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528 results for “Adenoma”
Raman spectra of the Adenoma-Carcinoma-Sequence in a mice model
<p>In the following, a short desciption for each csv files:</p> <ol> <li>Meta data: includes information about mice ID, scans collected from each mouse, location of extracted scans, activity of P53 gene, mouce gender, tissue type.</li> <li>MSpectra: contains mean spectra of tissue types with respect to each extracted scan.</li> <li>TissueLabels: describes different divisions of tissue types;e.g. normal vs abnormal, normal vs HB vs Karzinom, normal vs HB vs adenoma vs carcinoma</li> <li>Wavenumbers: includes Raman spectra wavenumbers. </li> </ol>
Supplementary material for "Towards a metagenomics machine learning interpretable model for understanding the transition from adenoma to colorectal cancer"
<p>Supplementary files for "Towards a metagenomics machine learning interpretable model for understanding the transition from adenoma to colorectal cancer".</p>
Colorectal adenoma IHC (CDX2) raw files
<p>Colorectal adenoma FFPE tissues, with a thickness of 2.5 µm, were mounted on PEN membrane microscopy slides. Tissues underwent immunohistochemistry staining against the marker CDX2 and were counterstained with hematoxylin. For image acquisition, we utilized the Axio Scan.Z1 from Leica.</p>
Colorectal cancer and adenoma metagenomes
<p>Normalized counts of species identified by shotgun sequencing in 156 stool samples of 51 colorectal cancer patients, 54 patients with adenoma, and 51 controls.</p> <p> </p>
Stitched Image files - adenoma quantification using Featurecounter
<p>Hugin-merged & stitched image files from Apc<sup>min</sup> mice</p>
Data files for simulated advanced adenoma age incidence, under aspirin treatment
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USP8 and TP53 drivers are associated with CNV in a corticotroph adenoma cohort enriched for aggressive tumors
<p><b>Context:</b> Pituitary corticotroph adenomas are rare tumors that can be associated with excess adrenocorticotropic hormone (ACTH) and adrenal cortisol production, resulting in the clinically debilitating endocrine condition Cushing disease. A subset of corticotroph tumors behave aggressively, and genomic drivers behind the development of these tumors are largely unknown.</p> <p><b>Objective</b><strong>:</strong> To investigate genomic drivers of corticotroph tumors at risk for aggressive behavior.</p> <p><b>Design:</b> Whole-exome sequencing of patient-matched corticotroph tumor and normal DNA from a patient cohort enriched for tumors at risk for aggressive behavior.</p> <p><b>Setting:</b> Tertiary care center.</p> <p><b>Patients:</b> 27 corticotroph tumors from 22 patients analyzed. 12 tumors were macroadenomas, of which 6 were silent ACTH tumors, 2 were Crooke's cell tumors, and 1 was a corticotroph carcinoma.</p> <p><b>Intervention:</b> Whole-exome sequencing.</p> <p><b>Main outcome measure:</b> Somatic mutation genomic biomarkers.</p> <p><b>Results:</b> We found recurrent somatic mutations in USP8 and TP53 genes, both with higher allelic fractions than other somatic mutations. These mutations were mutually exclusive, with TP53 mutations occurring only in USP8-wildtype (WT) tumors, indicating they may be independent driver genes. USP8-WT tumors were characterized by extensive somatic copy number variation compared to USP8-mutated tumors. Independent of molecular driver status, we found an association between invasiveness, macroadenomas, and aneuploidy.</p> <p><b>Conclusions: </b>Our data suggest that corticotroph tumors may be categorized into a USP8-mutated, genome-stable subtype versus a USP8-WT, genome-disrupted subtype, the latter of which has a TP53-mutated subtype with high level of chromosome instability. These findings could help identify high risk corticotroph tumors, namely those with widespread CNV, that may need closer monitoring and more aggressive treatment.</p>
Comparative Efficacy of Water & Indigo Carmine vs. Water or Air Method on Adenoma Detection Rate (ADR) - a Randomized Controlled Trial (RCT)
ClinicalTrials.gov study NCT01607255. IPD Sharing: NO. Countries: 1. Publications: 13.
Study of the MUC1 Peptide-Poly-ICLC Adjuvant Vaccine in Individuals With Advanced Colorectal Adenoma
ClinicalTrials.gov study NCT00773097. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Colorectal Cancer and Pre-Cancerous Adenoma Non-Invasive Detection Test Study
ClinicalTrials.gov study NCT04739722. IPD Sharing: NO. Countries: 1. Publications: 1.
Argon Plasma Coagulation Versus Endoscopic Mucosal Resection for Gastric Adenoma (CLER-GA)
ClinicalTrials.gov study NCT07161479. IPD Sharing: YES. Countries: 1. Publications: 5.
Comparison of Colon Adenoma Detection Rate Using Two Distal Colonoscope Attachments
ClinicalTrials.gov study NCT02665741. IPD Sharing: YES. Countries: 1. Publications: 4.
Use of a Distal Colonoscope Attachment to Increase Detection of Sessile Serrated Adenomas
ClinicalTrials.gov study NCT03560037. IPD Sharing: YES. Countries: 1. Publications: 6.
Use of Curcumin for Treatment of Intestinal Adenomas in Familial Adenomatous Polyposis (FAP)
ClinicalTrials.gov study NCT00927485. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy of Segmental Examination Twice of the Proximal Colon on Adenoma Detection
ClinicalTrials.gov study NCT02581475. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Adenoma Miss Rate With Water Exchange vs Carbon Dioxide Colonoscopy
ClinicalTrials.gov study NCT03832322. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Video Monitor Size on Adenoma Detection Rate
ClinicalTrials.gov study NCT01952418. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cap-fitted Colonoscopy: a Randomized, Tandem Colonoscopy Study of Adenoma Miss Rates
ClinicalTrials.gov study NCT00577083. IPD Sharing: NO. Countries: 1. Publications: 1.
I-scan for Adenoma Detection
ClinicalTrials.gov study NCT02811419. IPD Sharing: NO. Countries: 1. Publications: 1.
USP8 and TP53 drivers are associated with CNV in a corticotroph adenoma cohort enriched for aggressive tumors
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.