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54 results for “5-Aminolevulinic acid”
MAD diffraction images for yeast 5-aminolevulinic acid dehydratase (ALAD).
<p>Selenomethionine multiwavelength anomalous dispersion (MAD) diffraction images for the original structure determination of 5-aminolevulinic acid dehydratase (ALAD) from yeast collected at the bending magnet beamline BM14, ESRF, Grenoble (25-27 Sept 1996). There are separate folders for the data from different wavelengths (l1 is the edge dataset, l4 is the edge inverse beam, l2 is the peak, l5 and l55 are the peak inverse beam (l55 is an overlapping continuation of l5 due to beam loss), l3 is the remote and l6 is the remote inverse beam). The seoa folder contains the selenium 'optimised anomalous' peak data. The images were collected with a Mar Research image plate and each folder has a file called 'mos.com' giving the data collection parameters for that run except for the exposure times which were 45 seconds per image for both l1 and l2, 55 seconds per image for the remote l3 and 120 seconds per image for the optimised anomalous collection (seoa). The latter dataset does not have a file listing the parameters which were: crystal-to-detector distance 275mm, delta-phi 1 degree, wavelength 0.9791 Angstroms, big-MAR format (note other datasets were collected in small-MAR format). </p>
X-ray diffraction images for human recombinant 5-aminolevulinic acid dehydratase (ALAD).
<p>X-ray diffraction images for recominant human 5-aminolevulinic acid dehydratase (ALAD) collected at ESRF (Grenoble) beam line ID14-2 using an ADSC Quantum 4 detector to a resolution of 2.8 Å. A series of 1 ̊ oscillation images were recorded with an exposure time of 10 seconds per image. More details are given with the scanned notes and the log file. </p>
X-ray diffraction images for human native 5-aminolevulinic acid dehydratase (ALAD).
<p>X-ray diffraction images of human native ALAD collected at station 9.5 at synchrotron radiation source (SRS) Daresbury, UK, with a Marresearch 345 image plate detector on Sunday 26th April 1998. More details of the data collection are given in the files suffixed SUMMARY.</p>
Original X-ray diffraction images for 5-aminolevulinic acid dehydratase (ALAD) from E. coli complexed with porphobilinogen.
<p>The diffraction images which allowed the original 2.1 Angstrom resolution structure determination of <em>Escherichia coli</em> ALAD co-crystallised with a non-covalently bound moiety of the product, porphobilinogen (PBG), are presented. </p>
X-ray diffraction images for 5-aminolevulinic acid dehydratase with a putative reaction intermediate resembling the product porphobilinogen bound.
<p>X-ray diffraction images for yeast 5-aminolevulinic acid dehydratase co-crystallised with the substrate 5-aminolevulinic acid. The structure demonstrated a putative product-like intermediate bound covalently to Lys 263 with an amino side chain ligated to the active-site zinc ion in a position normally occupied by a catalytic hydroxide ion. The data were collected in two passes using the ESRF beamline ID29 in Feb 2002 and extend to approximately 1.6 Å resolution. </p>
Diffraction images for yeast 5-aminolevulinic acid dehydratase complexed with the inhibitor 5-hydroxylevulinic acid.
<p>Diffraction images for a co-crystal of 5-aminolaevulinic acid dehydratase (ALAD) from yeast with the competitive inhibitor 5-hydroxylevulinic acid extending to a resolution of 1.9 Å. The data were collected at beamline ID29 at ESRF in Feb 2002 using an ADSC detector. </p>
X-ray diffraction images for yeast 5-aminolevulinic acid dehydratase complexed with 4-oxosebacic acid.
<p>X-ray diffraction images for yeast 5-aminolaevulinic acid dehydratase complexed with 4-oxosebacic acid which were collected using beamline ID14-2 at the ESRF (Grenoble) in Feb 2001. </p>
X-ray diffraction images for 5-aminolevulinic acid dehydratase (ALAD) from E. coli.
