Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
421
datasets available to search
ShareScore release 0.9.0
Dataset results
421 results for “Aorta”
Full summary statistics of mixQTL for GTEx v8 Artery_Aorta
The mixQTL method is described in paper doi.org/10.1101/2020.04.22.050666. Please cite the original paper if using the data.
Research data supporting "Raman spectroscopy imaging reveals interplay between atherosclerosis and medial calcification in human aorta"
<p>Research data supporting the publication:</p> <p>You, A. Y. F. <em>et al.</em>, 2017, "Raman spectroscopy imaging reveals interplay between atherosclerosis and medial calcification in human aorta", Science Advances, DOI: 10.1126/sciadv.1701156.</p>
Data set used in "Effect of turbulence and viscosity models on wall shear stress derived biomarkers for aorta simulations"
<p>Data set used in "Effect of turbulence and viscosity models on wall shear stress derived biomarkers for aorta simulations"</p> <p>Includes the data for 20 heartbeats. Divided into external and internal walls regions. </p>
Validation of an Idealized Aorta Model Analysed through Fluid-Structure Interaction Simulation with Robin-Neumann Partitioned Approach
<p>The aorta is multiphysics system where hemodynamics and wall structural mechanic are mutually influenced. A fluid-structure interaction approach is appropriate to describe the mechanical alterations suffered by the aortic wall in response to altered hemodynamic patterns. This work demonstrates the validation of the simulated idealized aorta model with a fluid-structure interaction (FSI) model through modified PIMPLE solver to use Robin-Neumann partitioned approach for the strongly-coupled algorithm using solids4foam v2. The validation involves the comparison of streamlines, pressure, and displacements with in vivo measurements. The geometry is reconstructed from the healthy aorta presented in 10.5281/zenodo.5801938. Our analysis shows that the streamlines and pressure pattern are comparable with the literature data acquired using rich medical imaging data. The maximum diameter deformation at the level of abdominal aorta is comparable with measured data and the diameter deformation profile along the cardiac cycle correctly follow the velocity profile. According to this results, our work shows a high-performance simulation suitable for several future works.</p>
Covered CP Stents for the Prevention or Treatment of Aortic Wall Injury Associated With Coarctation of the Aorta
ClinicalTrials.gov study NCT01278303. IPD Sharing: NO. Countries: 1. Publications: 1.
Coarctation Of the Aorta Stent Trial
ClinicalTrials.gov study NCT00552812. IPD Sharing: NO. Countries: 1. Publications: 3.
Comparative analysis of patient-specific aortic dissections through computational fluid dynamics suggests increased likelihood of degeneration in partially thrombosed aorta
<p>Aortic dissection is a life-threatening cardiovascular disease associated with high rates of morbidity and mortality, especially in medically under-served communities. It compromises the hemodynamics of the arteries that originate from the aorta, and its outcomes include visceral ischemia and aortic rupture in the acute phase and aneurysmatic degeneration in the chronic phase. Understanding patients’ blood flow patterns is pivotal for non-invasive evidence-based treatment as they greatly influence both the disease onset and its outcome. In this paper, we combine diagnostic imaging techniques and computational fluid dynamics to analyze the flow patterns of three aorta dissections (fully perfused, partially thrombosed, and fully thrombosed), and compare them to a healthy aorta. Besides flow kinematics, we focus on time averaged wall shear stress and oscillatory shear index that are recognized risk factors for aneurysm and rupture. Our analysis shows that partially thrombosed dissection is the most prone to false lumen degeneration. In all dissections, the arteries connected to the false lumen are generally poorly supplied with blood. Further, both true and false lumens present higher turbulence levels than the healthy aorta, and critical stagnation points. Mesh sensitivity and a thorough comparison against literature data together support the methodology robustness.</p>
Virtual cohort of fetal cases with suspected coarctation of the aorta from fetal three-dimensional magnetic resonance images
<p>The present dataset is a supplementary dataset to the paper: Hermida, U., van Poppel, M.P.M., Lloyd, D.F.A. <em>et al.</em> Learning the Hidden Signature of Fetal Arch Anatomy: a Three-Dimensional Shape Analysis in Suspected Coarctation of the Aorta. <em>J. of Cardiovasc. Trans. Res.</em> (2022). https://doi.org/10.1007/s12265-022-10335-9</p> <p><strong>Dataset Description: </strong></p> <p>We present a database of fetal great arch anatomical models derived from a statistical shape model (SSM) of fetuses with suspected coarctation of the aorta (CoA). The dataset consists of 1000 meshes including the fetal ascending aorta, arterial duct and descending aorta. For each synthetic case, the corresponding PCA coefficients for the 10 first PCA modes, as well as their CoA risk score, are shared. PCA scores are provided both as raw scores and Z-scores. </p> <p>To build the SSM, a dataset of 112 motion-corrected 3D fetal cardiovascular magnetic resonance (CMR) images and their corresponding segmentations from cases with suspected CoA was used. Data included confirmed CoA cases as well as false positive (FP) cases. Centerlines were extracted and aligned to build the SSM of the fetal great arches. </p> <p><strong>Source of funding</strong></p> <p>This work was supported by the Wellcome Trust IEH Award [102431] (iFIND project), by core funding from the Wellcome/EPSRC Centre for Medical Engineering [WT203148/Z/16/Z] and by the Rosetrees Trust [A2725]. The research was funded by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London and supported by the NIHR Clinical Research Facility. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. D.F.A. Lloyd acknowledges support from the Rothschild Foundation (2020/2017). P. Lamata holds a Wellcome Trust Senior Research Fellowship (209450/Z/17/Z).</p>
