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209 results for “ABL”
QSPR models for bioconcentration factor (BCF): Are they able to predict data of industrial interest?
<p>This dataset is described and studied in the article </p> <p>"QSPR models for bioconcentration factor (BCF): Are they able to predict data of industrial interest?"</p> <p>published in <em>SAR and QSAR Environmental Research</em> (Taylor&Francis).</p> <p>Files description:</p> <p>SI_BCFtrainset.xlsx: a collection of 1129 chemical structures and CAS identifiers with their logBCF values extracted from various literature sources.</p> <p>SI_BCFtestset.xlsx: a collection of 204 chemical structures for which the logBCF is considered of lower reliability and used as an external test set.</p> <p>SI_FullDataset_rawdata.csv: the raw data composed of 15372 entries with the following columns: CASRN, Tissue, Duration [d], Test organism, Exposure type, Steady state, RESPONSE, RESPONSE UNIT, Media type, TakenFrom, TITLE, AUTHOR, YEAR, SOURCE, SMILES</p> <p>SI_ExcludedOutliers34.csv: 34 chemical structures that have been identified as suspicious during analysis.</p> <p> </p>
Will Biomimetic Robots Be Able to Change a Hivemind to Guide Honeybees' Ecosystem Services? (dataset)
<p>Simulation data for different simulation runs from the publication "Will Biomimetic Robots Be Able to Change a Hivemind to Guide Honeybees’ Ecosystem Services?"<br> <br> Dataset for figure 4: The Model replicates Seeleys Choice Experiment (1991).<br> (Shown in the folder: 'Model_Validation_Choice_Empirical','Model_Validation_Choice_Model')<br> Aditionally the accumulated energy [J] (net gain) gathered threw the foraging targets is displayed.<br> <br> Dataset for figure 5: The Model replicates Seeleys Cross Inhibition Experiment (2009).<br> (Shown in the folder: 'Model_Validation_Equilib_Empirical','SModel_Validation_Equilib_Model')<br> Aditionally the accumulated energy [J] (net gain) gathered threw the foraging targets is displayed.<br> <br> Dataset for figure 6: Model data of Seeley's choice experiment (1991) under more natural conditions.<br> The effect of the single parameters and the effect of all parameters together is shown.<br> (Shown in the folder: 'Natural_Foraging_Forager_Size','Natural_Foraging_crop_Load',<br> 'Natural_Foraging_CFS','Natural_Foraging_All_Conditions',)<br> <br> Dataset for figure 7: Model data of Seeley's Cross Inhibition Experiment under more natural conditions.<br> The effect of the single parameters and the effect of all parameters together is shown.<br> (Shown in the folder: 'Natural_Foraging_Equilib_Forager_Size','Natural_Foraging_Equilib_crop_Load',<br> 'Natural_Foraging_Equilib_CFS','Natural_Foraging_Equilib_All_Conditions',)<br> <br> Dataset for figure 8: The influence of waggle dancing robots on the foraging behaviour of honeybees with two different qualities of the foraging targets A and B.<br> After 14400 second (12:00) a pesticide is sprayed on the foraging target B under natural conditions.<br> The waggle dancing robot starts advertising foraging target B when time > 14400 seconds.<br> (The folder shows: 'robo_influence_bad_vs_bad','robo_influence_good_vs_bad','robo_influence_good_vs_good',)</p> <p>Dataset for figure 9: The influence of 10 waggle dancing robots on the foraging behaviour of honeybees with two different qualities of the foraging targets A and B<br> and varrying colony fill status (CFS).<br> After 14400 second (12:00) a pesticide is sprayed on the foraging target B under natural conditions.<br> The 10 waggle dancing robots start advertising foraging target B when time > 14400 seconds. The CFS is varried (0.1, 0.3, 0.5, 0.7, 0.9).<br> (The folder shows: 'robo_influence_bad_vs_bad','robo_influence_good_vs_bad','robo_influence_good_vs_good',)<br> <br> Dataset for figure 10: The effects at the end of the waggle dancing robots on the accumulated energy (through the trips), accumulated pesticides (through trips on foraging target<br> B, where after time>14400 pesticide was sprayed on the foraging target), pollination flights to foraging target A.<br> After 14400 second (12:00) a pesticide is sprayed on the foraging target B under natural conditions.<br> The waggle dancing robot starts advertising foraging target A when time > 14400 seconds.<br> (The folder shows: 'robo_influence_acc_energy','robo_influence_acc_pesticide','robo_influence_pollination')<br> <br> The datasets are contained in the zipped file folder Figures_data.zip.</p>
Operating diagram of hatching module in Zoug jars, this system consists of a 300-litre temperature-controlled isothermal enclosure containing 10 one-litre Zoug jars, each able to accommodate several hundred eggs. An ascending current holds the eggs in suspension and carries the larvae to the surface. Another bottle connected to this device collects the larvae. The water circulating in the jars is independent of that used in the filtration circuit. A cooling unit and UV sterilizer complete the installation. in Reproduction of Zingel asper (Linnaeus, 1758) in controlled conditions: an assessment of the experiences realized since 2005 at the Besançon Natural History Museum
Operating diagram of hatching module in Zoug jars, this system consists of a 300-litre temperature-controlled isothermal enclosure containing 10 one-litre Zoug jars, each able to accommodate several hundred eggs. An ascending current holds the eggs in suspension and carries the larvae to the surface. Another bottle connected to this device collects the larvae. The water circulating in the jars is independent of that used in the filtration circuit. A cooling unit and UV sterilizer complete the installation.
