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1,381 results for “Androgens”
An assessment of the (anti)androgenic properties of hexachloronaphthalene (HxCN) using a model of immature male rats (Hershberger Bioassay)
<p>The persistent organic pollutants (POPs) include polychlorinated naphthalenes (PCNs); of these, the most toxic, abundant and found in human tissues are the hexachloronaphthalenes (HxCNs). The aim of this study was to evaluate the (anti)androgenic action of HxCN using the Hershberger Bioassay (OECD 441). Castrated male Wistar rats were exposed per os to HxCN at daily doses ranging from 0.3-3.0 mg*kg b.w.-1 for 10 days. Testosterone propionate (TP) was used as the reference androgen, and flutamide (FLU) as the reference antiandrogen. Five assessor sex tissues (ASTs) were weighed: ventral prostate, seminal vesicles, levator ani-bulbocavernosus muscle (LABC), glans penis and Cowper gland. In addition to determining the absolute weight of the ASTs, a number of other tests were performed on serum hormone levels (testosterone [T], triiodothyronine 99 [T3], thyroxine [T4], LH and FSH) and the histopathology of the ASTs. </p>
docking result of androgen
<p> </p> <div>The docking result of androgen and androgenic blocker by using autodock tools and autodock vena </div> <p> </p>
How new communication behaviors evolve: Androgens as modifiers of neuromotor structure and function in foot-flagging frogs
<p>How diverse animal communication signals have arisen is a question that has fascinated many. <em>Xenopus</em> frogs have been a model system used for three decades to reveal insights into the neuroendocrine mechanisms and evolution of vocal diversity. Due to the ease of studying central nervous system control of the laryngeal muscles <em>in vitro</em>, <em>Xenopus</em> has helped us understand how variation in communication signals between sexes and between species is produced at the molecular, cellular, and systems levels. Yet, it is becoming easier to make similar advances in non-model organisms. Here, we summarize our research on a group of frog species that have evolved a novel hind limb signal known as 'foot flagging.' We have shown that the evolution of foot flagging in multiple species is accompanied by the evolution of higher androgen hormone sensitivity in the leg muscles and an increased density of spinal interneurons in the neuromotor system that controls the hind limb. Comparing this work to prior work in <em>Xenopus</em>, we highlight which patterns of hormone sensitivity and neural circuit properties are shared between <em>Xenopus</em> and foot-flagging frogs and which appear to be species-specific. Overall, we aim to illustrate the power of drawing inspiration from experiments in model organisms, in which the mechanistic details have been worked out, and then apply these ideas to a non-traditional model species to reveal new details, further complexities, and fresh hypotheses.</p>
Trajectories and Code from "Small molecules targeting the disordered transactivation domain of the androgen receptor induce the formation of collapsed helical states" Zhu et al. 2022
<p>Trajectories, GROMACS input files, and analysis code from the manuscript "Small molecules targeting the disordered transactivation domain of the androgen receptor induce the formation of collapsed helical states" Zhu et al. 2022 (Nature Communications, In Press)</p> <p>https://www.biorxiv.org/content/10.1101/2021.12.23.474012v1.abstract</p>
Fig. 2 in Fig. 8 in Androgenic Modulation in the Primary Ovarian Growth of the Japanese eel, .
Fig. 2. Mean (± 95% confidence intervals) defence score of male (M) and female (F) Red-backed Shrikes in relation to interspecific territory overlapping. (BW –) – pairs breeding in areas beyond the breeding territories of the associated species (Barred Warbler); (BW +) – pairs breeding within the boundaries of associate species.
Fig. 1 in Fig. 8 in Androgenic Modulation in the Primary Ovarian Growth of the Japanese eel, .
Fig. 1. Mean (± 95% confidence intervals) defence score of male (M) and female (F) Barred Warblers in relation to interspecific territory overlapping. (RBS –) – pairs breeding in areas beyond the breeding territories of the associated species (Red–backed Shrike); (RBS +) – pairs breeding within the boundaries of the associated species.
Fig. 7 in Androgenic Modulation in the Primary Ovarian Growth of the Japanese eel, .
Fig. 7. in vitro detection of arα and arβ expression during ovarian tissue culture within 24 hours. The serial time course of mRNA expression was screened within 24 hours. mRNA expression patterns of (A) arα and (B) arβ within 24 hours in L-15 medium tissue culture without treatment. Quantitative mRNA expression data are presented as the mean ± SD, and statistically significant differences were determined by one-way ANOVA and LSD post hoc tests (p <0.05).
Fig. 6 in Androgenic Modulation in the Primary Ovarian Growth of the Japanese eel, .
Fig. 6. in vivo mRNA expression of fshr following AR's agonist and antagonist treatments. Ovarian tissue was collected from female eels. (A) Controls, n = 4; SPH, n = 4; SPH + FLUT, n = 4. (B) Controls, n = 4; MT, n = 7; MT + FLUT, n = 4. The mRNA expression data from female eels' ovaries are presented as the mean ± SD, and statistically significant differences were determined via one-way ANOVA and LSD post hoc tests (p <0.05).
Fig. 3 in Androgenic Modulation in the Primary Ovarian Growth of the Japanese eel, .
Fig. 3. The ovarian composition of female eel undergoing hormonal induction in three stages: IA, IB, and IC (the grey tint from light to dark). Stage was categorized as the characteristics for follicle stage calculation. GSI was measured and is shown in each individual. The ovary composition is shown in each percentage bar. The stage composition is shown among female eels in (A) the control group, (B) weekly SPH injection for three weeks and (C) weekly SPH + MT injection for three weeks.
