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29,897 results for “activism”
Piezo2 in bladder-innervating sensory neurons contributes to regulation of contractile activity in cystitis
<p>Overactivity of the urinary bladder constitutes one of the main symptoms in various lower urinary tract disorders and it significantly deteriorates quality of life. The crucial role of mechanotransduction in bladder-innervating unmyelinated C-type primary sensory nerve fibres in initiating the voiding reflex in the overactive bladder has been well established. However, the molecular identity of the mechanotransducer(s) in bladder-innervating C-type sensory neurons is still elusive. The mechanosensitive ion channel Piezo2 in primary sensory neurons has been implicated in various physiological and pathological functions including proprioception, the detection of low and high threshold mechanical stimuli in the skin, and the development of mechanical hypersensitivity in peripheral pathologies. Here, we investigated whether or not Piezo2 expressed in primary sensory neurons could contribute to bladder overactivity in cystitis. Characterisation of Piezo2 expression revealed that about 1/5 of primary sensory neurons express this ion channel and at least half of the Piezo2-expressing cells express various markers for unmyelinated C-type sensory neurons. Further, we found that Piezo2 is expressed predominantly in lamina I and II of the spinal cord, where C-type sensory neurons terminate. We disclosed that Piezo2 is expressed in sensory neuron terminals innervating peripheral tissues including the bladder wall and noxious but not innocuous pressure in the urinary bladder activates Piezo2-expressing primary sensory neurons. Finally, we show that instillation of GsMTx that blocks Piezo2 significantly reduces overactivity in the inflamed but not in the naive urinary bladder. Together these findings indicate that Piezo2 in bladder-innervating unmyelinated C-type neurons contributes to the detection of noxious pressure and regulation of contractile activity in cystitis.</p>
Compound activity classes from ChEMBL for machine learning analysis
<p>Ten activity classes are provided that were extracted from ChEMBL version 24 for machine learning studies. Compounds are given in SMILES representations. The following selection criteria were applied. Compounds were required to be tested in a direct binding assay against a single human protein with a ChEMBL assay confidence score of 9. In addition, K<sub>i</sub> measurements had to be available. If multiple K<sub>i</sub> values were available for a compound and did not fall within the same order of magnitude, the compound was not selected. Furthermore only compounds with (mean) pK<sub>i</sub> of at least 5 were considered. Moreover, activity classes had to contain at least 200 compounds belonging to at least 50 computationally determined analog series. The 10 deposited classes consist of 243 to 955 compounds and 57 to 216 analog series.</p>
Dataset related to article "ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity"
<p>This record contains raw data related to article "ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity"</p> <p>Atypical chemokine receptors (ACKRs) are regulators of leukocyte traffic, inflammation, and immunity. ACKR2 is a scavenger for most inflammatory CC chemokines and is a negative regulator of inflammation. Here we report that ACKR2 is expressed in hematopoietic precursors and downregulated during myeloid differentiation. Genetic inactivation of ACKR2 results in increased levels of inflammatory chemokine receptors and release from the bone marrow of neutrophils with increased anti-metastatic activity. In a model of NeuT-driven primary mammary carcinogenesis ACKR2 deficiency is associated with increased primary tumor growth and protection against metastasis. ACKR2 deficiency results in neutrophil-mediated protection against metastasis in mice orthotopically transplanted with 4T1 mammary carcinoma and intravenously injected with B16F10 melanoma cell lines. Thus, ACKR2 is a key regulator (checkpoint) of mouse myeloid differentiation and function and its targeting unleashes the anti-metastatic activity of neutrophils in mice.</p>
Occupancy Sensing and Activity Recognition with Cameras and Wireless Sensors
<p>This dataset contains human activity data from a wireless sensing system, which includes a Doppler motion sensor and a wireless network. The Doppler sensor is a low-cost dual Doppler sensor modified from a commercial-off-the-shelf range-controlled radar, which operates at 5.8 GHz with two directional antennas. The wireless network uses four IEEE 802.15.4 radio nodes (CC2531 from TI) to create a mesh network to measure the RSS between each pair of radio nodes operating on the 16 frequency channels at 2.4 GHz.</p> <p>For the activity experiment, we recruited human subjects to perform 42 trials of four activities (each one with two minutes duration): (1) walking in a room (10 trials), (2) sitting in a chair (10 trials), (3) lying on a bed (12 trials), and (4) body turning on a bed (10 trials). For the walking activity, the human subjects walk along different paths at different locations in the room. For the lying on bed activity, we ask human subjects to breathe normally on bed with three orientations facing upwards, right and left. Finally, for the turning on bed case, human subjects turn their bodies from one side to the other on bed with random time intervals. We also recorded two-minute data of the empty room case before and after each human subject trial. Note that each data file name has its corresponding activity in it, so it is pretty self-explanatory. </p>
Synergistic activity of Hsp90 inhibitors and anticancer agents in pancreatic cancer cell cultures (raw data)
<p>This data set includes raw data supporting the paper "<strong>Synergistic activity of Hsp90 inhibitors and anticancer agents in pancreatic cancer cell cultures</strong>".</p> <p><strong>The files include the following data</strong>:</p> <p>1. MTT assay results used for calculation of <strong><em>EC</em><sub>50</sub> values</strong> of tested compounds and their combinations in cancer cells;</p> <p>2. The data used for calculating <strong>combination index</strong> in order to evaluate synergistic activity;</p> <p>3. The raw data from compound activity evaluation in <strong>3D tumor spheroid assay</strong>;</p> <p>4. The data from <strong>compound and hyperthermia </strong>effect evaluation in cancer cells.</p>
