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111 results for “Apolipoproteins”
Reprocessing of the dataset "Plasma Proteome Profiling Reveals the Effects of Weight Loss on the Apolipoprotein Family and Systemic Inflammation Status"
<p>Reprocessing of the MassIVE repository MSV000080596, originally generated to investigate the dynamic changes in the plasma proteomes of a cohort of individuals with obesity following weight loss and maintenance. The reprocessing included all samples from 52 individuals taken right after the weight-loss process and during the weight maintenance phase of the study (Weeks 0, 4, 13, 26, 39, and 52).</p> <p>We used the sequence database generated by ProHap (<a href="https://github.com/ProGenNo/ProHap">https://github.com/ProGenNo/ProHap</a>) representing all populations from the 1000 Genomes Project (doi.org/10.5281/zenodo.10149277). For the search, SearchGUI version 4.3.1 and PeptideShaker version 3.0.0 were used with the X!Tandem and Tide search engines. The modification settings specified were carbamidomethylation of C as fixed and oxidation of M, deamidation of N and Q, Pyrrolidone of E and Q, and acetylation of protein N-terminus as variable modifications. The maximum peptide length was set to 40 amino acids and the precursor and fragment ion tolerances were set to 7 and 20 ppm, respectively. Resulting PSMs were processed as described in (doi.org/10.1021/acs.jproteome.3c00243) using Percolator version 3.5 provided with features based on peptide retention time (DeepLC version 1.1.2) and fragmentation predictors (MS2PIP version 3.9.0), and filtered at a 1% estimated FDR.</p> <p>The attached file contains all the peptide-spectrum matches identified at 1% FDR. The peptides have been annotated with transcripts, genes, and alleles using the ProHap Peptide Annotator v1.1 (<a href="https://github.com/ProGenNo/ProHap_PeptideAnnotator">https://github.com/ProGenNo/ProHap_PeptideAnnotator</a>).</p>
Dataset for the Apolipoprotein E antibody screning study
<p>This project contains the following underlying data included in a study aiming at characterizing antibodies for the Apolipoprotein E protein. The study is available on Zenodo (https://doi.org/10.5281/zenodo.7249055).</p>
Apolipoprotein D (ApoD) In Human Serum As Marker Of Parkinson's Disease
ClinicalTrials.gov study NCT01467960. IPD Sharing: Not stated. Countries: 1. Publications: 12.
A Study to Evaluate Fasting/Postprandial Serum Apolipoprotein B-48 (ApoB-48) Levels in Diabetic Participants With Normal to Moderately High Low Density Lipoprotein-C (LDL-C) Levels (MK-0653A-259 AM1)
ClinicalTrials.gov study NCT01333436. IPD Sharing: NO. Countries: 1. Publications: 1.
Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity
Recently evolved alleles of Apolipoprotein L-1 (APOL1) provide increased protection against African trypanosome parasites while also significantly increasing the risk of developing kidney disease in humans. APOL1 protects against trypanosome infections by forming ion channels within the parasite, causing lysis. While the correlation to kidney disease is robust, there is little consensus concerning the underlying disease mechanism. We show in human cells that the APOL1 renal risk variants have a population of active channels at the plasma membrane, which results in an influx of both Na+ and Ca2+. We propose a model wherein APOL1 channel activity is the upstream event causing cell death, and that the activate-state, plasma membrane-localized channel represents the ideal drug target to combat APOL1-mediated kidney disease.
Data from: Lipids, apolipoproteins, and prognosis of amyotrophic lateral sclerosis
<p><span><b>Objective</b> To determine whether lipids and apolipoproteins predict prognosis of patients with amyotrophic lateral sclerosis in a cohort study of 99 amyotrophic lateral sclerosis patients who were diagnosed during 2015-2018 and followed until October 31, 2018, at the Neurology Clinic in Karolinska University Hospital in Stockholm, Sweden. </span></p> <p><span><b>Methods</b> Total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, apolipoprotein A-I, apolipoprotein B, and lipid ratios were measured at the time of amyotrophic lateral sclerosis diagnosis or shortly thereafter. Death after amyotrophic lateral sclerosis diagnosis was used as the main outcome. Cox model was used to estimate hazard ratios with 95% confidence intervals of death after amyotrophic lateral sclerosis diagnosis, after controlling for sex, age at diagnosis, site of symptoms onset, diagnostic delay, body mass index, Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised, and progression rate.</span></p> <p><span><b>Results </b>One-standard deviation increase of total cholesterol (hazard ratio, 0.60; 95% confidence interval, 0.41-0.89; P=0.01), low-density lipoprotein cholesterol (hazard ratio, 0.64; 95% confidence interval, 0.44-0.92; P=0.02), low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (hazard ratio, 0.65; 95% confidence interval, 0.46-0.92; P=0.02), apolipoprotein B (hazard ratio, 0.62; 95% confidence interval, 0.44-0.88; P=0.01), or apolipoprotein B/apolipoprotein A-I ratio (hazard ratio, 0.61; 95% confidence interval, 0.43-0.86; P<0.01) were all associated with a lower risk of death after amyotrophic lateral sclerosis diagnosis. A dose-response relationship was also noted when analyzing these biomarkers as categorical variables. </span></p> <p><span><b>Conclusions </b>Lipids and apolipoproteins are important prognostic indicators for amyotrophic lateral sclerosis and should be monitored at the diagnosis of amyotrophic lateral sclerosis.</span></p>
Data from: Apolipoprotein M-bound sphingosine-1-phosphate regulates blood-brain barrier paracellular permeability and transcytosis
The blood-brain barrier (BBB) is formed by the endothelial cells lining cerebral microvessels. Here, we report that the BBB permeability is modified by apolipoprotein M (apoM)-bound sphingosine 1–phosphate (S1P). We used two-photon microscopy to monitor changes in BBB permeability in apoM-deficient mice (apoM-/-), showing significant increases in paracellular BBB permeability to small molecules without structural changes in junctional complexes between endothelial cells. Lack of apoM-bound S1P increased vesicle-mediated transfer of albumin across endothelium of brain pial and penetrating arterioles, whereas transcytosis in capillaries and venules remained unchanged. S1PR1 agonist SEW2871 rapidly normalized BBB permeability along both the paracellular and transcellular routes in apoM-/- mice. Thus, apoM-bound S1P maintains low paracellular BBB permeability for small molecules in all cerebral microvessels and low levels of adsorptive transcytosis in penetrating arterioles. Modulation of apoM/S1P-dependent signaling may be a novel strategy for the protection of brain endothelial cells to preserve the BBB function.
