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376 results for “Alveolar macrophages”
RNA sequencing of macrophages co-cultured with MSCs and RNA sequencing of alveolar macrophages from mice with lung injury treated with MSCs
<p>RNA sequencing of macrophages co-cultured with MSCS Table 5</p> <p>RNA sequencing of alveolar macrophages from mice with lung injury treated with MSCS Table 8</p>
DATASET: Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP
<p>Complete data set to support content of the study: Cui, et al (2022) <strong>Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP</strong></p>
Nontuberculous mycobacteria persistence in a cell model mimicking alveolar macrophages (genome assembly and annotation dataset)
<p>This dataset includes the assembled contigs (.fasta and .gbk files), the nucleotide sequences of the prediction transcripts (CDS, rRNA, tRNA, tmRNA, misc_RNA) (.ffn files) and the respective amino acid sequences of the translated CDS sequences (.faa files) for the following Nontuberculous mycobacteria (NTM) strains: <em>Mycobacterium smegmatis </em>mc<sup>2</sup>155 (reference strain), <em>Mycobacterium avium</em> ATCC25921 (reference strain), <em>M. avium </em>60/08 (clinical strain), <em>Mycobacterium fortuitum</em> ATCC6841 (reference strain) and <em>M. fortuitum</em> 747/08 (clinical strain).</p> <p>All raw sequence reads used in this study were deposited in the European Nucleotide Archive (ENA) (BioProject PRJEB30455).</p> <p>The associated article can be found here: <a href="https://www.ncbi.nlm.nih.gov/pubmed/31035520">https://www.ncbi.nlm.nih.gov/pubmed/31035520</a></p> <p> </p>
Data from: Crystalline silica-induced proinflammatory eicosanoid storm in novel alveolar macrophage model quelled by docosahexaenoic acid
<p>Introduction: Workplace exposure to respirable crystalline silica (cSiO<sub>2</sub>) is associated with chronic inflammatory and autoimmune diseases. At the mechanistic level, cSiO<sub>2</sub> particles are quickly phagocytosed by resident alveolar macrophages (AMs) in the lung, causing a robust cycle of proinflammatory cytokine release, lysosomal rupture, mitochondrial toxicity, and immunogenic cell death if the particle is not efficiently cleared by the lung. We and others have demonstrated in bone marrow-derived and transformed macrophage models that supplementation with the ω-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) contributes to increased membrane phospholipid content of DHA and subsequent suppression of cSiO<sub>2</sub>-triggered inflammatory responses. However, mechanistic exploration of ω-3 PUFA effects in AMs is challenging due to reliance on short-lived primary AMs derived from lung lavage fluid.</p> <p>Methods: To address these limitations, we have employed a recently developed novel self-renewing AM model from C57BL/6 mice, fetal liver-derived alveolar-like macrophages (FLAMs), that is phenotypically representative of primary lung AM populations. We found that incubation of FLAMs with 25 µM DHA as ethanolic suspensions or as complexes with bovine serum albumin were equally effective at increasing ω-3 PUFA content of phospholipids at the expense of the ω-6 PUFA arachidonic acid (ARA) and the ω-9 monounsaturated fatty acid oleic acid. Based on these findings, FLAMs were treated with 25 µM DHA in EtOH or EtOH vehicle (VEH) for 24 h, with or without LPS for 2 h, and with or without cSiO<sub>2</sub> for 1.5 or 4 h then proinflammatory cytokine release, lysosomal membrane permeabilization, and mitochondrial depolarization assessed. In addition, oxylipin metabolites were measured using a targeted LC-MS lipidomics panel of 156 metabolites.</p> <p>Results: Regardless of whether FLAMs were LPS-primed, cSiO<sub>2</sub>-triggered lysosomal permeability, mitochondrial toxicity, and cell death were not impacted by DHA. LPS+cSiO<sub>2</sub> elicited marked IL-1α, IL-1β, and TNF-α release after 1.5 and 4 h of cSiO<sub>2</sub> exposure, which was significantly inhibited by DHA. In VEH-treated cells, cSiO<sub>2</sub> alone and LPS+cSiO2 induced synthesis of ARA-derived proinflammatory oxylipins including prostaglandins, leukotrienes, and thromboxanes that was suppressed by DHA. In addition, DHA promoted synthesis of pro-resolving DHA-derived oxylipins at the expense of ARA-derived oxylipins.</p> <p>Discussion: FLAMs were amenable to lipidome modulation by DHA, which suppressed cSiO<sub>2</sub>-triggered proinflammatory cytokine responses and ARA-derived oxylipins that potentially contribute to the particle's toxicity in the lung. FLAMs are a promising in vitro alternative to primary AMs for investigating interventions against toxicant-triggered inflammation and autoimmunity in the lung.</p>
Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria: RNA-seq statistics and results
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Gene expression analysis of alveolar macrophages tolerized to ozone
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Data from: Crystalline silica-induced proinflammatory eicosanoid storm in novel alveolar macrophage model quelled by docosahexaenoic acid
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A Multi-Omics Approach Reveals Mechanisms of Nanomaterial Toxicity and Structure-Activity-Relationships in Alveolar Macrophages
<p>This deposit contains the proteomics and metabolomics data belonging to the publication with the title "A Multi-Omics Approach Reveals Mechanisms of Nanomaterial Toxicity and Structure-Activity-Relationships in Alveolar Macrophages".</p>
Study on the Correlation Between Alveolar Macrophage-derived Autophagosomes and the Severity of Lung Injury in ARDS
ClinicalTrials.gov study NCT05101694. IPD Sharing: YES. Countries: 1. Publications: 13.
Study to Assess the Intrapulmonary Pharmacokinetics of SPR859 by Comparing the Plasma, Epithelial Lining Fluid (ELF), and Alveolar Macrophages (AM) Concentrations Following the Oral Administration of
ClinicalTrials.gov study NCT04710407. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study to Assess the Intrapulmonary Pharmacokinetics (PK) of SPR719 by Comparing the Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations Following the Oral Administration of Multi
ClinicalTrials.gov study NCT05955586. IPD Sharing: NO. Countries: 1. Publications: 1.
Comparison of Alveolar Macrophages in Individuals With COPD Versus Smokers With Normal Pulmonary Function
ClinicalTrials.gov study NCT00281190. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Apoptotic Cell (AC) Uptake by Human Alveolar Macrophages (AM)
ClinicalTrials.gov study NCT01099410. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Comparison of Alveolar Macrophages in Healthy Individuals Versus Individuals With COPD
ClinicalTrials.gov study NCT00281203. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Inhalation of Granulocyte-macrophage Colony-stimulating Factor (GM-CSF) for Autoimmune Pulmonary Alveolar Proteinosis (PAP)
ClinicalTrials.gov study NCT02243228. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD)
ClinicalTrials.gov study NCT02596347. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Data from: Chronic household air pollution exposure is associated with impaired alveolar macrophage function in Malawian non-smokers
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Inhaled Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) in Hereditary Pulmonary Alveolar Proteinosis (PAP)
ClinicalTrials.gov study NCT01511068. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Targeting BRD4 Ameliorates Experimental Emphysema Via Suppressing both M1 and M2 alveolar macrophage polarization-1[RNA-seq]
GEO Series GSE248962. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Resetting proteostasis in aged animals with ISRIB prevents recruitment of profibrotic monocyte-derived alveolar macrophages during pulmonary fibrosis [AT2]
GEO Series GSE145771. Mus musculus. 17 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.