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5 results for “Antioxidative metabolites”

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zenodo32/100

Effect of dietary Chlorella vulgaris and carbohydrate-active enzymes on the general health, immune status, antioxidant capacity, and liver lipids and metabolites of weaned piglets

It was evaluated the impact of dietary inclusion of Chlorella vulgaris (CH) and carbohydrases on the general health, immune and oxidative status, and hepatic lipids and metabolites of piglets. Forty-four male weaned piglets were allocated into four diets: control (n=11), CH (control diet with 5% CH, n=10), CH+R (control diet with 5% CH plus 0.005% Rovabio®Excel AP, n=10), and CH+M (control diet with 5% CH plus 0.01% of a pre-selected four-CAZyme mixture, n=11) for 15 days. Total cholesterol, LDL-cholesterol and VLDL-cholesterol were increased by CH. In piglets fed CH-based diets, the interplay observed between IgG increase and IgM decrease contributed for piglets’ survival during weaning. n-6 PUFA were lower in piglets fed CH with or without feed enzymes and the inverse occurred for n-3 PUFA, thus benefiting n-6/n-3 ratio in the liver. The discriminant analysis applied to hepatic variables revealed a good separation between control and CH-based diets but failed to discriminate feed enzymes addition. Minor variations were promoted by Rovabio or the pre-selected enzymatic mixture, thus suggesting some improvement on microalga nutrients digestibility. Taken together, our findings indicate a health promoting effect of CH as feed ingredient in piglets’ nutrition during the weaning period, without negatively impacting on animals’ performance.

opencc-by-4.0Jan 2022View details →

zenodo32/100

Fig. 2 in Callus cultures of Harpagophytum procumbens (Burch.) DC. ex Meisn.; production of secondary metabolites and antioxidant activity

Fig. 2. Iridoid (A, B) and phenylethanoid (C,D) glycoside contents estimated by HPLC in cotyledon-derived callus lines of H.procumbens in long-term cultures. The calli were cultured on SH medium with 0.5 or 2 mg L −1 picloram (CP0.5 and CP2 callus lines,respectively) or NAA (0.2 mg L −1) and BAP (1 mg L −1) (CNB callus line).* trace (content <0.01 mg g −1 DW).Results are means ± standard error (SE) from three independent experiments; for each metabolite, values with different letters are significantly different according to the Kruskal–Wallis test (p ≤ 0.05).

opennotspecifiedMar 2016View details →

zenodo32/100

Fig. 1. H.procumbens cotyledon-derived callus tissues grown for 4 in Callus cultures of Harpagophytum procumbens (Burch.) DC. ex Meisn.; production of secondary metabolites and antioxidant activity

Fig. 1. H.procumbens cotyledon-derived callus tissues grown for 4 weeks in Erlenmeyer flasks on agar SH medium with 0.5 mg L−1 picloram (CP0.5 callus line) (A), 2 mg L−1 picloram (CP2 callus line) (B), 0.2 mg L −1 NAA and 1 mg L −1 BAP (CNB callus line) (C). Bar 1 cm.

opennotspecifiedMar 2016View details →

dryad28/100

Data from: Effects of 9,10-phenanthrenequione on antioxidant indices and metabolite profiles in Takifugu obscurus plasma

Derived from polycyclic aromatic hydrocarbons (PAHs), oxygenated-PAHs (oxy-PAHs) may pose hazards to aquatic organisms, which remains largely unknown. Takifugu obscurus is an important anadromous fish species of high economic and ecological values. In the present study, T. obscurus was acutely exposed to 44.29 μg/L 9,10-phenanthrenequione (9,10-PQ) for 96 hours. Changes of antioxidant indices and metabolite profiles in plasma were compared between 9,10-PQ treatment and the control. The results showed that 9,10-PQ treatment significantly increased MDA content during 6 hours to 96 hours, increased SOD and CAT activities at 6 hours, but decreased them at 96 hours. These results indicated that 9,10-PQ induced oxidative stress to fish. Ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) analysis revealed that four metabolic pathways were influenced in response to treatment with 9,10-PQ, including glycerophospholipid metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, purine metabolism and sulfur metabolism. These pathways are associated with antioxidant mechanisms, biosynthesis of neurotransmitters and innate immune functions. Thus, the as-obtained results confirmed that 9,10-PQ induced oxidative stress and raised concerns of neurotoxicity and immunotoxicity to fish. Overall, the present study posed a high environmental risk of oxy-PAHs to aquatic ecosystems. Derived from polycyclic aromatic hydrocarbons (PAHs), oxygenated-PAHs (oxy-PAHs) may pose hazards to aquatic organisms, which remains largely unknown. Takifugu obscurus is an important anadromous fish species of high economic and ecological values. In the present study, T. obscurus was acutely exposed to 44.29 μg/L 9,10-phenanthrenequione (9,10-PQ) for 96 hours. Changes of antioxidant indices and metabolite profiles in plasma were compared between 9,10-PQ treatment and the control. The results showed that 9,10-PQ treatment significantly increased MDA content during 6 hours to 96 hours, increased SOD and CAT activities at 6 hours, but decreased them at 96 hours. These results indicated that 9,10-PQ induced oxidative stress to fish. Ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) analysis revealed that four metabolic pathways were influenced in response to treatment with 9,10-PQ, including glycerophospholipid metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, purine metabolism and sulfur metabolism. These pathways are associated with antioxidant mechanisms, biosynthesis of neurotransmitters and innate immune functions. Thus, the as-obtained results confirmed that 9,10-PQ induced oxidative stress and raised concerns of neurotoxicity and immunotoxicity to fish. Overall, the present study posed a high environmental risk of oxy-PAHs to aquatic ecosystems.

opencc-zeroJul 2020View details →

dryad28/100

Data from: Effects of 9,10-phenanthrenequione on antioxidant indices and metabolite profiles in Takifugu obscurus plasma

Open the record for dataset details and reuse information.

publicJul 2020View details →

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