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253 results for “Bone mineral density”
Supplement to "Endogenous DHEAS is causally linked with lumbar spine bone mineral density and forearm fractures in women - A mendelian randomization study"
<p>Supplemental tables to "Endogenous DHEAS is causally linked with lumbar spine bone mineral density and forearm fractures in women - A mendelian randomization study" by Johan Quester, Maria Nethander, Anna Eriksson and Claes Ohlsson.</p>
New Insights into the Correlation between Bone Mineral Density at Various Sites and Dental Caries: Highlighting the Role of Head Bone Mineral Density
<p> Investigate the relationship between bone mineral density (BMD) at various body sites and dental caries.<br>Materials and methods: Based on the National Health and Nutrition Examination Survey (NHANES) database from 2011-2016, the correlation between BMD at various body sites and the DMFS index among 7044 adults aged 20-59 years was analyzed. Multiple linear regression, restricted cubic splines (RCS), piecewise linear regression, logistic regression, weighted quantile sum regression (WQS) and mediation effects analysis were integrated to explore the relationship between BMD and dental caries.<br>Results: Under the linear assumption, except for arm BMD, the BMDs of all other sites are negatively correlated with the DMFS index of dental caries. RCS analysis indicates a U-shaped relationship between head BMD and the DMFS index (p for nonlinear < 0.0001). WQS analysis indicates that mixed BMD is significantly negatively correlated with the DMFS index for dental caries (estimate, −0.023; 95% CI, −0.025 ~ −0.020), and head BMD has the most significant impact on the DMFS index (weight = 91.4%). Simple mediation analysis of the effect of dental caries on BMD levels mediated by inflammation levels showed negative results, suggesting that dental caries may not influence BMD through inflammation levels.<br>Conclusion: Monitoring BMD should be combined with appropriate oral healthcare and caries management strategies to effectively address these interconnected health issues, and particular attention should be paid to the monitoring of head BMD.</p>
Study to Evaluate the Pharmacokinetics (PK), Pharmacodynamics (PD), and Usability of Abaloparatide-solid Microstructured Transdermal System (sMTS) in Postmenopausal Women With Low Bone Mineral Density
ClinicalTrials.gov study NCT04366726. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Bone Mineral Density in Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Adult Subjects Switching From a Tenofovir Regimen to a Dolutegravir Plus Rilpivirine Regimen
ClinicalTrials.gov study NCT02478632. IPD Sharing: YES. Countries: 6. Publications: 1.
Safety and Effectiveness of Alendronate for Bone Mineral Density in HIV-infected Children and Adolescents
ClinicalTrials.gov study NCT00921557. IPD Sharing: NO. Countries: 3. Publications: 4.
Phase 2 Safety and Efficacy Study of a Vitamin D Compound (DP001) in Postmenopausal Women With Low Bone Mineral Density
ClinicalTrials.gov study NCT00715676. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Effects of Zoledronic Acid and Raloxifene on Bone Turnover Markers in Postmenopausal Women With Low Bone Mineral Density
ClinicalTrials.gov study NCT00431444. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia Survivors
ClinicalTrials.gov study NCT00186901. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Bone Mineral Density Effects of Zoledronate in Postmenopausal Women With Breast Cancer
ClinicalTrials.gov study NCT00213980. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Clinical Trial of a Metal on Poly Component Versus CORAIL Stem: A Bone Mineral Density Study
ClinicalTrials.gov study NCT01558752. IPD Sharing: NO. Countries: 1. Publications: 2.