Annotated and processed 3D confocal microscopy images of dorsal aorta in wild-type and Endoglin-deficient zebrafish embryos at 48 hpf and 72 hpf
<p>This repository contains the original 3D confocal microscopy images that were used for the analysis of vessel geometry and endothelial cell morphology in the dorsal aorta of wild-type and Endoglin-deficient zebrafish embryos at 48 hours post fertilization (hpf) and 72 hpf in the article <a href="https://www.biorxiv.org/content/10.1101/2024.02.19.580931">Novel mathematical approach to accurately quantify 3D endothelial cell morphology and vessel geometry based on fluorescently marked endothelial cell contours: Application to the dorsal aorta of wild-type and Endoglin-deficient zebrafish embryos</a>. In this article, we developed a novel mathematical approach that allows to consistently estimate 3D vessel geometry and endothelial cell surface morphology using only information from endothelial cell contours. For the article's analysis, endothelial cell contours were manually annotated on Pecam1-EGFP-labeled cell junctions. Furthermore, dorsal aorta cross-sections were outlined on Dextran Texas Red-perfused vessel lumens. Further details are provided in the article's Materials and methods section.</p> <p>This repository contains 14 images of 7 wild-type embryos, each imaged at 48hpf and 72hpf. Furthermore, 12 images of 6 Endoglin-deficient embryos, each imaged at 48hpf and 72hpf are included. These combined files (called "analysis data" in the article) are stored in "eng_wt_data.zip". Secondly, images of 2 wild-types at 72hpf with repeated cell contour annotation and outlined vessel lumens (called "validation data" in the article) are located in "wt_angiogram_data.zip". The provided files are stored in Imaris format and can be inspected using the free <a href="https://imaris.oxinst.com/imaris-viewer">Imaris Viewer software</a>.</p> <p>To allow inspection of the endothelial cell contours that we manually annotated for the article's analysis and compare them against the intermediate results of our novel mathematical approach, i.e., contour enrichments by neighboring cells, contour smoothing splines and their projections onto the estimated vessel surfaces, we imported these contours into the Imaris files. Note that the contours' coordinates in these files are slightly less precise than in our article's analysis and thus are intended for visual inspection. To exactly reproduce the results in our article, refer to the files in <a href="https://doi.org/10.5281/zenodo.10549101">our other Zenodo repository</a>.</p>
Synthetic velocity profiles for simulations of blood flow in the aorta
<p>Synthetic dataset of aortic velocity profiles, suitable to be used for numerical simulations of blood flow.</p> <p>Please refer to the profile number ID when using it.</p>
Evaluation of the GORE® TBE Device in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta, Zone 2
ClinicalTrials.gov study NCT02777593. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Resuscitative Endovascular Balloon Occlusion of the Aorta in Non-traumatic Out of Hospital Cardiac Arrest
ClinicalTrials.gov study NCT04596514. IPD Sharing: YES. Countries: 3. Publications: 2.
Evaluation of the GORE® TBE Device in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta, Zone 0/1
ClinicalTrials.gov study NCT02777528. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Data from: Sex-specific vascular effects of menthol: TRPM8 and TRPA1-dependent relaxation in female mouse aorta and pudendal arteries
Open the record for dataset details and reuse information.
Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence
Open the record for dataset details and reuse information.
MicroCT and CECT-based images of a Zn alloy explant after 84 days of implantation in the rat abdominal aorta.
<p><span>(A) MicroCT slices showing the wire and the corrosion products and (B) CECT slices after staining with Lugol for 17 h showing the wire, the corrosion products, and the surrounding soft tissue for a Zn alloy explant.</span></p>
CECT-based images a Zn alloy explant, after 84 days of implantation in the rat abdominal aorta.
<p><span>(A) The original grayscale slices, (B) the segmentation of the wire, the aorta, and the neointima, and (C) the segmentation of the wire, the aorta, the neointima, and the corrosion products.</span></p>
Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair
ClinicalTrials.gov study NCT00339053. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Progression of Ascending Aorta Diameters in Bicuspid Aortic Valve After Transcatheter or Surgical Replacement.
ClinicalTrials.gov study NCT05708118. IPD Sharing: UNDECIDED. Countries: 1. Publications: 15.
Long-term Outcomes and Vascular Evaluation After Coarctation of the Aorta Treatment
ClinicalTrials.gov study NCT03262753. IPD Sharing: NO. Countries: 1. Publications: 76.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.