Data from: Apolipoprotein (ApoE) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?
The alleles that are detrimental to health, especially in older age, are thought to persist in populations because they also confer some benefits for individuals (through antagonistic pleiotropy). The ApoE4 allele at the ApoE locus, encoding apolipoprotein E (ApoE), significantly increases risk of poor health, and yet it is present in many populations at relatively high frequencies. Why has it not been replaced by natural selection with the health-beneficial ApoE3 allele? ApoE is a major supplier of cholesterol precursor for the production of ovarian oestrogen and progesterone, thus ApoE has been suggested as the potential candidate gene that may cause variation in reproductive performance. Our results support this hypothesis showing that in 117 regularly menstruating women those with genotypes with at least one ApoE4 allele had significantly higher levels of mean luteal progesterone (144.21 pmol l−1) than women with genotypes without ApoE4 (120.49 pmol l−1), which indicates higher potential fertility. The hormonal profiles were based on daily data for entire menstrual cycles. We suggest that the finding of higher progesterone in women with ApoE4 allele could provide first strong evidence for an evolutionary mechanism of maintaining the ancestral and health-worsening ApoE4 allele in human populations.
Systematic evaluation of lecithin:cholesterol acyltransferase binding sites in apolipoproteins via peptide based nanodiscs: regulatory role of charged residues at positions 4 and 7
<p>Molecular dynamics simulation systems of publication "Systematic evaluation of lecithin:cholesterol acyltransferase binding sites in apolipoproteins via peptide based nanodiscs: regulatory role of charged residues at positions 4 and 7" by Akseli Niemelä and Artturi Koivuniemi.</p>
Does Incorporation of EPA and DHA in Lipoproteins Differ According to Apolipoprotein E Genotype?
ClinicalTrials.gov study NCT01544855. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Do Apolipoprotein E Polymorphisms Influence Risk of Cognitive Decline by Modulating Omega-3 Fatty Acid Metabolism?
ClinicalTrials.gov study NCT01577004. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Assessment of Endothelial Function, Apolipoproteins and Adiponectin
ClinicalTrials.gov study NCT01300390. IPD Sharing: Not stated. Countries: 1. Publications: 25.
Fatty Acid Metabolism in Carriers of Apolipoprotein E Epsilon 4 Allele: Determining the Blood-to-brain Link
ClinicalTrials.gov study NCT04279743. IPD Sharing: NO. Countries: 1. Publications: 0.
The Association of SAA With Apolipoprotein B Affects Cardiovascular Risk
ClinicalTrials.gov study NCT02770872. IPD Sharing: NO. Countries: 1. Publications: 30.
Effect of Apolipoprotein E on the Prognosis of Patients With Intracerebral Hemorrhage
ClinicalTrials.gov study NCT05687201. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Supplementation of Dual Probiotic Strains Reduced Fasting Triglyceride and Enhanced Apolipoprotein A-V Levels
ClinicalTrials.gov study NCT02215694. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Erythrocyte-bound Apolipoprotein B After Withdrawal of Statin Therapy
ClinicalTrials.gov study NCT01634906. IPD Sharing: Not stated. Countries: 1. Publications: 15.
A Study to Evaluate the Effect of Bexarotene on Beta-Amyloid and Apolipoprotein E Metabolism in Healthy Subjects
ClinicalTrials.gov study NCT02061878. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Influence of Glycaemic Balance on the Ability of Apolipoprotein C1 to Inhibit Cholesteryl Ester Transfer Protein in Type-1 Diabetes Patients
ClinicalTrials.gov study NCT02816099. IPD Sharing: Not stated. Countries: 1. Publications: 2.
GeneMatch: A Program of the Alzheimer's Prevention Registry to Match Individuals to Studies Based on Apolipoprotein E (APOE) Genotype
ClinicalTrials.gov study NCT02564692. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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