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1,315 results for “Aberrations”
T1D-lipidome: Database of lipidomic aberrations during the pathogenesis of type 1 diabetes (T1D)
<p>This is the<strong> living database</strong> of <strong>lipidomic aberrations</strong> during the <strong>pathogenesis of type 1 diabetes</strong> (T1D).</p> <p>The database has been collected from scientific publications that report abnormalities related to the onset of T1D. In practice, this either means:</p> <ol> <li>lipids that are aberrated in blood samples collected from persons, who are later known to have been diagnosed with T1D,</li> <li>lipids that are aberrated in blood samples collected from persons, who are have islet auto-antibodies (IAA-positive), or</li> <li>lipids that are associated with the deterioration of insulin secretion in blood samples collected from persons recently diagnosed with T1D.</li> </ol> <p>This database is described in the following publication. Please cite the publication, if you use the database or related code:</p> <p><strong>Citation</strong></p> <p>Tommi Suvitaival. <strong>Lipidomic Abnormalities During the Pathogenesis of Type 1 Diabetes: a Quantitative Review</strong>. <em>Current Diabetes Reports</em>. 20, 46 (2020). <a href="http://dx.doi.org/10.1007/s11892-020-01326-8">http://dx.doi.org/10.1007/s11892-020-01326-8</a></p> <p><strong>Acknowledgement</strong></p> <p>This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 115797 (<a href="https://www.innodia.eu/">INNODIA</a>). This Joint Undertaking receives support from the Union’s Horizon 2020 research and innovation programme and “EFPIA”, ‘JDRF” and “The Leona M. and Harry B. Helmsley Charitable Trust”.</p>
Raw datasets for work on aberration-corrected transmission electron microscopy with Zernike phase plates
<p>Raw data (electron microscopy images and spectra) obtained for work on aberration-corrected transmission electron microscopy with Zernike phase plates as published in Ultramicroscopy.</p>
Figure 1 in Description of the aberrant Leptopilina lasallei n. sp.ı with an updated phylogeny of Leptopilina Förster (Hymenoptera: Figitidae: Eucoilinae)
Figure 1. Holotype of Leptopilina lasallei sp. nov. (USNMENT00896641). a. Lateral habitus. b. Close-up of mesosoma. c. Left fore and hind wings.
Figure 3. Male paratype. a. lateral habitus. b in Description of the aberrant Leptopilina lasallei n. sp.ı with an updated phylogeny of Leptopilina Förster (Hymenoptera: Figitidae: Eucoilinae)
Figure 3. Male paratype. a. lateral habitus. b. Scanning electron micrograph of head and basal segments of antennae.
Figure 2 in Description of the aberrant Leptopilina lasallei n. sp.ı with an updated phylogeny of Leptopilina Förster (Hymenoptera: Figitidae: Eucoilinae)
Figure 2. Scanning electron micrographs of the paratypes of Leptopilina lasallei sp. nov. (USNMENT01525765). a. Head, anterior view; I, distance from ventral margin of eye to posterior margin of malar space; II, height of eye; V, distance between inner rim of torulus to posterior clypeal margin; VI; distance between anterior ocellus and posterior rim of torulus; VII, tentorial pit; VIII, malar furrow. b. Head, dorsal view; III, width of lateral ocellus; IV, distance between lateral occeli. c. Female antenna, lateral view. d. Anterior aspect of pronotal plate, male. e. Close-up lateral aspect of metapleuron, propodeum, petiole and anterior margin of metasoma. f. Male scutellum, dorso-lateral view.
Figure 4 in Description of the aberrant Leptopilina lasallei n. sp.ı with an updated phylogeny of Leptopilina Förster (Hymenoptera: Figitidae: Eucoilinae)
Figure 4. Phylogeny of Leptopilina based on Bayesian analysis of concatenated nucleotide sequences of Cytochrome Oxidase I (COI) gene 'barcode' region, 28S D2 and ITS2 regions. Taxa denoted by 'DSZ' are newly sequenced for this study; other number/letter designations are those of Genbank sequences. See Table 1 for GenBank accession numbers and references.
