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128 results for “Activity restriction”
Dataset related to: Low Nephron Number Induced by Maternal Protein Restriction Is Prevented by Nicotinamide Riboside Supplementation Depending on Sirtuin 3 Activation
<p>The files contain all the dataset included in the manuscript divided by figures. For each figure, individual tabs indicate data from different figure panels.</p> <p> </p> <p><strong>Abstract</strong></p> <p>A reduced nephron number at birth, due to critical gestational conditions, including maternal malnutrition, is associated with the risk of developing hypertension and chronic kidney disease in adulthood. No interventions are currently available to augment nephron number. We have recently shown that sirtuin 3 (SIRT3) has an important role in dictating proper nephron endowment. The present study explored whether SIRT3 stimulation, by means of supplementation with nicotinamide riboside (NR), a precursor of the SIRT3 co-substrate nicotinamide adenine dinucleotide (NAD<sup>+</sup>), was able to improve nephron number in a murine model of a low protein (LP) diet. Our findings show that reduced nephron number in newborn mice (day 1) born to mothers fed a LP diet was associated with impaired renal SIRT3 expression, which was restored through supplementation with NR. Glomerular podocyte density, as well as the rarefaction of renal capillaries, also improved through NR administration. In mechanistic terms, the restoration of SIRT3 expression through NR was mediated by the induction of proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α). Moreover, NR restored SIRT3 activity, as shown by the reduction of the acetylation of optic atrophy 1 (OPA1) and superoxide dismutase 2 (SOD2), which resulted in improved mitochondrial morphology and protection against oxidative damage in mice born to mothers fed the LP diet. Our results provide evidence that it is feasible to prevent nephron mass shortage at birth through SIRT3 boosting during nephrogenesis, thus providing a therapeutic option to possibly limit the long-term sequelae of reduced nephron number in adulthood.</p>
Data of "Pen mates' interactions, potential precursors of damaging behaviours, object manipulation, straw rooting, and primary activity: A detailed data set in undocked pigs under dietary protein restriction"
<p>Damaging behaviours, such as tail biting, are common problems in pig production, compromising animal welfare and causing economic losses. Detailed studies are impeded by the difficulty of directly observing these behaviours. Tail biting is a broader phenomenon that begins long before lesions manifest, and behavioural problems caused by various stressors present themselves weeks before they escalate to damaging behaviour, resulting in serious injuries. Therefore, detailed data on behaviours, which can be considered precursors of tail biting, such as oral and nasal manipulation of conspecifics, should be collected. The present data were collected in the course of a large study on the genetic potential of protein efficiency, in which the crude protein content in the diet was reduced to 80% of the recommendations. Dietary protein reduction is a promising way to reduce nitrogen emissions in pig manure, but its implications for animal welfare are not yet clear. Pigs differ phenotypically and genetically in their ability to utilise dietary proteins; therefore, there might be individual differences in how they cope with the protein reduction. Here, we present detailed data of focal observations of 95 pigs at an experimental farm with undocked tails that were fed a protein-reduced diet. Pigs were observed directly in their home pens for 5 min each on four different days. All actions directed towards objects in the pen, interactions with and confrontations among pen mates, and straw rooting behaviour and general activity were recorded. After the behavioural observations, wounds on different parts of the body and the cleanliness of the pigs were noted. The protein efficiency of 94 pigs was obtained. The data set comprises six tables. The first table contains information on the animals, including the identities of their parents, farrowing group, sex, and protein efficiency. The other data tables contain four 5-min observations of each pig on 10 object-manipulation behaviours; 150 interaction behaviours, including reactions; 14 confrontation behaviours and their outcomes and reactions; 10 mounting behaviours, including reactions; two rooting behaviours; seven basic behaviours; and an index of general activity. The observations took place under comparatively good housing conditions. Pigs were not tail-docked and were given fresh straw daily, <em>ad libitum</em> access to feed, floor space above the legal requirements (only a partially slatted floor), and daily cleaning of pens, and they were closely monitored for signs of damaging behaviour; all of these are favourable conditions as they limit stress and the risk of damaging behaviour. These data can be used to further explore the relationships of specific behaviours and phenomena and their association with protein efficiency. The ethogram can be used as a template for further observations. Practitioners could use the data to support pigs’ need for occupation, such as by providing sufficient straw.</p>
Variation in foraging activity influences area-restricted search behaviour by bottlenose dolphins
<p>Area-restricted search (ARS) behaviour is commonly used to characterise spatio-temporal variation in foraging activity of predators, but evidence of the drivers underlying this behaviour in marine systems is sparse. Advances in underwater sound recording techniques and automated processing of acoustic data now provide opportunities to investigate these questions where species use different vocalisations when encountering prey. Here, we used passive acoustics to investigate drivers of ARS behaviour in a population of dolphins, to determine if residency in key foraging areas increased following encounters with prey. Analyses were based on two independent proxies of foraging: echolocation buzzes (widely used as foraging proxies), and bray calls (vocalizations linked to salmon predation attempts). Echolocation buzzes were extracted from echolocation data loggers and bray calls from broadband recordings by a convolutional neural network (CNN). We found a strong positive relationship between the duration of encounters and the frequency of both foraging proxies, supporting the theory that bottlenose dolphins engage in ARS behaviour in response to higher prey encounter rates. This study provides empirical evidence for one driver of ARS behaviour and demonstrates the potential for applying passive acoustic monitoring in combination with deep learning-based techniques to investigate the behaviour of vocal animals. </p>
Variation in foraging activity influences area-restricted search behaviour by bottlenose dolphins
Open the record for dataset details and reuse information.
