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242 results for “Beauty”
Enhanced Biosafety of the Sleeping Beauty Transposon System by Using mRNA as Source of Transposase to Efficiently and Stably Transfect Retinal Pigment Epithelial Cells
<p>Raw data of the publication "Enhanced Biosafety of the Sleeping Beauty Transposon System by Using mRNA as Source of Transposase to Efficiently and Stably Transfect Retinal Pigment Epithelial Cells".</p> <p>Abstract: Neovascular age-related macular degeneration (nvAMD) is characterized by choroidal<br> neovascularization (CNV), which leads to retinal pigment epithelial (RPE) cell and photoreceptor<br> degeneration and blindness if untreated. Since blood vessel growth is mediated by endothelial cell<br> growth factors, including vascular endothelial growth factor (VEGF), treatment consists of repeated,<br> often monthly, intravitreal injections of anti-angiogenic biopharmaceuticals. Frequent injections are<br> costly and present logistic difficulties; therefore, our laboratories are developing a cell-based gene<br> therapy based on autologous RPE cells transfected ex vivo with the pigment epithelium derived factor<br> (PEDF), which is the most potent natural antagonist of VEGF. Gene delivery and long-term expression<br> of the transgene are enabled by the use of the non-viral Sleeping Beauty (SB100X) transposon system<br> that is introduced into the cells by electroporation. The transposase may have a cytotoxic effect and a<br> low risk of remobilization of the transposon if supplied in the form of DNA. Here, we investigated<br> the use of the SB100X transposase delivered as mRNA and showed that ARPE-19 cells as well as<br> primary human RPE cells were successfully transfected with the Venus or the PEDF gene, followed<br> by stable transgene expression. In human RPE cells, secretion of recombinant PEDF could be detected<br> in cell culture up to one year. Non-viral ex vivo transfection using SB100X-mRNA in combination<br> with electroporation increases the biosafety of our gene therapeutic approach to treat nvAMD while<br> ensuring high transfection efficiency and long-term transgene expression in RPE cells.</p>
Research Data Management and Sharing for images: beautiful fountains require ugly piping!
<p>The consensus is clear: research data funded by public resources should be shared. Globally, the advantages of sharing research data are widely recognized. It promotes transparency and validation, reduces redundant efforts, accelerates discovery, enhances equity, and increases the impact of research through collaboration and efficient use of resources.</p> <p>Image data, however, presents unique challenges. Advanced technologies produce large, multimodal, and multiplexed datasets that span multiple targets across various spatiotemporal scales.</p> <p>This image data comes from a range of sources—such as optical, electron microscopy, and medical imaging—each with specific technical requirements. Managing this complexity is a daunting task without global metadata standardization as well as robust Research Data Management and Sharing (RDMS) cyberinfrastructure to bring it all together.</p> <p>The figure illustrates a common issue: while the importance of the <strong>“beautiful fountains”</strong> of scientific discoveries and medical treatments is widely understood, fewer people recognize the <strong>need to invest in building the often ignored “ugly plumbing” </strong>required to build a strong RDMS cyberinfrastructure.</p> <p> </p>
Fig. 7. A–F. Megaxyela langstoni Ross, 1936 in Big and beautiful: the Megaxyela species (Hymenoptera, Xyelidae) of East Asia and North America
Fig. 7. A–F. Megaxyela langstoni Ross, 1936, ♀ (A–C = holotype, DEI-GISHym 30821, INHS; D–F = 30822, USNM). G–K. M. major (Cresson, 1880), ♂, paratype (30823, ANSP). A–B. ♀, holotype, habitus dorsal/lateroventral. C. ♀, holotype, head frontal. D–E. ♀, metatarsus, lateral/ventral. F. ♀, abdomen lateroventral. G–H. Habitus dorsal/lateroventral. I. Head frontal. J–K. Metatarsus lateral/ ventral.
Fig. 10. Megaxyela togashii Shinohara, 1992 in Big and beautiful: the Megaxyela species (Hymenoptera, Xyelidae) of East Asia and North America
Fig. 10. Megaxyela togashii Shinohara, 1992, ♀, holotype, DEI-GISHym 22352 (NSMT); ♂, 22354, (NSMT). A–B. Habitus dorsal/lateroventral (♀). C. Head frontal (♀). D–E. Habitus dorsal/lateroventral (♂). F. Head frontal (♂). G–H. Metatarsus lateral/ventral (♀). I–J. Metatarsus lateral/ventral (♂). Arrows in Fig. 10B and 10F indicate dark spots of abdominal sterna, arrowheads in H and J indicate minute pulvilli.
