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150 results for “Achilles tendon”
Data description: Deprivation of loading during early healing of rat Achilles tendons affects extracellular matrix composition and structure, and reduces cell density and cell alignment
<p><a name="_Hlk158643946"></a><strong>Data description: Deprivation of loading during early healing of rat Achilles tendons affects extracellular matrix composition and structure, and reduces cell density and cell alignment</strong></p> <p><em>Malin Hammerman, Maria Pierantoni, Hanna Isaksson<sup> *</sup>, Pernilla Eliasson <sup>*</sup></em></p> <p><em><sup>* </sup></em><em>joint<sup> </sup>last authors</em></p> <p>This dataset contains microscope images obtained from sections of healing and intact rat Achilles tendons undergoing different in vivo loading protocols and different time points post-transection. The data presented are the full resolution microscope images available in lower resolution in the accompanying manuscript’s Supplementary Figures 4-6.</p> <p>Each zipped folders contain images (tif-files) from all time-points for each respective staining and loading group. </p> <ul> <li>Col1: Sections stained with Collagen 1 antibodies</li> <li>Col3: Sections stained with Collagen 3 antibodies</li> <li>Elastin: Sections stained with Elastin antibodies</li> <li>Full_loading: Free cage activity</li> <li>Reduced_loading: Paralysis of the calf muscle with Botox</li> <li>Minimal_loading: Botox combined with joint fixation using a steel-orthosis</li> <li>Intact_reference: Contralateral uninjured Achilles tendons, used as reference</li> </ul> <p>More description of the datasets inside the zipped files are available below and in the file 'Data Description.pdf'</p> <p> </p> <p><strong>Brief re-cap of methods</strong></p> <p>Histological analysis was performed on healing Achilles tendons from Female Sprague-Dawley rats, specific-pathogen free (11-12 weeks, weight 299 ± 15 g), that had undergone full transection [13] of the right Achilles tendon, and been exposed to different levels of loading. Altered loading was imposed through two mechanisms. Reduced loading involved intramuscular Botox injections in the right calf muscles to induce plantar flexor muscle paralysis [24]. Additionally, the rats in the minimal loading group received a steel-orthosis around their right hindlimb directly after surgery [24].</p> <p>Snap frozen tendons in OCT were sectioned longitudinally (7 μm thickness) and stained with immunofluorescent staining for collagen 1, collagen 3, or elastin. Sections were counterstained with DAPI followed by mounting. The tissue sections were imaged under a microscope (DMi8, Leica Microsystems, Wetzlar, Germany, with a Hamamatsu Orca LT Flash sCMOS camera) where fluorescence was detected at 550 nm (secondary antibody Alexa Fluor 594), 470 nm (secondary antibody Alexa Fluor 488) and 385 nm (DAPI), and exposure time was held constant for each color channel regarding magnification and staining.</p> <p>Mapping images of the entire tendon were obtained for one section per group (n=1 per healing time, loading group and ECM matrix protein). All images were adjusted to the negative control, where the primary antibody was omitted, to correct for unspecific antibody detection.</p> <p><strong>Microscope images and description of file-names </strong></p> <p>All data is presented in the form of .tif files. Please refer to the scale bars in the images. All image-files are named using the following abbreviations, as described below. As an example, the file name “Tendon_col1_FL_1W_col1.tif” refers to a tendon section stained for collagen 1 from a rat exposed to full loading for a period of 1 week after tendon transection, where only the channel for collagen 1 is shown, whereas “Tendon_col1_FL_1W_merged.tif” includes the channels for both staining for collagen 1 and DAPI of the same section.</p> <p>Col1: Sections stained with Collagen 1 antibodies<br>Col3: Sections stained with Collagen 3 antibodies<br>Elastin: Sections stained with Elastin antibodies<br>dapi: Sections stained with 4',6-Diamidino-2-Phenylindole Dihydrochloride.<br>FL: Full loading (free cage activity),<br>RL: Reduced loading (paralysis of the calf muscle with Botox),<br>ML: Minimal loading (Botox combined with joint fixation using a steel-orthosis)<br>IT: Intact contralateral Achilles tendons, used as reference.