Global Urban Activity Changes from COVID-19 Physical Distancing Restrictions Dataset: TRacking Anomalous COVID-19 induced changEs in NightTime Lights (TRACE-NTL)
<p>We use satellite-derived (NASA Black Marble) nighttime lights to identify, quantify, and map daily changes in human activity that are atypical for each urban area, globally, from the beginning of the pandemic until two years after its onset. The dataset TRACE-NTL consists of global daily urban disruption and recovery metrics as a response to COVID-19.</p> <p>TRACE-NTL:</p> <p>├───ancillary<br>├───data<br>└───metrics<br> ├───disruption<br> │ ├───change_segment<br> │ ├───city_uncertainty<br> │ ├───daily_change<br> │ └───daily_qa_flags<br> └───recovery</p> <p><a title="Dataset description" href="https://github.com/srijac/covid-19_Nightlights">https://github.com/srijac/covid-19_Nightlights</a></p> <p>Accompanying paper: Accompanying paper: Chakraborty, S., Stokes, E.C. & Alexander, O. Global urban activity changes from COVID-19 physical distancing restrictions. <em>Sci Data</em> <strong>12</strong>, 98 (2025). https://doi.org/10.1038/s41597-025-04398-x </p>
Datasets for: Colony-nesting gulls restrict activity levels of native top carnivore during the breeding season
<p>Although nesting in colonies can offer substantial reproductive benefits for many seabird species, increased visibility to predators remains a significant disadvantage for most colony-breeders. To counteract this, some seabird species have evolved aggressive nest defense strategies to protect vulnerable eggs and chicks. Here we used an experimental approach to test whether colony inhabitance by breeding gulls (<em>Larus</em> spp.) in western Norway impacts visitation rates of a native, mammalian predator, the Eurasian otter (<em>Lutra</em> <em>lutra</em>) during the breeding season. Camera traps were placed inside of and on the periphery of seabird colonies prior to the breeding season and left to run for one continuous year. Sighting frequency of otters on these cameras was compared to a control region free of gull nesting. We found that otter activity was significantly reduced on the colonies when gulls were incubating and rearing chicks, compared to time periods when gulls were building nests and absent from the colonies. Rhythmic activity patterns did not seem to be significantly impacted by the presence of gulls. This study provides clear evidence that certain colony-nesting species can have a direct, negative impact on visitation rates of a native carnivore. Seasonal carnivore activity patterns are likely to be highly dependent on differing nesting strategies and level of nest defense by seabirds.</p>
Data for: Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction
<p>In many organisms, dietary restriction (DR) leads to lifespan extension through the activation of cell protection and pro-longevity gene expression programs. In the nematode <em>C. elegans</em>, the DAF-16 transcription factor is a key aging regulator that governs the Insulin/IGF-1 signaling pathway and undergoes translocation from the cytoplasm to the nucleus of cells when animals are exposed to food limitation. However, how large is the influence of DR on DAF-16 activity, and its subsequent impact on lifespan has not been quantitatively determined. In this work, we assess the endogenous activity of DAF-16 under various DR regimes by coupling CRISPR/Cas9-enabled fluorescent tagging of DAF-16 with quantitative image analysis and machine learning. Our results indicate that DR regimes induce strong endogenous DAF-16 activity, although DAF-16 is less responsive in aged individuals. DAF-16 activity is in turn a robust predictor of mean lifespan in <em>C. elegans</em>, accounting for 78% of its variability under DR. Analysis of tissue-specific expression aided by a machine learning tissue classifier reveals that, under DR, the DAF-16 influence on lifespan extension mainly originates from the intestine and neurons. DR also drives DAF-16 activity in unexpected locations such as the germline and intestinal nucleoli.</p>
Postoperative Activity Restrictions in Children
ClinicalTrials.gov study NCT04145895. IPD Sharing: NO. Countries: 1. Publications: 1.
