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146 results for “Antigen-specific”
Antigen-specific CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph node and blood following vaccination in humans
<p><strong>Abstract: </strong><br>SARS-CoV-2 infection and mRNA vaccination induce robust CD4+ T cell responses that are critical for the development of protective immunity. Here, we evaluated spike-specific CD4+ T cells in the blood and draining lymph node (dLN) of human subjects following BNT162b2 mRNA vaccination using single-cell transcriptomics. We analyze multiple spike-specific CD4+ T cell clonotypes, including novel clonotypes we define here using Trex, a new deep learning-based reverse epitope mapping method integrating single-cell T cell receptor (TCR) sequencing and transcriptomics to predict antigen-specificity. Human dLN spike-specific T follicular helper cells (TFH) exhibited distinct phenotypes, including germinal center (GC)-TFH and IL-10+ TFH, that varied over time during the GC response. Paired TCR clonotype analysis revealed tissue-specific segregation of circulating and dLN clonotypes, despite numerous spike-specific clonotypes in each compartment. Analysis of a separate SARS-CoV-2 infection cohort revealed circulating spike-specific CD4+ T cell profiles distinct from those found following BNT162b2 vaccination. Our findings provide an atlas of human antigen-specific CD4+ T cell transcriptional phenotypes in the dLN and blood following vaccination or infection.</p> <p><strong>More Information:</strong></p> <ul> <li><strong>Preprint:</strong> <a href="https://www.researchsquare.com/article/rs-3304466/v1">Research Square.</a></li> <li><strong>Sample information</strong>: data_inventory.csv file.</li> <li><strong>Code</strong> code_github_repo.zip or at the <a href="https://github.com/ncborcherding/COVID_TCR">original github repo</a></li> <li><strong>Interactive Portal</strong>: <a href="https://cellpilot.emed.wustl.edu/">CellPilot</a></li> </ul>
Antigen-specific memory NK cell responses against HIV and influenza utilize the NKG2/HLA-E axis
<p>For over a decade, multiple studies have disputed the notion of natural killer (NK) cells as purely innate lymphocytes by demonstrating that they are capable of putative antigen-specific immunological memory against multiple infectious agents including two critical global health priorities – human immunodeficiency virus (HIV) and influenza. However, the mechanisms underlying antigen specificity remain unknown. Herein, we demonstrate that antigen-specific human NK cell memory develops upon exposure to both HIV and influenza, unified by a conserved and epitope-specific targetable mechanism largely dependent on the activating CD94/NKG2C receptor and its ligand HLA-E, and confirm these findings by three rigorous assays. We validated the permanent acquisition of antigen-specificity by individual memory NK cells by single-cell cloning. We identified biomarkers of antigen-specific NK cell memory through complex immunophenotyping by 30-parameter flow cytometry showing elevated expression of KLRG1, a4b7, and NKG2C. Finally, we show individual HLA-E-restricted peptides that may constitute the dominant NK cell response in HIV-1- and influenza-infected persons in vivo. Our findings clarify the mechanisms behind antigen-specific memory NK cell responses, and suggest they could be targeted for future vaccines, cure strategies, or other therapeutic interventions.</p>
Study of GSK2132231A Antigen-Specific Cancer Immunotherapeutic in Patients With Inoperable Metastatic Cutaneous Melanoma
ClinicalTrials.gov study NCT00896480. IPD Sharing: YES. Countries: 2. Publications: 1.
Antigen-specific Cancer Immunotherapy (TG01) and Gemcitabine as Adjuvant Therapy in Resected Pancreatic Cancer
ClinicalTrials.gov study NCT02261714. IPD Sharing: Not stated. Countries: 3. Publications: 3.
GSK1572932A Antigen-Specific Cancer Immunotherapeutic as Adjuvant Therapy in Patients With Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT00480025. IPD Sharing: YES. Countries: 34. Publications: 3.
Anti-TSLP (AMG 157) Plus Antigen-Specific Immunotherapy for Induction of Tolerance in Individuals With Cat Allergy
ClinicalTrials.gov study NCT02237196. IPD Sharing: YES. Countries: 1. Publications: 1.
Antigen-specific memory NK cell responses against HIV and influenza utilize the NKG2/HLA-E axis
Open the record for dataset details and reuse information.
Antigen-specific CD4+ T cells promote monocyte recruitment and differentiation into glycolytic lung macrophages to control Mycobacterium tuberculosis
Open the record for dataset details and reuse information.
TCR convergence is a indicator of antigen-specific T cell response in immunotherapies
<p>This compressed file contains all the convergent TCR sequence information involved in this study. </p>
Secondary Graft Loss After Third-party "Off-The-Shelf" Antigen-Specific T cell Infusion
<p>Here, we describe a severe adverse event of virus-specific T cell (VST therapy) in an infant with severe combined immunodeficiency who received VSTs for treatment of CMV viremia post-transplant and developed secondary graft rejection at 1-month post-VST infusion associated with the expansion of VST donor-derived T cells. Deposited here are the bulk repertoire, single-cell gene expression and TCR, and flow cytometry data from the study.</p><p><strong>bulk_rep.zip contains tables of alpha/beta TCR sequences for post-infusion, VST donor, and VST product samples, and samples stimulated with neoepitope peptides. </strong></p><p><strong>VST_agg_wTCR_SS.rds is an R Data Serialization file containing a Seurat object of the processed 10X single-cell gene expression and TCR profiling for the post-infusion, VST donor, and VST product samples. TCR information is stored in the meta.data slot.</strong></p><p><strong>P0230D neoantigen expansions.acs, P0230D pentamers.acs, and P0230D_MLR.acs contain the flow cytometry data for the neoantigen and mixed lymphocyte reaction experiments.</strong></p>
Safety and Immunogenicity of Recombinant WT1 Antigen-Specific Cancer Immunotherapeutic Combined With Infusion of Treg Depleted T Cells for Adult WT1 Acute Myeloid Leukemia
ClinicalTrials.gov study NCT01513109. IPD Sharing: Not stated. Countries: 1. Publications: 34.
Generation of Cancer Antigen-Specific T-cells From Human Induced Pluripotent Stem Cells (iPSC) for Research and Potential FutureTherapy
ClinicalTrials.gov study NCT03407040. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Phase I Trial of LMP2 Antigen-specific TCR T-cell Therapy for Recurrent and Metastatic NPC Patients
ClinicalTrials.gov study NCT03925896. IPD Sharing: NO. Countries: 1. Publications: 13.
MAGE-A3 Antigen-Specific Cancer Immunotherapeutic in Patients With Progressive Metastatic Cutaneous Melanoma
ClinicalTrials.gov study NCT00706238. IPD Sharing: Not stated. Countries: 3. Publications: 0.
CD8+ Antigen-Specific T Cells, Cyclophosphamide, Aldesleukin, and Ipilimumab in Treating Patients With Metastatic Melanoma
ClinicalTrials.gov study NCT02027935. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Nanoparticle immunoadjuvant complexes augment antigen-specific germinal center responses and enhance humoral immunity
GEO Series GSE278580. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis of antigen-specific CD4 T cells infiltrating the liver (Figure 6)
GEO Series GSE269525. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
CD38 endows local antigen-specific Foxp3+ Treg cells with stress resilience for compartmentalized control of CNS inflammation
GEO Series GSE311963. Mus musculus. 68 samples. Type: Expression profiling by high throughput sequencing.
Human RP105 monoclonal antibody enables the production of antigen-specific antibody
GEO Series GSE241135. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Narrow-band ultraviolet B induces peripheral regulatory T cells to exert antigen-specific immune suppression [RNA-seq]
GEO Series GSE285340. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.