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12 results for “Astragalus membranaceus”
Data from: Long read reference genome-free reconstruction of a full-length transcriptome from Astragalus membranaceus reveals transcript variants involved in bioactive compound biosynthesis
Astragalus membranaceus, also known as Huangqi in China, is one of the most widely used medicinal herbs in Traditional Chinese Medicine. Traditional Chinese Medicine formulations from Astragalus membranaceus have been used to treat a wide range of illnesses, such as cardiovascular disease, type 2 diabetes, nephritis and cancers. Pharmacological studies have shown that immunomodulating, anti-hyperglycemic, anti-inflammatory, antioxidant and antiviral activities exist in the extract of Astragalus membranaceus. Therefore, characterising the biosynthesis of bioactive compounds in Astragalus membranaceus, such as Astragalosides, Calycosin and Calycosin-7-O-β-D-glucoside, is of particular importance for further genetic studies of Astragalus membranaceus. In this study, we reconstructed the Astragalus membranaceus full-length transcriptomes from leaf and root tissues using PacBio Iso-Seq long reads. We identified 27 975 and 22 343 full-length unique transcript models in each tissue respectively. Compared with previous studies that used short read sequencing, our reconstructed transcripts are longer, and are more likely to be full-length and include numerous transcript variants. Moreover, we also re-characterised and identified potential transcript variants of genes involved in Astragalosides, Calycosin and Calycosin-7-O-β-D-glucoside biosynthesis. In conclusion, our study provides a practical pipeline to characterise the full-length transcriptome for species without a reference genome and a useful genomic resource for exploring the biosynthesis of active compounds in Astragalus membranaceus.
Data from: Long read reference genome-free reconstruction of a full-length transcriptome from Astragalus membranaceus reveals transcript variants involved in bioactive compound biosynthesis
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Supplementary material 1 from: Enchev P, Zarev Y, Ionkova I (2023) Biotechnological approaches for sustainable production of astragaloside I, II and IV from endemic species of Astracantha aitosensis (Ivan.) and Astragalus membranaceus (fisch.) by in vitro cultures. Pharmacia 70(4): 1449-1453. https://doi.org/10.3897/pharmacia.70.e114989
LC/MS spectra of astragalosides I, II and IV within the different fractions
Supplementary material 1 from: Enchev P, Zarev Y, Michler H, Ionkova I (2023) Production of rare cycloartane saponins from Astragalus thracicus (Griseb) compared to Astragalus membranaceus (Fisch.) Bunge – native and biotechnological sources. Pharmacia 70(1): 73-77. https://doi.org/10.3897/pharmacia.70.e97782
HR-ESI-MS of Astragaloside I, Astragaloside II and Astragaloside IV
Efficacy, Safety and Response Predictors of Astragalus Membranaceus on the Improvement of Cognitive Function in Mild-to-Moderate Alzheimer's Disease
ClinicalTrials.gov study NCT05578443. IPD Sharing: NO. Countries: 1. Publications: 0.
Efficacy, Safety of Astragalus Membranaceus in Mild-to-Moderate Alzheimer's Disease
ClinicalTrials.gov study NCT06694597. IPD Sharing: NO. Countries: 1. Publications: 0.
Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Astragalus Membranaceus in the Patients After Stroke With Fatigue
ClinicalTrials.gov study NCT01554787. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Transcriptomics data on muscle atrophy in the state of cancer cachexia, as well as the therapeutic effects of Astragalus membranaceus Decoction
GEO Series GSE301467. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Astragalus Membranaceus on Aneurysmal Subarachnoid Hemorrhage
ClinicalTrials.gov study NCT03271697. IPD Sharing: NO. Countries: 0. Publications: 0.
Astragalus Membranaceus for Brain Edema Induced by Hemorrhagic Stroke
ClinicalTrials.gov study NCT01428401. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Expression data from colon cancer cell HCT116 mouse xenograft - Control vs. traditional Chinese medicine Astragalus membranaceus-treated conditions
GEO Series GSE70772. Homo sapiens. 16 samples. Type: Expression profiling by array.
Regulation of electro-acupuncture(EA) and astragalus membranaceus (AM) on genes in bone marrow
GEO Series GSE163828. Mus musculus. 4 samples. Type: Expression profiling by array.
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