Datasets for: Colony-nesting gulls restrict activity levels of native top carnivore during the breeding season
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Data for: Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction
Open the record for dataset details and reuse information.
Data from: Earthworm activity and availability for meadow birds is restricted in intensively managed grasslands
1. Earthworms are an important prey for the endangered meadow birds of north-west Europe. Although intensive grassland management with high manure inputs generally promotes earthworm abundance, it may reduce the effective food availability for meadow birds through desiccation of the topsoil, which causes earthworms to remain deeper in the soil. 2. We studied the response of Red Worm Lumbricus rubellus, a detritivore, and Grey Worm Aporrectodea caliginosa, a geophage, to soil moisture profiles in the field and under experimental conditions. Surfacing earthworms were counted weekly in eight intensively managed grasslands (treated with high inputs of slurry by slit injection) with variable groundwater tables in the Netherlands. At each count, soil penetration resistance, soil moisture tension and groundwater level were measured, while air temperature and humidity were obtained from a nearby weather station. The response to variation in the vertical distribution of soil moisture was also experimentally studied in the two earthworm species. 3. In the field, earthworms' surfacing activity at night was negatively associated with soil moisture tension and positively by relative air humidity. Surprisingly, there was no effect of groundwater level; an important management variable in meadow bird conservation. Under experimental conditions, both L. rubellus and A. caliginosa moved to deeper soil layers (>20 cm) in drier soil moisture treatments, avoiding the upper layer when moisture levels dropped below 30%. 4. Synthesis and applications. We propose that in intensively managed grasslands with slurry application, topsoil desiccation reduces earthworm availability for meadow birds. This can be counteracted by keeping soil moisture tensions of the top soil above -15 kPa. We suggest that the late raising of groundwater tables in spring and the disturbance of the soil by slit injection of slurry increase topsoil desiccation. This decreases earthworm availability when it matters most for breeding meadow birds. Meadow bird conservation will benefit from revised manure application strategies that promote earthworm activity near or at the soil surface.
Distribution. Now restricted to the Channel Country of SW Queensland and the Lake Eyre Basin in NE South Australia. Descriptive notes. Head-body 95-120 mm, tail 105-160 mm, ear 23-29 mm, hindfoot 32-37 mm; weight 30-50 g. The Fawn Hopping Mouse has body form typical of hopping mice, with very long hindfeet, long tail with distal brush of longer hairs, very long ears, and large protruberant eyes. Dorsal fur is of variable color, from pale pinkish fawn to gray; ventral fur white. Unlike most other hopping mice, it has no throat pouch, but males have a glandular area of naked skin on the chest. Habitat. Occurs in low shrublands and tussock grasslands on stony ("gibber") plains and claypans. Shows marked habitat segregation from the Dusky Hopping Mouse (N. fuscus), which is closely associated with sandy substrates. Food and Feeding. The Fawn Hopping Mouse is mostly granivorous, but also eats other plant material (stems, leaves) and occasionally invertebrates. It uses succulent, salt-adapted plants around edges of claypans as a source of water. Breeding. Reproduction is probably largely opportunistic and aseasonal, with high reproductive output from near-continuous breeding after periods of high rainfall; reported littersize is 1-5, most commonly three; gestation period 38-43 days for nonlactating females. Females may mature later than other hopping mice, with reproductive maturity reached at about six months. Activity patterns. Terrestrial and nocturnal. Fawn Hopping Mice shelter during day in burrow systems that are typically simpler and shallower than those of other hopping mice. Movements, Home range and Social organization. Fawn Hopping Mice generally live singly or in small groups; typically uncommon within range, but population density may increase by an order of magnitude following periods of high rainfall. Status and Conservation. Classified as Near Threatened on The IUCN Red List. The Fawn Hopping Mouse has shown marked decline in range (estimated at greater than 50%), and presumably population size, since European settlement of Australia. This is mostlikely due to predation by the introduced house cat and Red Fox (Vulpes vulpes), and to habitat degradation associated with pastoralism. Bibliography. Brazenor (1934), Burbidge et al. (2008), Finlayson (1939), Gould (1853), Jackson & Groves (2015), Murray et al. (1999), Ogilby (1892), Thomas (1921h), Van Dyck & Strahan (2008), Waite (1898), Watts & Aslin (1981), Woinarski et al. (2014), Wood Jones (1925). in Muridae
