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15,277 results for “GENETICS”
Figure 2 in A Lessepsian invader round herring (Etrumeus golanii) with high genetic diversity without bottlenecking in the northeastern Mediterranean Sea
Figure 2. Neighbor-joining tree of E. golanii populations.
Figure 1 in A Lessepsian invader round herring (Etrumeus golanii) with high genetic diversity without bottlenecking in the northeastern Mediterranean Sea
Figure 1. Sampling localities (1. İskenderun, 2. Antalya, 3. Marmaris).
Figure 1 in Microsatellite based genetic diversity of Mediterranean fruit fly (Ceratitis capitata, Diptera: Tephritidae) populations from Southwest Turkey
Figure 1. Map of Turkey with sampling sites.
Figure 2 in Occlusal surface variations in genetically-identified specimens of the genus Apodemus (Mammalia: Rodentia) distributed in the Northern Anatolia region and three Turkish islands: Gökçeada, Marmara Island, and Bozcaada
Figure 2. Nomenclature of upper (a) and lower (b) teeth (Zykov and Izvarin 2020).
Fig. 2 in Genetic and morphological variation of metacercariae of Microphallus piriformes (Trematoda, Microphallidae): Effects of paraxenia and geographic location
Fig. 2. Scheme of landmarks and semilandmarks on the metacercarial body.
Fig. 1 in Genetic diversity of Halyomorpha halys (Hemiptera, Pentatomidae) in Korea and comparison with COI sequence datasets from East Asia, Europe, and North America
Fig. 1. Halyomorpha halys collection sites in Korea and the USA.
Fig. 5 in Revision of the genus Thinophilus Wahlberg (Diptera: Dolichopodidae) from Singapore and adjacent regions: A long term study with a prudent reconciliation of a genetic to a classic morphological approach
Fig. 5. Thinophilus apicatus sp. nov. Phenology during a 2-year survey (MIP).
Fig. 2 in Revision of the genus Thinophilus Wahlberg (Diptera: Dolichopodidae) from Singapore and adjacent regions: A long term study with a prudent reconciliation of a genetic to a classic morphological approach
Fig. 2. Thinophilus apicatus sp. nov., male habitus.
Figure 1 in Genetic, morphometric and meristic analyses of first Acanthurus monroviae specimens recorded in Maltese waters (Central Mediterranean)
Figure 1. – Locations where specimens were collected and sighted.
Fig. 1 in Co-infection of Echinococcus equinus and Echinococcus canadensis (G6/7) in a gray wolf in Turkey: First report and genetic variability of the isolates
Fig. 1. Stereomicroscopic view of adult parasites obtained from gray wolf's intestine.
FIGURE 1 in Population genetics of the endangered catfish Pseudoplatystoma magdaleniatum (Siluriformes: Pimelodidae) based on species-specific microsatellite loci
FIGURE 1 | Sampling sites of Pseudoplatystoma magdaleniatum in the Magdalena-Cauca basin.
FIGURE 5 in A new species of Knodus (Characiformes: Characidae), with deep genetic divergence, from the Mearim and Munim river basins, Northeastern Brazil, and evidence for hidden diversity in adjacent river basins
FIGURE 5 | Geographical distribution of Knodus guajajara.
Figure 1 in Effects of nanoparticles treatments and salinity stress on the genetic structure and physiological characteristics of Lavandula angustifolia Mill.
Figure 1. The XRD pattern for the used Fe O nanoparticles.
Figure 2 in Effects of nanoparticles treatments and salinity stress on the genetic structure and physiological characteristics of Lavandula angustifolia Mill.
Figure 2. The XRD pattern for the used ZnO nanoparticles.
