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70 results for “Basophils”
Basophils as a predictive hematological biomarker of canine visceral leishmaniasis in the treatment with miltefosine
<p><strong>BACKGROUND:</strong> Basophils are initiators of the Th2 response related to the progression of canine visceral leishmaniasis (CanL). Miltefosine has been presented as an alternative in treatment due to its leishmanicide and immunomodulatory effects. Many blood cells have been used as predictive biomarkers, but none of them focused on the immunomodulatory action of miltefosine in the different stages of the disease.</p> <p><strong>OBJECTIVE:</strong> Identifying the predictive hematological biomarkers in dogs with visceral leishmaniasis treated with miltefosine.</p> <p><strong>METHODS:</strong> The animals were divided into three groups: sick dogs; infected dogs, dogs exposed. The animals were submitted to differential blood cell count and CanL diagnosis, through DPP, ELISA and qPCR. The groups were monitored from the time zero (T0) before treatment, and the times twenty (T20) and thirty (T30) days after the beginning of treatment using miltefosine at a dose of 1mL/10kg per day for 28 days.</p> <p><strong>FINDINGS:</strong> Basophils showed an exponential increase in the infected and sick group with an increase of IgG, suggesting a Th2 response. In the exposed group there was reduction of basophils with increase in monocytes and IgG reduction, suggesting a Th1 response.</p> <p><strong>CONCLUSIONS:</strong> We suggest basophils as a predictive biomarker of immunomodulation in the treatment of CanL with miltefosine.</p> <p><strong>BACKGROUND:</strong> Basophils are initiators of the Th2 response related to the progression of canine visceral leishmaniasis (CanL). Miltefosine has been presented as an alternative in treatment due to its leishmanicide and immunomodulatory effects. Many blood cells have been used as predictive biomarkers, but none of them focused on the immunomodulatory action of miltefosine in the different stages of the disease.</p> <p><strong>OBJECTIVE:</strong> Identifying the predictive hematological biomarkers in dogs with visceral leishmaniasis treated with miltefosine.</p> <p><strong>METHODS:</strong> The animals were divided into three groups: sick dogs; infected dogs, dogs exposed. The animals were submitted to differential blood cell count and CanL diagnosis, through DPP, ELISA and qPCR. The groups were monitored from the time zero (T0) before treatment, and the times twenty (T20) and thirty (T30) days after the beginning of treatment using miltefosine at a dose of 1mL/10kg per day for 28 days.</p> <p><strong>FINDINGS:</strong> Basophils showed an exponential increase in the infected and sick group with an increase of IgG, suggesting a Th2 response. In the exposed group there was reduction of basophils with increase in monocytes and IgG reduction, suggesting a Th1 response.</p> <p><strong>CONCLUSIONS:</strong> We suggest basophils as a predictive biomarker of immunomodulation in the treatment of CanL with miltefosine.</p>
Effect of Omalizumab (Xolair) on Basophils in Patients With Chronic Idiopathic Urticaria
ClinicalTrials.gov study NCT01701583. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Basophil Activation Test to Diagnose Food Allergy
ClinicalTrials.gov study NCT03309488. IPD Sharing: Not stated. Countries: 1. Publications: 2.
The Basophil Activation Test For Egg Allergy
ClinicalTrials.gov study NCT06559319. IPD Sharing: Not stated. Countries: 1. Publications: 16.
Basophil Activation Test (BAT) Sensitivity in Child Food Allergy
ClinicalTrials.gov study NCT01966640. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Basophil Activation Test as a Diagnostic Tool in Pediatric Food Allergy
ClinicalTrials.gov study NCT03265262. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Predicting the Clinical Response to Omalizumab With Anti-Immunoglobulin E (IgE) Ab Response or Syk Expression in Basophils
ClinicalTrials.gov study NCT02023151. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Single cell transcriptomics resolves basophil differentiation trajectory and identifies pre-basophils
GEO Series GSE206631. Mus musculus. 52 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiles of IL-3 stimulated bone marrow-derived basophils (BMBAs).
GEO Series GSE206593. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Single-cell RNA-sequence of basophils under homeostatic conditions
GEO Series GSE206589. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
A cell atlas of mouse lung development reveals a signaling role for lung basophils in alveolar macrophage maturation
GEO Series GSE119228. Mus musculus. 180 samples. Type: Expression profiling by high throughput sequencing.
Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition
GEO Series GSE150793. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
E-cadherin marks the early commitment of murine hematopoietic progenitors to the basophil and mast cell fate
GEO Series GSE132122. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Lung function, airway and peripheral basophils and eosinophils are associated with molecular pharmacogenomic endotypes of steroid response in severe asthma.
GEO Series GSE184433. Homo sapiens. 46 samples. Type: Expression profiling by high throughput sequencing.
Bulk RNA-seq analysis of WT and tristetraprolin (TTP)-knockout basophils treated with antigen/IgE stimulation
GEO Series GSE272532. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
A Basophil-Fibroblast Pro-inflammatory Axis Fuels Type 2 Skin Inflammation
GEO Series GSE288255. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic profile of Sialyl-Lewis X (CD15s)+ basophils and Sialyl Lewis X- basophils
GEO Series GSE122281. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional heterogeneity of mast cells and basophils upon activation. [basophils]
GEO Series GSE96694. Mus musculus. 18 samples. Type: Expression profiling by array.
A Basophil-Fibroblast Pro-inflammatory Axis Fuels Type 2 Skin Inflammation [RNA-Seq]
GEO Series GSE288163. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
A Basophil-Fibroblast Pro-inflammatory Axis Fuels Type 2 Skin Inflammation [scRNA-Seq]
GEO Series GSE288250. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
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