p><span>sim_data_interactions_pos.tar.gz: directory containing simulated data for interactions model with positive interaction effects </span></p> </li> <li> <p><span>sim_data_interactions_neg.tar.gz: directory containing simulated data for interactions model with negative interaction effects </span></p> </li> <li><span>NMU.xlsx: spreadsheet containing data from the <em>NMU</em> RT-qPCR experiment </span></li> </ul>
Human pancreatic cancer single cell atlas reveals association of CXCL10+ fibroblasts and basal subtype tumor cells
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CRISPRi with barcoded expression reporters dissects regulatory networks in human cells
<p>Genome-wide CRISPR screens have emerged as powerful tools for uncovering the genetic underpinnings of diverse biological processes. Incisive screens often depend on directly measuring molecular phenotypes, such as regulated gene expression changes, provoked by CRISPR-mediated genetic perturbations. Here, we provide quantitative measurements of transcriptional responses in human cells across genome-scale perturbation libraries by coupling CRISPR interference (CRISPRi) with barcoded expression reporter sequencing (CiBER-seq). To enable CiBER-seq in mammalian cells, we optimize the integration of highly complex, barcoded sgRNA libraries into a defined genomic context. CiBER-seq profiling of a nuclear factor kappa B (NF-κB) reporter delineates the canonical signaling cascade linking the transmembrane TNF-alpha receptor to inflammatory gene activation and highlights cell-type-specific factors in this response. Importantly, CiBER-seq relies solely on bulk RNA sequencing to capture the regulatory circuit driving this rapid transcriptional response. Our work demonstrates the accuracy of CiBER-seq and its potential for dissecting genetic networks in mammalian cells with superior time resolution.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.