Fragility fractures and bone mineral density in male patients affected by type 1 and type 2 myotonic dystrophy
<p>Abstract</p> <p>Myotonic dystrophy is a multisystemic disorder affecting skeletal muscle. Male patients have an increased risk of fractures and develop a number of endocrine/metabolic impairments known to adversely affect bone health. The aim of this study was primarily to determine the occurrence of fragility fractures and the bone mineralization status (lumbar spine, hip and total body by dual X-ray absorptiometry) in 36 male patients affected with type 1 myotonic dystrophy and 13 male patients affected with type 2 myotonic dystrophy. Fragility fractures occurred in 15 type 1 and 7 type 2 myotonic dystrophy in non-classical osteoporotic sites, such as metatarses. Hip osteopenia was the most frequent finding, particularly in type 2 (n = 6) than type 1 myotonic dystrophy patients (n = 1), while osteoporosis was rare. Patients with type 1 myotonic dystrophy presented higher total body bone mass density than patients with type 2 myotonic dystrophy and healthy controls and lumbar spine was associated positively with the severity of the disease. Gonadic failure, with low testosterone and reduced INSL3 levels, visceral adiposity and insulin resistance correlated with reduced body mass index in both type 1 and type 2 myotonic dystrophic patients. The independent determinant of fragility fractures were low total body mass index, low blood testosterone and low global muscle mass.</p>
Clinical, biochemical and genetic findings in adult patients with low bone mineral density and chronic hypophosphatasemia
<p>Clinical, biochemical and genetic findings in adult patients with low bone mineral density and chronic hypophosphatasemia</p>
Efficacy of switching from teriparatide to zoledronic acid or denosumab on bone mineral density and bone markers in patients with severe fractured osteoporosis: a real-life study
<p><strong>Abstract</strong></p> <p>Purpose: Osteoporosis is characterized by a loss of bone mass, increased bone fragility and susceptibility to fracture. Sequential treatment with bisphosphonates or denosumab (Dmab) after teriparatide (TPT) discontinuation may represent a valid treatment option, but the optimal sequential treatment strategy is unknown.</p> <p>Methods: This retrospective study enrolled 56 osteopenic/osteoporotic patients with fragility fractures who received 24 months of treatment with TPT followed by 24 months of treatment with zoledronic acid (ZOL) (TPT+ZOL) or Dmab (TPT+Dmab). Clinical features, incident fractures, bone mineral density (BMD) measurements, and bone marker profiles were characterized. Ordinary one-way ANOVA adjusted for multiple testing analyzed the difference between median T-scores at baseline, after 24 months of TPT, and after 2 doses of ZOL or at least 3 doses of Dmab when variables failed the normality test.</p> <p>Results: Twenty-three patients received TPT+ZOL (19 females, 4 males; median [IR] age, 74.3 [66.9, 78.6] years) and 33 patients received TPT+Dmab (31 females, 2 males; mean±SD age, 66.6±11.3 years). Mean lumbar and hip T-scores were significantly higher after sequential treatment with both TPT+ZOL and TPT+Dmab (all p<0.05 vs baseline). In particular, the mean lumbar T-score increased in about 80% of patients by 8.5±58% after ZOL, while after Dmab, the mean lumbar T-score was -9.6±36%. Mean±SD femur neck and hip T-scores increased by 12±13% and 9±31%, respectively, after treatment with ZOL, while the change in femur neck and hip T-scores after Dmab were 5±41% and 27±36%, respectively, No significant between-group differences were identified. Fragility fractures occurred in 3 (13%) patients treated with TPT+ZOL and in 5 (15%) patients treated with TPT+Dmab.</p> <p>Conclusion: Sequential therapy with TPT+ZOL increased bone mineralization at the lumbar level and stabilized bone mineralization at the femoral level. Both ZOL and Dmab are effective sequential treatments after TPT.</p>
Hypercalciuria in postmenopausal women with reduced bone mineral density is associated with different mineral metabolic profiles: effects of treatment with thiazides and anti-resorptives
<pre>Hypercalciuria in postmenopausal women with reduced bone mineral density is associated with different mineral metabolic profiles: effects of treatment with thiazides and anti-resorptives</pre>
Effects of Mometasone Furoate Dry Powder Inhaler, Fluticasone Propionate, and Montelukast on Bone Mineral Density in Asthmatics (Study P03418)
ClinicalTrials.gov study NCT00394355. IPD Sharing: NO. Countries: 0. Publications: 1.
Calcium and High-dose Vitamin D Supplementation on Bone Mineral Density Among HIV-infected Children and Adolescents
ClinicalTrials.gov study NCT02426840. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Bone Mineral Density in Postmenopausal Women With Primary Breast Cancer Who Are Receiving Treatment on Clinical Trial
ClinicalTrials.gov study NCT00354302. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy of Monthly Ibandronate in Women With RA and Reduced Bone Mineral Density Receiving Long-term Steroids
ClinicalTrials.gov study NCT01287533. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Laser Acupuncture on Forearm Bone Mineral Density and Wrist Pain in Osteoporotic Postmenopausal Women
ClinicalTrials.gov study NCT05559619. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Determine the Efficacy, Safety and Tolerability of Denosumab (AMG 162) in the Treatment of Postmenopausal Women With Low Bone Mineral Density
ClinicalTrials.gov study NCT00043186. IPD Sharing: Not stated. Countries: 0. Publications: 5.
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Allen Brain Atlas
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International Brain Laboratory public data
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OpenNeuro
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