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Fig. 1 in Comprehensive evaluation of Bletilla striata and its substitutes by combining phenotypic characteristic, chemical composition, and anti-melanogenic activity

Fig. 1. Plant morphological characteristics of B. striata (A1 aerial part, A2 pseudobulb), B. ochracea (B1 aerial part, B2 pseudobulb) and B. formosana (C1 aerial part, C2 pseudobulb).

Fig. 3 in Comprehensive evaluation of Bletilla striata and its substitutes by combining phenotypic characteristic, chemical composition, and anti-melanogenic activity

Fig. 3. UPLC chromatographic fingerprints of 27 Bletillae Rhizoma samples (S1–S27) and the reference fingerprint (R). The peaks marked with 1–19 represent the 19 common peaks.

Fig. 2 in Comprehensive evaluation of Bletilla striata and its substitutes by combining phenotypic characteristic, chemical composition, and anti-melanogenic activity

Fig. 2. Microscopic characteristics of B. striata (A), B. ochracea (B), and B. formosana (C). (1.Epidermal cell 2. Raphid of calcium oxalate 3. Mucilage cell 4. Vessel 5. Fiber 6. Starch granule).

Fig. 9 in Comprehensive evaluation of Bletilla striata and its substitutes by combining phenotypic characteristic, chemical composition, and anti-melanogenic activity

Fig. 9. The docking complex of two compounds with tyrosinase and adenylate cyclase. (A) Coelonin in active pocket site of tyrosinase. (B) Batatasin III in an active pocket site of adenylate cyclase. (C) Coelonin formed 2 hydrogen bonds with the amino acid residues of tyrosinase. (D) Batatasin III formed 2 hydrogen bonds with the amino acid residues of adenylate cyclase.

Fig. 8 in Comprehensive evaluation of Bletilla striata and its substitutes by combining phenotypic characteristic, chemical composition, and anti-melanogenic activity

Fig. 8. Total optical density of melanin(A) and anti-melanogenic effect(B) comparison of Control, Winona, B. striata (SR), B. formosana (FS), and B. ochracea (OS). Values given are the means ± SD (n = 30). *P <0.05, ***P <0.001 versus control group.

Fig. 4 in Comprehensive evaluation of Bletilla striata and its substitutes by combining phenotypic characteristic, chemical composition, and anti-melanogenic activity

Fig. 4. Results of HCA (A) and PLS-DA analysis (B) for 27 batches of Bletillae Rhizoma.

Fig. 6 in Comprehensive evaluation of Bletilla striata and its substitutes by combining phenotypic characteristic, chemical composition, and anti-melanogenic activity

Fig. 6. The variable importance in the projection (VIP) of peak.

Fig. 5 in Comprehensive evaluation of Bletilla striata and its substitutes by combining phenotypic characteristic, chemical composition, and anti-melanogenic activity

Fig. 5. PLS-DA Loading scores plot of three different species of Bletillae Rhizoma.

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Fig. 1 in HPLC-PDA-Guided isolation of glucosyloxybenzyl 2-isobutylmalates from the pseudobulbs of Bletilla striata with neuroprotective and antimicrobial activities

Fig. 1. Structures of compounds 1–12 isolated from the pseudobulbs of Bletilla striata.

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Fig. 3. Key 2D in HPLC-PDA-Guided isolation of glucosyloxybenzyl 2-isobutylmalates from the pseudobulbs of Bletilla striata with neuroprotective and antimicrobial activities

Fig. 3. Key 2D NMR correlations of compound 12.

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Fig. 2. Key 2D in HPLC-PDA-Guided isolation of glucosyloxybenzyl 2-isobutylmalates from the pseudobulbs of Bletilla striata with neuroprotective and antimicrobial activities

Fig. 2. Key 2D NMR correlations of compounds 1, 3, 6, and 8.

Fig. 1 in Phenanthrene, 9,10-dihydrophenanthrene and bibenzyl enantiomers from Bletilla striata with their antineuroinflammatory and cytotoxic activities

Fig. 1. Structures of compounds 1–25.

Fig. 2 in Phenanthrene, 9,10-dihydrophenanthrene and bibenzyl enantiomers from Bletilla striata with their antineuroinflammatory and cytotoxic activities

Fig. 2. Key HMBC (→) and COSY (bold) correlations of compounds 1, 2, 4, 7, 9, 11 and 13.

Fig. 5 in Phenanthrene, 9,10-dihydrophenanthrene and bibenzyl enantiomers from Bletilla striata with their antineuroinflammatory and cytotoxic activities

Fig. 5. Plausible Biogenetic Pathway of Compounds 1–13.

Fig. 3 in Phenanthrene, 9,10-dihydrophenanthrene and bibenzyl enantiomers from Bletilla striata with their antineuroinflammatory and cytotoxic activities

Fig. 3. Key NOESY/ROESY correlations of compounds 1, 2, 4, 7, 9–11, and 13.

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Fig. 7 in Comprehensive evaluation of Bletilla striata and its substitutes by combining phenotypic characteristic, chemical composition, and anti-melanogenic activity

Fig. 7. Anti-melanogenic effects comparison of Control(A),Winona(B), B. striata (C), B. formosana (D), and B. ochracea (E). Values given are the means ±SD (n =30). *P <0.05, ***P <0.001 versus control group.