Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
46
datasets available to search
ShareScore release 0.9.0
Dataset results
46 results for “Aminoglycosides”
E. coli aminoglycoside treatment
<p>Aminoglycosides are broad-spectrum antibiotics whose mechanism of action is under debate. It is widely accepted that membrane voltage potentiates aminoglycoside activity, which is ascribed to voltage-dependent drug uptake. In this paper, we measured the response of <i>Escherichia coli</i> treated with aminoglycosides and discovered that the bactericidal action arises not from the downstream effects of voltage dependent drug uptake, but rather directly from dysregulated membrane potential. In the absence of voltage, aminoglycosides are taken into cells and exert bacteriostatic effects by inhibiting translation. However, cell killing was immediate upon re-polarization. The hyperpolarization arose from altered ATP flux, which induced a reversal of the F1Fo-ATPase to hydrolyze ATP and generated the deleterious voltage. Heterologous expression of an ATPase inhibitor completely eliminated bactericidal activity, while loss of the F-ATPase reduced the electrophysiological response to aminoglycosides. Our data support a model of voltage induced death, and separates aminoglycoside bacteriostasis and bactericide in <i>E. coli</i>.</p>
Data for: Purine and pyrimidine synthesis differently affect the strength of the inoculum effect for aminoglycoside and β-lactam antibiotics
Open the record for dataset details and reuse information.
E. coli aminoglycoside treatment
Open the record for dataset details and reuse information.
Pharmacokinetics of an Aminoglycoside in Hemodialysis Patients.
ClinicalTrials.gov study NCT01982864. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Acute Kidney Injury in Septic Critically Ill Patients : Are Aminoglycosides Really Harmful?
ClinicalTrials.gov study NCT01932814. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Aminoglycoside Plasma Level Measurement in Neonates With Infection
ClinicalTrials.gov study NCT01624324. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Auditive and Renal Long Term Outcomes - Risk After Aminoglycoside Therapy in Neonates (AURORA)
ClinicalTrials.gov study NCT03253614. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Potentiated Aminoglycosides in Postoperative Urinary Tract Infection Prophylaxis
ClinicalTrials.gov study NCT05761405. IPD Sharing: YES. Countries: 1. Publications: 1.
Ciprofloxacin Versus an Aminoglycoside Followed by Ciprofloxacin for Bubonic Plague
ClinicalTrials.gov study NCT04110340. IPD Sharing: YES. Countries: 1. Publications: 3.
Single Dose Aminoglycosides for Acute Uncomplicated Cystitis in the Emergency Department Setting
ClinicalTrials.gov study NCT05702762. IPD Sharing: NO. Countries: 1. Publications: 6.
An International Survey on Aminoglycoside Practices in Critically Ill Patients: AMINO III Survey
ClinicalTrials.gov study NCT02850029. IPD Sharing: NO. Countries: 5. Publications: 1.
Aminoglycosides in Early Sepsis
ClinicalTrials.gov study NCT06712641. IPD Sharing: NO. Countries: 1. Publications: 0.
Stop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 1]
GEO Series GSE138638. Homo sapiens. 26 samples. Type: Expression profiling by high throughput sequencing.
Aminoglycoside heteroresistance in Enterobacter cloacae is driven by the cell envelope stress response.
GEO Series GSE236124. Enterobacter cloacae subsp. cloacae ATCC 13047. 9 samples. Type: Expression profiling by high throughput sequencing.
Gene expression data from aminoglycoside-treated vaginal tissues.
GEO Series GSE94909. Mus musculus. 6 samples. Type: Expression profiling by array.
Influence of the aminoglycoside antibiotic apramycin on host and phage DNA transcription during infection of S. venezuelae ATCC 10712 with phage Alderaan
GEO Series GSE171784. Streptomyces venezuelae ATCC 10712. 8 samples. Type: Expression profiling by high throughput sequencing.
Stop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 3]
GEO Series GSE138640. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional response to aminoglycoside antibiotics in cochlear hair cells at 3 hour
GEO Series GSE66775. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
The inner ear heat shock transcriptional signature identifies otoprotective compounds against aminoglycoside ototoxicity
GEO Series GSE116515. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Stop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides
GEO Series GSE138643. Homo sapiens. 41 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.