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1,051 results for “Bariatric surgery”
VISION Invited lecture - Bariatric surgery and non-alcoholic fatty liver disease
<p>Recording and presentation of the invited lecture that took place online on 16 June 2021 - <strong>Pantelis Antonakis, MD, PhD - Bariatric surgery and non-alcoholic fatty liver disease.</strong></p> <p>Bariatric surgery is a documented solution for morbid obesity. Additionally to excess weight loss, significant improvement in comorbidities is an established benefit after bariatric operations. In recent years, non-alcoholic fatty liver disease (NAFLD) has emerged as one of these comorbidities. Herein we will review the data supporting the positive effect of bariatric surgery in patients with NAFLD.</p>
Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery
ClinicalTrials.gov study NCT07337135. IPD Sharing: NO. Countries: 1. Publications: 0.
Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery
<p>Bariatric surgery is becoming more prevalent as a sustainable weight loss approach, with vertical sleeve gastrectomy (VSG) being the first line of surgical intervention. We and others have shown that obesity exacerbates tumor growth while diet-induced weight loss impairs obesity-driven progression. It remains unknown how bariatric surgery-induced weight loss impacts cancer progression or alters responses to therapy. Using a pre-clinical model of diet induced obesity followed by VSG or diet-induced weight loss, breast cancer progression and immune checkpoint blockade therapy was investigated. Weight loss by bariatric surgery or weight matched dietary intervention before tumor engraftment protected against obesity-exacerbated tumor progression. However, VSG was not as effective as dietary intervention in reducing tumor burden despite achieving similar extent of weight and adiposity loss. Circulating leptin did not associate with changes in tumor burden. Uniquely, tumors in mice that received VSG displayed elevated inflammation and checkpoint ligand PD-L1. Further, mice that received VSG had reduced tumor infiltrating T lymphocytes suggesting an ineffective anti-tumor microenvironment. VSG-associated elevation of PD-L1 prompted us to next investigate the efficacy of immune checkpoint inhibitors in lean, obese, and formerly obese mice that lost weight by VSG or weight matched controls. While obese mice were resistant to immunotherapy, anti-PD-L1 potently impaired tumor progression after VSG through improved anti-tumor immunity. Thus, in formerly obese mice, surgical weight loss followed by immunotherapy reduced breast cancer burden. Further studies are necessary to determine how bariatric surgery sensitizes tumors to immune checkpoint inhibition.</p>
Modulation of the Inflammatory Response in Bariatric Surgery
ClinicalTrials.gov study NCT06915558. IPD Sharing: NO. Countries: 1. Publications: 13.
Investigation of the Effects of Bariatric Surgery on Taste Reward in Humans
ClinicalTrials.gov study NCT01531738. IPD Sharing: NO. Countries: 1. Publications: 1.
Plasma and Tissue Concentration of Cefazolin in Preoperative Prophylaxis in Patients Undergoing Bariatric Surgery
ClinicalTrials.gov study NCT07253805. IPD Sharing: NO. Countries: 1. Publications: 21.
Comparison of Two Magnesium Sulfate Protocols in Opioid-Free Anesthesia for Bariatric Surgery
ClinicalTrials.gov study NCT07077031. IPD Sharing: NO. Countries: 1. Publications: 15.
Apnea, Bariatric Surgery Versus Continuous Positive Airway Pressure (CPAP) Trial
ClinicalTrials.gov study NCT01187771. IPD Sharing: Not stated. Countries: 1. Publications: 2.
The Effect of Liposomal Bupivacaine on Post Operative Pain and Narcotic Use After Bariatric Surgery
ClinicalTrials.gov study NCT03196505. IPD Sharing: NO. Countries: 1. Publications: 1.
Denosumab to Prevent High-Turnover Bone Loss After Bariatric Surgery
ClinicalTrials.gov study NCT04087096. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
The Use of Intraperitoneal Ropivacaine in Bariatric Bypass Surgery
ClinicalTrials.gov study NCT02154763. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
The Effect of Postoperative Incentive Spirometry on Pulmonary Function and Pulmonary Complications in Bariatric Surgery
ClinicalTrials.gov study NCT02431455. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Physical Exercise in Postoperative Bariatric Surgery Patients
ClinicalTrials.gov study NCT04235842. IPD Sharing: NO. Countries: 1. Publications: 29.
Focusing on Body Functionality After Bariatric Surgery
ClinicalTrials.gov study NCT04883268. IPD Sharing: YES. Countries: 1. Publications: 2.
Dexmedetomidine to Treat Bariatric Surgery-associated Pain
ClinicalTrials.gov study NCT02880540. IPD Sharing: UNDECIDED. Countries: 1. Publications: 12.
Pilot Behavioral Support Intervention After Bariatric Surgery
ClinicalTrials.gov study NCT03092479. IPD Sharing: NO. Countries: 1. Publications: 53.
The Medically Reproducing Bariatric Surgery (MRB) II Study
ClinicalTrials.gov study NCT06363747. IPD Sharing: YES. Countries: 1. Publications: 28.
Metabolic Parameters 3 Months, 9 Months, and 2 Years After Bariatric Surgery
ClinicalTrials.gov study NCT00178633. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Effect of Lidocaine-Dexmedetomidine on Pain, Inflammation, and Oxidative Stress After Bariatric Surgery.
ClinicalTrials.gov study NCT07073846. IPD Sharing: YES. Countries: 1. Publications: 30.
Advanced Medical Therapy Versus Advanced Medical Therapy Plus Bariatric Surgery for the Resolution of Type 2 Diabetes
ClinicalTrials.gov study NCT00432809. IPD Sharing: Not stated. Countries: 1. Publications: 12.
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