Aberrant development of pancreatic beta cells derived from human iPSCs with FOXA2 deficiency
<p><strong>Project manager(s)</strong><strong>: </strong>Essam M. Abdelalim</p> <p>Induced pluripotent stem cells (iPSCs) were generated from a patient with a heterozygous deletion of the short arm of chromosome 20 at bands p11.22 to p11.21 (~969 kb deletion), which contains only one gene, <em>FOXA2 </em>(<em>FOXA2<sup>+/-</sup></em>iPSCs) as well as healthy controls (Ctr1 iPSCs and Ctr2 iPSCs). <em>FOXA2<sup>+/-</sup></em>iPSCs were differentiated into different stages of beta cell development to understand the role of FOXA2 during pancreatic beta cell development as described in the article entitled "<strong>Aberrant development of pancreatic beta cells derived from human iPSCs with <em>FOXA2</em> deficiency" by Elsayed et al</strong>. The dataset represents RNA-seq data generated from pancreatic progenitors (PP2) and endocrine progenitors (EPs) derived from Ctr1 iPSCs, Ctr2 iPSCs, and three clones of <em>FOXA2<sup>+/-</sup></em>iPSCs. </p> <p>The file name is: Sample name _overall sample number_read direction_001 where:</p> <p>- PP2-Ctr 1: pancreatic progenitors (PP2) derived from Ctr1 iPSCs (healthy control 1)</p> <p>- PP2-Ctr 2: pancreatic progenitors (PP2) derived from Ctr2 iPSCs (healthy control 2)</p> <p>- PP2-FOX1, PP2-FOX2, and PP2-FOX3: pancreatic progenitors (PP2) derived from three different clones of patient-derived <em>FOXA2<sup>+/-</sup></em>iPSCs.</p> <p>- EP-Ctr1: endocrine progenitors (Eps) derived from Ctr1 iPSCs (healthy control 1)</p> <p>- EP-Ctr2: endocrine progenitors (Eps) derived from Ctr2 iPSCs (healthy control 2)</p> <p>- EP-FOX R1, EP-FOX R2, and EP-FOX R3: endocrine progenitors (EPs) derived from three different clones of patient-derived <em>FOXA2<sup>+/-</sup></em>iPSCs.</p> <p>- The RNA-Seq data were generated from two Ctr-iPSC lines and three FOXA2<sup>+/-</sup>iPSC lines.</p> <p>- Read direction: R1 (Forward), R2 (Reverse).</p>
Analysis of 3,760 hematologic malignancies reveals rare transcriptomic aberrations of driver genes
<p>Abnormal gene expression and splicing play a key role in hematologic malignancy. Here, we provide a catalog of transcriptomic and genomic aberrations of 3,760 hematologic malignancy samples spanning 24 disease entities. This version contains 19,732 protein-coding genes from GRCh37 annotated by Gencode (v33b).</p> <p>doi: <a href="https://doi.org/10.1101/2023.08.08.23293420">https://doi.org/10.1101/2023.08.08.23293420</a></p>
Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease
<p><span><span><span><span><span><span><span><span><span><span><span>Some patients hospitalized with acute COVID-19 suffer respiratory symptoms that persist for many months. We delineated the immune-proteomic landscape in the airway and peripheral blood of healthy controls and post-COVID-19 patients 3 to 6 months after hospital discharge. Post-COVID-19 patients showed abnormal airway (but not plasma) proteomes, with elevated concentration of proteins associated with apoptosis, tissue repair and epithelial injury versus healthy individuals. Increased numbers of cytotoxic lymphocytes were observed in individuals with greater airway dysfunction, while increased B cell numbers and altered monocyte subsets were associated with more widespread lung abnormalities. 1 year follow-up of some post-COVID-19 patients indicated that these abnormalities resolved over time. In summary, COVID-19 causes a prolonged change to the airway immune landscape in those with persistent lung disease, with evidence of cell death and tissue repair linked to ongoing activation of cytotoxic T cells. </span></span></span></span></span></span></span></span></span></span></span></p>
The spindle assembly checkpoint is a therapeutic vulnerability of CDK4/6 inhibitor-resistant ER+ breast cancer with mitotic aberrations
<p>This study aims to investigate the accumulation of genomic instability and chromosome segregation errors after the acquisition of resistance to CDK4/6i in ER+ breast cancer and to test the efficacy of mitotic kinase inhibitors as a potential treatment for CDK4/6i-resistant breast cancer patients.</p> <p><strong>This repository contains whole-exome and shallow whole-genome sequencing from luminal breast cancer cell lines (T47D, LY2, MDA-MB-361, CAMA1, MCF7, KPL1, ZR751, HCC1428) both at the untreated or Parental state and post resistance to Palbociclib.</strong></p> <p>Palbociclib resistance was developed by continuous dose-escalation of palbociclib up to 0.5-1 μM until cell growth was observed in the presence of the drug (6-8 months for cell lines). During this time, parental cell lines and organoids were cultured in regular media to match the time spent in culture. Once resistance was established, Palbo-R cell lines were cultured in a regular growth medium without palbociclib. Cells were cultured without palbociclib for at least two weeks before evaluating resistance.</p>
Fig. 1 in Short Communication An aberrant coloured Southern crested caracara Caracara plancus Miller 1777 (Falconiformes: Falconidae) from Brazil
Fig. 1 - Female Southern caracara recorded in the municipality of Nossa Senhora Aparecida, Sergipe, northeastern Brazil. (A) Freeliving individual before capture; (B) yellowish plumage due to local dust; (C) same individual after being washed. / Femmina di caracara meridionale osservata nel comune di Nossa Senhora Aparecida, Sergipe, Brasile nord-orientale. (A) Individuo libero prima della cattura; (B) piumaggio giallastro dovuto alla polvere locale; (C) stesso individuo dopo essere stato lavato.
