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9 results for “Aminoacyl-tRNA synthetases”
The Structural Basis of the Genetic Code: Amino Acid Recognition by Aminoacyl-tRNA Synthetases
<p>Data sets for the characterization of amino acid recognition in aminoacyl-tRNA synthetases:</p> <ul> <li>multiple-sequence alignment files in FASTA format</li> <li>Excel tables to infer original sequence positions from renumbered positions</li> </ul> <p>Accompanying the paper: <a href="https://www.biorxiv.org/content/10.1101/606459v1">https://www.biorxiv.org/content/10.1101/606459v1</a></p>
Aminoacyl-tRNA synthetase gene alignments from multiple Sileneae species generated from full-length transcripts using Iso-Seq and raw microscopy image files
<p>Trimmed and untrimmed alignments for the final aminoacyl-tRNA synthetases in <em>Sileneae </em>species and <em>Arabidopsis thaliana. W</em>e investigated the evolution of subcellular localization of aaRS enzymes in five different species from the plant lineage <em>Sileneae</em> that has experienced extensive and rapid mitochondrial tRNA loss. By analyzing full-length mRNA transcripts with single-molecule sequencing technology (PacBio Iso-Seq) and searching genome sequences, we found instances of predicted retargeting of an ancestrally cytosolic aaRS to the mitochondrion as well as scenarios where enzyme localization does not appear to change despite functional tRNA replacement.</p> <p>Nikon .nd2 raw microscopy files for the transient expression and imaging of predicted transit peptides and colocalization assays in <em>N. benthamiana</em> epithelial cells. The amino acid sequence plus 10 upstream amino acids of the protein body were fused to GFP and co-transfected with an eqFP611-tagged transit peptide from a known mitochondrially localized protein (isovaleryl-CoA dehydrogenase).</p>
A translation-independent directed evolution strategy to engineer aminoacyl-tRNA synthetases_NGS data analysis
<p>These data files are associated with the NGS analysis done in the publication :"A translation-independent directed evolution strategy to engineer aminoacyl-tRNA synthetases". This compressed file contains the raw file as well as the processed files to arrive at the conclusions published. The python scripts used for processing the data are available on github (link provided in the manuscript).</p>
Aminoacyl-tRNA synthetase gene alignments from multiple Sileneae species generated from full-length transcripts using Iso-Seq and raw microscopy image files
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RNA immunoprecipitation and sequencing of aminoacyl-tRNA synthetase-specific genes
GEO Series GSE120182. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
Angiogenesis induced by aminoacyl-tRNA synthetase deficiency is dependent on AAR but not UPR pathways
GEO Series GSE130193. Danio rerio. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase is associated with Charcot-Marie-Tooth neuropathy
GEO Series GSE125311. Drosophila melanogaster. 17 samples. Type: Expression profiling by high throughput sequencing.
Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic "integrated stress response"
GEO Series GSE155309. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Growth Optimized Aminoacyl-tRNA Synthetase Levels Prevent Maximal tRNA Charging
GEO Series GSE141389. Bacillus subtilis. 40 samples. Type: Other; Expression profiling by high throughput sequencing.
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