Dataset: Abacus Life, Inc. (ABL) Stock Performance
This dataset provides historical stock market performance data for specific companies. It enables users to analyze and understand the past trends and fluctuations in stock prices over time. This information can be utilized for various purposes such as investment analysis, financial research, and market trend forecasting.
Dataset: Able View Global Inc. (ABLVW) Stock Performance
This dataset provides historical stock market performance data for specific companies. It enables users to analyze and understand the past trends and fluctuations in stock prices over time. This information can be utilized for various purposes such as investment analysis, financial research, and market trend forecasting.
Dataset: Able View Global Inc. (ABLV) Stock Performance
This dataset provides historical stock market performance data for specific companies. It enables users to analyze and understand the past trends and fluctuations in stock prices over time. This information can be utilized for various purposes such as investment analysis, financial research, and market trend forecasting.
Dataset: Able View Global Inc. (ABLVW) Stock Performance
This dataset provides historical stock market performance data for specific companies. It enables users to analyze and understand the past trends and fluctuations in stock prices over time. This information can be utilized for various purposes such as investment analysis, financial research, and market trend forecasting.
Dataset: Able View Global Inc. (ABLV) Stock Performance
This dataset provides historical stock market performance data for specific companies. It enables users to analyze and understand the past trends and fluctuations in stock prices over time. This information can be utilized for various purposes such as investment analysis, financial research, and market trend forecasting.
Dataset: Abacus Life, Inc. (ABL) Stock Performance
This dataset provides historical stock market performance data for specific companies. It enables users to analyze and understand the past trends and fluctuations in stock prices over time. This information can be utilized for various purposes such as investment analysis, financial research, and market trend forecasting.
A Genetic Algorithm Approach to Regenerate Image from a Reduce Scaled Image Using Bit Data Count-In Figure 15 we were able to generate the symbol H without any help from a small image we used only for row and column data
<p>In Figure 15 we were able to generate the symbol H without any help from a small image we used only for row and column data.</p>
"The sound comes from a meadow in the Sierra Nevada Mountains in California. The meadow is at an elevation of 2400 meters near a mountain named Olancha Peak, which is 3700 meters in altitude. Ihave a group of friends with which Ibackpack (trek) into the mountains. Our goal was to spend some time in the mountains and hike to the top of Olancha Peak (…) By the time we reached the meadow, we were in a forest and there was still snow on the ground in some places. We took the trip in June of 2006. The Sierra Nevada Mountains are a large mountain range. Much of the range is protected by national parks or preserved areas we call 'wilderness areas' (…) Ihave been backpacking for nearly 40 years and Iwill hopefully continue with this challenging activity for 40 years more! Many of my friends are much younger than Iam and it gives me much satisfaction to be able to have as much or more stamina for this activity than they have! When we are on these trips, we hike up peaks, catch fish, drink some whiskey around campfires and enjoy our time in the beautiful solitude. My memories of this trip were of the steep, hot hike from the desert to the cool meadow; the overall beauty of the nature, the absolute solitude of our campsite near the meadow; the strenuous hike to the top of Olancha Peak; the camaraderie of my friends; and, of course the sound of the frogs in the meadow. The frog sounds were astounding to me and Iwould listen in awe of the creature's instinctual desire to reproduce and continue the existence of their kind. Surely there were different species in the meadow for some of the frog sounds were different than others. The sounds only occurred after the Sun went down for the evening. Istood next to the creek in the meadow and recorded the sounds using my digital camera." [Peter/plentz1960]16 in Collecting Sounds. Online Sharing of Field Recordings as Cultural Practice