<p>X-ray diffraction images for <em>Escherichia coli</em> 5-aminolevulinic acid dehydratase (ALAD) which was crystallised in the presence of the inhibitor levulinic acid (15 mM) and bismuth nitrate (1 mM). The data were collected at beamline 9.6 at the SRS Daresbury Laboratory (UK) on 10th March 1994 using a 30 cm Marresearch image plate detector, a crystal temperature of 100 K, a wavelength of 0.88 Å and a crystal-to-detector distance was 300 mm. The oscillation angle was 2.5 degrees and 21 images were collected at constant dose in the time available. A wax image for determining the direct beam position was taken with the detector at a distance of 400 mm.</p>
X-ray diffraction images for yeast 5-aminolevulinic acid dehydratase complexed with 4-keto-5-aminohexanoic acid.
<p>X-ray diffraction images which were collected at the EMBL beamline BW7B, DESY (Hamburg) on 28th June 1999 using a Marresearch 345 image plate detector. The data were collected in three passes, images in the first main one having file prefix hykah, the second being a low-resolution run (lr) and, the last, a very high resolution (vhr) pass. More details are given in the notebook pages. </p>
X-ray diffraction images for yeast 5-aminolevulinic acid dehydratase complexed with succinylacetone.
<p>X-ray diffraction images which were collected on 28th March 1999 at the EMBL beamline BW7B at DESY (Hamburg) using a Marresearch 345 image plate detector. More information in the notes. </p>
X-ray diffraction images of yeast 5-aminolevulinic acid dehydratase complexed with substrate 5-aminolevulinic acid.
<p>X-ray diffraction images collected at the BW7B beamline at DESY (Hamburg) on 2 Jun 1998. More details in the notes. </p>
High resolution X-ray diffraction images for yeast 5-aminolevulinic acid dehydratase complexed with levulinic acid.
<p>X-ray diffraction images collected at DESY Hamburg in June 1998 using beamline BW7B. </p>
Dataset related to article "Intracranial Sonodynamic Therapy With 5-Aminolevulinic Acid and Sodium Fluorescein Safety Study in a Porcine Model"
<p>pigs treatments</p>
A Study of the Specificity and Sensitivity of 5- Aminolevulinic Acid (ALA) Fluorescence in Malignant Brain Tumors
ClinicalTrials.gov study NCT01128218. IPD Sharing: NO. Countries: 1. Publications: 5.
Diffraction images for 5-aminolevulinic acid dehydratase (ALAD) from E. coli complexed with porphobilinogen.
<p>The diffraction images which allowed the 2.1 Angstrom resolution structure determination of <em>Escherichia coli</em> ALAD co-crystallised with a non-covalently bound moiety of the product, porphobilinogen (PBG), are presented. The structure revealed that the pyrrole side chain amino group is datively bound to the active site zinc ion and that the PBG carboxylates interact with the enzyme via hydrogen bonds and salt-bridges with invariant residues. A number of hydrogen bond interactions that were previously observed in the structure of yeast ALAD with a cyclic intermediate resembling the product PBG appear to be weaker in the new structure suggesting that these interactions are only optimal in the transition state. </p>
Diffraction images for yeast 5-aminolevulinic acid dehydratase complexed with mercury and lead ions.
<p>The diffraction images corresponding to the data used to refine the Hg- and Pb- complexes of yeast ALAD as described in this paper: ‘MAD analyses of yeast 5-aminolaevulinate dehydratase. Their use in structure determination and in defining the metal binding sites.’ P.T. Erskine, E.M.H. Duke, I.J. Tickle, N. Senior, M.J.Warren and J.B. Cooper. Acta Crystallogr. D. (2000), D56, 421-430. </p>
Comparison Between 5-aminolevulinic Acid Photodynamic Therapy Versus Cryotherapy for Actinic Keratosis Treatment
ClinicalTrials.gov study NCT01459393. IPD Sharing: Not stated. Countries: 1. Publications: 17.
A Clinical Trial Evaluating the Role of Systemic Antihistamine Therapy in the Reduction of Adverse Effects Associated With Topical 5-aminolevulinic Acid Photodynamic Therapy
ClinicalTrials.gov study NCT02451579. IPD Sharing: Not stated. Countries: 1. Publications: 1.
5-Aminolevulinic Acid (5-ALA) Gliolan®: Usage Increase Proposal for Neurosurgical Procedures in High-Grade Gliomas
ClinicalTrials.gov study NCT05850377. IPD Sharing: NO. Countries: 1. Publications: 25.
5-AminoLevulinic Acid Aided Resection Margins in Sarcoma
ClinicalTrials.gov study NCT07038278. IPD Sharing: NO. Countries: 1. Publications: 8.
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