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ShareScore release 0.9.0
Dataset results
19 results for “Basolateral Amygdala”
Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances learning of cue-reward contingency
<p>The basolateral amygdala (BLA) is critical for associating initially neutral cues with appetitive and aversive stimuli and receives dense neuromodulatory acetylcholine (ACh) projections. We measured BLA ACh signaling and activity of neurons expressing CaMKIIα (a marker for glutamatergic principal cells) in mice during cue-reward learning using a fluorescent ACh sensor and calcium indicators. We found that ACh levels and nucleus basalis of Meynert (NBM) cholinergic terminal activity in the BLA (NBM-BLA) increased sharply in response to reward-related events and shifted as mice learned the cue-reward contingency. BLA CaMKIIα<sup> </sup>neuron activity followed reward retrieval and moved to the reward-predictive cue after task acquisition. Optical stimulation of cholinergic NBM-BLA terminal fibers led to quicker acquisition of the cue-reward contingency. These results indicate BLA ACh signaling carries important information about salient events in cue-reward learning and provides a framework for understanding how ACh signaling contributes to shaping BLA responses to emotional stimuli.</p>
Excitatory synaptic structural abnormalities produced by templated aggregation of α-syn in the basolateral amygdala
<p>Tabular raw data for each graph in the manuscript</p>
Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens
<p>In substance use disorders, drug use as unconditioned stimulus (US) reinforces drug taking. Meanwhile, drug-associated cues (conditioned stimulus, CS) also gain incentive salience to promote drug seeking. The basolateral amygdala (BLA) is implicated in both US- and CS-mediated responses. Here, we show that two genetically distinct BLA neuronal types, expressing Rspo2 versus Ppp1r1b, respectively, project to the nucleus accumbens (NAc) and form monosynaptic connections with both dopamine D1 and D2 receptor-expressing neurons. While intra-NAc stimulation of Rspo2 or Ppp1r1b presynaptic terminals establishes intracranial self-stimulation (ICSS), only Ppp1r1b-stimulated mice exhibit cue-induced ICSS seeking. Furthermore, increasing versus decreasing the Ppp1r1b-to-NAc, but not Rspo2-to-NAc, subprojection increases versus decreases cue-induced cocaine seeking after cocaine withdrawal. Thus, while both BLA-to-NAc subprojections contribute to US-mediated responses, the Ppp1r1b subprojection selectively encodes CS-mediated reward and drug reinforcement. Such differential circuit representations may provide insights into precise understanding and manipulation of drug- versus cue-induced drug seeking and relapse.</p>
Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances learning of cue-reward contingency
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Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens
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Data from: Basolateral amygdala oscillations enable fear learning in a biophysical model
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Comparative basolateral amygdala connectomics reveals dissociable single-neuron projection patterns to frontal cortex in macaques and mice
<p>Zeisler et al., (2024) <em>Current Biology</em></p> <p> </p> <p>This repository contains data and code necessary to generate the main figures contained in the paper.</p> <p> </p> <p>The macaque data used is available at: https://zenodo.org/records/8319819</p>
hCyfip1 overexpression in the basolateral amygdala of mice
GEO Series GSE125697. Mus musculus. 31 samples. Type: Expression profiling by high throughput sequencing.
miRNA expression in male mice in the basolateral amygdala following restraint stress
GEO Series GSE227028. Mus musculus. 8 samples. Type: Non-coding RNA profiling by array.
Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction
GEO Series GSE244860. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
THE EFFECTS OF ALCOHOLISM ON THE HUMAN BASOLATERAL AMYGDALA
GEO Series GSE18212. Homo sapiens. 2 samples. Type: Expression profiling by array.
Activity-dependent transcriptional profiling of basolateral amygdala neurons in response to valence-specific stimuli
GEO Series GSE78137. Mus musculus. 12 samples. Type: Expression profiling by array.
The basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice
GEO Series GSE227159. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNAseq of brian cells in the basolateral amygdala with fear conditioning
GEO Series GSE246147. Mus musculus. 6361 samples. Type: Expression profiling by high throughput sequencing.
Discrete and continuous heterogeneity in the basolateral amygdala
GEO Series GSE148866. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Expression data from the basolateral amygdala of Long-Evans rats with a history of limited intermittent sucrose snacks
GEO Series GSE20344. Rattus norvegicus. 12 samples. Type: Expression profiling by array.
Effect of Isoflurane and LTM on basolateral amygdala
GEO Series GSE1779. Rattus norvegicus. 29 samples. Type: Expression profiling by array.
Transcriptomic profiling of KLB expressing cells in the basolateral amygdala
GEO Series GSE192367. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Ketamine reverses stress-induced behavior by restoring excitatory synapses in the basolateral amygdala-projecting infralimbic prefrontal cortex neurons
<p>Coding and data demo</p>
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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