</p> <p>1W: Healing time point 1 week after transection<br>2W: Healing time point 2 weeks after transection<br>3W: Healing time point 3 weeks after transection<br>20W: Healing time point 20 weeks after transection</p> <p><strong>Settings for brightness and contrast</strong></p> <p><em>Collagen 1</em><br>1w FL 2000-12 000, UL 4000-10 000, ML 4000-12 000<br>2w FL 2500-10 000, UL 4000-10 000, ML 5000-12 000<br>3w FL 2000-12 000, UL 3500-13 000, ML 3500-14 000<br>12w FL 3000-12 000<br>20w FL 3000-11 000<br>IT 2000-8 000</p> <p>Collagen 3<br>1w FL 3000-12 000, UL 4000-10 000, ML 4000-13 000<br>2w FL 2000 - 7 000, UL 2500-12 000, ML 2000-12 000<br>3w FL 2000-12 000, UL 3500-13 000, ML 3500-14 000<br>12w FL 3000-12 000<br>20w FL 2000-12 000<br>IT 3000-12 000</p> <p>Elastin<br>1w FL 4000-10 000, UL 5000 - 8000, ML 3500-12 000<br>2w FL 3000-12 000, UL 3000-12 000, ML 3000-12 000<br>3w FL 2500-12 000, UL 2000-12 000, ML 2500-12 000,<br>12w FL 3500-12 000<br>20w FL 3500-12 000<br>IT 2000-12 000</p>
Study of Efficacy and Safety of Secukinumab in Psoriatic Arthritis and Axial Spondyloarthritis Patients With Active Enthesitis Including One Achilles Tendon Site
ClinicalTrials.gov study NCT02771210. IPD Sharing: UNDECIDED. Countries: 8. Publications: 3.
Data - Medial gastrocnemius muscle remodeling correlates with reduced plantar flexor kinetics fourteen weeks following Achilles tendon rupture
<p>ultrasound images and biodex data published used in analysis.</p> <p>study timeline:</p> <p>s1 - week 0</p> <p>s2 - week 2</p> <p>s3 - week 4</p> <p>s4 - week 6</p> <p>s5 - week 10</p> <p>s6 - week 14</p>
Data from: Nanoscale characterization of collagen structural responses to in situ loading in rat Achilles tendons
<p>This dataset is originally used in:</p> <p>I. Silva Barreto, M. Pierantoni, M. Hammerman, E. Törnquist, S. Le Cann, A. Diaz, J. Engqvist, M. Liebi, P. Eliasson, H. Isaksson, <em>Nanoscale characterization of collagen structural responses to in situ loading in rat Achilles tendons</em>, <strong>Matrix Biology</strong> (2022), doi:https://doi.org/10.1016/j.matbio.2022.11.006</p> <p><strong>Abstract:</strong> The specific viscoelastic mechanical properties of Achilles tendons are highly dependent on the structural characteristics of collagen at and between all hierarchical levels. Research has been conducted on the deformation mechanisms of positional tendons and single fibrils, but knowledge about the coupling between the whole tendon and nanoscale deformation mechanisms of more commonly injured energy-storing tendons, such as Achilles tendons, remains sparse. By exploiting the highly periodic arrangement of tendons at the nanoscale, <em>in situ</em> loading of rat Achilles tendons during small-angle X-ray scattering acquisition was used to investigate the collagen structural response during load to rupture, cyclic loading and stress relaxation. The fibril strain was substantially lower than the applied tissue strain. The fibrils strained linearly in the elastic region of the tissue, but also exhibited viscoelastic properties, such as an increased stretchability and recovery during cyclic loading and fibril strain relaxation during tissue stress relaxation. We demonstrate that the changes in the width of the collagen reflections could be attributed to strain heterogeneity and not changes in size of the coherently diffracting domains. Fibril strain heterogeneity increased with applied loads and after the toe region, fibrils also became increasingly disordered. Additionally, a thorough evaluation of radiation damage was performed. In conclusion, this study clearly displays the simultaneous structural response and adaption of the collagen fibrils to the applied tissue loads and provide novel information about the transition of loads between length scales in the Achilles tendon.</p> <p>Any queries related to the data set or the publication may be directed to Hanna Isaksson by email (hanna.isaksson@bme.lth.se).</p>
Endoscopic Flexor Hallucis Longus Transfer vs Minimally Invasive Repair in Acute Achilles Tendon Rupture
ClinicalTrials.gov study NCT06114368. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Compression Treatment Effects on Complications and Healing of Achilles Tendon Rupture
ClinicalTrials.gov study NCT01317160. IPD Sharing: YES. Countries: 1. Publications: 8.