Fig. 2 in Short Communication An aberrant coloured Southern crested caracara Caracara plancus Miller 1777 (Falconiformes: Falconidae) from Brazil
Fig. 2 - Female Southern Caracara hosted in Parque dos Falcões, municipality of Itabaiana, Sergipe, northeastern Brazil. The images allow us to observe its previous and current white plumage, comparing (A) its first record in 2018 a few days after being rescued; (B) its back view in 2022; and (C) its side view five years later in 2023. / Femmina di caracara meridionale ospitata nel Parque dos Falcões, comune di Itabaiana, Sergipe, Brasile nord-orientale. Le immagini ci permettono di osservare il piumaggio bianco precedente e quello attuale, confrontando (A) la prima osservazione nel 2018, pochi giorni dopo il salvataggio; (B) la vista posteriore nel 2022; e (C) la vista laterale cinque anni dopo, nel 2023.
Fig. 7 in A new Loriciferan, Scaberiloricus samba gen. et sp. nov., links the Higgins larva and the aberrant Shira larva
Fig. 7 Light micrographs showing overviews and details of intermediate instar Higgins larva of Scaberiloricus samba gen. et sp. nov., containing next larval instar, NHMD-1184552. A Overview, focused on dorsal cuticle. B Overview, focused internally in larva, on subsequent larval instar. C Head, dorsal view. D Head, focused internally. E Posterior part of lorica, focused on posterodorsal seta. F Posterior part of lorica, focused on posterolateral seta. G Posterior part of
Fig. 1 in A new Loriciferan, Scaberiloricus samba gen. et sp. nov., links the Higgins larva and the aberrant Shira larva
Fig. 1 Map showing the three stations on the continental shelf and slope off Rio de Janeiro marked with flags. Inset shows South America with the sampling region marked
Fig. 5 in A new Loriciferan, Scaberiloricus samba gen. et sp. nov., links the Higgins larva and the aberrant Shira larva
Fig. 5 Scanning electron micrographs showing head morphology details of holotypic, early instar Higgins larva of Scaberiloricus samba gen. et sp. nov., NHMD-1184551. A Mouth cone, lateral view. B Head, frontal view, dorsal is left. C Detail showing clavoscalids of introvert Row 1. D–I Rotating series showing introvert morphol-
Figure 2. – A in Transmission of Induced Chromosomal Aberrations through Successive Mitotic Divisions in Human Lymphocytes after In Vitro and In Vivo Radiation
Figure 2. – A: Transverse section of the brown meagre otolith. B: Focus on annual marks (red points).
Figure 1 in Transmission of Induced Chromosomal Aberrations through Successive Mitotic Divisions in Human Lymphocytes after In Vitro and In Vivo Radiation
Figure 1. – Photograph of the proximal (left) and distal (right) sides of the brown meagre sagittae (LT = 497 mm). Scale bar = 1 cm.
Fig. 6 in An aberrant amphicyonid mammal from the latest Eocene of the Bose Basin, Guangxi, China
Fig. 6. Guangxicyon sinoamericanus gen. et sp. nov., IVPP V11818−2, left humerus and right tibia, IVPP V11818−3, line drawings. A. Left humerus, posterior view. B. Right tibia in lateral (B1) and posterior (B2) views. Scale bar 2 cm.
Fig. 5 in An aberrant amphicyonid mammal from the latest Eocene of the Bose Basin, Guangxi, China
Fig. 5. Guangxicyon sinoamericanus gen et sp. nov, IVPP V11818−2, left humerus in anterior (A) and posterior (B) views. Scale bar 2 cm.
Fig. 2 in An aberrant amphicyonid mammal from the latest Eocene of the Bose Basin, Guangxi, China
Fig. 2. Guangxicyon sinoamericanus gen.et sp.nov., IVPP V11818, in situ, immediately prior to jacketing and removal, mandible (A), humerus (B), tibia (C). Table 1. Dental dimensions (mm) of Guangxicyon sinoamericanus gen. et sp. nov. (holotype) compared with two European amphicyonids, Brachycyon palaeolycos and Pseudocyonopsis quercensis (measurements taken from Ginsburg, 1966).
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
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