Improving quality of life among healthy individuals through theatre activities: a theatre-in-health pilot project
<p><strong>Background</strong></p> <p>Review of previous studies regarding arts and health reveals knowledge gaps regarding the use of theatre activities outside a clinical setting with healthy participants. The purpose of this study was to evaluate quality of life benefits of structured theatre training improvisations among generally healthy individuals.</p> <p><strong>Methods</strong></p> <p>A mixed methods approach was used at three theatre activities workshops. Pre- and post-quality of life surveys were completed at administered at each workshop. workshop. Participants also free wrote after the workshops, reflecting on their experiences.</p> <p><strong>Results</strong></p> <p>The surveys showed that there was a statistically significant shift in a positive direction in each domain studied. Themes that emerged from the free-writing responses were those of play, social acceptance, gratitude, and community.</p> <p><strong>Conclusions</strong></p> <p>Findings demonstrate that structured theatre activities produce quality of life benefits across all domains. This pilot study indicates the potential for such theatre-in-health projects as a tool for quality of life improvement.</p>
Predominance of Secondary Organic Aerosol to Particle-bound Reactive Oxygen Species Activity in Fine Ambient Aerosol
<p>Reactive oxygen species (ROS) are believed to contribute to the adverse health effects of aerosols. This may happen by inhaled particle-bound (exogenic) ROS (PB-ROS) or by ROS formed within the respiratory tract by certain aerosol components (endogenic ROS). We investigated the chemical composition of aerosols and their exogenic ROS content at the two contrasting locations Beijing (China) and Bern (Switzerland). We apportioned the ambient organic aerosol to different sources and attributed the observed water-soluble PB-ROS to them. The oxygenated organic aerosol (OOA, a proxy for secondary organic aerosol, SOA) explained the highest fraction of the exogenic ROS concentration variance at both locations. We also characterized primary and secondary aerosol emissions generated from different biogenic and anthropogenic sources in smog chamber experiments. The exogenic PB-ROS content in the OOA from these emission sources was comparable to that in the ambient measurements. Our results imply that SOA from gaseous precursors of different anthropogenic emission sources is a crucial source of water-soluble PB-ROS and should be additionally considered in toxicological and epidemiological studies in an adequate way besides primary emissions. The importance of PB-ROS may be connected to the seasonal trends in health effects of PM reported by epidemiological studies, with elevated incidences of adverse effects in warmer seasons, which are accompanied by more intense atmospheric oxidation processes.</p>
Promiscuous compounds with activity against different target classes
<p>Reported are 1063 promiscuous compounds with activity against multiple target classes identified in PubChem. The tab-separated file consists of four columns:</p> <p>- cid: compound identifier (CID) from PubChem</p> <p>- NonstereoAromaticSMILES: SMILES representation of a compound</p> <p>- Number_of_tested_targets: total number of targets a compound was tested against in PubChem</p> <p>- PD: promiscuity degree (PD) of a compound, defined as the number of targets it was found active against</p>
Can metal organic frameworks outperform adsorptive removal of harmful phenolic compound 2-chlorophenol by activated carbon?
<p>A more complete version of this dataset, along with publication details, is available from <a href="https://zenodo.org/record/2586955">https://zenodo.org/record/2586955</a></p>
ROS-Specific Huntingtin Interactions: Testing PARG activity in HD patient fibroblasts
<p>Comparison nuclear PAR levels in wild type and HD (TruHD) fibroblasts in response to a PARG inhibitor concentration gradient (as a measure of PARG activity).</p>
Figure 3 in Recently resighted population of Blue-breasted Quail (Synoicus chinensis) in and around East Kolkata Wetland is under threat due to development activities
Figure 3. Showing LULC of the area where the BBQ were sighted.
Figure 1 in Diurnal activity pattern of age-sex groups of a small and fragmented population of Blackbuck (Antilope cervicapra L.) in Western Haryana, India
Figure 1. Map of the study site.
Figure 2 in Diurnal activity pattern of age-sex groups of a small and fragmented population of Blackbuck (Antilope cervicapra L.) in Western Haryana, India
Figure 2. (a) Adult male, (b) Sub adult female, (c) Adult females and sub adult
Figure 1 in Effects of agroecosystems on insect and insectivorous bat activity: a preliminary finding based on light trap and mist net captures
Figure 1. Map of Sekyere Central District showing study area (Kwamang) in Ghana.
Figure 2 in Habitat use and activity of European glass lizard, Pseudopus apodus (Pallas, 1775), in southeastern Bulgaria
Figure 2. Segregation spaces of the captured individuals in Habitat 1.
Figure 1 in Habitat use and activity of European glass lizard, Pseudopus apodus (Pallas, 1775), in southeastern Bulgaria
Figure 1. Location of the studied habitats in the region of southeastern Bulgaria.
Figure 2 in The influence of temperature on the hibernation patterns and activity of Vertigo moulinsiana (Dupuy, 1849) (Gastropoda: Pulmonata: Vertiginidae)
Figure 2. (A) The site of V. moulinsiana; (B) awoken individuals of V. moulinsiana in test tubes.
Figure 1 in The influence of temperature on the hibernation patterns and activity of Vertigo moulinsiana (Dupuy, 1849) (Gastropoda: Pulmonata: Vertiginidae)
Figure 1. Shell of V. moulinsiana collected at the studied site.
Figure 1 in Short-time salinity fluctuations are strong activators of oxidative stress in Mediterranean mussel (Mytilus galloprovincialis)
Figure 1. Scheme illustrating the experimental design.
Study on the role of AIMP1 gene activating PINK1/Parkin pathway in mediating mitochondrial autophagy in the pathogenesis of ARHL
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International Brain Laboratory public data
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