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34 results for “Bacteroides thetaiotaomicron”
Chemoproteomic identification of a DPP4 homolog in Bacteroides thetaiotaomicron
<p>Serine hydrolases play important roles in signaling and human metabolism, yet little is known about their functions in gut commensal bacteria. Using bioinformatics and chemoproteomics, we identify serine hydrolases in the gut commensal <em>Bacteroides thetaiotaomicron</em> that are specific to the Bacteroidetes phylum. Two are predicted homologs of the human protease dipeptidyl peptidase 4 (hDPP4), a key enzyme that regulates insulin signaling. Functional studies reveal that BT4193 is a true homolog of hDPP4 that can be inhibited by FDA-approved type 2 diabetes medications targeting hDPP4, while the other is a misannotated proline-specific triaminopeptidase. We demonstrate that BT4193 is important for envelope integrity and that loss of BT4193 reduces <em>B. thetaiotaomicron</em> fitness during <em>in vitro</em> growth within a diverse community. However, neither function is dependent on BT4193 proteolytic activity, suggesting a scaffolding or signaling function for this bacterial protease.</p>
Construction and characterization of a genome-scale ordered mutant collection of Bacteroides thetaiotaomicron
<p>Ordered transposon-insertion collections, in which specific transposon-insertion mutants are stored as monocultures in a genome-scale collection, represent a promising tool for genetic dissection of human gut microbiota members. However, publicly available collections are scarce and the construction methodology remains in the early stages of development. This dataset contains the raw data associated with the statistics and figures reported in an accompanying paper which describes the assembly of a genome-scale ordered collection of transposon-insertion mutants in the model gut anaerobe <em>Bacteroides</em> <em>thetaiotaomicron</em> VPI-5482 that we created as a resource for the research community.</p>
Construction and characterization of a genome-scale ordered mutant collection of Bacteroides thetaiotaomicron
Open the record for dataset details and reuse information.
Study of Bacteroides Thetaiotaomicron in Young People Aged 16 to 18 Years With Stable Crohn's Disease
ClinicalTrials.gov study NCT02704728. IPD Sharing: NO. Countries: 1. Publications: 1.
Bacteroides thetaiotaomicron ameliorates colon inflammation in preclinical models of Crohn’s Disease [Bacteroides]
GEO Series GSE118525. Bacteroides thetaiotaomicron VPI-5482. 10 samples. Type: Expression profiling by array.
Bacteroides thetaiotaomicron ameliorates colon inflammation in preclinical models of Crohn’s Disease
GEO Series GSE118526. Mus musculus; Bacteroides thetaiotaomicron VPI-5482. 18 samples. Type: Expression profiling by array.
Effect of Bifidobacterium infantis or its secreted byproducts, Bacteroides thetaiotaomicron or heat-killed B. infantis on human colonic epithelial cells transcriptome
GEO Series GSE233865. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Characterizing the interactions between a naturally-primed IgA (mAb 260.8) and its conserved Bacteroides thetaiotaomicron species-specific epitope in gnotobiotic mice
GEO Series GSE65456. Methanobrevibacter smithii; Lachnospira eligens; Bacteroides thetaiotaomicron; Agathobacter rectalis; Phocaeicola vulgatus; Parabacteroides distasonis. 22 samples. Type: Expression profiling by high throughput sequencing; Expression profiling by array.
An expanded transcriptome atlas for Bacteroides thetaiotaomicron reveals a small RNA that modulates tetracycline sensitivity
GEO Series GSE234958. Bacteroides thetaiotaomicron. 40 samples. Type: Expression profiling by high throughput sequencing.
In vitro transcriptional profiling of Bacteroides thetaiotaomicron in lactose, galactose and human milk oligosaccharides
GEO Series GSE26772. Bacteroides thetaiotaomicron; Bifidobacterium longum. 8 samples. Type: Expression profiling by array; Third-party reanalysis.
Transcriptomic analysis of Bacteroides thetaiotaomicron inositol lipid knockout strains
GEO Series GSE193734. Bacteroides thetaiotaomicron. 8 samples. Type: Expression profiling by high throughput sequencing.
Characterizing the interactions between a naturally-primed IgA and its conserved Bacteroides thetaiotaomicron species-specific epitope in gnotobiotic mice [RNA-Seq]
GEO Series GSE65449. Bacteroides thetaiotaomicron. 10 samples. Type: Expression profiling by high throughput sequencing.
Effect of Bifidobacterium infantis, Bacteroides thetaiotaomicron or heat-killed B. infantis on murine colonic transcriptome
GEO Series GSE233864. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing.
Antibiotic Susceptibility Influenced by Carbon Source in Bacteroides thetaiotaomicron
GEO Series GSE251676. Bacteroides thetaiotaomicron VPI-5482. 64 samples. Type: Expression profiling by high throughput sequencing.
Ruminococcus torques is a keystone degrader of intestinal mucin glycoprotein, releasing oligosaccharides used by Bacteroides thetaiotaomicron
GEO Series GSE262875. [Ruminococcus] torques VIII-239. 6 samples. Type: Expression profiling by high throughput sequencing.
CRISPR-based screening of small RNA modulators of bile susceptibility in Bacteroides thetaiotaomicron
GEO Series GSE235620. Bacteroides thetaiotaomicron. 9 samples. Type: Other.
Analysis of the transcriptome of Bacteroides thetaiotaomicron during growth on complex N-glycan as the sole carbon source
GEO Series GSE129572. Bacteroides thetaiotaomicron VPI-5482. 6 samples. Type: Expression profiling by high throughput sequencing.
Chronic colitis in Bacteroides Thetaiotaomicron-Monoassociated HLA-B27 Transgenic rats alters expression of receptor and metabolic genes in luminal bacteria.
GEO Series GSE34966. Parabacteroides distasonis; Agathobacter rectalis; Phocaeicola vulgatus; Methanobrevibacter smithii; Bacteroides thetaiotaomicron; Lachnospira eligens. 6 samples. Type: Expression profiling by array.
Elucidating BT4338 binding in Bacteroides thetaiotaomicron following 10 minutes of carbon starvation.
GEO Series GSE134116. Bacteroides thetaiotaomicron. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Bacteroides thetaiotaomicron ameliorates colon inflammation in preclinical models of Crohn’s Disease [mouse colon]
GEO Series GSE118524. Mus musculus. 8 samples. Type: Expression profiling by array.
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