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56 results for “Action potentials”
Data from: Prospection of potential actions during visual working memory starts early, is flexible, and predicts behavior.
<p>Raw data (EEG and behavior) reported in the manuscript "Prospection of potential actions in visual working memory starts early, is flexible, and predicts behavior" by Rose Nasrawi, Sage E.P. Boettcher, and Freek van Ede</p>
Action potential evoked dendritic calcium signals in the medial superior olive (MSO) during development
<p>Dataset underlying the analysis of dendritic calcium signals evoked by somatic action potentials in MSO neurons during development (postnatal day 10 - 60). The data includes recordings from Mongolian gerbils (<em>Meriones unguiculatus</em>) raised in a normal acoustic environment and in omnidirectional white noise.</p> <p><strong>Linked paper:</strong> Franzen DL, Gleiss SA, Kellner CJ, Kladisios N, Felmy F. Activity-Dependent Calcium Signaling in Neurons of the Medial Superior Olive during Late Postnatal Development. J Neurosci. 2020 Feb 19;40(8):1689–700. <a href="https://doi.org/10.1523/JNEUROSCI.1545-19.2020">https://doi.org/10.1523/JNEUROSCI.1545-19.2020</a>.</p> <p><strong>Files included:</strong></p> <ul> <li> <p>A folder entitiled <em>data</em> containing:</p> <ul> <li>The imaging files (<code>.nix</code>) (1 file per imaged neuron). NIX files contain the kymograph data extracted from a ROI in the raw images along with the metadata. The imaging kymographs and associated <code>.nix</code> files were created with the <a href="https://zenodo.org/record/2575542#.XiYdAS2ZNo4">CaManager: ImageJ Plugin For Ca²⁺ Imaging</a>.</li> <li>An <code>excludes.csv</code> file that contains cells/trials to be excluded (e.g. recording error, movement, difficulty in tracing)</li> <li>A <code>Megatable_C.csv</code> file containing the electrophysiological data corresponding to imaged cells</li> </ul> </li> <li> <p>A <code>.nix</code> intermediate analysis file for <em>default parameters</em></p> </li> <li> <p>A <code>.csv</code> file with the combined electrophysiological and imaging data for <em>default parameters</em></p> </li> <li> <p>Several <code>.xlsx</code> files with the single cell data in Figures 2C, 2D, 2F.</p> </li> </ul> <p><strong>Jupyter notebook:</strong></p> <p>The <a href="https://github.com/delwen/CaJupyter">CaJupyter</a> GitHub repository contains a Jupyter notebook with a step-by-step guide of the analysis. It also allows for further exploration of the data.</p> <p><strong>See also:</strong></p> <ul> <li> <p>The original analysis code (without adaptations for the Jupyter notebook and Python 3) can be found at <a href="https://zenodo.org/record/2575675#.Xi%E2%80%A6">CaAnalysis: Analysis Toolbox for Ca²⁺ Imaging</a>.</p> </li> <li> <p>More information on NIX can be found at this <a href="https://g-node.github.io/nix/">link</a>.</p> </li> </ul>
Genetic algorithm-based personalized models of human cardiac action potential
<p>We present a novel modification of genetic algorithm (GA) which determines personalized parameters of cardiomyocyte electrophysiology model based on set of experimental human action potential (AP) recorded at different heart rates. In order to find the steady state solution, the optimized algorithm performs simultaneous search in the parametric and slow variables spaces. We demonstrate that several GA modifications are required for effective convergence. Firstly, we used a mutation operator, based on Cauchy amplitude distribution along with a random direction in the parametric space. Secondly, relatively large number of elite organisms (6-10 % of the population passed on to new generation) was required for effective convergence. Test runs with synthetic AP as input data indicate that algorithm error is low for high amplitude ionic currents (1.6±1.6% for IKr, 3.2±3.5% for IK1, 3.9±3.5% for INa, 8.2±6.3% for ICaL). Experimental signal-to-noise ratio above 28 dB was required for high quality GA performance. GA was validated against optical mapping recordings of human ventricular AP and mRNA expression profile of donor hearts. In particular, GA output parameters were rescaled proportionally to mRNA levels ratio between patients. We have demonstrated that mRNA-based models predict the AP waveform dependence on heart rate with high precision. The latter also provides a novel technique of model personalization that makes it possible to map gene expression profile to cardiac function. </p>