Distribution. Now restricted to the Channel Country of SW Queensland and the Lake Eyre Basin in NE South Australia. Descriptive notes. Head-body 95-120 mm, tail 105-160 mm, ear 23-29 mm, hindfoot 32-37 mm; weight 30-50 g. The Fawn Hopping Mouse has body form typical of hopping mice, with very long hindfeet, long tail with distal brush of longer hairs, very long ears, and large protruberant eyes. Dorsal fur is of variable color, from pale pinkish fawn to gray; ventral fur white. Unlike most other hopping mice, it has no throat pouch, but males have a glandular area of naked skin on the chest. Habitat. Occurs in low shrublands and tussock grasslands on stony ("gibber") plains and claypans. Shows marked habitat segregation from the Dusky Hopping Mouse (N. fuscus), which is closely associated with sandy substrates. Food and Feeding. The Fawn Hopping Mouse is mostly granivorous, but also eats other plant material (stems, leaves) and occasionally invertebrates. It uses succulent, salt-adapted plants around edges of claypans as a source of water. Breeding. Reproduction is probably largely opportunistic and aseasonal, with high reproductive output from near-continuous breeding after periods of high rainfall; reported littersize is 1-5, most commonly three; gestation period 38-43 days for nonlactating females. Females may mature later than other hopping mice, with reproductive maturity reached at about six months. Activity patterns. Terrestrial and nocturnal. Fawn Hopping Mice shelter during day in burrow systems that are typically simpler and shallower than those of other hopping mice. Movements, Home range and Social organization. Fawn Hopping Mice generally live singly or in small groups; typically uncommon within range, but population density may increase by an order of magnitude following periods of high rainfall. Status and Conservation. Classified as Near Threatened on The IUCN Red List. The Fawn Hopping Mouse has shown marked decline in range (estimated at greater than 50%), and presumably population size, since European settlement of Australia. This is mostlikely due to predation by the introduced house cat and Red Fox (Vulpes vulpes), and to habitat degradation associated with pastoralism. Bibliography. Brazenor (1934), Burbidge et al. (2008), Finlayson (1939), Gould (1853), Jackson & Groves (2015), Murray et al. (1999), Ogilby (1892), Thomas (1921h), Van Dyck & Strahan (2008), Waite (1898), Watts & Aslin (1981), Woinarski et al. (2014), Wood Jones (1925).
Effects of a Short Term Caloric Restriction on T Cell Activation in Fat
ClinicalTrials.gov study NCT02473835. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Nutritional Restriction and Activity Thermogenesis
ClinicalTrials.gov study NCT00065338. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Intermittent Versus Continuous Energy Restriction on Compensatory Mechanisms Activated During Weight Reduction
ClinicalTrials.gov study NCT02169778. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Trial of Neurostimulation and Blood Flow Restriction for PFPS in Active Duty
ClinicalTrials.gov study NCT04086615. IPD Sharing: NO. Countries: 1. Publications: 1.
Time-Restricted Feeding Plus Resistance Training in Active Females
ClinicalTrials.gov study NCT03404271. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Postoperative Activity Restrictions After Slings
ClinicalTrials.gov study NCT04552457. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Long-Term Impact of COVID-19 Restrictions on Physical Activity and Social Interactions in Young Adults
ClinicalTrials.gov study NCT06135623. IPD Sharing: NO. Countries: 1. Publications: 3.
"Increasing Physical Activity in Canadian Adults Affected by COVID-19 Social Distancing Restrictions: A Feasibility Trial of an Online Intervention"
ClinicalTrials.gov study NCT04400305. IPD Sharing: NO. Countries: 1. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.