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162 results for “Alzheimer disease (AD),”
BRAIN Journal-New Computer Assisted Diagnostic to Detect Alzheimer Disease-Figure 20. The accuracy of classification using the three methods, KNN, SVM and our method, for AD subjects
<p>Whatever the patient condition, Normal, MCI or AD, our method has provided us with better results. Advocate Example precision for Normal Patients was found 96% as opposed to 88% for the SVM method and 84% for KNN. For MCI patients was found 88% as opposed to 80% for the SVM method and 72% for KNN. Also for AD patients were found 92% as opposed to 88% for the SVM method and 80% for KNN. Our classification method gave us the best results, finding overall accuracy of 92% as opposed to 84% for the SVM method and 78.66% for KNN. </p>
BRAIN Journal-New Computer Assisted Diagnostic to Detect Alzheimer Disease-Figure 2. Three Corpus Calosum: Normal, MCI, AD
<p>The three figures above present the Corpus Callosum relating to three topics: Normal Topic by MCI (Mild Cognitive Impairment), Alzheimer’s topic. Secondly, we will present our clustering method to classify the test subject between 3 classes: N (Normal), MCI (Mild Cognitive Impairment), and AD (Alzheimer's disease). </p>
BRAIN Journal-New Computer Assisted Diagnostic to Detect Alzheimer Disease-Figure 1. Three hippocampus: Normal, MCI, AD
<p>In this context is our work: performing a diagnostic computer-aided system for detecting Alzheimer's disease. Like any diagnostic system, our system contains three parts: preprocessing, segmentation and classification. Initially, we will present a new segmentation method to segment the Hippocampus and Corpus Callosum regardless of the patient's condition. </p>
Data from: Sleep, inflammation, and cognitive behavior of aged wild-type mice subjected to diffuse brain injury and aged 3xTg-AD mice as a model of Alzheimer's disease
<p>Identifying differential responses between sexes following traumatic brain injury (TBI) can elucidate the mechanisms behind disease pathology. Peripheral and central inflammation in the pathophysiology of TBI can increase sleep in male rodents, but this remains untested in females. We hypothesized that diffuse TBI would increase inflammation and sleep in males more so than in females. Diffuse TBI was induced in C57BL/6J mice and serial blood samples were collected (baseline, 1, 5, 7 days post‐injury [DPI]) to quantify peripheral immune cell populations and sleep regulatory cytokines. Brains and spleens were harvested at 7DPI to quantify central and peripheral immune cells, respectively. Mixed‐effects regression models were used for data analysis. Female TBI mice had 77%–124% higher IL‐6 levels than male TBI mice at 1 and 5DPI, whereas IL‐1β and TNF‐α levels were similar between sexes at all timepoints. Despite baseline sex differences in blood‐measured Ly6Chigh monocytes (females had 40% more than males), TBI reduced monocytes by 67% in TBI mice at 1DPI. Male TBI mice had 31%–33% more blood‐measured and 31% more spleen‐measured Ly6G+ neutrophils than female TBI mice at 1 and 5DPI, and 7DPI, respectively. Compared with sham, TBI increased sleep in both sexes during the first light and dark cycles. Male TBI mice slept 11%–17% more than female TBI mice, depending on the cycle. Thus, sex and TBI interactions may alter the peripheral inflammation profile and sleep patterns, which might explain discrepancies in disease progression based on sex.</p>
A Study to Evaluate the Efficacy and Safety of Gantenerumab in Participants at Risk for or at the Earliest Stages of Alzheimer's Disease (AD)
ClinicalTrials.gov study NCT05256134. IPD Sharing: YES. Countries: 10. Publications: 2.
A Study of SB-742457, Added to Donepezil for the Treatment of Mild-to-moderate Alzheimer's Disease
ClinicalTrials.gov study NCT00710684. IPD Sharing: Not stated. Countries: 9. Publications: 1.
Pilot Study of Aerobic Exercise in Early Alzheimer's Disease(AD)
ClinicalTrials.gov study NCT01128361. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Pharmacology of p38 MAP Kinase Inhibitor, VX-745, in Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD
ClinicalTrials.gov study NCT02423200. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Crenezumab Versus Placebo to Evaluate the Efficacy and Safety in Participants With Prodromal to Mild Alzheimer's Disease (AD)
ClinicalTrials.gov study NCT03114657. IPD Sharing: Not stated. Countries: 27. Publications: 4.
A Study of LY3002813 in Participants With Memory Damage Due to Alzheimer's Disease (AD) or AD
ClinicalTrials.gov study NCT02624778. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Efficacy and Safety Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)
ClinicalTrials.gov study NCT03444870. IPD Sharing: YES. Countries: 15. Publications: 5.
A PET Study of the Effects of p38 MAP Kinase Inhibitor, VX-745, on Amyloid Plaque Load in Alzheimer's Disease (AD)
ClinicalTrials.gov study NCT02423122. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Evaluate the Safety, Tolerability, and Efficacy of Long-Term Gantenerumab Administration in Participants With Alzheimer's Disease (AD)
ClinicalTrials.gov study NCT04374253. IPD Sharing: YES. Countries: 29. Publications: 1.
A Study Evaluating the Efficacy and Safety of Crenezumab Versus Placebo in Participants With Prodromal to Mild Alzheimer's Disease (AD).
ClinicalTrials.gov study NCT02670083. IPD Sharing: Not stated. Countries: 30. Publications: 4.
Evaluate the Safety, Tolerability, Immunogenicity and Efficacy of UB-311 in Mild Alzheimer's Disease (AD) Patients
ClinicalTrials.gov study NCT02551809. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Comparative Efficacy, Safety, and Tolerability of Rivastigmine 10 and 15 cm^2 Patch in Patients With Alzheimer's Disease (AD) Showing Cognitive Decline
ClinicalTrials.gov study NCT00506415. IPD Sharing: Not stated. Countries: 7. Publications: 2.
A Study of Crenezumab Versus Placebo in Preclinical Presenilin1 (PSEN1) E280A Mutation Carriers to Evaluate Efficacy and Safety in the Treatment of Autosomal-Dominant Alzheimer's Disease (AD), Includi
ClinicalTrials.gov study NCT01998841. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Safety and Efficacy Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)
ClinicalTrials.gov study NCT03443973. IPD Sharing: YES. Countries: 19. Publications: 5.
Biomarker Qualification for Risk of Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease (AD) and Safety and Efficacy Evaluation of Pioglitazone in Delaying Its Onset
ClinicalTrials.gov study NCT01931566. IPD Sharing: YES. Countries: 5. Publications: 2.
Early ultrasonic vocalization deficits and related thyroarytenoid muscle pathology in the transgenic TgF344-AD rat model of Alzheimer’s disease
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.