Action potential dependent sIPSCs from juvenile (P21-30) C57BL/6J male mice
<p>species : Mus musculus</p> <p>sex : male</p> <p>strain : C57BL/6J</p> <p>age : post-natal day 21-30</p> <p>Voltage-clamp recordings of GABAA spontaneous inhibitory post-synaptic currents (sIPSCs) were obtained from juvenile (P21-30) C57BL/6J male mice. The dataset contains 267 individual events recorded from 3 different neurons (expA1-A3). </p>
Action potential dependent sIPSCs from juvenile (P21-30) C57BL/6J male mice from CA1 pyramidal neurons receiving input from PV+ interneurons
<p>species : Mus musculus</p> <p>sex : male</p> <p>strain : C57BL/6J</p> <p>age : post-natal day 21-30</p> <p>Voltage-clamp recordings of GABAA spontaneous inhibitory post-synaptic currents (sIPSCs) were obtained from juvenile (P21-30) C57BL/6J male mice and recorded from hippocampal CA1 pyramidal neurons receiving input from parvalbumin positive (PV+) interneurons. The dataset contains 614 individual events recorded from 3 different neurons (expC1-C3).</p>
Action potential dependent sIPSCs from juvenile (P21-30) C57BL/6J male mice CA1 pyramidal neurons receiving input from PV+ and CCK+ interneurons
<p>species : Mus musculus</p> <p>sex : male</p> <p>strain : C57BL/6J</p> <p>age : post-natal day 21-30</p> <p>Voltage-clamp recordings of GABAA spontaneous inhibitory post-synaptic currents (sIPSCs) were obtained from juvenile (P21-30) C57BL/6J male mice and recorded from hippocampal CA1 pyramidal neurons receiving input from parvalbumin positive and cholecystokinin positive (CCK+) interneurons. The dataset contains 2130 individual events recorded from 3 different neurons (expD1-D3).</p>
Action potential dependent sIPSCs from 3-4 months old C57BL/6J X SJL female mice hippocampus CA1 pyramidal cell
<p>species : Mus musculus</p> <p>sex : female</p> <p>strain : C57BL/6J X SJL</p> <p>age : 3 - 4 months</p> <p>Voltage-clamp recordings of GABAA spontaneous inhibitory post-synaptic currents (sIPSCs) were obtained from 3-4 months old C57BL/6J X SJL female mice . The dataset contains 701 individual events recorded from 7 different neurons (expB1-B7).</p>
Action potential dependent sIPSCs from 3-4 months old Tg2576 female mice
<p>species : Mus musculus</p> <p>sex : female</p> <p>strain : Tg2576</p> <p>age : post-natal day 90 - 120</p> <p>Voltage-clamp recordings of GABAA spontaneous inhibitory post-synaptic currents (sIPSCs) were obtained from 3-4 months old Tg2576 (carrying the Amyloid Precursor Protein KM670/N671L Swedish mutation) female mice. The dataset contains 1000 individual events recorded from 10 different neurons (expE1-E10)<strong>.</strong></p>
Ca transient properties vs action potential morphology
<p>Analysis and raw data on properties of intracellular Ca transients recorded in voltage-clamped rabbit atrial myocytes. Ca transients were elicited by pacing atrial myocytes with 2 different action potential (AP) waveforms prerecorded during Ca and AP alternans.</p>
SUMOylation of NaV1.2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons
<p>Voltage-gated sodium channels located in axon initial segments (AIS) trigger action potentials (AP) and play pivotal roles in the excitability of cortical pyramidal neurons. The differential electrophysiological properties and distributions of Na<sub>V</sub>1.2 and Na<sub>V</sub>1.6 channels lead to distinct contributions to AP initiation and backpropagation. While Na<sub>V</sub>1.6 at the distal AIS promotes AP initiation and forward propagation, Na<sub>V</sub>1.2 at the proximal AIS promotes backpropagation of APs to the soma. Here, we show the Small Ubiquitin-like Modifier (SUMO) pathway modulates persistent sodium current (I<sub>NaP</sub>) generation at the AIS to increase neuronal gain and the speed of backpropagation. Since SUMO does not affect Na<sub>V</sub>1.6, these effects were attributed to SUMOylation of Na<sub>V</sub>1.2. Moreover, SUMO effects were absent in a mouse engineered to express Na<sub>V</sub>1.2-Lys38Gln channels that lack the site for SUMO linkage. Thus, SUMOylation of Na<sub>V</sub>1.2 exclusively controls I<sub>NaP</sub> generation and AP backpropagation, thereby playing a prominent role in synaptic integration and plasticity.</p>