Fig. 1 in Androgenic Modulation in the Primary Ovarian Growth of the Japanese eel, .
Fig. 1. Histological comparison of ovarian development among the control and three weekly SPH- and SPH + MT- injected groups. Histological analyses are shown in controls (A, GSI = 0.42%; B, GSI = 0.46%; C, GSI = 0.5%; D, GSI = 0.75%), weekly SPH injection for three weeks (E, GSI = 0.63%; F, GSI = 1.02%; G, GSI = 1.07%) and weekly SPH + MT for three weeks (H, GSI = 0.93%; I, GSI = 1.34%; J, GSI = 1.38%; K, GSI = 1.41%). Stage IA follicles are labeled as A; Stage IB follicles are labeled as B; Stage IC follicles are labeled as C. Ovarian tissue was sampled 72 hours after the third injection. Sections underwent HE staining. 10-fold magnified LM images were obtained by digital camera photography. Scale bar = 100 μm.
Fig. 8 in Androgenic Modulation in the Primary Ovarian Growth of the Japanese eel, .
Fig. 8. in vitro detection of arα and arβ expression during ovarian tissue culture with and without hormone treatment. mRNA expression was detected after FSH, MT, or FSH + MT treatments. ara expression is shown after (A) 1 and (B) 12 hours of hormonal treatments; arβ expression is shown after (C) 1 and (D) 12 hours of hormonal treatments. Relative mRNA expression data are presented as mean ± SD, and statistically significant differences were determined by one-way ANOVA and LSD post hoc tests (p <0.05).
Fig. 5 in Androgenic Modulation in the Primary Ovarian Growth of the Japanese eel, .
Fig. 5. Correlations between gene (arα, arβ, and fshr) expression and GSI. Correlations between gene expression and GSI are displayed. (A, B, and C) are correlations between fshr expression and GSI. (D, E and F) are correlations between arα expression and GSI. (G, H, and I) are correlations between arβ expression and GSI. The three groups displayed are the control (A, D, and G; n = 6), weekly SPH injection for three weeks (B, E and H; n = 9) and weekly SPH+MT injection for three weeks (C, F and I; n = 6). The correlation between mRNA expression and previtellogenic ovary growth condition was analyzed using Spearman's rho correlations. GSI is plotted against the mRNA expression level. p <0.05 indicates significant correlation, and r-value represents the positive or negative correlation coefficient.
Fig. 2 in Androgenic Modulation in the Primary Ovarian Growth of the Japanese eel, .
Fig. 2. Calculation of follicle stage among female eels undergoing hormonal induction of ovary development. (A) Ovarian development was demonstrated by GSI, and GSI percentage was calculated as mean ± SD (control, n = 4; SPH, n = 3 and SPH + MT, n = 4). Stage IA, IB, and IC follicles were categorized as the characteristics for follicle stage calculation among female eels in the control, weekly SPH-injected, and weekly SPH + MT-injected groups. Each stage calculation is displayed in (B) stage IA follicles, (C) stage IB follicles, and (D) stage IC follicles. Significant differences are compared using one-way ANOVA and LSD post hoc tests; p <0.05.
Fig. 4 in Androgenic Modulation in the Primary Ovarian Growth of the Japanese eel, .
Fig. 4. in vivo mRNA expression of arα, arβ, and fshr after weekly hormone injection for three weeks. Relative mRNA expression of (A) arα, (B) arβ, and (C) fshr among the control (n = 6), SPH (n = 9) and SPH + MT (n = 6) groups. The mRNA of 18S rRNA was used as the internal standard for relative mRNA normalized quantification. The mRNA expression data from female eels' ovaries were collected and calculated as mean ± SD. Statistically significant differences are identified by one-way ANOVA and LSD post hoc tests. p <0.05 is considered significant.
Figure 1 in Androgenic hormones in crustacean aquaculture: a review
Figure 1. Male crayfish showing location of male reproductive tract accessible via the base of the fifth walking leg. ag = androgenic gland, g = gonopore, t = testes, and vd = vas deferens (adapted from Mead, 2008).
Validation of highly sensitive method based on UHPLC-ESI-MS/MS for the quantification of progestogens and androgens in plant material.
<p>We prepared a highly sensitive method for the quantification of progestogens and androgens in plant materials. This method is based on UHPLC-ESI-MS/MS. We show here the data used for the method validation. This includes the determination of linearity, recovery, precision, limits of detection and limits of quantification. </p> <p>The general procedure can be found in the txt or pdf file. </p> <p>The resulting data are collected in the excel file and can be found in the csv files, additonally.</p>
Tissue microarray data and processing scripts for The molecular consequences of androgen activity in the human breast
<p>This repository contains raw and processed data from the CODEX imaging dataset in this publication.</p> <p>The RAW data tables provide the resulting nuclei and membrane staining signals obtained from the nuclei segmentation described in the Methods.</p> <p>The processed data file provides the clustered and annotated version described in Methods.</p> <p>The repository also contains two scripts describing the processing of snRNA-seq and snATAC-seq data.</p>
177Lu-PSMA-617 vs. Androgen Receptor-Directed Therapy in the Treatment of Progressive Metastatic Castrate Resistant Prostate Cancer
ClinicalTrials.gov study NCT04689828. IPD Sharing: YES. Countries: 14. Publications: 2.
Targeted Radiotherapy in Androgen-suppressed Prostate Cancer Patients.
ClinicalTrials.gov study NCT03644303. IPD Sharing: YES. Countries: 1. Publications: 1.
How new communication behaviors evolve: Androgens as modifiers of neuromotor structure and function in foot-flagging frogs
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.