"The sound comes from a meadow in the Sierra Nevada Mountains in California. The meadow is at an elevation of 2400 meters near a mountain named Olancha Peak, which is 3700 meters in altitude. Ihave a group of friends with which Ibackpack (trek) into the mountains. Our goal was to spend some time in the mountains and hike to the top of Olancha Peak (…) By the time we reached the meadow, we were in a forest and there was still snow on the ground in some places. We took the trip in June of 2006. The Sierra Nevada Mountains are a large mountain range. Much of the range is protected by national parks or preserved areas we call 'wilderness areas' (…) Ihave been backpacking for nearly 40 years and Iwill hopefully continue with this challenging activity for 40 years more! Many of my friends are much younger than Iam and it gives me much satisfaction to be able to have as much or more stamina for this activity than they have! When we are on these trips, we hike up peaks, catch fish, drink some whiskey around campfires and enjoy our time in the beautiful solitude. My memories of this trip were of the steep, hot hike from the desert to the cool meadow; the overall beauty of the nature, the absolute solitude of our campsite near the meadow; the strenuous hike to the top of Olancha Peak; the camaraderie of my friends; and, of course the sound of the frogs in the meadow. The frog sounds were astounding to me and Iwould listen in awe of the creature's instinctual desire to reproduce and continue the existence of their kind. Surely there were different species in the meadow for some of the frog sounds were different than others. The sounds only occurred after the Sun went down for the evening. Istood next to the creek in the meadow and recorded the sounds using my digital camera." [Peter/plentz1960]16
Window[1]resorcin[3]arenes: A novel macrocycle able to self-assemble to a catalytically active hexameric cage
<p>open data for paper Window[1]resorcin[3]arenes: A novel macrocycle able to self-assemble to a catalytically active hexameric cage</p>
Data from: Myristoyl's dual role in allosterically regulating and localizing Abl kinase
<p>c-Abl kinase, a key signalling hub in many biological processes ranging from cell development to proliferation, is tightly regulated by two inhibitory Src homology domains. An N-terminal myristoyl-modification can bind to a hydrophobic pocket in the kinase C-lobe, which stabilizes the auto-inhibitory assembly. Activation is triggered by myristoyl release. We used molecular dynamics simulations to show how both myristoyl and the Src homology domains are required to impose the full inhibitory effect on the kinase domain, and reveal the allosteric transmission pathway at residue-level resolution. Importantly, we find myristoyl insertion into a membrane to thermodynamically compete with binding to c-Abl. Myristoyl thus not only localizes the protein to the cellular membrane, but membrane attachment at the same time enhances activation of c-Abl by stabilizing its pre-activated state. Our data put forward a model in which lipidation tightly couples kinase localization and regulation, a scheme that currently appears to be unique for this non-receptor tyrosine kinase.</p>
Artificial selection on cis-element of Abl contributes cocoon yield increase in domestic silkworm
<p><span>The silkworm (</span><em><span>Bombyx mori</span></em><span>) is an important silk-producing domestic insect.</span><span> The quality and yield of the silk produced by <em>B. mori </em>exceeds that of its ancestor, the wild silkworm <em>B. mandarina</em>. However, to date little is known about the molecular mechanisms underlying domestication-related increases in silk yield. Here, we identified a gene associated with both domestication and silk-related quantitative trait locus (QTL): Abelson tyrosine protein kinase (<em>Abl</em>). </span><span>Population genomic data for <em>B. mori</em> and <em>B. mandarina</em> identified obvious signatures of artificial selection in the genomic region bearing the <em>Abl</em></span><span><em> </em>gene. T</span><span>here were two fixed nucleotide substitutions (−244 and −1311) in the </span><span>tran</span><span>scription factor binding motif of the upstream regulatory region of <em>B. mori Abl</em>.</span> <span>Compared to <em>Abl </em>in the wild silkworm <em>B. mandarina</em>, <em>B. mori Abl</em> exhibited significantly greater promoter activity and was upregulated in the silk gland from the last day of the 5<sup>th</sup> larval instar to pupal stage (P0). Compared to the wild type, CRISPR/Cas9-generated <em>Abl </em>loss-of-function mutants </span><span>exhibited a higher sensitivity to diseases, shorter developmental duration, and reductions in economically important silk traits, including cocoon weight, pupal weight, and cocoon layer thickness. Comparison of silk-gland transcriptomes between the wild type and the mutant indicated that genes enriched in ribosome biosynthesis, splicing, RNA transport, and the carbon metabolism were significantly downregulated in the mutants. Weighted gene co-expression network analysis (WGCNA) confirmed that genes related to ribosome biosynthesis were pivotal, driving the significant differentiation in silk yield between <em>B. mori</em> and <em>B. mandarina</em>. Here, we demonstrated that artificial selection acts on the cis-elements of silk-trait QTL gene <em>Abl </em>in a novel case (the domestic silkworm), and that this selection pressure increased <em>Abl </em>promoter activity and expression level. By promoting protein translation and synthesis, artificial selection further enhanced the robustness of silkworm larvae and improved cocoon silk synthesis.</span></p>