Fig. 11 in Big and beautiful: the Megaxyela species (Hymenoptera, Xyelidae) of East Asia and North America
Fig. 11. Species of Megaxyela Ashmead, 1898, ovipositor sheaths. A. M. euchroma Blank, Shinohara & Wei sp. nov. (holotype, DEI-GISHym 22554, CSCS). B. M. fulvago Blank, Shinohara & Wei sp. nov. (5752, NSMT). C. M. gigantea Mocsáry, 1909, holotype of M. mikado Sato, 1930 (22350, NSMT). D. M. inversa Blank & D.R. Smith sp. nov., paratype (22356, USNM). E. M. langstoni Ross, 1936, holotype (30821, INHS). F. M. parki Shinohara, 1992 (18510, NSMT). G. M. pulchra Blank, Shinohara & Sundukov sp. nov., holotype (18501, NSMT). H. M. togashii Shinohara, 1992, holotype (22352, NSMT). Images not to the same scale.
Fig. 2 in Big and beautiful: the Megaxyela species (Hymenoptera, Xyelidae) of East Asia and North America
Fig. 2. Phylogenetic hypothesis of Megaxyela Ashmead, 1898, based on a Maximum Likelihood analysis of the barcoding region (COI-5P) applying the the Jukes-Cantor model. Two specimens of Macroxyela ferruginea (Say, 1824) have been included as outgroup. See Material and Methods for details. Bootstrap values above 50 % are shown next to the concerning nodes. The labels of the individual specimens consist of species name, voucher number (for Megaxyela identical with the DEI-GISHym numbers used in the text, for Macroxyela GenBank accession number), sex (♀ for females, ♂ for males) or larva, country and province of origin, and sequence length.
Fig. 3 in Big and beautiful: the Megaxyela species (Hymenoptera, Xyelidae) of East Asia and North America
Fig. 3. Megaxyela euchroma Blank, Shinohara & Wei sp. nov. A–B. Habitus dorsal/lateral (♀, holotype, DEI-GISHym 22554, CSCS). C. Abdomen ventral, arrowheads indicating white stripe along ventral edge of terga (♀, 22511, NSMT). D–E. Habitus dorsal/lateroventral (♂, 22514, NSMT). F–G. Head, obliquely lateral/frontal, arrowheads indicating carina along inner orbit (♂, 22510, NSMT). H–K. Metatarsus, lateroventral (♀, holotype, 22554, CSCS), ventral (♀, 22510, NSMT), tarsomeres 1–2, ventral, arrowheads indicating small pulvilli (♀, 22509, NSMT), lateroventral (♂, 22513, NSMT).
Fig. 13 in Big and beautiful: the Megaxyela species (Hymenoptera, Xyelidae) of East Asia and North America
Fig. 13. Species of Megaxyela Ashmead, 1898, penis valves (A–F) and genitalia capsules (G–I). A. M. euchroma Blank, Shinohara & Wei sp. nov. (DEI-GISHym 22513, NSMT). B. M. fulvago Blank, Shinohara & Wei sp. nov. (5239, NSMT). C. M. gigantea Mocsáry, 1909 (708, NSMT). D. M. parki Shinohara, 1992 (710, NSMT). E. M. pulchra Blank, Shinohara & Sundukov sp. nov. (18503, NSMT). F. M. togashii Shinohara, 1992 (22521, NSMT). G–H. M. gigantea, genitalia capsule in dorsal/ventral view (18507, NSMT). I. M. pulchra sp. nov., genitalia capsule in dorso-posterior view (22349, NSMT). Arrow heads in Fig. 13H–I indicate lobe of upper side of valviceps coiled laterally. Images not to same scale.
Fig. 1. Megaxyela Ashmead, 1898, morphological terminology. A. M in Big and beautiful: the Megaxyela species (Hymenoptera, Xyelidae) of East Asia and North America
Fig. 1. Megaxyela Ashmead, 1898, morphological terminology. A. M. major (Cresson, 1880) (♀, paralectotype, DEI-GISHym 30823, ANSP), wings. B. M. parki Shinohara, 1992 (♀, 18509, NSMT), section of fore wing. C. M. euchroma Blank, Shinohara & Wei sp. nov. (♂, paratype, 22513, NSMT), penis valve. D. M. parki (♂, 710, NSMT), antenna. E. M. gigantea Mocsáry, 1909 (♀, holotype of M. mikado Sato, 1930, 22350, NSMT), ovipositor and ovipositor sheath, with indication of measurement of length of valvifer 2 (blue), valvula 3 (white), and width of valvula 3 (yellow). F. M. euchroma sp. nov. (♀, paratype, 22558, CSCS), section of ovipositor, white arrow heads indicating teeth of ctenidia on valvulae 1 and 2.
Fig. 12 in Big and beautiful: the Megaxyela species (Hymenoptera, Xyelidae) of East Asia and North America
Fig. 12. Species of Megaxyela Ashmead, 1898, ovipositors. A. M. euchroma Blank, Shinohara & Wei sp. nov., paratype, DEI-GISHym 22510 (NSMT). B–C. M. fulvago Blank, Shinohara & Wei sp. nov., paratype (5752, NSMT). C. Complete valvula 2 (incident light) and tip of valvula 2 (insert, transmitted light). D. M. inversa Blank & D.R. Smith sp. nov., paratype (22356, USNM). E. M. gigantea Mocsáry, 1909, holotype of M. mikado Sato, 1930 (22350, NSMT). F. M. parki Shinohara, 1992, paratype (18510, NSMT). G. M. pulchra Blank, Shinohara & Sundukov sp. nov., paratype (22348, NSMT). H. M. togashii Shinohara, 1992 (22353, NSMT). The images in B and H have been flipped horizontally.