An Investigation Into The Anti-hypertensive And Potential Anti-inflammatory Actions Of Dapagliflozin
ClinicalTrials.gov study NCT02433678. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Benzyl alcohol synergistic effect with deltamethrin against Musca domestica with molecular docking of potential modes of action
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Genetic algorithm-based personalized models of human cardiac action potential
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SUMOylation of NaV1.2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons
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Dataset for Learning in Continuous Action Space for Developing High Dimensional Potential Energy Models
<p>The NN potentials developed in this study and the other available MLIP methods such as GAP, SNAP, qSNAP, and MEGNET used for benchmarking.</p>
An action potential initiation mechanism in distal axons for the control of dopamine release
<p>Data table for An action potential initiation mechanism in distal axons for the control of dopamine release</p>
Data table for an action potential initiation mechanism in distal axons for the control of dopamine release
<p>Data table for the article: An action potential initiation mechanism in distal axons for the control of dopamine release</p>
Source Data For: "Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel Piezo2"
<p>Source Data For: "Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel Piezo2"</p>
In 2017, Plantix, a free smartphone app that helps identify plant damage, was introduced to the Indian state of Andhra Pradesh, with an extension partner. Plantix was created by Progressive Environmental and Agricultural Technologies (PEAT), a German startup. Two PEAT cofounders, Charlotte Schuman (second from the right) and Alex Kennepohl (center, with eyeglasses), confer about the smartphone app with students from Angrau University. Farmers and gardeners can transmit their plant images to Plantix, which uses deep learning and computer vision to help identify diseases and pests. The smartphone app offers symptom descriptions, treatment recommendations, and potential preventive actions. Photographs: Courtesy of PEAT GmbH. in Deep learning brings speed, accuracy to the life sciences.
In 2017, Plantix, a free smartphone app that helps identify plant damage, was introduced to the Indian state of Andhra Pradesh, with an extension partner. Plantix was created by Progressive Environmental and Agricultural Technologies (PEAT), a German startup. Two PEAT cofounders, Charlotte Schuman (second from the right) and Alex Kennepohl (center, with eyeglasses), confer about the smartphone app with students from Angrau University. Farmers and gardeners can transmit their plant images to Plantix, which uses deep learning and computer vision to help identify diseases and pests. The smartphone app offers symptom descriptions, treatment recommendations, and potential preventive actions. Photographs: Courtesy of PEAT GmbH.
Medium spiny neuron electrophysiological properties across male rats and female rats in different estrous cycle phases in the nucleus accumbens core: Excitatory synaptic input, action potential, and intrinsic properties
<p>This dataset presents electrophysiological properties from whole-cell patch clamped nucleus accumbens core medium spiny neurons from male rats and female rats recorded in different estrous cycle phases. Excitatory synaptic input, action potential, and intrinsic properties are presented in an analyzed format, as well as the original electrophysiological recordings of each neuron. These data were originally presented across two different papers (Proaño et al., 2018, 2020) and further analyzed in an additional paper (Long et al., 2024), all of which are cited below. These data were key for establishing that nucleus accumbens neuron electrical function changed across the estrous cycle in response to its associated hormones, programming a phase-dependent sex difference in adulthood. This finding provided a new framework for understanding how biological sex and hormone cyclicity regulate the neurons implicated in motivated behaviors and related functions and disorders.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.