E-Stim and Achilles Tendon Repair Study
ClinicalTrials.gov study NCT01833936. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Endoscopic FHL Transfer for Acute Achilles Tendon Rupture
ClinicalTrials.gov study NCT06641401. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Single-cell Transcriptomic Analysis Identifies Extensive Heterogeneity in the Cellular Composition of Mouse Achilles Tendons
<p>Tendon is a dense connective tissue that stores and transmits forces between muscles and bones. Cellular heterogeneity is increasingly recognized as an important factor in the biological basis of tissue homeostasis and disease, yet little is known about the diversity of cell types that populate tendon. To address this, we determined the heterogeneity of cell populations within mouse Achilles tendons using single-cell RNA sequencing. In assembling a transcriptomic atlas of Achilles tendons, we identified 11 distinct types of cells, including 3 previously undescribed populations of tendon fibroblasts. This table contains differential gene expression for specific genes identified in distinct populations of cells within tendon tissue. </p>
The effects of cholesterol accumulation on Achilles tendon biomechanics: A cross-sectional study DATASET
<p>Data set for "The effects of cholesterol accumulation on Achilles tendon biomechanics: A cross-sectional study"</p>
The Efficacy of Different Immobilization Times After Achilles Tendon Rupture Surgery
ClinicalTrials.gov study NCT04663542. IPD Sharing: NO. Countries: 1. Publications: 2.
Biomechanical and Viscoelastic Properties of Achilles Tendon in Pregnant Women-Pilot Study
ClinicalTrials.gov study NCT05308121. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Treatment Results After Acute Rupture of the Achilles Tendon.
ClinicalTrials.gov study NCT01785264. IPD Sharing: NO. Countries: 1. Publications: 1.
Use of Ultrasonography for Measuring Achilles Tendon Thickness: a Novel Measurement Method
ClinicalTrials.gov study NCT06867211. IPD Sharing: NO. Countries: 1. Publications: 7.
Eendoscopic Versus Open Flexor Hallucis Longus Transfer in Managing Various Tendon Achilles Disorders
ClinicalTrials.gov study NCT06639308. IPD Sharing: NO. Countries: 1. Publications: 7.
A Comparison of ThermaWedge™ Device and Achilles Tendon Stretching for the Treatment of Plantar Fasciopathy
ClinicalTrials.gov study NCT02518841. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Medium Term Outcome of Nonoperative Treatment After Achilles Tendon Rupture.
ClinicalTrials.gov study NCT02760784. IPD Sharing: NO. Countries: 1. Publications: 4.
Eccentric Training Effects on Functionality and Neuromechanical Properties After Achilles Tendon Surgical Repair
ClinicalTrials.gov study NCT03861572. IPD Sharing: Not stated. Countries: 1. Publications: 35.
Early Mobilization After Achilles Tendon Rupture
ClinicalTrials.gov study NCT02318472. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Early Controlled Loading on Conservative Treated Achilles Tendon Ruptures
ClinicalTrials.gov study NCT02805751. IPD Sharing: NO. Countries: 1. Publications: 1.
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