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5 results for “Aconitum carmichaelii”
Fig. 5 in Diverse alkaloids from the aerial parts of Aconitum carmichaelii and antiproliferative activity of costemline via inhibiting SIRT1/ROCK1/ P-STAT3 pathways
Fig. 5. The protein levels of ROCK1/SIRT1 and STAT3/P-STAT3 in colorectal cancer (CRC). (A) Western blot was used to analyze the expression or phosphorylation level of ROCK1, SIRT1 and STAT3 after HCT116 cells in the above groups were treated with 20 μM/40 μM compound 1 for 24 h. (B) At the protein level, the relative expression of SIRT1 and ROCK1/STAT3 signal was inhibited by compound 1 in HCT-116 cells. **p <0.01, ***p <0.001, ****p <0.0001 vs. control group.
Fig. 4. Compound 1 in Diverse alkaloids from the aerial parts of Aconitum carmichaelii and antiproliferative activity of costemline via inhibiting SIRT1/ROCK1/ P-STAT3 pathways
Fig. 4. Compound 1 inhibited invasion of HCT116 colon cancer cells in a transwell assay, which showed by representative images (A) and attached data (B). Cells were incubated with compound 1 (a) 0 μM, (b) 5 μM, (c) 10 μM for 24 h (original magnification, × 200). Quantitative data are presented as the mean ± standard deviation of 3 replicates, relative to the 0 μM control group. **p <0.01 vs. the 0 μM control group.
Fig. 3. Hypothetical biosynthetic pathways for 1, 6 in Diverse alkaloids from the aerial parts of Aconitum carmichaelii and antiproliferative activity of costemline via inhibiting SIRT1/ROCK1/ P-STAT3 pathways
Fig. 3. Hypothetical biosynthetic pathways for 1, 6, and 21.
Fig. 2. Key 1H–1H in Diverse alkaloids from the aerial parts of Aconitum carmichaelii and antiproliferative activity of costemline via inhibiting SIRT1/ROCK1/ P-STAT3 pathways
Fig. 2. Key 1H–1H COSY and HMBC correlations of 1–6.
De novo RNA-sequencing and transcriptome analysis of Aconitum carmichaelii to analyze key genes involved in the biosynthesis of diterpene alkaloids
GEO Series GSE106247. Aconitum carmichaelii. 4 samples. Type: Expression profiling by high throughput sequencing.
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