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5 results for “ALK2”
Deposition of ALK2 (ACVR1) co-crystallised with M4K2117 (PDB: 6SRH)
<p>Desposition of the structure of ALK2 co-crystallised with the compound M4K2117 in the PDB database with code 6SRH.</p> <p>You can read more about it over on the <a href="https://openlabnotebooks.org/?p=3575&preview=true">Open Lab Notebooks project.</a></p> <p> </p>
Deposition of crystal structure of ACVR1 / ALK2 with M4K2009
<p>Deposition of the structure of ACVR1 / ALK2 bound to the compound M4K2009</p> <p>You can read more over at <a href="https://openlabnotebooks.org/?p=3643&preview=true">Open Lab Notebooks</a></p>
Determining the suitability of C2C12 and HEK293 in dual luciferase assay (DLA) for ACVR1 (ALK2) and TGFBR1 (ALK5)
<p>Aside from having high potency towards ACVR1/ALK2, inhibitor compounds ideally should be highly selective and not target other members of the Transforming Growth Factor beta (TGFb) superfamily. TGFBR1/ALK5 is selected for off-target screening because of its potential role in cardiac functions.</p>
Evaluating the inhibition of ALK2 phosphorylation of SMAD1/5 by M4K lead compounds in DIPG patient-derived cells (SU-DIPG-IV, HSJD-DIPG-007, HSJD-DIPG-018 and SU-DIPG-XXI)
<p>The binding potency of M4K compounds to ALK2 has been assayed in biochemical assay and cellular assays in HEK293 or C2C12 myoblast cell lines. However, the potency of ALK2 inhibition by M4K compounds has not determined directly in DIPG patient-derived cell lines. While no major deviation from existing assay data is expected, direct experimental evidence is essential.</p> <p>DIPG cells will be trypsinized and resuspended in TSM-base medium without any growth factor for one-hour starvation. Subsequently, equal volume of TSM-base with 2X Activin A (200ng/mL) and M4K compounds or DMSO vehicle control will be added. After one-hour treatment, the cells will be pelleted and lysed in buffer with protease and phosphatase inhibitors for Western Blot analysis.</p> <p>For other related studies, please refer to my opennotebook blog.</p> <p><a href="https://openlabnotebooks.org/evaluating-the-inhibition-of-alk2-phosphorylation-of-smad1-5-by-m4k-lead-compounds-in-dipg-patient-derived-cells-su-dipg-iv-hsjd-dipg-007-hsjd-dipg-018-and-su-dipg-xxi/">https://openlabnotebooks.org/evaluating-the-inhibition-of-alk2-phosphorylation-of-smad1-5-by-m4k-lead-compounds-in-dipg-patient-derived-cells-su-dipg-iv-hsjd-dipg-007-hsjd-dipg-018-and-su-dipg-xxi/</a></p>
Concurrent progress of reprogramming and gene-correction to overcome limitation of gene therapy of ALK2 mutant iPSCs
GEO Series GSE68766. Homo sapiens. 5 samples. Type: Expression profiling by array.
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International Brain Laboratory public data
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OpenNeuro
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