Not Only Systemin Prosystemin Harbors Other Active Regions Able to Protect Tomato Plants
<p>Prosystemin is a 200-amino acid precursor expressed in Solanaceae plants which releases at the C-terminal part a peptidic hormone called Systemin in response to wounding and herbivore attack. We recently showed that Prosystemin is not only a mere scaffold of Systemin but, even when deprived of Systemin, is biologically active. These results, combined with recent discoveries that Prosystemin is an intrinsically disordered protein containing disordered regions within its sequence, prompted us to investigate the N-terminal portions of the precursor, which contribute to the greatest disorder within the sequence. To this aim, PS1-70 and PS1-120 were designed, produced, and structurally and functionally characterized. Both the fragments, which maintained their intrinsic disorder, were able to induce defense-related genes and to protect tomato plants against <em>Botrytis cinerea</em> and <em>Spodoptera littoralis</em> larvae. Intriguingly, the biological activity of each of the two N-terminal fragments and of Systemin is similar but not quite the same and does not show any toxicity on experimental non-targets considered. These regions account for different anti-stress activities conferred to tomato plants by their overexpression. The two N-terminal fragments identified in this study may represent new promising tools for sustainable crop protection.</p>
The c-Abl inhibitor IkT-148009 therapeutically suppresses neurodegeneration in models of heritable and sporadic Parkinson's Disease
<p>Parkinson's Disease (PD) is the second most prevalent neurodegenerative disease of the central nervous system, with an estimated 5,000,000 cases worldwide. PD pathology is characterized by the accumulation of misfolded a-synuclein, which is thought to play a critical role in the etiopathogenesis of the disease. Animal models of PD suggest that activation of the Abelson Tyrosine Kinase, or c-Abl, plays an essential role in the initiation and progression of a-synuclein pathology and initiates processes leading to the degeneration of dopaminergic and non-dopaminergic neurons. Given the essential role of c-Abl in the disease, a proprietary c-Abl inhibitor library was developed to identify potent, orally bioavailable c-Abl inhibitors capable of crossing the blood-brain barrier based on pre-defined characteristics, leading to the discovery of IkT-148009. IkT-148009 is a selective, potent, brain-penetrant c-Abl inhibitor with a favorable toxicology profile that was analyzed for therapeutic potential in animal models of slowly progressive, a-synuclein-dependent disease. In models of both inherited and sporadic Parkinson's disease in the mouse, IkT-148009 suppressed c-Abl activation to baseline and substantially protected neurons from degeneration when administered therapeutically by once daily oral gavage beginning four weeks after disease initiation. Recovery of normal behavioral function in diseased mice occurred within 8 weeks of initiating treatment and occurred concomitantly with a substantial reduction of a-synuclein pathology in the brain. These disease-modifying outcomes in mice suggest IkT-148009 has the potential to be a disease-modifying therapy in human disease.</p>
Data to Deliverable 3.4 - Co-creation process for innovative planning and governance able to facilitate the transition to a water circular economy
<p>Transcription of co-creation workshops; Worksheets filled by groups of the co-creation workshops; and final worksheets filled of the co-creation workshops.<br> </p>
Homoharringtonine (Omacetaxine Mepesuccinate) in Treating Patients With Chronic Myeloid Leukemia (CML) With the T315I BCR-ABL Gene Mutation
ClinicalTrials.gov study NCT00375219. IPD Sharing: Not stated. Countries: 10. Publications: 1.
Nilotinib in Newly Diagnosed Adult Philadelphia Chromosome & /or BCR-ABL Positive Chronic Myeloid Leukaemia in Chronic Phase
ClinicalTrials.gov study NCT01061177. IPD Sharing: Not stated. Countries: 26. Publications: 2.
I Am Able: Population Based Rehabilitation in a Family Health Team
ClinicalTrials.gov study NCT00859638. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.