Fig. 14 in Big and beautiful: the Megaxyela species (Hymenoptera, Xyelidae) of East Asia and North America
Fig. 14. Distribution of species of Megaxyela Ashmead, 1898 in East Asia. Records of M. togashii Shinohara, 1992 include reliable records published by Shinohara (1992, 2006), Tanaka (1999), Yamada (2000), Naito et al. (2004) and Shinohara et al. (2017). Other distribution data are based on examination of material in course of this work.
Fig. 5 in Big and beautiful: the Megaxyela species (Hymenoptera, Xyelidae) of East Asia and North America
Fig. 5. Megaxyela gigantea Mocsáry, 1909. A–B. Habitus dorsal/lateroventral (♀, holotype of M. mikado, DEI-GISHym 22350, NSMT). C–D. Habitus dorsal/lateroventral (♂, 18507, NSMT). E. Head frontal (♀, holotype of M. mikado, 22350, NSMT). F–G. Metatarsus lateral/ventral (♀, holotype of M. mikado, 22350, NSMT). H. Metatarsus ventral (♂, 18507, NSMT).
Fig. 6. Megaxyela inversa Blank & D.R in Big and beautiful: the Megaxyela species (Hymenoptera, Xyelidae) of East Asia and North America
Fig. 6. Megaxyela inversa Blank & D.R. Smith sp. nov. (♀, paratype, DEI-GISHym 22356, USNM). A. Habitus, lateral; small insertion: original collection labels. B. Antenna. C. Head, frontal, arrowhead indicating carina along inner orbit. D–E. Metatarsus, lateral/lateroventral view. F–G. Wings.
Fig. 4 in Big and beautiful: the Megaxyela species (Hymenoptera, Xyelidae) of East Asia and North America
Fig. 4. Megaxyela fulvago Blank, Shinohara & Wei sp. nov. A. Habitus lateral (♀, DEI-GISHym 5752, NSMT). B. Metatarsus lateral (♀, 5752, NSMT). C–D. Metatarsus lateral/ventral (♂, holotype, 5236, CSCS). E–F. Habitus dorsal/lateroventral (♂, holotype, 5236, CSCS). G. Head frontal (♂, 5239, NSMT).
Fig. 9 in Big and beautiful: the Megaxyela species (Hymenoptera, Xyelidae) of East Asia and North America
Fig. 9. Megaxyela pulchra Blank, Shinohara & Sundukov sp. nov. A–B. Habitus dorsal/lateroventral (♀, holotype, DEI-GISHym 86249, ZIN). C. Abdomen lateroventral, arrowheads indicating black anterolateral spots on sterna (♀, 18504, NSMT). D–E. Habitus dorsal/lateroventral (♂, 22349, NSMT). F. Head frontal (♀, holotype, 86249, ZIN). G–I. Metatarsus ventral (♀, 22346, NSMT), lateral (♀, 22346, NSMT), lateral (♂, 22349, NSMT).
Fig. 8. Megaxyela parki Shinohara, 1992. A–B in Big and beautiful: the Megaxyela species (Hymenoptera, Xyelidae) of East Asia and North America
Fig. 8. Megaxyela parki Shinohara, 1992. A–B. Habitus dorsal/lateroventral (♀, DEI-GISHym 18509, NSMT). C–D. Habitus dorsal/lateroventral (♂, 710, NSMT). E. Head frontal (♂, 710, NSMT). F–G. Metatarsus lateral/ventral, arrowheads indicate pulvilli (♀, 18509, NSMT). H. Metatarsus lateral (♂, 710, NSMT).
Dataset: Ulta Beauty, Inc. (ULTA) Stock Performance
This dataset provides historical stock market performance data for specific companies. It enables users to analyze and understand the past trends and fluctuations in stock prices over time. This information can be utilized for various purposes such as investment analysis, financial research, and market trend forecasting.
Dataset: The Beauty Health Company (SKIN) Stock Performance
This dataset provides historical stock market performance data for specific companies. It enables users to analyze and understand the past trends and fluctuations in stock prices over time. This information can be utilized for various purposes such as investment analysis, financial research, and market trend forecasting.
Fig. 4 in A social beauty: distribution, ecology and conservation of Iris oratoria in the Central Mediterranean Region (Insecta: Mantodea)
Fig. 4 – Comparison of the Extent Of Occurrence (EOO) of the Mediterranen populations of Iris oratoria calculated on scientific records (red polygon) and on records from citizen science (green polygon). Base map: OpenStreetMap.
Fig. 2 in A social beauty: distribution, ecology and conservation of Iris oratoria in the Central Mediterranean Region (Insecta: Mantodea)
Fig. 2 – The strip transect at the Dune di Giovino (southern Italy, Calabria) in a retrodunal area (left) and a sub-adult male of Iris oratoria on Artemisia vulgaris.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.