A Versatile Chemical-Genetic Approach to Examine Sodium Channelopathies
<p>The voltage-gated sodium channel Na<sub>V</sub>1.5 controls cardiac excitability and is an established therapeutic target. Mutations in the <em>SCN5A</em> gene, which encodes Na<sub>V</sub>1.5, are associated with inherited arrhythmia syndromes, including Brugada and Long-QT. To advance the general understanding of Na<sub>V</sub>1.5-related conduction biology, we have developed a chemical-genetic model to achieve acute and reversible silencing of Na<sub>V</sub>1.5 <em>in vitro </em>and <em>in vivo</em>. To this end, a human Na<sub>V</sub>1.5 chimeric channel was engineered to contain a high-affinity, isoform-specific binding site for acylsulfonamide (GX) drugs. The GX drug binding site is comprised of an extracellular-facing pocket formed by the DIV voltage-sensor (VSD4) thus enabling a structure-based chimera design strategy. The Na<sub>V</sub>1.5-GX channel has WT voltage-dependent gating and, unlike WT Na<sub>V</sub>1.5, is rapidly and reversibly inhibited by nanomolar GX compound. Using CRISPR, the GX binding site has been engineered into the homologous region of the endogenous <em>Scn5a</em> locus, thus phenocopying the chimeric construct. Inheritance of the Na<sub>V</sub>1.5-GX allele follows expected Mendelian ratios, allowing for the production of a Na<sub>V</sub>1.5<sup>GX/GX </sup>homozygous strain. In the absence of GX compound, Na<sub>V</sub>1.5<sup>GX/GX </sup>hearts<sup> </sup>display normal cardiac phenotypes <em>in vivo</em> measured by EKG and echocardiography. Patch-clamped Na<sub>V</sub>1.5<sup>GX/GX </sup>sodium channels in isolated adult myocytes have WT gating but nanomolar GX compound ablates the Na<sub>V</sub>1.5 mediated current. </p>
Genetic instruments for blood cell traits
<p>This dataset includes summary statistics for genetic instruments for 9 blood cell trait phenotypes. These genetic instruments were developed in the UK Biobank and were used in several Mendelian randomization studies, including an analysis of childhood acute lymphoblastic leukemia (Kachuri et al. 2021; PMID 34469753) and glioma subtypes (Kachuri et al. 2024). Details of the GWAS and instrument development process are described in: https://pubmed.ncbi.nlm.nih.gov/34469753/</p>
Data from: The genetic architecture of adaptations to high altitude in Ethiopia
<p>Data from </p> <p>Alkorta-Aranburu G, Beall CM, Witonsky DB, Gebremedhin A, Pritchard JK, Di Rienzo A. The genetic architecture of adaptations to high altitude in Ethiopia. PLoS Genet. 2012;8(12):e1003110. doi: 10.1371/journal.pgen.1003110. Epub 2012 Dec 6. PMID: 23236293; PMCID: PMC3516565.</p> <p>Phenotypic and raw methylation data measured at 27,578 CpG sites on Infinium HumanMethylation27 arrays for 66 Ethiopian samples. Initially, 17 HA and 17 LA Amhara and Oromo DNA samples were measured;, however, two LA Amhara sample data were discarded due to low data quality. </p>
Global Parkinson's Genetics Program Data Release 8
<p>In September 2024, GP2 announced the eighth data release on the Terra and the Verily® Workbench platforms in collaboration with AMP® PD. This release includes 5,481 additional whole genome sequences and 10,454 clinical exome sequences. Additional genotyping will be provided in the following release.</p> <ul> <li> <p>The whole genome sequencing (WGS) data now consists of a total of 7,734 sequenced participants (6,113 PD cases, 617 Controls, and 1,004 ‘Other’ phenotypes).</p> </li> <ul> <li> <p>When removing the locally-restricted samples, these now consist of 4,713 participants (4,098 PD cases, 390 Controls, and 225 ‘Other’ phenotypes).</p> </li> <li> <p>Of note, cases recruited via the Monogenic network are coded as ‘Other’</p> </li> </ul> <li> <p>Additionally, included in this WGS release is a partial release of whole genome sequences from two AMP-PD cohorts (BioFind and PPMI) that have been joint-called with GP2 WGS. Released samples can be linked back to the original AMP-PD IDs through an ID crosswalk file included with the release.</p> </li> <li> <p>This release also includes 10,454 joint-called clinical exome sequencing (CES) participants from the Parkinson’s Foundation.</p> </li> <li>This release includes a total of 62,087 individuals who have core clinical data available. Among these, 16,800 individuals have deep clinical phenotyping and genetic data available</li> </ul> <p>---</p> <p>Please see the accompanying blog for further description of this release. To obtain data access, please see <a href="https://amp-pd.org/researchers/data-use-agreement">https://amp-pd.org/researchers/data-use-agreement</a>. For any publications using data from this release, please reference the DOI number and the following statement: "<em>Data (DOI <strong>10.5281/zenodo.13755496</strong>, release 8) used in the preparation of this article were obtained from the Global Parkinson’s Genetics Program (GP2)."</em></p>
Genetic fine-mapping results for 56 NMR metabolites measured in 246,683 UK Biobank participants
<p>Fine-mapping credible sets for 56 metabolites measured in 246,683 UK Biobank participants using the Nightingale Health platform. Fine-mapping was performed using the https://github.com/AlasooLab/reGSusie workflow.<br><br>The 56_metabolites_finemapping_credible_sets.tsv file contains the fine-mapped credible sets for all 56 metabolites. The *_coloc5_final.tsv.gz files contain the log Bayes factors for each metabolite in each fine-mapped region. </p>
Seasonality and inter-annual stability in the population genetic structure of Batrachospermum gelatinosum (Rhodophyta)
<p>Data used for Shainker-Connelly et al. in biorxiv: https://www.biorxiv.org/content/10.1101/2024.09.20.614195v1</p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.