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130 results for “γδ T cells”
Payload-delivering engineered γδ T cells display enhanced cytotoxicity, persistence, and efficacy in preclinical models of osteosarcoma
<p>T cell-based cancer immunotherapy has typically relied on membrane-bound cytotoxicity enhancers such as chimeric antigen receptors expressed in autologous αβ T cells. These approaches are limited by tonic signaling of synthetic constructs and costs associated with manufacturing. γδ T cells are an emerging alternative for cellular therapy, possessing innate anti-tumor activity, potent antibody-dependent cellular cytotoxicity, and minimal alloreactivity. We present an immunotherapeutic platform technology built around the innate properties of the Vγ9Vδ2 T cell, harnessing specific characteristics of this cell type and offering an allo-compatible cellular therapy that recruits bystander immunity. We engineered γδ T cells to secrete synthetic tumor-targeting opsonins in the form of an scFv-Fc fusion protein and a mitogenic IL-15Ra–IL-15 fusion protein (stIL15). Using GD2 as a model antigen, we show that GD2-specific opsonin-secreting Vγ9Vδ2 T cells (stIL15-OPS-γδ T cells) have enhanced cytotoxicity and promote bystander activity of other lymphoid and myeloid cells. Secretion of stIL-15 abrogated the need for exogenous cytokine supplementation and further mediated activation of bystander natural killer cells. Compared to unmodified γδ T cells, stIL15-OPS-γδ T cells exhibited superior in vivo control of subcutaneous tumors and persistence in the blood. Moreover, stIL15-OPS-γδ T cells were efficacious against patient-derived osteosarcomas in animal models and in vitro, where efficacy could be boosted with the addition of zoledronic acid. Together the data identify stIL15-OPS-γδ T cells as a candidate allogeneic cell therapy platform combining direct cytolysis with bystander activation to promote tumor control.</p>
Payload-delivering engineered γδ T cells display enhanced cytotoxicity, persistence, and efficacy in preclinical models of osteosarcoma
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Supplementary file for "Expression of CD226 on γδ T cells is lower in advanced chronic lymphocytic leukaemia and correlates with IgA, IgG and LDH levels"
<p>Supplementary Data for an article entitled: "Expression of CD226 on γδ T cells is lower in advanced chronic lymphocytic leukaemia and correlates with IgA, IgG and LDH levels", published in the Advances in Clinical and Experimental Medicine (advances.uwm.edu.pl)</p>
Novel Gamma-Delta (γδ)T Cell Therapy for Treatment of Patients With Newly Diagnosed Glioblastoma
ClinicalTrials.gov study NCT04165941. IPD Sharing: NO. Countries: 1. Publications: 2.
Safety and Efficiency of IRE Plus γδ T Cell Against Locally Advanced Pancreatic Cancer
ClinicalTrials.gov study NCT03180437. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Efficiency of γδ T Cell Against Hepatocellular Liver Cancer
ClinicalTrials.gov study NCT02425735. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Allogeneic NKG2DL-targeting CAR γδ T Cells (CTM-N2D) in Advanced Cancers (ANGELICA)
ClinicalTrials.gov study NCT05302037. IPD Sharing: NO. Countries: 1. Publications: 6.
A Phase 1b / 2 Drug Resistant Immunotherapy With Activated, Gene Modified Allogeneic or Autologous γδ T Cells (DeltEx) in Combination With Maintenance Temozolomide in Subjects With Recurrent or Newly
ClinicalTrials.gov study NCT05664243. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue [scRNA-Seq]
GEO Series GSE137076. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq profiling of malaria pre-exposed but resting effector memory γδ T cells
GEO Series GSE159532. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Fetal-derived activated CD83+ γδ T cells expand in preterm infants with sepsis.
GEO Series GSE245131. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing; Other.
RNA Sequencing of Fetal and Adult Mature Thymic Vγ1+ γδ T-Cells
GEO Series GSE166086. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic therapy strengthens immune synapses to potentiate susceptibility of lung cancer cells to adoptive γδ T cell therapy [seq]
GEO Series GSE145663. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Investigating in the implications of the γδ T cell receptor in the acquisition of IL-17 producing effector functions.
GEO Series GSE284167. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Single-cell RNA-sequencing of γδ-T cells from peripheral blood and breast tumour microenvironment.
GEO Series GSE141665. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
In Vitro Expanded Cord Blood γδ T Cells Acquired Unique Cell State Composition to Mediate Sustained Human AML Suppression.
GEO Series GSE214289. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Distinct metabolic programs control the effector fate of γδ T cell subsets and their activities in the tumour microenvironment
GEO Series GSE150585. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
γδ+ T cell-derived IL-17A stimulates airway epithelial/stromal cells to secrete G-CSF, promoting lung-specific pathogenic Siglec-F+ neutrophil development in PPE-induced emphysema
GEO Series GSE297403. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Exhausted intratumoral Vδ2- γδ T cells in human kidney cancer retain effector function [bulk RNA-seq]
GEO Series GSE223806. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
Isolation and expansion of murine γδ T cells from mouse splenocytes
GEO Series GSE182882. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.