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185
datasets available to search
ShareScore release 0.9.0
Dataset results
185 results for “Anthracyclines”
A Study of Limited Heart Monitoring During Non-anthracycline Trastuzumab-based Therapy in Breast Cancer Patients
ClinicalTrials.gov study NCT03983382. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study of Trastuzumab Emtansine (Kadcyla) Plus Pertuzumab (Perjeta) Following Anthracyclines in Comparison With Trastuzumab (Herceptin) Plus Pertuzumab and a Taxane Following Anthracyclines as Adjuva
ClinicalTrials.gov study NCT01966471. IPD Sharing: Not stated. Countries: 36. Publications: 1.
A Study Evaluating Pertuzumab (Perjeta) Combined With Trastuzumab (Herceptin) and Standard Anthracycline-based Chemotherapy in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positiv
ClinicalTrials.gov study NCT02132949. IPD Sharing: Not stated. Countries: 12. Publications: 1.
Ph II Study of Pembrolizumab & Eribulin in Patients With HR+/HER2- MBC Previously Treated With Anthracyclines & Taxanes
ClinicalTrials.gov study NCT03222856. IPD Sharing: NO. Countries: 1. Publications: 1.
Preventing Anthracycline Cardiovascular Toxicity With Statins (PREVENT)
ClinicalTrials.gov study NCT01988571. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Phase II Study of E7389 in Patients With Breast Cancer, Previously Treated With Anthracycline, Taxane and Capecitabine
ClinicalTrials.gov study NCT00246090. IPD Sharing: Not stated. Countries: 2. Publications: 1.
A Study of Trastuzumab Emtansine (T-DM1) Sequentially With Anthracycline-based Chemotherapy, as Adjuvant or Neoadjuvant Therapy for Patients With Early Stage Herceptin (HER)2-positive Breast Cancer
ClinicalTrials.gov study NCT01196052. IPD Sharing: Not stated. Countries: 8. Publications: 1.
E7389 Versus Capecitabine in Patients With Locally Advanced or Metastatic Breast Cancer Previously Treated With Anthracyclines and Taxanes
ClinicalTrials.gov study NCT00337103. IPD Sharing: Not stated. Countries: 23. Publications: 5.
STOP-CA (Statins TO Prevent the Cardiotoxicity From Anthracyclines)
ClinicalTrials.gov study NCT02943590. IPD Sharing: NO. Countries: 2. Publications: 4.
Data from: Anthracycline induced cardiotoxicity: prospective cohort study from Pakistan.
Objectives: To identify anthracycline induced acute (within one month) and early onset chronic progressive (within year) cardiotoxicity in children younger than 16 years of age with childhood malignancies at tertiary care center of Pakistan. Design: Prospective Cohort study. Setting: Aga Khan University, Karachi, Pakistan. Participants: 110 children (aged 1 month to 16 years). Intervention: Anthracycline (Doxorubicin and/or Daunorubicin). Outcome measurements: All children who received anthracycline as chemotherapy and three echocardiographic evaluations (baseline, one month and 1 year) between July 2010 and June 2012 were prospectively analyzed for cardiac dysfunction. Statistical analysis including systolic and diastolic functions at baseline, 1 month and 1 year were made by repeated measures analysis of variance (r-ANOVA). Results: Mean age was 74±44 months and 75 (68.2%) were males. Acute lymphoblastic leukemia (ALL) was seen in 70 (64%) patients. Doxorubicin alone was used in 59 (54%) and combination therapy was used in 35(32%). A cumulative dose of anthracycline <300mg/m2 was in 95 (86%). Fifteen (14%) children developed cardiac dysfunction within a month and 28(25%) children within a year. Of these 10/15 (66.6%) and 12/28 (42%) had isolated diastolic dysfunction respectively, while 5/15 (33.3%) and 16/28 (57%) had combined systolic and diastolic dysfunction. Seven (6.4%) patients expired due to severe cardiac dysfunction. 8/59 (13.5%) children receiving doxorubicin showed dysfunction mostly related to higher cumulative dose (p=<0.001). Cardiotoxicity was high where combination of doxorubicin and daunorubicin was used (p=0.004). Conclusion: Anthracycline induced cardiac dysfunction is high. Long term follow-up is essential in children received any dosage of anthracyclines because of its late manifestation.
Study of Myocardial Function by Speckle Tracking After Cancer Treatment With Anthracyclines in Childhood
ClinicalTrials.gov study NCT02893787. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Primary Chemotherapy With Anthracycline Followed by Nab-paclitaxel and Trastuzumab
ClinicalTrials.gov study NCT01432223. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Carvedilol on Cardiotoxicity in Cancer Patients Submitted to Anthracycline Therapy
ClinicalTrials.gov study NCT04939883. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study of Pyrotinib Plus Capecitabine Versus Lapatinib Plus Capecitabine in Patients With HER2+Metastatic Breast Cancer Who Have Prior Received Anthracyclin, Taxane or Trastuzumab
ClinicalTrials.gov study NCT02422199. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Clinical Trial on Topotect® (Dexrazoxane) in the Treatment of Accidental Extravasation of Anthracyclines
ClinicalTrials.gov study NCT00548704. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Erlotinib and Gemcitabine in Treating Patients With Metastatic Breast Cancer Previously Treated With An Anthracycline and/or a Taxane
ClinicalTrials.gov study NCT00059852. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy of TopotectTM (Dexrazoxane) for Accidental Extravasation of Anthracyclines
ClinicalTrials.gov study NCT00548561. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Docetaxel and Cyclophosphamide Compared to Anthracycline-Based Chemotherapy in Treating Women With HER2-Negative Breast Cancer
ClinicalTrials.gov study NCT01547741. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Statins for the Primary Prevention of Heart Failure in Patients Receiving Anthracycline Pilot Study
ClinicalTrials.gov study NCT03186404. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study of AVE8062 in Advanced-stage Soft Tissue Sarcoma After Failure of Anthracycline and Ifosfamide Chemotherapies
ClinicalTrials.gov study NCT00699517. IPD Sharing: Not stated. Countries: 10. Publications: 1.
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