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76 results for “Adrenocortical carcinoma”
Outcome of Childhood Adrenocortical Carcinoma in Developing Countries. Supplementary Table 3: Pathological details
<p>The outcome of Childhood Adrenocortical Carcinoma in Developing Countries; a scene for surgeons or a chance for medicines</p> <p>Supplementary Table 3: Pathological details</p>
The outcome of Childhood Adrenocortical Carcinoma in Developing Countries; Supplementary Table 2: Metastatic sites
<p>The outcome of Childhood Adrenocortical Carcinoma in Developing Countries; a scene for surgeons or a chance for medicines.</p> <p>Supplementary Table 2: Metastatic sites</p>
Outcome of Childhood Adrenocortical Carcinoma in Developing Countries. Supplementary Table 1: Patients' characteristics and endocrinal manifestations
<p>Outcome of Childhood Adrenocortical Carcinoma in Developing Countries. Supplementary Table 1: Patients’ characteristics and endocrinal manifestations</p>
Leptomeningeal metastasis from Adrenocortical carcinoma: a case report
<p>Adrenocortical carcinoma (ACC) is an uncommon endocrine malignancy with limited treatment options. While overall 5-year survival rate in patients with ACC is 35%, the disease is often rapidly progressive with long-term survival in only 5% of patients. Although tumor stage, grade and excess hormonal activity predict unfavorable prognosis, additional biomarkers are needed to identify patients with aggressive disease.</p> <p>A 23-year-old woman presented with rapidly progressing signs and symptoms of Cushing's syndrome, with associated abdominal pain and fullness. Evaluation revealed a large left adrenal mass which had developed over 8 months. En bloc surgical resection was performed by an endocrine surgeon, and pathology revealed adrenocortical carcinoma with Ki67 of 60%. Despite adjuvant treatment with mitotane and etoposide-doxorubicin-carboplatin chemotherapy, the patient had rapid disease progression with metastatic spread to liver, lung, bone, brain and leptomeningies and she died eleven months after the initial diagnosis. Subsequent analysis of patient's tumor revealed mutations in TP53 and MEN1. RNA sequencing was compared against the The Cancer Genome Atlas data set and clustered with the high steroid, proliferative subtype, associated with the worst prognosis. The tumor also demonstrated a low BUB1B/PINK1 ratio as well as G0S2 hypermethylation, both predictive of very aggressive ACC.</p> <p>This case represents a subset of ACC characterized by rapid and fatal progression. Clinically available predictors as well as recently reported molecular signatures and biomarkers correlated with this tumor's aggressiveness, suggesting that development and validation of combinations of biomarkers may be useful in guiding personalized approaches to patients with ACC.</p>
Single Agent Pembrolizumab in Subjects With Advanced Adrenocortical Carcinoma
ClinicalTrials.gov study NCT02673333. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Sunitinib in Refractory Adrenocortical Carcinoma
ClinicalTrials.gov study NCT00453895. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Surgery and Heated Chemotherapy for Adrenocortical Carcinoma
ClinicalTrials.gov study NCT01833832. IPD Sharing: NO. Countries: 1. Publications: 4.
Trial in Locally Advanced and Metastatic Adrenocortical Carcinoma Treatment (FIRM-ACT)
ClinicalTrials.gov study NCT00094497. IPD Sharing: Not stated. Countries: 8. Publications: 1.
Cabozantinib in Treating Patients With Locally Advanced or Metastatic Unresectable Adrenocortical Carcinoma
ClinicalTrials.gov study NCT03370718. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Leptomeningeal metastasis from Adrenocortical carcinoma: a case report
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Cabozantinib in Advanced Adrenocortical Carcinoma
ClinicalTrials.gov study NCT03612232. IPD Sharing: NO. Countries: 1. Publications: 2.
Evaluation of the Efficacy of Addition of Progesterone to Standard Chemotherapy in Adrenocortical Carcinoma (ACC)
ClinicalTrials.gov study NCT05913427. IPD Sharing: NO. Countries: 1. Publications: 5.
Natural History and Tissue Acquisition Study of Adrenocortical Carcinoma
ClinicalTrials.gov study NCT02015026. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Study of Combination Chemotherapy and Surgical Resection in the Treatment of Adrenocortical Carcinoma: Continuous Infusion Doxorubicin, Vincristine and Etoposide With Daily Mitotane Before and After
ClinicalTrials.gov study NCT00001339. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Phase II Study for Combination of Camrelizumab and Apatinib in the Second-line Treatment of Recurrent or Metastatic Adrenocortical Carcinoma
ClinicalTrials.gov study NCT04318730. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Preclinical Study Towards an Immunotherapy in Adrenocortical Carcinoma
ClinicalTrials.gov study NCT00457587. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Adjuvant Chemotherapy vs. Observation/Mitotane After Primary Surgical Resection of Localized Adrenocortical CarcInoma
ClinicalTrials.gov study NCT03723941. IPD Sharing: UNDECIDED. Countries: 1. Publications: 17.
A Study of OSI-906 in Patients With Locally Advanced or Metastatic Adrenocortical Carcinoma
ClinicalTrials.gov study NCT00924989. IPD Sharing: YES. Countries: 9. Publications: 1.
German Adrenocortical Carcinoma Registry
ClinicalTrials.gov study NCT00453674. IPD Sharing: Not stated. Countries: 1. Publications: 19.
Cabazitaxel Activity in Patients With Advanced AdrenoCortical-Carcinoma Progressing After Previous Chemotherapy Lines
ClinicalTrials.gov study NCT03257891. IPD Sharing: UNDECIDED. Countries: 1. Publications: 15.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.