Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
11
datasets available to search
ShareScore release 0.9.0
Dataset results
11 results for “Alzheimer's disease','Cognitive aging”
OpenData for the Independent morphological variables correlate to aging, Mild Cognitive Impairment, and Alzheimer's Disease manuscript
<p>Results from processed structural MRI images from the <a href="https://www.sciencedirect.com/science/article/pii/S1053811920306868">AHEAD</a> and <a href="https://www.nature.com/articles/s41597-021-00870-6">AOMIC</a> dataset included in the Supplementary Information at the Independent morphological variables correlate to aging, Mild Cognitive Impairment, and Alzheimer's Disease manuscript from de Moraes et al. submitted to PNAS.</p> <p>For this data, we processed the datasets with <a href="https://surfer.nmr.mgh.harvard.edu/">FreeSurfer</a> v6.0.0 standard processing pipeline (<em>recon-all</em>) and the estimation of the <a href="https://surfer.nmr.mgh.harvard.edu/fswiki/LGI">local Gyrification Index</a> from <a href="http://ltswww.epfl.ch/~schaer/Schaer_TMI.pdf">Schaer, M. et al. 2008</a>. We further extracted the morphological measurements from the generated surfaces using the Cortical Folding Analysis Tools from <a href="https://zenodo.org/record/3608675">Wang et al. 2019</a>. Here, we included the raw morphological datasets joined with the demographics and subjects' information.</p>
Data from: Sleep, inflammation, and cognitive behavior of aged wild-type mice subjected to diffuse brain injury and aged 3xTg-AD mice as a model of Alzheimer's disease
<p>Identifying differential responses between sexes following traumatic brain injury (TBI) can elucidate the mechanisms behind disease pathology. Peripheral and central inflammation in the pathophysiology of TBI can increase sleep in male rodents, but this remains untested in females. We hypothesized that diffuse TBI would increase inflammation and sleep in males more so than in females. Diffuse TBI was induced in C57BL/6J mice and serial blood samples were collected (baseline, 1, 5, 7 days post‐injury [DPI]) to quantify peripheral immune cell populations and sleep regulatory cytokines. Brains and spleens were harvested at 7DPI to quantify central and peripheral immune cells, respectively. Mixed‐effects regression models were used for data analysis. Female TBI mice had 77%–124% higher IL‐6 levels than male TBI mice at 1 and 5DPI, whereas IL‐1β and TNF‐α levels were similar between sexes at all timepoints. Despite baseline sex differences in blood‐measured Ly6Chigh monocytes (females had 40% more than males), TBI reduced monocytes by 67% in TBI mice at 1DPI. Male TBI mice had 31%–33% more blood‐measured and 31% more spleen‐measured Ly6G+ neutrophils than female TBI mice at 1 and 5DPI, and 7DPI, respectively. Compared with sham, TBI increased sleep in both sexes during the first light and dark cycles. Male TBI mice slept 11%–17% more than female TBI mice, depending on the cycle. Thus, sex and TBI interactions may alter the peripheral inflammation profile and sleep patterns, which might explain discrepancies in disease progression based on sex.</p>
Effects of Methylene Blue in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease
ClinicalTrials.gov study NCT02380573. IPD Sharing: Not stated. Countries: 1. Publications: 15.
Data from: Sleep, inflammation, and cognitive behavior of aged wild-type mice subjected to diffuse brain injury and aged 3xTg-AD mice as a model of Alzheimer’s disease
Open the record for dataset details and reuse information.
Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition in miceted pathology and cognition in mice
GEO Series GSE245658. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
Human iPSC-Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease
GEO Series GSE220548. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Amitriptyline-mediated cognitive enhancement in aged 3xTg Alzheimer’s disease mice is associated with neurogenesis and neurotrophic activity
GEO Series GSE26836. Mus musculus. 12 samples. Type: Expression profiling by array.
DSS-colitis induced in young age accelerates the onset of cognitive defects in Tg2576 mice, a model of Alzheimer disease
GEO Series GSE253108. Mus musculus. 44 samples. Type: Other.
Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition
ClinicalTrials.gov study NCT05231798. IPD Sharing: YES. Countries: 1. Publications: 0.
Sleep Disordered Breathing and Alzheimer's Disease Biomarkers in Normal Aging and Mild Cognitive Impairment
ClinicalTrials.gov study NCT03912571. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Aging African Green Monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer’s disease
GEO Series GSE108282. Chlorocebus aethiops; Macaca mulatta. 88 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.