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10 results for “BA.5”
Omicron sub-lineage BA.5 infection results in attenuated pathology in hACE2 transgenic mice
<p>Omicron recently emerged sub-lineage BA.5, together with BA.4, caused a 5th wave of coronavirus disease (COVID-19) in South Africa and subsequently emerged as a predominant strain globally due to its high transmissibility. The lethality of BA.5 infection has not been studied in acute hACE2 transgenic (hACE2.Tg) mice models. Here, we investigated tissue-tropism and immuno-pathology induced by BA.5 infection in hACE2.Tg mice. Our data show that intranasal BA.5 infection in hACE2.Tg mice result in attenuated pulmonary infection and pathology with diminished COVID-19-induced clinical and pathological manifestations. BA.5, similar to Omicron (B.1.1.529), infection led to attenuated production of inflammatory cytokines, anti-viral response and effector T cell response as compared to the ancestral strain. Mice recovered from B.1.1.529 infection showed robust protection against BA.5 infection with reduced lung viral load and pathology. Our data provide insights as to why BA.5 infection escapes previous SARS-CoV-2 exposure induced-T cell immunity but may result in milder immuno-pathology and alleviated chances of re-infectivity in Omicron-recovered individuals.</p>
Omicron sub-lineage BA.5 infection results in attenuated pathology in hACE2 transgenic mice
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Clinical Trial of COVID-19 Vaccine（SARS-CoV-2 Variant(Omicron BA.5) mRNA Vaccine） in Participants Aged 18 Years and Over
ClinicalTrials.gov study NCT05745545. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Antibody from Single Human VH-rearranging Mouse Potently Neutralizes All SARS-CoV-2 Variants Through BA.5 by Inhibiting Membrane Fusion
GEO Series GSE197255. Mus musculus. 15 samples. Type: Other.
COVID-19 Omicron BA.5 Subvariant Dose Finding Infection Study
ClinicalTrials.gov study NCT06478420. IPD Sharing: NO. Countries: 1. Publications: 0.
A Preliminary Exploratory Cohort Study of SARS-CoV-2 Variant (Omicron BA.5) mRNA Vaccine in Participants Aged 18 Years and Over in China
ClinicalTrials.gov study NCT05550142. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Dose, Safety and Pathogenicity of SARS-CoV-2 (COVID-19) Omicron Virus (BA.5)
ClinicalTrials.gov study NCT06492564. IPD Sharing: NO. Countries: 1. Publications: 0.
Single-cell characteristics of longitudinal immune profiling in subjects with breakthrough infections caused by Omicron BA.5 sublineages
GEO Series GSE248669. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
A Phase Ⅲ Clinical Trial of Recombinant COVID-19 Trivalent (XBB+BA.5+Delta) Protein Vaccine (Sf9 Cell) in Booster Vaccination
ClinicalTrials.gov study NCT05911061. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A Cohort Study of SARS-CoV-2 Variant (Omicron BA.5) mRNA Vaccine in Participants Aged 18 Years and Over in Chinese People
ClinicalTrials.gov study NCT05549206. IPD Sharing: Not stated. Countries: 0. Publications: 0.
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