Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
18
datasets available to search
ShareScore release 0.9.0
Dataset results
18 results for “African swine fever virus”
Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs
<p>Raw data for manuscript. Contains temperature, clinical scores, qPCR, blood cell numbers and immune responses over time for two groups of pigs immunised with low virulent African swine fever virus and challenged with highly virulent virus. Data for each panel or figure is displayed on a separate worksheet in the file. The readme worksheet contains a brief description of each figure. The majority of data is displayed in an XY table format, with the number of days post immunisation with low virulent virus indicated.</p>
Supplementary material from the study on survival of African swine fever virus in feed, bedding materials and mechanical vectors, and their potential role in virus transmission
<p><span>Supplementary material from the experimental studies developed to analyse the survival of African swine fever virus in feed, bedding materials and mechanical vectors, and their potential role in virus transmission. </span></p> <p> </p>
Ecological drivers of African swine fever virus persistence in wild boar populations: insight for control
Environmental sources of infection can play a primary role in shaping epidemiological dynamics, however the relative impact of environmental transmission on host-pathogen systems is rarely estimated. We developed and fit a spatially-explicit model of African swine fever virus (ASFV) in wild boar to estimate what proportion of carcass-based transmission is contributing to the low-level persistence of ASFV in Eastern European wild boar. Our model was developed based on ecological insight and data from field studies of ASFV and wild boar in Eastern Poland. We predicted that carcass-based transmission would play a substantial role in persistence, especially in low-density host populations where contact rates are low. By fitting the model to outbreak data using Approximate Bayesian Computation, we inferred that between 53 to 66% of transmission events were carcass-based – i.e., transmitted through contact of a live host with a contaminated carcass. Model fitting and sensitivity analyses showed that the frequency of carcass-based transmission increased with decreasing host density, suggesting that management policies should emphasize the removal of carcasses and consider how reductions in host densities may drive carcass-based transmission. Sensitivity analyses also demonstrated that carcass-based transmission is necessary for the autonomous persistence of ASFV under realistic parameters. Autonomous persistence through direct transmission alone required high host densities; otherwise re-introduction of virus periodically was required for persistence when direct transmission probabilities were moderately high. We quantify the relative role of different persistence mechanisms for a low-prevalence disease using readily collected ecological data and viral surveillance data. Understanding how the frequency of different transmission mechanisms vary across host densities can help identify optimal management strategies across changing ecological conditions.
Ecological drivers of African swine fever virus persistence in wild boar populations: insight for control
Open the record for dataset details and reuse information.
Supplementary Figure 1. Comparison of diagnostic sensitivity of African swine fever virus (ASFV) real-time PCR kits using artificially spiked samples (ASSs)
Open the record for dataset details and reuse information.
African swine fever virus E120R protein inhibits interferon-β production by interacting with IRF3 to block its activation
<p><span><span>African swine fever is a devastating disease of swine caused by African swine fever virus (ASFV). The pathogenesis of the disease remains largely unknown, leaving the uncontrolled spreading of the disease in many countries and regions. Here, we identified the E120R, a structural protein of ASFV, as a key virulent factor and late phase expression protein of the virus. E120R revealed an activity to suppress host antiviral response through blocking IFN-β production, and the 72-73 amino acid sites in the C-terminal domain were essential for this function. E120R interacted with the interferon regulatory factor 3 (IRF3) and interfered with the recruitment of IRF3 to TBK1, which in turn suppressed IRF3 phosphorylation, decreasing interferon production. The recombinant mutant ASFV was further constructed to confirm the claimed mechanism. The ASFV lacking the complete E120R region could not be rescued, whereas the virus could tolerate the deletion of the 72nd and 73rd residuals in the E120R (ASFV E120R-Δ72-73aa). ASFV E120R with the two amino acids deletion failed to interact with IRF3 during ASFV E120R-Δ72-73aa infection, and the viral infection highly activated IRF3 phosphorylation and induced more robust type I interferon production in comparison with its parental ASFV. An unbiased transcriptome-wide analysis of gene expression also confirmed that a considerably higher level of ISGs was detected in ASFV E120R-Δ72-73aa-infected porcine alveolar macrophages (PAMs) than that in the wildtype ASFV-infected PAMs. Together, our findings found a novel mechanism evolved by ASFV to inhibit host antiviral response and provide a new target for guiding the development of ASFV live-attenuated vaccine.</span></span></p>
African swine fever virus E120R protein inhibits interferon-β production by interacting with IRF3 to block its activation
Open the record for dataset details and reuse information.
Whole Transcriptome analysis for porcine alveolar macrophage infected by African Swine Fever Virus
GEO Series GSE145954. Sus scrofa. 42 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Infection characteristics and transcriptomics of African swine fever virus in Bama mini-pigs
GEO Series GSE215197. Sus scrofa domesticus. 12 samples. Type: Expression profiling by high throughput sequencing.
Cyclophilin A Stabilizes the Capsid Protein p72 to Facilitate African Swine Fever Virus Replication
GEO Series GSE300823. Sus scrofa. 12 samples. Type: Expression profiling by high throughput sequencing.
The African Swine Fever Virus pH108R Protein Negatively Regulates Innate Immune Response by Inhibiting NF-kappaB Activation.
GEO Series GSE287718. Sus scrofa. 12 samples. Type: Expression profiling by high throughput sequencing.
The gene expression difference of African swine Fever virus (ASF) outer membrane protein CD2v in iPAM cell line analyzed by RNA-SEQ
GEO Series GSE189708. Sus scrofa. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome profiling in swine macrophages infected with African swine fever virus at single-cell resolution
GEO Series GSE168113. Sus scrofa. 13 samples. Type: Expression profiling by high throughput sequencing.
Toosendanin suppresses African swine fever virus replication through upregulating IRF1 in porcine alveolar macrophage cultures
GEO Series GSE206118. Sus scrofa. 12 samples. Type: Expression profiling by high throughput sequencing.
The effect of African Swine Fever Virus infection on porcine host microRNAs
GEO Series GSE115512. Sus scrofa. 18 samples. Type: Non-coding RNA profiling by high throughput sequencing.
EP152R-Mediated Endoplasmic Reticulum Stress Contributes to African Swine Fever Virus Infection via the PERK-eIF2α Pathway
GEO Series GSE275101. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
African swine fever virus tropism for different organ tissues and host transcriptomic responses in experimentally infected pigs
GEO Series GSE230340. Sus scrofa. 90 samples. Type: Expression profiling by high throughput sequencing.
Expression profiles of long noncoding RNAs and mRNAs in primary porcine macrophages (PAMs) Infected with African swine fever virus
GEO Series GSE180939. Sus scrofa. 6 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.