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63 results for “Axillary dissection”
Cyanoacrylate glue in breast surgery: the GLUBREAST Trial Can cyanoacrylate glue reduce seroma after axillary dissection?
<p>In 2018, the National Cancer Institute of Naples has launched the GLUBREAST Trial to verify the efficacy of cyanoacrylate sealing glue to reduce seroma after axillary dissection in breast surgery. The glue is a synthetic sealant, CE approved for internal human uses and surgical procedures. The assumed mechanism of action in breast surgery is that the glue create a seal coating in the operative field to occlude lymphatic leaks and limit seroma formation. Methods The trial included one hundred-eighty patients scheduled for breast conserving surgery or total mastectomy without reconstruction.Ninety-one were randomized to receive suction drain and sealant glue after axillary dissection (Experimental Arm), whereas eighty-nine patients (Control Arm) received suction drain without glue. Statistics A multivariable mixed effect model on presence of liquid drained and volume drained were calculated. Stratified models by visits were performed. Results The trial ended in June 2022. Older age was associated with a higher volume of seroma drained per day (β 0.30; 95% CI: 0.00‐0.60). 5‐U increase in Body Mass Index was associated with higher daily drained seroma volume in patients underwent breast conserving surgery (β 5.0; 95% CI: 0.62‐9.4), but not in patients underwent<br>mastectomy (β 2.5; 95% CI: ‐3.6‐8.6). We did not find statistically significant differences in presence of liquid drained and volume<br>drained among the study groups. An advantage for the Experimental Arm was observed from 3 th and 4 th to 5 th outpatient<br>visits without reaching a statistical significance (p=0.069 and p=0.072, respectively), so far 5% of patients in the Experimental<br>Group had clinical benefit from the glue.Conclusions. Data in the literature come from case series, and surgeons need higher level<br>of evidence to drive surgical decision-making and choose proper devices to increase patient quality of life. GLUBREAST randomized trial tested the efficacy of cyanoacrylate sealing glue to prevent post-operative seroma in breast surgery. Although only a small number of patients benefited from sealant application, we regret to say this trial has some limitation, i.e. the prolonged presence of suction drain. Further research is warranted to better clarify the benefit of cyanoacrylate glue in breast surgery.</p>
Education With or Without Exercise and Counseling in Preventing Lymphedema in Women With Stage I, Stage II, or Stage III Breast Cancer Who Are Undergoing Axillary Lymph Node Dissection
ClinicalTrials.gov study NCT00376597. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study for Lymphocele and Lymphorrhea Control Following Inguinal and Axillary Radical Lymph Node Dissection
ClinicalTrials.gov study NCT02476357. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Surgical Resection With or Without Axillary Lymph Node Dissection in Treating Women With Node-Negative Breast Cancer and Sentinel Lymph Node Micrometastases
ClinicalTrials.gov study NCT00072293. IPD Sharing: Not stated. Countries: 10. Publications: 2.
Effectivenes of Cyanoacrylate (Glubran 2®) in Reducing Seroma Formation in Breast Cancer Patients Post-Axillary Dissection
ClinicalTrials.gov study NCT02141373. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparison of Axillary Lymph Node Dissection with Axillary Radiation for Patients with Node-Positive Breast Cancer Treated with Chemotherapy
ClinicalTrials.gov study NCT01901094. IPD Sharing: Not stated. Countries: 3. Publications: 3.
Effect of Gentamicin Lavage of the Axillary Surgical Bed After Lymph Node Dissection on Drainage Discharge Volume
ClinicalTrials.gov study NCT01700504. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Selective Axillary Lymph Node Dissection Vs Complete Axillary Dissection: A Randomised Clinical Trial to Assess the Prevention of Lymphedema in Breast Cancer Treatment
ClinicalTrials.gov study NCT03083314. IPD Sharing: NO. Countries: 1. Publications: 7.
Feasibility of Serratus Plane Block Associated With Sedation in Axillary Dissection
ClinicalTrials.gov study NCT03740815. IPD Sharing: UNDECIDED. Countries: 1. Publications: 18.
Targeted Axillary Dissection (TAD) in Early-stage Node Positive Breast Cancer
ClinicalTrials.gov study NCT04671511. IPD Sharing: NO. Countries: 1. Publications: 12.
GF-GS 01: Comparing Conventional Axillary Dissection Versus Sentinel Node Resection in Clinically Node-negative Operable Breast Cancer
ClinicalTrials.gov study NCT00144898. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Anti-adhesive Effect and Safety of a Mixed Solid of Poloxamer, Gelatin and Chitosan(Mediclore®) After Axillary Dissection for Breast Cancer
ClinicalTrials.gov study NCT02967146. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Nodal Burden and Nodal Recurrence in Patients With Isolated Tumor Cells After Neoadjuvant Chemotherapy Treated With Axillary Dissection or Nodal Radiation: the OPBC-05/EUBREAST-14R/ICARO Study
ClinicalTrials.gov study NCT06464341. IPD Sharing: NO. Countries: 18. Publications: 1.
Tailored Axillary Surgery With or Without Axillary Lymph Node Dissection Followed by Radiotherapy in Patients With Clinically Node-positive Breast Cancer (TAXIS)
ClinicalTrials.gov study NCT03513614. IPD Sharing: Not stated. Countries: 13. Publications: 4.
3-Dimensional Conformal Radiation Therapy In Treating Women With Stage I or Stage II Breast Cancer Previously Treated With Lumpectomy and Axillary Node Dissection
ClinicalTrials.gov study NCT00068263. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Comparison of Local Infiltration Analgesia and Pecs Block for Analgesia in Mastectomy With Axillary Dissection - an Equivalence Study
ClinicalTrials.gov study NCT03602794. IPD Sharing: NO. Countries: 1. Publications: 1.
Axillary Reverse Mapping in Preventing Lymphedema in Patients With Breast Cancer Undergoing Axillary Lymph Node Dissection
ClinicalTrials.gov study NCT03927027. IPD Sharing: NO. Countries: 1. Publications: 1.
Comparison of Complete Axillary Lymph Node Dissection With Axillary Radiation Therapy in Treating Women With Invasive Breast Cancer
ClinicalTrials.gov study NCT00014612. IPD Sharing: Not stated. Countries: 8. Publications: 6.
Pasireotide LAR Administration in Lymphocele Prevention After Axillary Node Dissection for Breast Cancer
ClinicalTrials.gov study NCT01356862. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Comparative Study of Erector Spinae Plane Block and Serratus Posterior Superior Intercostal Plane Block on Postoperative Opioid Consumption Following Breast and Axillary Dissection Surgery
ClinicalTrials.gov study NCT06833697. IPD Sharing: YES. Countries: 1. Publications: 3.
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