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195 results for “Amyotrophic Lateral Sclerosis (ALS)”
Extended data 'It's become a theatre': relational experiences of family carers and people with Amyotrophic lateral sclerosis (ALS) after cognitive impairment emerges [Version 2]
<p>This upload contains suplimentary files to the research article ‘It’s become a theatre’: relational experiences of family carers and people with Amyotrophic lateral sclerosis (ALS) after cognitive impairment emerges [Version 2]</p>
Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT05237284. IPD Sharing: YES. Countries: 13. Publications: 1.
Altered mitochondria-associated ER membranes (MAM) function shifts mitochondrial metabolism in amyotrophic lateral sclerosis (ALS)
<p><span>Mitochondrial function is modulated by its functional interaction with the endoplasmic reticulum.</span><span> Recent research indicates that these contacts are disrupted in familial models of amyotrophic lateral sclerosis. We report here this impairment in the crosstalk between mitochondria and the endoplasmic reticulum impedes the use of glucose-derived pyruvate as mitochondrial fuel, causing a shift to fatty acids to sustain energy production. Over time, this deficiency alters mitochondrial electron flow and the active/dormant status of complex I in spinal cord tissues, but not in the brain. These findings suggest MAM plays a crucial role in regulating cellular glucose metabolism and that its dysfunction may underlie the bioenergetic deficits observed in ALS. The dataset includes the lipid profiles of the total homogenates and motchondrial fractions from SOD1.</span></p>
Effects of Oral Levosimendan on Respiratory Function in Patients With Amyotrophic Lateral Sclerosis (ALS): Open-Label Extension
ClinicalTrials.gov study NCT03948178. IPD Sharing: Not stated. Countries: 14. Publications: 1.
HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT02437110. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Safety Extension Study of Oral Edaravone Administered in Subjects With Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT04577404. IPD Sharing: UNDECIDED. Countries: 6. Publications: 1.
FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)
ClinicalTrials.gov study NCT04768972. IPD Sharing: YES. Countries: 16. Publications: 1.
Immunosuppression in Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT01884571. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Safety and Tolerability Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT00647296. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Safety and Tolerability Study of ILB® in Patients With Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT03705390. IPD Sharing: NO. Countries: 1. Publications: 1.
Study to Investigate the Safety and Efficacy of Lithium in Volunteers With Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT00818389. IPD Sharing: Not stated. Countries: 2. Publications: 3.
An Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of BIIB067 (Tofersen) in Adults With Inherited Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT02623699. IPD Sharing: YES. Countries: 12. Publications: 3.
Rasagiline in Subjects With Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT01786603. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT03160898. IPD Sharing: NO. Countries: 6. Publications: 5.
Insulin-like Growth Factor-1 in Amyotrophic Lateral Sclerosis (ALS) Trial
ClinicalTrials.gov study NCT00035815. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Early Treatment of Amyotrophic Lateral Sclerosis (ALS) With Nutrition and Non-Invasive Positive Pressure Ventilation
ClinicalTrials.gov study NCT00116558. IPD Sharing: NO. Countries: 1. Publications: 3.
Therapeutic Nanocatalysis to Slow Disease Progression of Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT04098406. IPD Sharing: NO. Countries: 1. Publications: 3.
Tolerability and Efficacy of L-Serine in Patients With Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT03580616. IPD Sharing: Not stated. Countries: 1. Publications: 37.
A Study to Assess the Safety, Tolerability, and Effect on Disease Progression of BIIB105 in Participants With Amyotrophic Lateral Sclerosis (ALS) and Participants With the ALS Ataxin-2 (ATXN2) Genetic
ClinicalTrials.gov study NCT04494256. IPD Sharing: YES. Countries: 4. Publications: 1.
Expanded Controlled Study of Safety and Efficacy of MCI-186 in Patients With Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT00424463. IPD Sharing: Not stated. Countries: 1. Publications: 2.
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OpenNeuro
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